JPS5728035A - Preparation of gamma-amino-beta-hydroxybutyric acid - Google Patents

Preparation of gamma-amino-beta-hydroxybutyric acid

Info

Publication number
JPS5728035A
JPS5728035A JP10333180A JP10333180A JPS5728035A JP S5728035 A JPS5728035 A JP S5728035A JP 10333180 A JP10333180 A JP 10333180A JP 10333180 A JP10333180 A JP 10333180A JP S5728035 A JPS5728035 A JP S5728035A
Authority
JP
Japan
Prior art keywords
hydroxybutyric acid
amino
catalyst
acid ester
pref
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10333180A
Other languages
Japanese (ja)
Other versions
JPS5950661B2 (en
Inventor
Iwao Kobayashi
Kyoji Aoki
Mitsukuni Ayabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denka Co Ltd
Original Assignee
Denki Kagaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denki Kagaku Kogyo KK filed Critical Denki Kagaku Kogyo KK
Priority to JP10333180A priority Critical patent/JPS5950661B2/en
Publication of JPS5728035A publication Critical patent/JPS5728035A/en
Publication of JPS5950661B2 publication Critical patent/JPS5950661B2/en
Expired legal-status Critical Current

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as an antiepileptic agent, in high yield, without using highly toxic and expensive hydrocyanic acid compound, by the hydrolysis of a γ-chloro-β-hydroxybutyric acid ester in the presence of a catalyst, followed by amination.
CONSTITUTION: γ-Cholo-β-hydroxybutyric acid ester is hydrolyzed in the presence of an acidic catalyst such as hydrochloric acid, sulfuric acid, etc., or a basic catalyst such as alkali metal, etc., at 0W80°C, and the resulted γ-chloro-β-hydroxybutyric acid or its salt is neutralized. The product is concentrated if necessary, and aminated with an aminating agent (e.g. ammonia, ammonium carbonate, etc.) to obtain the objective compound. The amount of the catalyst is 1W100mol%, pref. 2W 50mol%, based on the γ-amino-β-hydroxybutyric acid ester, and that of the aminating agent is 5W100mol, pref. 20W60mol per 1mol of the γ-amino-β-hydroxybutyric acid.
COPYRIGHT: (C)1982,JPO&Japio
JP10333180A 1980-07-28 1980-07-28 Method for producing γ-amino-β-hydroxybutyric acid Expired JPS5950661B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10333180A JPS5950661B2 (en) 1980-07-28 1980-07-28 Method for producing γ-amino-β-hydroxybutyric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10333180A JPS5950661B2 (en) 1980-07-28 1980-07-28 Method for producing γ-amino-β-hydroxybutyric acid

Publications (2)

Publication Number Publication Date
JPS5728035A true JPS5728035A (en) 1982-02-15
JPS5950661B2 JPS5950661B2 (en) 1984-12-10

Family

ID=14351175

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10333180A Expired JPS5950661B2 (en) 1980-07-28 1980-07-28 Method for producing γ-amino-β-hydroxybutyric acid

Country Status (1)

Country Link
JP (1) JPS5950661B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59118093A (en) * 1982-12-06 1984-07-07 シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア Production of l-carnitine and chemical intermediate used therein
JPH0767674A (en) * 1982-12-06 1995-03-14 Sigma Tau Ind Farmaceut Riunite Spa Optically active γ-substituted β-hydroxybutyric acid derivative

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59118093A (en) * 1982-12-06 1984-07-07 シグマ−タウ・インズストリエ・フアルマチエウチケ・リウニテ・エツセ・ピ・ア Production of l-carnitine and chemical intermediate used therein
JPH0767674A (en) * 1982-12-06 1995-03-14 Sigma Tau Ind Farmaceut Riunite Spa Optically active γ-substituted β-hydroxybutyric acid derivative

Also Published As

Publication number Publication date
JPS5950661B2 (en) 1984-12-10

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