JPS5767584A - Thiazolo(3,2-a)pyrimidine derivative, its preparation, and drug containing the same - Google Patents

Thiazolo(3,2-a)pyrimidine derivative, its preparation, and drug containing the same

Info

Publication number
JPS5767584A
JPS5767584A JP55142869A JP14286980A JPS5767584A JP S5767584 A JPS5767584 A JP S5767584A JP 55142869 A JP55142869 A JP 55142869A JP 14286980 A JP14286980 A JP 14286980A JP S5767584 A JPS5767584 A JP S5767584A
Authority
JP
Japan
Prior art keywords
thiazolo
preparation
same
drug containing
pyrimidine derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55142869A
Other languages
Japanese (ja)
Inventor
Kiyoshi Sakauchi
Takeshi Yu
Takeo Oba
Toshio Tanaka
Noriaki Okamura
Kenzo Watanabe
Seiji Kurozumi
Tatsuyuki Naritomo
Keiji Komoriya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP55142869A priority Critical patent/JPS5767584A/en
Priority to EP81108283A priority patent/EP0049902A3/en
Priority to US06/311,329 priority patent/US4421914A/en
Publication of JPS5767584A publication Critical patent/JPS5767584A/en
Pending legal-status Critical Current

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The compound of formulaI(R is H, halogen, lower alkyl or lower alkyloxy).
EXAMPLE: 6-p-Chloroanilino-5-H-2,3,6,8-tetrahydro-5,7-dioxothiazolo[3,2-a]pyridine.
USE: Immunoregulating agent. It has immunoregulating activity and is extremely useful for the remedy, etc. of autoimmune diseases such as nephritis, rheumatic arthritis, etc., or malignant tumors.
PROCESS: The compound of formulaIis prepared by the condensation cyclization reaction of the malonic acid derivative of formula II (R1 and R2 are lower alkyl) with 2-aminothiazoline in an alcohol in the presence of an alkali metal alkoxide usually at 40W150°C for 30minW72hr.
COPYRIGHT: (C)1982,JPO&Japio
JP55142869A 1980-10-15 1980-10-15 Thiazolo(3,2-a)pyrimidine derivative, its preparation, and drug containing the same Pending JPS5767584A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP55142869A JPS5767584A (en) 1980-10-15 1980-10-15 Thiazolo(3,2-a)pyrimidine derivative, its preparation, and drug containing the same
EP81108283A EP0049902A3 (en) 1980-10-15 1981-10-13 Novel thiazolo(3,2-a)pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof
US06/311,329 US4421914A (en) 1980-10-15 1981-10-14 Thiazolo[3,2-a]pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55142869A JPS5767584A (en) 1980-10-15 1980-10-15 Thiazolo(3,2-a)pyrimidine derivative, its preparation, and drug containing the same

Publications (1)

Publication Number Publication Date
JPS5767584A true JPS5767584A (en) 1982-04-24

Family

ID=15325486

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55142869A Pending JPS5767584A (en) 1980-10-15 1980-10-15 Thiazolo(3,2-a)pyrimidine derivative, its preparation, and drug containing the same

Country Status (1)

Country Link
JP (1) JPS5767584A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5826891A (en) * 1981-08-10 1983-02-17 Teijin Ltd Thiazolo(3,2-a)pyrimidine derivative and its preparation
JPS58110595A (en) * 1981-12-25 1983-07-01 Teijin Ltd Novel thiazolo(3,2-a)pyrimidines, their derivatives, their preparation, and immunoregulator containing said compound as active component

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5826891A (en) * 1981-08-10 1983-02-17 Teijin Ltd Thiazolo(3,2-a)pyrimidine derivative and its preparation
JPS58110595A (en) * 1981-12-25 1983-07-01 Teijin Ltd Novel thiazolo(3,2-a)pyrimidines, their derivatives, their preparation, and immunoregulator containing said compound as active component

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