JPS5754166A - 88azaa16 166jifuruorupurosutanoido - Google Patents

88azaa16 166jifuruorupurosutanoido

Info

Publication number
JPS5754166A
JPS5754166A JP56124205A JP12420581A JPS5754166A JP S5754166 A JPS5754166 A JP S5754166A JP 56124205 A JP56124205 A JP 56124205A JP 12420581 A JP12420581 A JP 12420581A JP S5754166 A JPS5754166 A JP S5754166A
Authority
JP
Japan
Prior art keywords
88azaa16
stereo
active
prostanoids
aza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56124205A
Other languages
English (en)
Inventor
Meriru Sukuraibunaa Richaado
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of JPS5754166A publication Critical patent/JPS5754166A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
JP56124205A 1980-08-11 1981-08-10 88azaa16 166jifuruorupurosutanoido Pending JPS5754166A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/176,784 US4320136A (en) 1980-08-11 1980-08-11 8-Aza-16,16-difluoroprostanoids

Publications (1)

Publication Number Publication Date
JPS5754166A true JPS5754166A (en) 1982-03-31

Family

ID=22645804

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56124205A Pending JPS5754166A (en) 1980-08-11 1981-08-10 88azaa16 166jifuruorupurosutanoido

Country Status (7)

Country Link
US (1) US4320136A (ja)
EP (1) EP0046082B1 (ja)
JP (1) JPS5754166A (ja)
AT (1) ATE13667T1 (ja)
CA (1) CA1161447A (ja)
DE (1) DE3170838D1 (ja)
DK (1) DK352281A (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024647A1 (en) * 2000-09-21 2002-03-28 Ono Pharmaceutical Co., Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
JP2012111767A (ja) * 2001-07-23 2012-06-14 Ono Pharmaceut Co Ltd Ｅｐ４アゴニストを有効成分とする骨量低下疾患の治療剤

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4530933A (en) * 1982-12-27 1985-07-23 E. I. Du Pont De Nemours And Company 8-Aza-13-thiaprostanoids and a method of use thereof as anti-ulcer agents
US4456613A (en) * 1982-12-27 1984-06-26 E. I. Du Pont De Nemours And Company 6-Keto- and 6-hydroxy-8-azaprostanoids and anti-ulcer use thereof
NZ525164A (en) * 2000-11-27 2005-04-29 Pfizer Prod Inc EP4 receptor selective agonists in the treatment of osteoporosis
EP1408961B1 (en) * 2001-07-16 2007-07-11 F. Hoffmann-La Roche Ag 2 pyrrolidone derivatives as prostanoid agonists
ES2254726T3 (es) 2001-07-16 2006-06-16 F. Hoffmann-La Roche Ag Analogos de prostaglandina como agonistas receptores de ep4.
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
BRPI0406717A (pt) * 2003-01-10 2005-12-20 Hoffmann La Roche Composto, composição farmacêutica que compreende o mesmo, método de tratamento de uma enfermidade em um mamìfero, utilização do composto e processo para a sua produção
US7179820B2 (en) * 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
US20080058375A1 (en) * 2004-01-08 2008-03-06 Elworthy Todd R 2-Piperidone derivatives as prostaglandin antagonists
CA2738045C (en) * 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
HUE031885T2 (en) 2012-07-19 2017-08-28 Cayman Chemical Co Inc Difluoro lactam preparations for EP4-mediated osteo-related diseases and conditions
WO2014144500A2 (en) 2013-03-15 2014-09-18 Cayman Chemical Company, Inc. Methods of synthesizing a difluorolactam analog
US9676712B2 (en) 2013-03-15 2017-06-13 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
ES2635635T3 (es) 2013-03-15 2017-10-04 Cayman Chemical Company, Incorporated Compuestos de difluorolactama como agonistas selectivos del receptor EP4 para su uso en el tratamiento de enfermedades y afecciones mediadas por EP4
KR20160048054A (ko) 2013-07-19 2016-05-03 카이맨 케미칼 컴파니 인코포레이티드 골 성장의 촉진을 위한 방법, 시스템 및 조성물
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
US10400000B2 (en) 2015-06-12 2019-09-03 Simon Fraser University Amide-linked EP4 agonist-bisphosphonate compounds and uses thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873566A (en) * 1973-02-28 1975-03-25 Du Pont 3-Pyrazolidinones and pyrazolidines
US3974189A (en) * 1973-07-20 1976-08-10 The Upjohn Company 16-Fluoro prostaglandin E2 analogs
US3962293A (en) * 1973-07-20 1976-06-08 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin F1
US3969376A (en) * 1973-07-20 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin E1 analogs
US3974191A (en) * 1973-07-20 1976-08-10 The Upjohn Company 16-Fluoro prostaglandin F1 analogs
US3974192A (en) * 1973-07-20 1976-08-10 The Upjohn Company 16-Fluoro prostaglandin B1 analogs
US3974190A (en) * 1973-07-20 1976-08-10 The Upjohn Company 16-Fluoro prostaglandin A1 analogs
US3974193A (en) * 1973-07-20 1976-08-10 The Upjohn Company 16-Fluoro prostaglandin B2 analogs
US3969378A (en) * 1973-07-20 1976-07-13 The Upjohn Company 16-Fluoro prostaglandin A2 analogs
US4187381A (en) * 1973-08-06 1980-02-05 Hoffmann-La Roche Inc. 16-Substituted prostaglandins
US4017534A (en) * 1974-06-03 1977-04-12 American Cyanamid Company 16-Fluoro-11-deoxy-13-dihydro-prostaglandin
US3975399A (en) * 1974-08-06 1976-08-17 E. I. Du Pont De Nemours And Company 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones
US3969381A (en) * 1975-02-21 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin B1 analogs
US3969379A (en) * 1975-02-21 1976-07-13 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin A1 analogs
US3969380A (en) * 1975-02-21 1976-07-13 The Upjohn Company 16-Fluoro prostaglandin F2 analogs
US3969377A (en) * 1975-02-21 1976-07-13 The Upjohn Company 16-Fluoro prostaglandin E1 analogs
US4113873A (en) * 1975-04-26 1978-09-12 Tanabe Seiyaku Co. Ltd. 8-azaprostanoic acid derivatives
US4003911A (en) * 1975-09-26 1977-01-18 E. I. Du Pont De Nemours And Company Selected 3-pyrrolidinones and 2,4-pyrrolidindiones
US4032533A (en) * 1976-02-19 1977-06-28 E. I. Du Pont De Nemours And Company 3,4-disubstituted-1,3,4-thiadiazoline-2,5-diones
IL49325A (en) * 1976-03-31 1979-11-30 Labaz 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them
DE2619638A1 (de) 1976-05-04 1977-11-17 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung
US4177346A (en) * 1976-08-06 1979-12-04 Pfizer Inc. 1,5-Disubstituted-2-pyrrolidones
US4211876A (en) * 1979-06-13 1980-07-08 E. I. Du Pont De Nemours And Company 3-Pyrazolidinone carboxamides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024647A1 (en) * 2000-09-21 2002-03-28 Ono Pharmaceutical Co., Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
JP2012111767A (ja) * 2001-07-23 2012-06-14 Ono Pharmaceut Co Ltd Ｅｐ４アゴニストを有効成分とする骨量低下疾患の治療剤

