JPS5728073A - Inhibitor for aldose reducing enzyme - Google Patents
Inhibitor for aldose reducing enzymeInfo
- Publication number
- JPS5728073A JPS5728073A JP10471780A JP10471780A JPS5728073A JP S5728073 A JPS5728073 A JP S5728073A JP 10471780 A JP10471780 A JP 10471780A JP 10471780 A JP10471780 A JP 10471780A JP S5728073 A JPS5728073 A JP S5728073A
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- compound
- reducing enzyme
- sorbitol
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- 150000001323 aldoses Chemical class 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000000600 sorbitol Substances 0.000 abstract 2
- 206010007749 Cataract diabetic Diseases 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010029333 Neurosis Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 210000000695 crystalline len Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000007025 diabetic cataract Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 208000015238 neurotic disease Diseases 0.000 abstract 1
- -1 nitro, amino Chemical group 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
- 150000003548 thiazolidines Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
PURPOSE: An inhibitor for aldose reducing enzyme useful for preventing and remedying diabetic cataract, neurosis, retinopathy, etc., comprising a thazolidine derivative.
CONSTITUTION: An inhibitor for aldose reducing enzyme comprising a thiazolidine derivative shown by the formula (R is H, lower alkyl, OH, alkoxy, nitro, amino, lower acylamino, halogen, or CF3). The compound suppresses the reduction from glucose to sorbitol, prevents or reduces the accumulation of sorbitol in the lens, peripheral nervous system, and liver of diabetic patient, and controls complicating diseases. A compound shown by the formula wherein R is H or halogen other than F is a novel compound. A dose per adult is 0.2W1,000mg per day, and the compound is used as 0.001W1wt% solution for instillation.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10471780A JPS5728073A (en) | 1980-07-29 | 1980-07-29 | Inhibitor for aldose reducing enzyme |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10471780A JPS5728073A (en) | 1980-07-29 | 1980-07-29 | Inhibitor for aldose reducing enzyme |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5728073A true JPS5728073A (en) | 1982-02-15 |
| JPH0135831B2 JPH0135831B2 (en) | 1989-07-27 |
Family
ID=14388230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10471780A Granted JPS5728073A (en) | 1980-07-29 | 1980-07-29 | Inhibitor for aldose reducing enzyme |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5728073A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59137474A (en) * | 1983-01-17 | 1984-08-07 | ファイザ−・インコ−ポレ−テッド | 5-(2-alkoxyphenyl)thiazolidindiones inhibiting aldose reductase |
| US4602026A (en) * | 1984-08-03 | 1986-07-22 | Senju Pharmaceutical Co., Ltd. | Ophthalmic topical agent for remedy of diseases of iris and ciliary body |
| US4617312A (en) * | 1983-01-17 | 1986-10-14 | Pfizer Inc. | Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones |
| WO1992014719A1 (en) * | 1991-02-25 | 1992-09-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivative, salt thereof, and production of the same |
| WO1992014730A1 (en) * | 1991-02-25 | 1992-09-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivative, salt thereof, and production thereof |
| WO1997022600A1 (en) * | 1995-12-18 | 1997-06-26 | Kyorin Pharmaceutical Co., Ltd. | N-substituted dioxothiazolidylbenzamide derivatives and process for producing the same |
| JPH10167986A (en) * | 1995-06-20 | 1998-06-23 | Takeda Chem Ind Ltd | Medicine |
-
1980
- 1980-07-29 JP JP10471780A patent/JPS5728073A/en active Granted
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59137474A (en) * | 1983-01-17 | 1984-08-07 | ファイザ−・インコ−ポレ−テッド | 5-(2-alkoxyphenyl)thiazolidindiones inhibiting aldose reductase |
| US4617312A (en) * | 1983-01-17 | 1986-10-14 | Pfizer Inc. | Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones |
| US4602026A (en) * | 1984-08-03 | 1986-07-22 | Senju Pharmaceutical Co., Ltd. | Ophthalmic topical agent for remedy of diseases of iris and ciliary body |
| WO1992014719A1 (en) * | 1991-02-25 | 1992-09-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivative, salt thereof, and production of the same |
| WO1992014730A1 (en) * | 1991-02-25 | 1992-09-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivative, salt thereof, and production thereof |
| US5308856A (en) * | 1991-02-25 | 1994-05-03 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives, salts and preparation processes thereof |
| US5342850A (en) * | 1991-02-25 | 1994-08-30 | Kyorin Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives, their salts and their preparation processes |
| JPH10167986A (en) * | 1995-06-20 | 1998-06-23 | Takeda Chem Ind Ltd | Medicine |
| US7538125B2 (en) | 1995-06-20 | 2009-05-26 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition |
| US7842706B2 (en) | 1995-06-20 | 2010-11-30 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition |
| WO1997022600A1 (en) * | 1995-12-18 | 1997-06-26 | Kyorin Pharmaceutical Co., Ltd. | N-substituted dioxothiazolidylbenzamide derivatives and process for producing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0135831B2 (en) | 1989-07-27 |
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