JPS58155352U - DNA synthesis equipment - Google Patents
DNA synthesis equipmentInfo
- Publication number
- JPS58155352U JPS58155352U JP5247182U JP5247182U JPS58155352U JP S58155352 U JPS58155352 U JP S58155352U JP 5247182 U JP5247182 U JP 5247182U JP 5247182 U JP5247182 U JP 5247182U JP S58155352 U JPS58155352 U JP S58155352U
- Authority
- JP
- Japan
- Prior art keywords
- side block
- communication hole
- rotating
- reactors
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
第１図はこの考案のＤＮＡ等合成装置の一実施例である
ＤＮＡ自動合成装置の構成説明図、第２図は複流路切換
パルプ機構の一具体例の斜視図、第３図Ａは第２図に示
す複流路切換バルブ機構の縦断面図、第３図ＢおよびＣ
はそれぞれ第２図に示す複流路切換バルブ機構の固定側
ブロックおよび回転側ブロックをそれぞれ第２図におけ
る左側から見た図、第４図は第１図に示す装置の動作の
フローチャート図、第５図は複流路切換バルブ機構の他
の具体例の第３図相当図である。
１・・・・・・ＤＮＡ自動合成装置、２Ａ、 ２Ｂ、
２Ｇ・・・・・・反応器、１２・・・・・・窒素ガ
ス供給流路切換手段、１３・・・・・・洗浄用溶媒等供
給用複流路切換バルブ機構、１３′・・・・・・ヌクレ
オチド試薬溶液等供給用複流路切換バルブ機構、１７．
１７’・・・・・・固定側ブロック、１８．１８’・・
・・・・回転側ブロック、１９ａ 〜１９ｆ、 １９
ａ’ 〜１９ｆ’ −−−−−一連通孔、２０ａ〜２
ＱＣ，２０ａ’ 〜２ ＱＣ’ −−−−−一連通孔。Fig. 1 is an explanatory diagram of the configuration of an automatic DNA synthesizer which is an embodiment of the DNA synthesis apparatus of this invention, Fig. 2 is a perspective view of a specific example of a double flow path switching pulp mechanism, and Fig. 3A is a Longitudinal cross-sectional view of the dual flow path switching valve mechanism shown in the figure, Figures 3B and C
are views of the stationary side block and rotating side block of the dual flow path switching valve mechanism shown in FIG. 2, respectively, viewed from the left side in FIG. 2, FIG. 4 is a flowchart of the operation of the device shown in FIG. 1, and FIG. The figure is a diagram corresponding to FIG. 3 of another specific example of the dual flow path switching valve mechanism. 1... Automatic DNA synthesizer, 2A, 2B,
2G...Reactor, 12...Nitrogen gas supply channel switching means, 13...Double channel switching valve mechanism for supplying cleaning solvent, etc., 13'... ...Dual flow path switching valve mechanism for supplying nucleotide reagent solutions, etc., 17.
17'...Fixed side block, 18.18'...
...Rotating side block, 19a to 19f, 19
a' ~ 19f' ----- Series of holes, 20a ~ 2
QC, 20a' to 2 QC' -------Series of holes.
Claims (1)
液等が所定の手順で反応器に供給されてＤＮＡ等の合成
を行う装置において、 （ａ） Ｍ個の連通孔が同一円周上に角度αの間隔で
穿設された固定側ブロックと、Ｎ個の連通孔が同一円周
上に角度βの間隔で穿設された回転側ブロックとからな
り、前記Ｍ、αＩ Ｎｌβの間に、 Ｏ＜Ｍ×α≦３６０度 ０〈Ｎ×β≦３６０度 斎−ｘＫ＝β Ｋ、Ｈの倍数を除く自然数なる関係であ
り、かつ前記回転側ブロックを前記固定側ブロックに対
して回転摺動させることによって前記固定側ブロックの
任意の連通孔と前記回転側ブロックの任意の連通孔とを
切換連結しうる複流路切換バルブ機構、および（ｂ）
複数の反応器 を具備し、前記固定側ブロックまたは前記回転側ブロッ
クのいずれか一方の連通孔に複数の試薬溶液等の供給流
路が接続され、他方の連通孔に前記複数の反応器が接続
され、これにより複数の反応器において多種類のＤＮＡ
等の合成を可能にしたことを特徴とするＤＮＡ等合成装
置。[Scope of Claim for Utility Model Registration] In an apparatus in which a reagent solution, etc. supply means is connected to a reactor, and a plurality of reagent solutions, etc. are supplied to the reactor in a predetermined procedure to synthesize DNA, etc., (a) M number of reagent solutions, etc. consisting of a stationary side block in which N communication holes are bored at intervals of an angle α on the same circumference, and a rotating side block in which N communication holes are bored in the same circumference at intervals of an angle β, The relationship between M and αI Nlβ is O<M×α≦360 degrees 0<N×β≦360 degrees - xK=β K, a natural number excluding multiples of H, and the rotating side block is (b) a dual flow path switching valve mechanism capable of switching and connecting any communication hole of the fixed side block and any communication hole of the rotating side block by rotating and sliding with respect to the stationary side block; and (b)
A plurality of reactors are provided, and a plurality of supply channels for reagent solutions, etc. are connected to a communication hole of either the stationary side block or the rotation side block, and the plurality of reactors are connected to the communication hole of the other side. This allows multiple types of DNA to be processed in multiple reactors.
A device for synthesizing DNA, etc., characterized in that it is capable of synthesizing, etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5247182U JPS58155352U (en) | 1982-04-10 | 1982-04-10 | DNA synthesis equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5247182U JPS58155352U (en) | 1982-04-10 | 1982-04-10 | DNA synthesis equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58155352U true JPS58155352U (en) | 1983-10-17 |
| JPS6118014Y2 JPS6118014Y2 (en) | 1986-06-02 |
Family
ID=30063182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5247182U Granted JPS58155352U (en) | 1982-04-10 | 1982-04-10 | DNA synthesis equipment |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58155352U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59172500A (en) * | 1983-01-20 | 1984-09-29 | ゲゼルシャフト・フユア・ビオテクノロギッシエ・フオルシュンク・ミット・ベシュレンクテル・ハフツング | Continuous synthesis of some oligonucleotides on solid phase |
-
1982
- 1982-04-10 JP JP5247182U patent/JPS58155352U/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59172500A (en) * | 1983-01-20 | 1984-09-29 | ゲゼルシャフト・フユア・ビオテクノロギッシエ・フオルシュンク・ミット・ベシュレンクテル・ハフツング | Continuous synthesis of some oligonucleotides on solid phase |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6118014Y2 (en) | 1986-06-02 |
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