JPS57109751A - Novel 4-amino-2,6-dialkylbenzoic acid alkyl ester derivative - Google Patents
Novel 4-amino-2,6-dialkylbenzoic acid alkyl ester derivativeInfo
- Publication number
- JPS57109751A JPS57109751A JP55184089A JP18408980A JPS57109751A JP S57109751 A JPS57109751 A JP S57109751A JP 55184089 A JP55184089 A JP 55184089A JP 18408980 A JP18408980 A JP 18408980A JP S57109751 A JPS57109751 A JP S57109751A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- alkyl ester
- ester derivative
- acid alkyl
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002253 acid Substances 0.000 title 1
- 125000005907 alkyl ester group Chemical group 0.000 title 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000000302 ischemic effect Effects 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- WVBOQYCGIMZUKZ-UHFFFAOYSA-N ethyl 4-amino-2,6-dimethylbenzoate Chemical compound CCOC(=O)C1=C(C)C=C(N)C=C1C WVBOQYCGIMZUKZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
NEW MATERIAL:The benzoic acid alkyl ester derivative of formulaI(R1 and R2 are lower alkyl; R3 is alkyl).
EXAMPLE: 4-Amino-2,6-dimethylbenzoic acid ethyl ester.
USE: Synthetic intermediate of pharmaceuticals. It is useful for example, as a synthetic intermediate of 6-alkoxycarbonyl-5,7-dialkyl-3-phenyl-2(1H)-quinoxalinone derivative useful as a remedy for hypertension, ischemic cardiopathy, and ischemic cerebral vascular lesion.
PROCESS: The compound of formulaIcan be prepared by the decarbonation of the compound of formula II. The reaction is carried out in a solvent such as toluene, pref. in the presence of a catalyst such as copper powder, by heating at 100W200°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55184089A JPS57109751A (en) | 1980-12-26 | 1980-12-26 | Novel 4-amino-2,6-dialkylbenzoic acid alkyl ester derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55184089A JPS57109751A (en) | 1980-12-26 | 1980-12-26 | Novel 4-amino-2,6-dialkylbenzoic acid alkyl ester derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57109751A true JPS57109751A (en) | 1982-07-08 |
Family
ID=16147198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55184089A Pending JPS57109751A (en) | 1980-12-26 | 1980-12-26 | Novel 4-amino-2,6-dialkylbenzoic acid alkyl ester derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57109751A (en) |
-
1980
- 1980-12-26 JP JP55184089A patent/JPS57109751A/en active Pending
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