Also Published As

Publication number Publication date
CA1161447A (en) 1984-01-31
EP0046082A2 (en) 1982-02-17
DK352281A (da) 1982-02-12
EP0046082B1 (en) 1985-06-05
EP0046082A3 (en) 1982-03-03
DE3170838D1 (en) 1985-07-11
ATE13667T1 (de) 1985-06-15
US4320136A (en) 1982-03-16

Similar Documents

Publication Publication Date Title
DE3170838D1 (en) 8-aza-16,16-difluoroprostanoids
GR3005168T3 (ja)
ES8203375A1 (es) Procedimiento de preparar triazoloquinoxalin-4-onas substi- tuidas antihipertensoras
AU564189B2 (en) 2 substituted phenyl 4, 5, 6, 7 tetrahydro-2h-isoindole- 13 diones
AU1615983A (en) Bipolar membrane
JPS579745A (en) Manufacture of low nitrosamine quantity n-di-n-propyl-2,6-dinitro-4-trifluoromethylaniline
MY102059A (en) Naphthoxazines
ES8801647A1 (es) Un procedimiento para la preparacion de piridazinilimidazolidinonas
SU1269296A1 (ru) Гербицидный состав
ZA837270B (en) 2-amino-3,5-dicyano-6-(substituted)pyrazine antimicrobial compounds
SU1184129A1 (ru) Центробежно-вакуумный пеногаситель
TR22871A (tr) Birden fazla aktif bilesen ihtiva eden piretroid terkipleri
SU1083739A1 (ru) Стокс-калибратор
BG42351A3 (bg) Средство за регулиране растежа на растения
SU1091783A1 (ru) Биполярный транзистор
SU1124506A1 (ru) Рабочая среда для электроэрозионной обработки
SU908198A1 (ru) Тиристор
SU1269688A1 (ru) Источник ионов
SU1042321A1 (ru) 6-ФЕНАЦИЛИДЕН-5-ОКСО-4,5,6,7-ТЕТРАГИДРОФУРАЗАНО [3,4-b]ПИРАЗИН, ПРОЯВЛЯЮЩИЙ ТРАНКВИЛИЗИРУЮЩУЮ АКТИВНОСТЬ
SU1112747A1 (ru) 2-диаллиламино-6-фенил-1,3-оксазин-4-он, проявляющий анальгетическую активность
SU1120886A1 (ru) P-i-n-ДИОД
SU1102116A2 (ru) Реакционная камера
SU1271275A1 (ru) Матричный автоэлектронный катод
SU858490A1 (ru) Полупроводниковый диод
SU1096943A1 (ru) Способ получения многополюсных магнитов