JPS577557A - Fine particle for agglutination - Google Patents

Fine particle for agglutination

Info

Publication number
JPS577557A
JPS577557A JP8090780A JP8090780A JPS577557A JP S577557 A JPS577557 A JP S577557A JP 8090780 A JP8090780 A JP 8090780A JP 8090780 A JP8090780 A JP 8090780A JP S577557 A JPS577557 A JP S577557A
Authority
JP
Japan
Prior art keywords
fine particles
agglutination
conkurchinine
body fluid
covalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8090780A
Other languages
Japanese (ja)
Other versions
JPS6363864B2 (en
Inventor
Shuntaro Hosaka
Takashi Uchida
Yasuo Murao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP8090780A priority Critical patent/JPS577557A/en
Publication of JPS577557A publication Critical patent/JPS577557A/en
Publication of JPS6363864B2 publication Critical patent/JPS6363864B2/ja
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PURPOSE:To obtain fine particles for agglutination, used for the measurement of the immune composite bodies in a body fluid, which are sensitive and excellent both in maintaining a constant quality and in the preservation stability, by fixing conkurchinine to individually separated fine particles whose particle sizes are within a specified range by means of a physical absorption or chemical bonding. CONSTITUTION:Conkurchinine is physically absorved or chemically bonded to a hydrophobic macromolecular compound, the erythrocyte of an animal which has been treated with formalin and moreover treated with tanic acid or the like, and fine particle carriers of a hydrophilic insoluble substance or the like which has a functional group capable of chemically bonding conkurchinine by means of covalent or ionic bonding. As said fine particles, fine particles of average particle size 0.01- 20mu and individually separated are used. Specially, the fine particles covalent-bonded to a hydrophilic macromolecular compound hardly cause a nonspecific agglutination. The dispersion of sid fine particles and a body fluid are reacted with each other to measure the settling image resulting from an agglutination. Thereby, the measurement of the immune composite bodies in the body fluid is readily performed with high sensitivity.
JP8090780A 1980-06-17 1980-06-17 Fine particle for agglutination Granted JPS577557A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8090780A JPS577557A (en) 1980-06-17 1980-06-17 Fine particle for agglutination

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8090780A JPS577557A (en) 1980-06-17 1980-06-17 Fine particle for agglutination

Publications (2)

Publication Number Publication Date
JPS577557A true JPS577557A (en) 1982-01-14
JPS6363864B2 JPS6363864B2 (en) 1988-12-08

Family

ID=13731442

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8090780A Granted JPS577557A (en) 1980-06-17 1980-06-17 Fine particle for agglutination

Country Status (1)

Country Link
JP (1) JPS577557A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4530900A (en) * 1982-09-13 1985-07-23 Seragen Diagnostics Inc. Soluble insoluble polymers in enzymeimmunoassay
WO1995006254A1 (en) * 1993-08-24 1995-03-02 Applied Immune Sciences, Inc. Site-specific covalent attachment of conglutinin to solid phase materials and related methods
EP0767377A1 (en) * 1995-10-04 1997-04-09 Dr. Fooke Laboratorien GmbH Diagnosis of pneumococcal infection by measurement of antigen specific immune complexes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLIN.EXP.LMMUNOL=1979 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4530900A (en) * 1982-09-13 1985-07-23 Seragen Diagnostics Inc. Soluble insoluble polymers in enzymeimmunoassay
WO1995006254A1 (en) * 1993-08-24 1995-03-02 Applied Immune Sciences, Inc. Site-specific covalent attachment of conglutinin to solid phase materials and related methods
EP0767377A1 (en) * 1995-10-04 1997-04-09 Dr. Fooke Laboratorien GmbH Diagnosis of pneumococcal infection by measurement of antigen specific immune complexes

Also Published As

Publication number Publication date
JPS6363864B2 (en) 1988-12-08

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