JPS582923B2 - toothpaste composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a toothpaste composition containing calcium sulfate as an abrasive and an anionic surfactant as a foaming agent.

It has been known to use calcium sulfate as an abrasive for toothpaste, but calcium sulfate has 10 times the solubility in water compared to general abrasives for toothpaste such as dicalcium phosphate, calcium carbonate, and aluminum hydroxide. Since the above is also large, there is a problem that the divalent ions Ca2+ combine with the surfactant to produce an insoluble salt and deactivate the surfactant.

On the other hand, surfactants are blended into toothpaste compositions in order to improve the cleaning action and make oral cleaning more effective.
Stable formulation due to good emulsifying and dispersing properties, toxicity, taste, odor, irritation to oral mucosa, and compatibility with other ingredients.
Because it must be sufficiently resistant to economic stability, influence on viscosity index, and corrosion of tube containers, SDS (sodium dodecyl sulfate), AO
Anionic surfactants such as S (α-olefin sulfonate) are widely used.

However, these anionic activators have the problem that they become water-insoluble salts due to the presence of divalent ions such as Ca2+, and their functionality is greatly reduced. In toothpaste containing calcium sulfate, the active agent is deactivated and the feeling of use becomes very poor.

This is also clear from the test results of the foam height of the anionic surfactant in calcium phosphate water mixing system A and calcium sulfate water mixing system B shown in FIG.

That is, Figure 1 shows the following formulation of propylene glycol.
4 parts by weight Glycerin 17 〃 Sonolevit 18 〃 Satukarin 0.5 〃 Water
57.5 SDS
3. A water preparation system obtained by blending 2% by weight of each of calcium phosphate and calcium sulfate with respect to the composition (therefore, both calcium phosphate and calcium sulfate exist in a supersaturated state in each water preparation system.

), the degree of foaming was investigated using the Ross-Miles method at predetermined intervals, and the results shown in Figure 1 (foam height after 5 minutes) indicate that the foaming power of calcium sulfate systems is approximately half that of calcium phosphate systems. or lower, indicating poor stability over time.

In addition, in toothpaste containing calcium sulfate, the effectiveness of the foaming agent is suppressed due to the relatively high solubility of calcium sulfate, which results in poor dispersibility in the oral cavity and poor usability. It has various problems such as poor shape retention and stability such as liquid separation after long-term storage.Therefore, there is a strong demand for solving the above-mentioned drawbacks of conventional toothpaste compositions containing calcium sulfate. It had been.

The inventors of the present invention have conducted various studies in view of the above circumstances, and have found that soluble ammonium salts such as diammonium hydrogen phosphate, ammonium sulfate, ammonium acetate, ammonium chloride, and ammonium nitrate are blended with calcium sulfate as an abrasive and as a foaming agent. It acts specifically on toothpaste compositions containing anionic surfactants, increasing the foaming effect and providing foaming power greater than that of conventional toothpastes containing calcium phosphate. The present invention was made based on the discovery that the solubility of anionic activators can be improved and increased to enhance the effect of suppressing precipitation at low temperatures. It has foam quality, and has good dispersibility and water solubility of the anionic active agent in the oral cavity, and has an excellent feeling of use, as well as good fluidity at low temperatures, low temperature stability, and stability over time. It is an object of the present invention to provide a toothpaste composition having excellent properties and good quality.

That is, the present invention provides a toothpaste composition characterized in that a soluble ammonium salt is blended into a toothpaste composition containing calcium sulfate as an abrasive and an anionic surfactant as a foaming agent.

The present invention will be explained in detail below.

In the present invention, the calcium sulfate used as the abrasive is a dihydrate salt, an anhydrous salt of the type ■, an anhydrous salt of the type ■, etc., and one or more of these are usually added in an amount of 1 to 60% by weight in the toothpaste composition. Use within a range of %.

This calcium sulfate has a mild abrasive effect as shown in Table 1, and therefore, toothpaste compositions containing calcium sulfate as the main abrasive are suitable for users with sensitive teeth, such as those with tooth sensitivity. In addition to using the calcium sulfate alone as an abrasive, other abrasives such as dibasic calcium phosphate, tertiary calcium phosphate, insoluble sodium metaphosphate, magnesium phosphate, calcium pyrophosphate, aluminum hydroxide, calcium carbonate, Magnesium carbonate, crystalline silica, colloidal silica, bentonite, calcium silicate, talc, etc. can also be used in combination, and even if these abrasives are used in combination with calcium sulfate, the stability and feel of the toothpaste composition will not be impaired. By using these abrasives in combination, a dentifrice composition having appropriate abrasive properties can be produced.

