JPS5750896A - Preparation of antibiotic substance saframycin s - Google Patents
Preparation of antibiotic substance saframycin sInfo
- Publication number
- JPS5750896A JPS5750896A JP12545680A JP12545680A JPS5750896A JP S5750896 A JPS5750896 A JP S5750896A JP 12545680 A JP12545680 A JP 12545680A JP 12545680 A JP12545680 A JP 12545680A JP S5750896 A JPS5750896 A JP S5750896A
- Authority
- JP
- Japan
- Prior art keywords
- saframycin
- extracted
- liquid medium
- solution
- antibiotic substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930190585 Saframycin Natural products 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 241000187389 Streptomyces lavendulae Species 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 235000013372 meat Nutrition 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To obtain the titled antibiotic substance from the cultured product, by culturing Streptomyces lavendulae No.314.
CONSTITUTION: Streptomyces lavendulae No.314 is cultured in a liquid medium containing glucose, maltose, starch, etc. as carbon sources, meat extract, urea, etc. as nitrogen sources, and metal salts, etc. by submerged technique. After the completion of the cultivation, the liquid medium is filtered, the filtrate is mixed with 10N sodium hydroxide solution, the solvent phase is concentrated and dried under reduced pressure and dissolved in ethyl acetate, the solution is shaken with an aqueous solution of sodium carbonate, the mixture is settled, and the solvent layer is extracted with hydrochloric acid. The aqueous phase is made basic, and extracted with chloroform. The above steps are repeated to obtain the component containing saframycin complex.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12545680A JPS5750896A (en) | 1980-09-10 | 1980-09-10 | Preparation of antibiotic substance saframycin s |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12545680A JPS5750896A (en) | 1980-09-10 | 1980-09-10 | Preparation of antibiotic substance saframycin s |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5750896A true JPS5750896A (en) | 1982-03-25 |
Family
ID=14910541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12545680A Pending JPS5750896A (en) | 1980-09-10 | 1980-09-10 | Preparation of antibiotic substance saframycin s |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5750896A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6809099B2 (en) | 2000-11-03 | 2004-10-26 | President And Fellows Of Harvard College | Saframycins, analogues and uses thereof |
| US7183054B2 (en) | 2003-06-03 | 2007-02-27 | President And Fellows Of Harvard College | Assay for identifying biological targets of polynucleotide-binding compounds |
-
1980
- 1980-09-10 JP JP12545680A patent/JPS5750896A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6809099B2 (en) | 2000-11-03 | 2004-10-26 | President And Fellows Of Harvard College | Saframycins, analogues and uses thereof |
| US7122549B2 (en) | 2000-11-03 | 2006-10-17 | President And Fellows Of Harvard College | Saframycins, analogues and uses thereof |
| US7183054B2 (en) | 2003-06-03 | 2007-02-27 | President And Fellows Of Harvard College | Assay for identifying biological targets of polynucleotide-binding compounds |
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