JPS57126441A - Novel cinnamoylcinnamic acid derivative, manufacture and therapeutical composition containing same - Google Patents
Novel cinnamoylcinnamic acid derivative, manufacture and therapeutical composition containing sameInfo
- Publication number
- JPS57126441A JPS57126441A JP56168921A JP16892181A JPS57126441A JP S57126441 A JPS57126441 A JP S57126441A JP 56168921 A JP56168921 A JP 56168921A JP 16892181 A JP16892181 A JP 16892181A JP S57126441 A JPS57126441 A JP S57126441A
- Authority
- JP
- Japan
- Prior art keywords
- group
- atom
- hydrogen
- lower alkyl
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- QKRFLHKPAVTXOV-UHFFFAOYSA-N 2-benzylidene-3-oxo-5-phenylpent-4-enoic acid Chemical class C=1C=CC=CC=1C=CC(=O)C(C(=O)O)=CC1=CC=CC=C1 QKRFLHKPAVTXOV-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004429 atom Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- HFYXHQBRHCHWAO-UHFFFAOYSA-N 3-[3-(3-phenylprop-2-enoyl)phenyl]prop-2-enoic acid Chemical class OC(=O)C=CC1=CC=CC(C(=O)C=CC=2C=CC=CC=2)=C1 HFYXHQBRHCHWAO-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8022693A FR2492815A1 (fr) | 1980-10-23 | 1980-10-23 | Nouveau derive d'acide cinnamoyl-cinnamique, son procede de preparation et son application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57126441A true JPS57126441A (en) | 1982-08-06 |
Family
ID=9247239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56168921A Pending JPS57126441A (en) | 1980-10-23 | 1981-10-23 | Novel cinnamoylcinnamic acid derivative, manufacture and therapeutical composition containing same |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4421927A (2) |
| EP (1) | EP0051514B1 (2) |
| JP (1) | JPS57126441A (2) |
| KR (1) | KR830007484A (2) |
| AT (1) | ATE5397T1 (2) |
| CS (1) | CS231183B2 (2) |
| DD (1) | DD201773A5 (2) |
| DE (1) | DE3161510D1 (2) |
| ES (1) | ES506471A0 (2) |
| FR (1) | FR2492815A1 (2) |
| GR (1) | GR74679B (2) |
| HU (1) | HU185463B (2) |
| ZA (1) | ZA817275B (2) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6429308A (en) * | 1987-07-02 | 1989-01-31 | Richiyaado Soonfueruto Kaaru | Treatment of hyperhydrosis, psoriasis and wrinkle |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4673687A (en) * | 1983-04-22 | 1987-06-16 | Source Technology Biologicals, Inc. | New chemotherapeutic agents for the control of plant and animal diseases |
| US4544666A (en) * | 1983-04-22 | 1985-10-01 | Phyton/Ag, Inc. | Chemotherapeutic agents for the control of plant diseases |
| SE8400239D0 (sv) * | 1984-01-19 | 1984-01-19 | Pharmacia Ab | Nya arylettiksyraderivat |
| IT1203634B (it) * | 1984-08-13 | 1989-02-15 | Oreal | Derivati 1-sostituiti del 4-metossi-2,3,6-trimetilbenzene loro procedimento di preparazione e composizioni medicamentose e cosmetiche che li contengono |
| IL112205A0 (en) * | 1994-01-06 | 1995-03-15 | Res Dev Foundation | Curcumin, analogues of curcumin and novel uses thereof |
| US5610185A (en) * | 1995-02-17 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the treatment of hyperproliferative epithelial skin diseases by topical application of hydroxylated aromatic protein cross-linking compounds |
| EP0998939A1 (en) * | 1998-09-09 | 2000-05-10 | The School Of Pharmacy, University Of London | Chalcone plant extracts for use in therapy |
| WO2008144933A1 (en) * | 2007-05-29 | 2008-12-04 | Université de Montréal | Cinnamoyl inhibitors of transglutaminase |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3255241A (en) * | 1961-01-19 | 1966-06-07 | Merck & Co Inc | (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids |
| JPS5111748A (en) * | 1974-07-16 | 1976-01-30 | Taisho Pharmaceutical Co Ltd | Suchirubenjudotaino seizoho |
| US4124724A (en) * | 1975-12-08 | 1978-11-07 | Agoro John W | Crystalline caffeic acid derivatives and compositions and method for treating snakebite |
| US4190671A (en) * | 1977-03-17 | 1980-02-26 | Biorex Laboratories Limited | Chalcone derivatives |
| US4163859A (en) * | 1977-07-18 | 1979-08-07 | G. D. Searle & Co. | Phenoxyldialkyl acetic acids and esters |
-
1980
- 1980-10-23 FR FR8022693A patent/FR2492815A1/fr not_active Withdrawn
-
1981
- 1981-10-15 DE DE8181401611T patent/DE3161510D1/de not_active Expired
- 1981-10-15 EP EP81401611A patent/EP0051514B1/fr not_active Expired
- 1981-10-15 AT AT81401611T patent/ATE5397T1/de active
- 1981-10-20 HU HU813054A patent/HU185463B/hu unknown
- 1981-10-20 CS CS817693A patent/CS231183B2/cs unknown
- 1981-10-21 GR GR66317A patent/GR74679B/el unknown
- 1981-10-21 ZA ZA817275A patent/ZA817275B/xx unknown
- 1981-10-22 US US06/314,041 patent/US4421927A/en not_active Expired - Fee Related
- 1981-10-22 ES ES506471A patent/ES506471A0/es active Granted
- 1981-10-23 DD DD81234330A patent/DD201773A5/de unknown
- 1981-10-23 KR KR1019810004026A patent/KR830007484A/ko not_active Withdrawn
- 1981-10-23 JP JP56168921A patent/JPS57126441A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6429308A (en) * | 1987-07-02 | 1989-01-31 | Richiyaado Soonfueruto Kaaru | Treatment of hyperhydrosis, psoriasis and wrinkle |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0051514B1 (fr) | 1983-11-23 |
| KR830007484A (ko) | 1983-10-21 |
| CS231183B2 (en) | 1984-10-15 |
| DD201773A5 (de) | 1983-08-10 |
| DE3161510D1 (en) | 1983-12-29 |
| US4421927A (en) | 1983-12-20 |
| EP0051514A1 (fr) | 1982-05-12 |
| ES8301196A1 (es) | 1982-11-16 |
| HU185463B (en) | 1985-02-28 |
| ZA817275B (en) | 1982-10-27 |
| ES506471A0 (es) | 1982-11-16 |
| ATE5397T1 (de) | 1983-12-15 |
| CS769381A2 (en) | 1984-02-13 |
| GR74679B (2) | 1984-07-03 |
| FR2492815A1 (fr) | 1982-04-30 |
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