JPS57200366A - Isoquinoline compound - Google Patents

Isoquinoline compound

Info

Publication number
JPS57200366A
JPS57200366A JP56082559A JP8255981A JPS57200366A JP S57200366 A JPS57200366 A JP S57200366A JP 56082559 A JP56082559 A JP 56082559A JP 8255981 A JP8255981 A JP 8255981A JP S57200366 A JPS57200366 A JP S57200366A
Authority
JP
Japan
Prior art keywords
formulai
remedy
compound
cerebral
isoquinoline compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56082559A
Other languages
Japanese (ja)
Other versions
JPS6361942B2 (en
Inventor
Hiroyoshi Hidaka
Takanori Sone
Taiji Sasaki
Tasuke Sugihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Priority to JP56082559A priority Critical patent/JPS57200366A/en
Priority to US06/357,770 priority patent/US4456757A/en
Priority to DE8282102291T priority patent/DE3261029D1/en
Priority to EP82102291A priority patent/EP0061673B1/en
Publication of JPS57200366A publication Critical patent/JPS57200366A/en
Priority to US06/572,419 priority patent/US4560755A/en
Priority to US06/572,418 priority patent/US4525589A/en
Publication of JPS6361942B2 publication Critical patent/JPS6361942B2/ja
Granted legal-status Critical Current

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  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An isoquinoline compound of formulaI(R1 and R2 are H, lower alkyl or directly link or through O or N to form a heterocyclic ring with the adjacent N) and an acid addition salt thereof.
EXAMPLE: 5-Isoquinolinesulfonamide.
USE: Useful as a vasodilator, ameliorant of the cerebral circulation, remedy for angina pectoris, and preventing agent and remedy for thrombosis in cerebral and cardiovascular systems having powerful relaxing action on smooth muscles and increasing action on the blood stream.
PROCESS: A 5-isoquinolinesulfonyl chloride of formula II is reacted with an amine of formula III, preferably in the presence of an acid acceptor, e.g. sodium bicarbonate or sodium hydroxide, in a solvent, e.g. methanol, to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56082559A 1981-03-20 1981-06-01 Isoquinoline compound Granted JPS57200366A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP56082559A JPS57200366A (en) 1981-06-01 1981-06-01 Isoquinoline compound
US06/357,770 US4456757A (en) 1981-03-20 1982-03-12 Isoquinolinesulfonyl derivatives and process for the preparation thereof
DE8282102291T DE3261029D1 (en) 1981-03-20 1982-03-19 Isoquinolinesulfonyl derivatives and process for the preparation thereof
EP82102291A EP0061673B1 (en) 1981-03-20 1982-03-19 Isoquinolinesulfonyl derivatives and process for the preparation thereof
US06/572,419 US4560755A (en) 1981-03-20 1984-01-20 Isoquinolinesulfonyl derivatives which possess a relaxatory action
US06/572,418 US4525589A (en) 1981-03-20 1984-01-20 Isoquinolinesulfonyl derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56082559A JPS57200366A (en) 1981-06-01 1981-06-01 Isoquinoline compound

Publications (2)

Publication Number Publication Date
JPS57200366A true JPS57200366A (en) 1982-12-08
JPS6361942B2 JPS6361942B2 (en) 1988-11-30

Family

ID=13777844

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56082559A Granted JPS57200366A (en) 1981-03-20 1981-06-01 Isoquinoline compound

Country Status (1)

Country Link
JP (1) JPS57200366A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61227581A (en) * 1985-04-02 1986-10-09 Asahi Chem Ind Co Ltd Isoquinoline derivative bearing sulfone group
WO1998006433A1 (en) 1996-08-12 1998-02-19 Yoshitomi Pharmaceutical Industries, Ltd. MEDICINES COMPRISING Rho KINASE INHIBITOR
WO2000064478A1 (en) 1999-04-27 2000-11-02 Mitsubishi Pharma Corporation Preventives/remedies for liver diseases
JP2006063018A (en) * 2004-08-27 2006-03-09 Asahi Kasei Fainkemu Kk Method for producing isoquinolinesulfonyl chloride
JP2006076932A (en) * 2004-09-10 2006-03-23 Asahi Kasei Fainkemu Kk Method for producing isoquinolinesulfonyl chloride
WO2009004792A1 (en) * 2007-07-02 2009-01-08 Asahi Kasei Pharma Corporation Sulfonamide compound, and crystal thereof
US7618984B2 (en) 2005-08-30 2009-11-17 Asahi Kasei Pharma Corporation Sulfonamide compound
US7964613B2 (en) 2007-02-28 2011-06-21 Asahi Kasei Pharma Corporation Sulfonamide compound
US8415372B2 (en) 2007-02-27 2013-04-09 Asahi Kasei Pharma Corporation Sulfonamide compound

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61227581A (en) * 1985-04-02 1986-10-09 Asahi Chem Ind Co Ltd Isoquinoline derivative bearing sulfone group
CZ301044B6 (en) * 1996-08-12 2009-10-21 Mitsubishi Tanabe Pharma Medicaments comprising Rho kinase inhibiting amide derivatives
WO1998006433A1 (en) 1996-08-12 1998-02-19 Yoshitomi Pharmaceutical Industries, Ltd. MEDICINES COMPRISING Rho KINASE INHIBITOR
WO2000064478A1 (en) 1999-04-27 2000-11-02 Mitsubishi Pharma Corporation Preventives/remedies for liver diseases
JP2006063018A (en) * 2004-08-27 2006-03-09 Asahi Kasei Fainkemu Kk Method for producing isoquinolinesulfonyl chloride
JP2006076932A (en) * 2004-09-10 2006-03-23 Asahi Kasei Fainkemu Kk Method for producing isoquinolinesulfonyl chloride
US7618984B2 (en) 2005-08-30 2009-11-17 Asahi Kasei Pharma Corporation Sulfonamide compound
US8415372B2 (en) 2007-02-27 2013-04-09 Asahi Kasei Pharma Corporation Sulfonamide compound
US7964613B2 (en) 2007-02-28 2011-06-21 Asahi Kasei Pharma Corporation Sulfonamide compound
WO2009004792A1 (en) * 2007-07-02 2009-01-08 Asahi Kasei Pharma Corporation Sulfonamide compound, and crystal thereof
US8232292B2 (en) 2007-07-02 2012-07-31 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof
JP2012236858A (en) * 2007-07-02 2012-12-06 Asahi Kasei Pharma Kk Method for producing sulfonamide compound salt
JP5234825B2 (en) * 2007-07-02 2013-07-10 旭化成ファーマ株式会社 Sulfonamide compounds and crystals thereof
US8664243B2 (en) 2007-07-02 2014-03-04 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof

Also Published As

Publication number Publication date
JPS6361942B2 (en) 1988-11-30

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