The amount of all abrasives containing calcium sulfate is usually 2
It is 0 to 60% by weight.

Further, the anionic surfactant used as a foaming agent in the present invention may be any surfactant commonly used for toothpaste, such as a water-soluble salt of an alkyl sulfate having 10 to 18 carbon atoms such as SDS, Water-soluble salts of sulfuric esters of monoglycerides of fatty acids having 10 to 18 carbon atoms, such as sodium monoglyceride sulfonate, α-
Olefin sulfonate and the like are used, and the usual sodium salt thereof is used.

In this case, these anionic activators may be used alone or in combination, and nonionic activators and the like may also be used in combination.

The anionic surfactant is usually blended into the toothpaste composition in a proportion of 0.1 to 5% by weight.

Furthermore, in addition to the abrasives and foaming agents, humectants such as glycerin, sorbitol, propylene glycol, and polyethylene glycol, as well as binders, fragrances, sweeteners, pigments, preservatives, or fluorine compounds, antibacterial agents, and antiseptics may be added. Regular toothpaste ingredients such as enzymes are blended.

As the binder, since calcium sulfate used as an abrasive has a high solubility in water, it is preferable to use an ion-resistant binder, such as carrageenan, hydroxyethyl cellulose, guar gum, locust pea gum, xanthan gum, and alginic acid. Propylene glycol, carboxymethyl cellulose, etc. are used alone or in combination.

Therefore, in the present invention, calcium sulfate is blended as an abrasive and an anionic surfactant is blended as a foaming agent.
Furthermore, ammonium hydrogen phosphate, ammonium sulfate,
Add a soluble ammonium salt such as ammonium chloride.

These soluble ammonium salts can be used alone or in combination, and the combination of the above ammonium salts can increase foaming power and improve fluidity at low temperatures, etc., as described below. To significantly improve the quality of toothpaste compositions based on calcium-anionic surfactants.

In this case, the ammonium salt is 1% aqueous solution of PH
is 5 or more and a neutral or alkaline ammonium salt such as diammonium hydrogen phosphate, triammonium phosphate, ammonium sulfate, ammonium acetate, ammonium chloride, ammonium nitrate, etc. is used.

In addition, especially when ammonium sulfate or diammonium hydrogen phosphate is blended, the foaming power is increased compared to general calcium phosphate-based products.

The amount of the ammonium salt blended in the toothpaste composition is 0.2~
It is preferably 5% by weight, particularly 0.3 to 1% by weight, and if the amount is less than this, the foaming properties of the dentifrice composition may deteriorate.

Moreover, if the blending amount is larger than this, the foaming agent tends to salt out, which may have an adverse effect on solubility, fluidity, and foaming properties.

The toothpaste composition according to the present invention is manufactured from the above-mentioned components by a conventional method.

In this case, since the ammonium salt is water-soluble, it is sufficient to simply dissolve it in water and add it, making it possible to easily produce a dentifrice composition without changing the conventional production process.

Next, experimental examples will be shown to explain the effects of the present invention.

Experimental Example 1 Using various additives shown in Table 2, a composition (water mixing system) having the following composition was prepared.

255.5 parts by weight of saccharin
2.5 Propyl/glycol 25 85% glycerin 127 60% sorbitol 190 Foaming agent (SDS) 19 Calcium sulfate dihydrate 10 Additives Appropriate amounts of each of the above compositions were left for one week, After stabilizing the system, the Ross-Miles method (JISK-
The foam stability (foam height after 5 minutes) was measured using 3362), and the foam quality was measured using a sensory test, and the foaming properties were evaluated to obtain the results shown in Table 2.

Note that the foaming property was evaluated according to the following criteria.

○: Foaming of 18cm or more after 5 minutes and fine-textured foam As can be seen from the results in Figure 1, foaming of 18cm or more is equivalent to that of calcium phosphate diluted water. It has foaming power and foam stability, and there is little decrease in foaming power due to changes over time.

Δ: Foaming after 5 minutes of 15 to 18 cm Foaming power and foam stability are slightly inferior to those based on calcium phosphate diluted water, and some foaming power decreases over time.

x: If the foaming after 5 minutes is 15 cm or less or if the foam quality is rough, it is susceptible to changes over time and the foaming power decreases to about the same level as the calcium sulfate diluted water system shown in FIG.

