JPS5735512A - Preventive and remedy for thrombosis - Google Patents

Preventive and remedy for thrombosis

Info

Publication number
JPS5735512A
JPS5735512A JP8807280A JP8807280A JPS5735512A JP S5735512 A JPS5735512 A JP S5735512A JP 8807280 A JP8807280 A JP 8807280A JP 8807280 A JP8807280 A JP 8807280A JP S5735512 A JPS5735512 A JP S5735512A
Authority
JP
Japan
Prior art keywords
remedy
thrombosis
preventive
long period
active component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8807280A
Other languages
Japanese (ja)
Other versions
JPH0141604B2 (en
Inventor
Chikayuki Naito
Jun Kawai
Yoshiaki Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOF Corp
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Nippon Oil and Fats Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Nippon Oil and Fats Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP8807280A priority Critical patent/JPS5735512A/en
Priority to PCT/JP1981/000148 priority patent/WO1982000095A1/en
Priority to DE19813152174 priority patent/DE3152174A1/en
Priority to GB8204905A priority patent/GB2090529B/en
Publication of JPS5735512A publication Critical patent/JPS5735512A/en
Publication of JPH0141604B2 publication Critical patent/JPH0141604B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To provide a preventive and remedy for thrombosis, capable of inhibiting the coagulation of blood platelet and dissolving the coagulated blood platelet, by using (all-Z)-4,7,10,13,16,19-docosahexanoic acid, etc. as active component.
CONSTITUTION: A preventive and remedy for thrombosis, having excellent for the prevention and remedy of deep phlebothrombosis, etc., and cardiac infarction, etc. caused thereby, can be obtained by using a compound selected from (all-Z)-4,7,10, 13,16,19-docosahexanoic acid, its pharmacologically permissible salt, ester, and amide as an active component. As the compound can be easily absorbed through the intestines, is orally administrable, and is stable in blood, it keeps the effect for a long period. Furthermore, it can be taken in a relatively high dose for a long period, without getting too fat by the excessive caloric intake. The above acid can be separated from aquatic animals by conventional process.
COPYRIGHT: (C)1982,JPO&Japio
JP8807280A 1980-06-27 1980-06-27 Preventive and remedy for thrombosis Granted JPS5735512A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP8807280A JPS5735512A (en) 1980-06-27 1980-06-27 Preventive and remedy for thrombosis
PCT/JP1981/000148 WO1982000095A1 (en) 1980-06-27 1981-06-27 Thrombosis-prophylatic and curing agent
DE19813152174 DE3152174A1 (en) 1980-06-27 1981-06-27 THROMBOSIS-PROPHYLATIC AND CURING AGENT
GB8204905A GB2090529B (en) 1980-06-27 1981-06-27 Thrombosis-prophylactic and curing agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8807280A JPS5735512A (en) 1980-06-27 1980-06-27 Preventive and remedy for thrombosis

Publications (2)

Publication Number Publication Date
JPS5735512A true JPS5735512A (en) 1982-02-26
JPH0141604B2 JPH0141604B2 (en) 1989-09-06

Family

ID=13932644

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8807280A Granted JPS5735512A (en) 1980-06-27 1980-06-27 Preventive and remedy for thrombosis

Country Status (3)

Country Link
JP (1) JPS5735512A (en)
GB (1) GB2090529B (en)
WO (1) WO1982000095A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60237017A (en) * 1984-05-09 1985-11-25 Nippon Light Metal Co Ltd fat infusion
JPS60248610A (en) * 1984-05-23 1985-12-09 Nitsusui Seiyaku Kk Preventive and remedy for complicated diabetes
JPH0249723A (en) * 1988-04-18 1990-02-20 Taiyo Fishery Co Ltd Encephalon function improving composition, learning ability enhancing agent, memory enhancing agent, preventive and remedy for dementia or functional food having encephalon function improving effect

