JPS5777651A - Indane derivative and its preparation - Google Patents

Indane derivative and its preparation

Info

Publication number
JPS5777651A
JPS5777651A JP55154394A JP15439480A JPS5777651A JP S5777651 A JPS5777651 A JP S5777651A JP 55154394 A JP55154394 A JP 55154394A JP 15439480 A JP15439480 A JP 15439480A JP S5777651 A JPS5777651 A JP S5777651A
Authority
JP
Japan
Prior art keywords
compound
formulai
lower alkyl
reducing conditions
indane derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55154394A
Other languages
Japanese (ja)
Other versions
JPS6212800B2 (en
Inventor
Yoshikazu Oka
Kohei Nishikawa
Akio Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP55154394A priority Critical patent/JPS5777651A/en
Priority to AU76521/81A priority patent/AU543804B2/en
Priority to US06/312,639 priority patent/US4822818A/en
Priority to ZA817253A priority patent/ZA817253B/en
Priority to IE2471/81A priority patent/IE51918B1/en
Priority to DE8181304940T priority patent/DE3165862D1/en
Priority to GB8131719A priority patent/GB2086393B/en
Priority to EP81304940A priority patent/EP0051391B1/en
Priority to AT81304940T priority patent/ATE9220T1/en
Priority to PH26409A priority patent/PH18357A/en
Priority to FI813383A priority patent/FI73698C/en
Priority to SU813350151A priority patent/SU1271372A3/en
Priority to GR66380A priority patent/GR75368B/el
Priority to KR1019810004142A priority patent/KR880000890B1/en
Priority to DK478181A priority patent/DK164917C/en
Priority to HU813176A priority patent/HU183652B/en
Priority to NO813662A priority patent/NO155133C/en
Priority to CA000389042A priority patent/CA1287444C/en
Priority to MX7586A priority patent/MX154997A/en
Priority to IL64168A priority patent/IL64168A0/en
Priority to ES506714A priority patent/ES506714A0/en
Priority to PT73912A priority patent/PT73912B/en
Priority to NZ198826A priority patent/NZ198826A/en
Publication of JPS5777651A publication Critical patent/JPS5777651A/en
Priority to ES515269A priority patent/ES8401445A1/en
Priority to US06/494,061 priority patent/US4474692A/en
Priority to ES524148A priority patent/ES8504671A1/en
Priority to PH29829A priority patent/PH21390A/en
Priority to CA000468185A priority patent/CA1287446C/en
Priority to MY500/85A priority patent/MY8500500A/en
Priority to NO862859A priority patent/NO157103C/en
Priority to KR1019860009085A priority patent/KR880001007B1/en
Priority to HK198/87A priority patent/HK19887A/en
Publication of JPS6212800B2 publication Critical patent/JPS6212800B2/ja
Priority to MX661087A priority patent/MX6610A/en
Priority to US07/302,940 priority patent/US5098892A/en
Granted legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:An indane derivative of formulaI(R1 and R3 are H or lower alkyl; R2 is H, lower alkyl or lower aralkyl) or a salt thereof.
EXAMPLE: N-(1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl-N-(2-indanyl)glycine hydrochloride.
USE: Useful as a diagnostic agent, preventing agent or remedy for hypertension, having inhibitory action on antiotensin converting enzymes and on bradykinin hydrolytic enzymes (kininase) with low toxicity and improved stability, and easily absorbable even by the oral administration.
PROCESS: A compound of formula II is condensed with a compound of formula III under reducing conditions to give the compound of formulaI. The reduction or electrolytic reduction with a metallic hydride compound may be cited as the reducing conditions. The reaction is carried out usually in the presence of water or an organic solvent, preferably at -20W+100°C.
COPYRIGHT: (C)1982,JPO&Japio
JP55154394A 1980-10-31 1980-10-31 Indane derivative and its preparation Granted JPS5777651A (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
JP55154394A JPS5777651A (en) 1980-10-31 1980-10-31 Indane derivative and its preparation
AU76521/81A AU543804B2 (en) 1980-10-31 1981-10-16 Amides having bicyclic substituents on nitrogen
US06/312,639 US4822818A (en) 1980-10-31 1981-10-19 Bicycle compounds, their production and use
ZA817253A ZA817253B (en) 1980-10-31 1981-10-20 Bicyclic compounds,their production and use
IE2471/81A IE51918B1 (en) 1980-10-31 1981-10-21 Bicyclic compounds their production and use
DE8181304940T DE3165862D1 (en) 1980-10-31 1981-10-21 Bicyclic compounds, their production and use
GB8131719A GB2086393B (en) 1980-10-31 1981-10-21 Bicyclic compounds
EP81304940A EP0051391B1 (en) 1980-10-31 1981-10-21 Bicyclic compounds, their production and use
AT81304940T ATE9220T1 (en) 1980-10-31 1981-10-21 BICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE.
PH26409A PH18357A (en) 1980-10-31 1981-10-28 Bicyclic compounds,their production and use
FI813383A FI73698C (en) 1980-10-31 1981-10-28 Process for the preparation of novel pharmaceutically active N-indanylg lycin derivatives.
CA000389042A CA1287444C (en) 1980-10-31 1981-10-29 Bicyclic compounds, their production and use
MX7586A MX154997A (en) 1980-10-31 1981-10-29 PROCEDURE TO PREPARE BICYCLE COMPOUNDS
KR1019810004142A KR880000890B1 (en) 1980-10-31 1981-10-29 Process for preparing bicyclic compound
DK478181A DK164917C (en) 1980-10-31 1981-10-29 ANALOGY PROCEDURE FOR THE PREPARATION OF BICYCLICALLY SUBSTITUTED DIPEPTIDE DERIVATIVES AND THEIR PHARMACEUTICAL ACCEPTABLE SALTS
HU813176A HU183652B (en) 1980-10-31 1981-10-29 Process for preparing bicyclic compounds
NO813662A NO155133C (en) 1980-10-31 1981-10-29 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE DICYCLIC RELATIONS.
SU813350151A SU1271372A3 (en) 1980-10-31 1981-10-29 Method of producing bicyclic combination or pharmaceutically acceptable salts thereof
GR66380A GR75368B (en) 1980-10-31 1981-10-29
IL64168A IL64168A0 (en) 1980-10-31 1981-10-30 Carboxamidoindan and naphthalene derivatives,their production and pharmaceutical compositions containing them
ES506714A ES506714A0 (en) 1980-10-31 1981-10-30 A PROCEDURE FOR OBTAINING BICYCLE COMPOUNDS
PT73912A PT73912B (en) 1980-10-31 1981-10-30 Bicyclic compounds their production and use
NZ198826A NZ198826A (en) 1980-10-31 1981-10-30 Bicyclic compounds and pharmaceutical compositions
ES515269A ES8401445A1 (en) 1980-10-31 1982-08-26 Bicyclic compounds, their production and use.
US06/494,061 US4474692A (en) 1980-10-31 1983-05-12 L-Alanyl-N-(indan-2-yl)glycine, its esters and salts thereof
ES524148A ES8504671A1 (en) 1980-10-31 1983-07-15 Bicyclic compounds, their production and use.
PH29829A PH21390A (en) 1980-10-31 1983-10-12 Process for producing l-alanyl-n-(indian-2-yl)glycine derivatives
CA000468185A CA1287446C (en) 1980-10-31 1984-11-19 Bicyclic compounds, their production and use
MY500/85A MY8500500A (en) 1980-10-31 1985-12-30 Bicyclic compounds their production and use
NO862859A NO157103C (en) 1980-10-31 1986-07-15 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE DICYCLIC COMPOUNDS.
KR1019860009085A KR880001007B1 (en) 1980-10-31 1986-10-29 Method for producing acyclic compound
HK198/87A HK19887A (en) 1980-10-31 1987-03-05 Bicyclic compounds their production and use
MX661087A MX6610A (en) 1980-10-31 1987-05-22 BICYCLE COMPOUNDS AND PROCEDURE FOR ITS PREPARATION
US07/302,940 US5098892A (en) 1980-10-31 1989-01-30 Process for preparation of bicyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55154394A JPS5777651A (en) 1980-10-31 1980-10-31 Indane derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5777651A true JPS5777651A (en) 1982-05-15
JPS6212800B2 JPS6212800B2 (en) 1987-03-20

