JPS57128643A - Freeze-drying method - Google Patents
Freeze-drying methodInfo
- Publication number
- JPS57128643A JPS57128643A JP1257981A JP1257981A JPS57128643A JP S57128643 A JPS57128643 A JP S57128643A JP 1257981 A JP1257981 A JP 1257981A JP 1257981 A JP1257981 A JP 1257981A JP S57128643 A JPS57128643 A JP S57128643A
- Authority
- JP
- Japan
- Prior art keywords
- freeze
- mannitol
- cooling
- drying process
- drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000004108 freeze drying Methods 0.000 title abstract 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 4
- 229930195725 Mannitol Natural products 0.000 abstract 4
- 235000010355 mannitol Nutrition 0.000 abstract 4
- 239000000594 mannitol Substances 0.000 abstract 4
- 238000001816 cooling Methods 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 2
- 238000001704 evaporation Methods 0.000 abstract 2
- 230000008020 evaporation Effects 0.000 abstract 2
- 238000007710 freezing Methods 0.000 abstract 2
- 230000008014 freezing Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 2
- 239000003085 diluting agent Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain a mannitol-containing freeze-dried product useful in the medicinal field, in the form of fine powder having excellent solubility, by carrying out the freezing process of an aqueous solution containing mannitol in the freeze-drying process keeping the rate of the temperature decrease of the material at a specific level.
CONSTITUTION: The freeze-drying of an aqueous solution containing about 1W 10wt% mannitol (based on water) is carried out as follows. The cooling rate of the material in the freezing process is adjusted to ≥1°C/min, pref. 1W10°C/min, more pref. 2W4°C/min (in view of the cost of energy for cooling). The evaporation of water in the drying process is performed at ≤-20°C, and the evaporation conditions are selected to evaporate at least 1% of the whole water content at the initial stage of the drying process. There is no generation of precipitate during the cooling process nor generation of spherulite having a diameter of ≥1mm, and a freeze-dried product containng mannitol as a diluent and useful esp. as an injection can be prepared.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1257981A JPS57128643A (en) | 1981-01-30 | 1981-01-30 | Freeze-drying method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1257981A JPS57128643A (en) | 1981-01-30 | 1981-01-30 | Freeze-drying method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57128643A true JPS57128643A (en) | 1982-08-10 |
| JPH0255410B2 JPH0255410B2 (en) | 1990-11-27 |
Family
ID=11809261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1257981A Granted JPS57128643A (en) | 1981-01-30 | 1981-01-30 | Freeze-drying method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57128643A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104387232A (en) * | 2014-11-11 | 2015-03-04 | 常州大学 | Method for extracting mannose from sea vegetable |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612580A (en) * | 1979-07-13 | 1981-02-06 | Rhythm Watch Co Ltd | Alarm setting device for clock |
-
1981
- 1981-01-30 JP JP1257981A patent/JPS57128643A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612580A (en) * | 1979-07-13 | 1981-02-06 | Rhythm Watch Co Ltd | Alarm setting device for clock |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104387232A (en) * | 2014-11-11 | 2015-03-04 | 常州大学 | Method for extracting mannose from sea vegetable |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0255410B2 (en) | 1990-11-27 |
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