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3307244A1 (en) * 1982-08-06 1984-02-16 Theodor 6450 Hanau Splithoff Carrier preferably for holding a sign
US4607052A (en) * 1983-04-15 1986-08-19 Roussel-Uclaf Triglycerides, dietetic and therapeutical applications and compositions containing them
US4701469A (en) * 1983-04-15 1987-10-20 Roussel Uclaf Triglycerides, process for therapeutical applications and compositions containing them
GB8603621D0 (en) * 1986-02-14 1986-03-19 Habib N Modifying lipid structure of cell membranes
DE3615710A1 (en) * 1986-05-09 1987-11-26 Hoechst Ag PREPARATIONS FOR THE SYNTHESIS OF PROSTAGLANDINES AND HYDROXY FATTY ACIDS IN BIOLOGICAL SYSTEMS
GB8729751D0 (en) * 1987-12-21 1988-02-03 Norsk Hydro As Feed additive & feed containing such additive
GB2218904A (en) * 1988-05-27 1989-11-29 Renafield Limited Pharmaceutical composition based on high-concentration esters of docosahexaenoic acid
GB2218984B (en) * 1988-05-27 1992-09-23 Renafield Limited Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses
GB8819110D0 (en) * 1988-08-11 1988-09-14 Norsk Hydro As Antihypertensive drug & method for production
GB2223943A (en) * 1988-10-21 1990-04-25 Tillotts Pharma Ag Oral disage forms of omega-3 polyunsaturated acids
FR2643637B1 (en) * 1989-02-27 1991-09-20 Natura Medica Laboratoires CALCIUM ION COMPLEX WITH AT LEAST ONE UNSATURATED FATTY ACID, BIOMEDIATING AGENT COMPRISING SUCH A COMPLEX, PHARMACEUTICAL COMPOSITION INCORPORATING SAME AND PLANT OR ORGAN EXTRACTS CONTAINING THE SAME
ITMI20010129A1 (en) 2001-01-25 2002-07-25 Pharmacia & Upjohn Spa ESSENTIAL FATTY ACIDS IN THE THERAPY OF HEART INSUFFICIENCY AND HEART FAILURE
GB0403247D0 (en) 2004-02-13 2004-03-17 Tillotts Pharma Ag A pharmaceutical composition
RS57777B1 (en) 2012-01-06 2018-12-31 Omthera Pharmaceuticals Inc Dpa-enriched compositions of omega-3 polyunsaturated fatty acids in free acid form
EP2846779A4 (en) 2012-05-07 2015-12-16 Omthera Pharmaceuticals Inc Compositions of statins and omega-3 fatty acids
CN104958725A (en) * 2015-07-05 2015-10-07 四川金堂海纳生物医药技术研究所 Oral administration medicament for treating venous thrombosis and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU527784B2 (en) * 1978-05-26 1983-03-24 Bang, Hans Olaf Dr. Treatment of thromboembolic conditions withall-z)-5, 8, 11, 14, 17-eicosapentaenoic acid
ZA784083B (en) * 1978-05-26 1980-02-27 Wellcome Found Fatty acid and derivatives thereof,and formulations containing them for use in treatment or prophyllaxis of thrombo-embolic conditions

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60237017A (en) * 1984-05-09 1985-11-25 Nippon Light Metal Co Ltd fat infusion
JPS60248610A (en) * 1984-05-23 1985-12-09 Nitsusui Seiyaku Kk Preventive and remedy for complicated diabetes
JPH0249723A (en) * 1988-04-18 1990-02-20 Taiyo Fishery Co Ltd Encephalon function improving composition, learning ability enhancing agent, memory enhancing agent, preventive and remedy for dementia or functional food having encephalon function improving effect

Also Published As

Publication number Publication date
GB2090529A (en) 1982-07-14
GB2090529B (en) 1985-04-24
WO1982000095A1 (en) 1982-01-21
JPH0141604B2 (en) 1989-09-06

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