Family

ID=15583174

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55154394A Granted JPS5777651A (en) 1980-10-31 1980-10-31 Indane derivative and its preparation

Country Status (4)

Country Link
JP (1) JPS5777651A (en)
MX (1) MX6610A (en)
SU (1) SU1271372A3 (en)
ZA (1) ZA817253B (en)

Also Published As

Publication number Publication date
ZA817253B (en) 1982-09-29
JPS6212800B2 (en) 1987-03-20
SU1271372A3 (en) 1986-11-15
MX6610A (en) 1993-11-01

Similar Documents

Publication Publication Date Title
KR890700601A (en) Peptidylaminodiol
ATE87473T1 (en) MEDICATIONS FOR INHIBITION OF SKIN fold.
IE823069L (en) Cyclic octapeptides
JPS5697266A (en) Proline derivative and its preparation
JPS57118563A (en) Indole derivative and preparation of peptide
JPS5716852A (en) Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same
JPS57192340A (en) Isoprenylamine derivative
JPS57123157A (en) Indane derivative and its preparation
JPS57206657A (en) Sulfamoylbenzoic acid derivative and remedying composition containing said derivative as active component
JPS56104883A (en) Novel pyridinecarboxamide derivative and its preparation
JPS55151555A (en) Proline derivatives and their production
JPS55133343A (en) Thiopronine derivative
JPS5718680A (en) Indole derivative
JPS57169464A (en) Tetrahydroisoquinoline derivative and its preparation
ES8400397A1 (en) New peptide, process for preparation thereof and use thereof.
JPS56158753A (en) Kyotorphin derivative
JPS57193437A (en) Amino acid derivative
JPS5777652A (en) Preparation of peptide and arginine derivative
JPS5412369A (en) Preparation of thienylacetic acid
JPS57122041A (en) Phenylclohexane derivative
JPS57183757A (en) 5-oxopyrrolidine derivative, antiulcer comprising it as active ingredient, and its preparation
JPS57203050A (en) Alicyclic compound and its preparation
EP0273732A3 (en) Streptovaricin c derivatives as anti-aids virus agents
JPS57116035A (en) Novel benzylideneaminocarboxylic acid derivative and its preparation
JPS5758694A (en) Monobenzylphosphorylalanylproline and hypotensive comprising it