JPS57162702A - Method of giving anticoagulant property to regenerated cellulose - Google Patents
Method of giving anticoagulant property to regenerated celluloseInfo
- Publication number
- JPS57162702A JPS57162702A JP56046287A JP4628781A JPS57162702A JP S57162702 A JPS57162702 A JP S57162702A JP 56046287 A JP56046287 A JP 56046287A JP 4628781 A JP4628781 A JP 4628781A JP S57162702 A JPS57162702 A JP S57162702A
- Authority
- JP
- Japan
- Prior art keywords
- regenerated cellulose
- derivative
- heparin
- giving
- aqueous solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004627 regenerated cellulose Substances 0.000 title abstract 4
- 230000002429 anti-coagulating effect Effects 0.000 title 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 4
- 239000002628 heparin derivative Substances 0.000 abstract 3
- 239000003125 aqueous solvent Substances 0.000 abstract 2
- XMPZTFVPEKAKFH-UHFFFAOYSA-P ceric ammonium nitrate Chemical compound [NH4+].[NH4+].[Ce+4].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O XMPZTFVPEKAKFH-UHFFFAOYSA-P 0.000 abstract 2
- 239000000178 monomer Substances 0.000 abstract 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000012567 medical material Substances 0.000 abstract 1
- 239000012299 nitrogen atmosphere Substances 0.000 abstract 1
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 abstract 1
- 239000003505 polymerization initiator Substances 0.000 abstract 1
- 238000010526 radical polymerization reaction Methods 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Graft Or Block Polymers (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
PURPOSE: A specific heparin derivative, polymerizable vinyl monomers and regenerated cellulose or its derivative are made to react to produce anticoagulant regenerated cellulose used as a medical material of high practical use in low costs.
CONSTITUTION: Heparin derivative is prepared by reaction between heparin and glycidyl acrylate or methacrylate in the presence of a radical polymerization inhibitor in an aqueous solvent. (A) 0.001W0.5pts.wt. of the resultant heparin derivative per 1pt. of water, (B) 0.0001W0.1pts. of at least one of polymerizable monomers such as N-vinylpyrrolidone are made to act on (C) less than 0.06pts. of regenerated cellulose or its derivative, preferably its formed product, in the presence of a polymerization initiator such as ceric ammonium nitrate in an aqueous solvent in a nitrogen atmosphere at the freezing point to 60°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56046287A JPS5941656B2 (en) | 1981-03-31 | 1981-03-31 | Method for imparting anticoagulant properties to regenerated cellulose |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56046287A JPS5941656B2 (en) | 1981-03-31 | 1981-03-31 | Method for imparting anticoagulant properties to regenerated cellulose |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57162702A true JPS57162702A (en) | 1982-10-06 |
| JPS5941656B2 JPS5941656B2 (en) | 1984-10-08 |
Family
ID=12742993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56046287A Expired JPS5941656B2 (en) | 1981-03-31 | 1981-03-31 | Method for imparting anticoagulant properties to regenerated cellulose |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5941656B2 (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3341113A1 (en) * | 1983-11-12 | 1985-05-23 | Akzo Gmbh, 5600 Wuppertal | DIALYSIS MEMBRANE WITH IMPROVED TOLERABILITY |
| DE3410133A1 (en) * | 1984-03-20 | 1985-10-03 | Akzo Gmbh, 5600 Wuppertal | Dialysis membrane made of cellulose with improved biocompatibility |
| US4741927A (en) * | 1984-03-20 | 1988-05-03 | Akzo Nv | Production of cellulose dialysis membrane with improved biocompatibility |
| JPS63102752A (en) * | 1986-09-29 | 1988-05-07 | ジヨンソン・アンド・ジヨンソン・プロダクツ・インコーポレイテツド | Fusion preventing barrier containing heparin and method |
| US4962140A (en) * | 1988-04-28 | 1990-10-09 | Akzo N.V. | Process for producing cellulosic dialysis membranes having improved biocompatibility and device for carrying out the process |
| US5055570A (en) * | 1988-08-04 | 1991-10-08 | Akzo N.V. | Cuprammonium-stable cellulose esters and carbamates for dialysis membranes |
| FR2715934A1 (en) * | 1994-02-09 | 1995-08-11 | Serbio | Antithrombogenic glycosaminoglycan polymeric material for coating a wall in contact with blood, method of preparation and use. |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62148773U (en) * | 1986-03-12 | 1987-09-19 |
-
1981
- 1981-03-31 JP JP56046287A patent/JPS5941656B2/en not_active Expired
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3341113A1 (en) * | 1983-11-12 | 1985-05-23 | Akzo Gmbh, 5600 Wuppertal | DIALYSIS MEMBRANE WITH IMPROVED TOLERABILITY |
| DE3341113C2 (en) * | 1983-11-12 | 1989-05-24 | Akzo Patente Gmbh, 5600 Wuppertal, De | |
| US4882060A (en) * | 1983-11-12 | 1989-11-21 | Akzo Nv | Dialysis membranes with improved compatibility |
| US5035801A (en) * | 1983-11-12 | 1991-07-30 | Akzo Nv | Analysis membranes with improved compatibility |
| DE3410133A1 (en) * | 1984-03-20 | 1985-10-03 | Akzo Gmbh, 5600 Wuppertal | Dialysis membrane made of cellulose with improved biocompatibility |
| US4741927A (en) * | 1984-03-20 | 1988-05-03 | Akzo Nv | Production of cellulose dialysis membrane with improved biocompatibility |
| US4772393A (en) * | 1984-03-20 | 1988-09-20 | Akzo Nv | Cellulose dialysis membrane with improved biocompatibility |
| JPS63102752A (en) * | 1986-09-29 | 1988-05-07 | ジヨンソン・アンド・ジヨンソン・プロダクツ・インコーポレイテツド | Fusion preventing barrier containing heparin and method |
| US4962140A (en) * | 1988-04-28 | 1990-10-09 | Akzo N.V. | Process for producing cellulosic dialysis membranes having improved biocompatibility and device for carrying out the process |
| US5055570A (en) * | 1988-08-04 | 1991-10-08 | Akzo N.V. | Cuprammonium-stable cellulose esters and carbamates for dialysis membranes |
| FR2715934A1 (en) * | 1994-02-09 | 1995-08-11 | Serbio | Antithrombogenic glycosaminoglycan polymeric material for coating a wall in contact with blood, method of preparation and use. |
| WO1995021869A1 (en) * | 1994-02-09 | 1995-08-17 | Serbio | Anticoagulant polymer |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5941656B2 (en) | 1984-10-08 |
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