JPS57144221A - Antitumor substance - Google Patents

Antitumor substance

Info

Publication number
JPS57144221A
JPS57144221A JP56029404A JP2940481A JPS57144221A JP S57144221 A JPS57144221 A JP S57144221A JP 56029404 A JP56029404 A JP 56029404A JP 2940481 A JP2940481 A JP 2940481A JP S57144221 A JPS57144221 A JP S57144221A
Authority
JP
Japan
Prior art keywords
cell bodies
gluconobacter
cell
contrifugation
strain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56029404A
Other languages
Japanese (ja)
Inventor
Seiichi Fujiyama
Masahiro Fukaya
Morimasa Hata
Hiroyuki Mizukami
Koki Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nakano Vinegar Co Ltd
Original Assignee
Nakano Vinegar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nakano Vinegar Co Ltd filed Critical Nakano Vinegar Co Ltd
Priority to JP56029404A priority Critical patent/JPS57144221A/en
Publication of JPS57144221A publication Critical patent/JPS57144221A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PURPOSE: An antitumor substance that contains the cell wall fraction of cell bodies of a strain in Gluconobacter as an active ingredient.
CONSTITUTION: A strain of a bacterium in Gluconobacter such as Gluconobacter oxydans IFO-3287 is aerobically cultured at 20W45°C and its cell bodies are collected by centrifugation. These cell bodies are washed with a physiological salt solution to remove components in the culture medium and products formed outside cells to collects its cell bodies, which are crushed by means of, e.g., Dyno-Mill KDL. Then, the crushed product is subjected to low-speed contrifugation to remove uncrushed cell bodies as a precipitate and the upper layer solution is subjected to high-speed contrifugation. After the insoluble substance is separated, it is dispersed in distilled water, placed in a dialysis tube to effect dialysis in 20W50 times volume of distilled water one overnight. Then, the inner dialyzate is freeze dried into a powder to give the cell wall fraction of cell bodies. The objective antitumor agent is prepared by using the product as an active ingredient. Its does to, e.g., a mouse is intraperitoneally 1W200mg/kg and hypodemically 0.5W100mg/kg.
COPYRIGHT: (C)1982,JPO&Japio
JP56029404A 1981-03-03 1981-03-03 Antitumor substance Pending JPS57144221A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56029404A JPS57144221A (en) 1981-03-03 1981-03-03 Antitumor substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56029404A JPS57144221A (en) 1981-03-03 1981-03-03 Antitumor substance

Publications (1)

Publication Number Publication Date
JPS57144221A true JPS57144221A (en) 1982-09-06

Family

ID=12275194

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56029404A Pending JPS57144221A (en) 1981-03-03 1981-03-03 Antitumor substance

Country Status (1)

Country Link
JP (1) JPS57144221A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001097869A (en) * 1999-09-28 2001-04-10 Fuso Pharmaceutical Industries Ltd New antitumor agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001097869A (en) * 1999-09-28 2001-04-10 Fuso Pharmaceutical Industries Ltd New antitumor agent

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