From the results shown in Table 2, it was found that the soluble ammonium salt increases the foaming power, improves the stability of the foam, and improves the foam quality.

On the other hand, sodium salts, potassium salts, and barium salts did not have much of an effect on improving foaming properties (note that some salts such as lithium salts, aluminum salts, and magnesium salts have a foaming property when the amount added is increased). Although an improvement effect was observed, when added to actual toothpaste as described below,
(This resulted in inconveniences such as deterioration of stability over time and feeling of use.)

In addition, other anions (e.g. PO43-, CH3COO
-, etc.) and the above-mentioned cations, similar results were obtained.

Experimental Example 2 In the same water mixing system as in Experimental Example 1, the effect of the amount of diammonium hydrogen phosphate added on the foaming power was investigated with and without calcium sulfate.
The results shown in Figure 2 were obtained.

In the figure, C is the foam height after 1 minute when calcium sulfate is mixed, D is the foam height after 5 minutes, E is the foam height after 1 minute with calcium phosphate, and F is the foam height after 5 minutes. This is the bubble height.

As is clear from the results in Figure 2, the foaming power of the calcium sulfate system containing around 0.5% diammonium hydrogen phosphate is greater than that of the calcium phosphate system; It has been found that it can act specifically on a horse anionic active agent system to improve its foaming properties.

Note that even when ammonium sulfate was used instead of diammonium hydrogen phosphate, its foaming power was greater than that of the calcium phosphate system, and the same tendency as above was observed.

Experimental Example 3 A toothpaste composition having the following composition was manufactured, and its stability, foaming, and feeling of use were examined after 3 months, and the results shown in Table 3 were obtained.

Abrasive (calcium sulfate CaSO4.2H2O and/or calcium phosphate) 50.0% by weight sorbitol liquid 25.0 Carrageenan
1.1 Fragrance
1.0 〃Saccharin 0.1 〃
Sodium dodecyl sulfate 0.5 Additive
0.5% water by weight
Balance stability Investigated by sensory test.

○: Good moldability, skin surface condition, no liquid separation; △: Slightly poor moldability, skin surface condition, liquid separation; ×: Poor moldability, skin surface condition, liquid separation. Poor separation properties, foaming, feeling of use Statistical analysis of sensory test results ○: Same level or better than calcium phosphate type △: Slightly inferior to calcium phosphate type.

×: Poor compared to calcium latrate based The results in Table 3 show that by incorporating ammonium salts, the foaming of the calcium sulfate blended toothpaste composition can be improved, as well as the stability and feeling of use after 3 months. However, products containing aluminum salts, magnesium salts, and lithium salts deteriorated the binder, adversely affecting liquid separation and moldability, and reducing stability and usability. Ta.

Therefore, aluminum salts, lithium salts, and magnesium salts are effective in improving foaming power as shown in Table 2, but
It is not preferred as an additive for dentifrice compositions for the above reasons.

Experimental Example 4 Compositions similar to those in Experimental Example 1 were produced, and the amount of blowing agent (SDS) dissolved in each composition was measured, and the results shown in Table 4 were obtained.

From the above results, it was found that the soluble ammonium salt improves the solubility of the anionic active agent in the presence of calcium sulfate.

As explained above, the present invention is characterized by incorporating a soluble ammonium salt such as diammonium hydrogen phosphate or ammonium sulfate into a toothpaste composition containing calcium sulfate and an anionic surfactant. According to the present invention, by blending the ammonium salt, (1) the foaming property can be improved more than that of ordinary calcium phosphate toothpaste, and the quality of the foam is fine, so that it feels soft in the oral cavity; (2) It improves and increases the solubility of anionic surfactants in the presence of calcium sulfate, and precipitates at low temperatures. It can enhance the inhibitory effect, improve solidification caused by long-term storage at low temperatures, difficulty extruding from tube containers, and decrease in fluidity due to precipitation, as well as improve oral dispersibility and water solubility. (3) In this way, the solubility of the anionic surfactant in the dentifrice composition is improved, and its foaming power is greater than that of the calcium phosphate compound, so a foaming agent can be used to increase the same foaming performance. The amount of (activator) used can be reduced,
This allows the fragrance concentration to be relatively reduced,
It has the following characteristics: it has a smaller effect on the viscosity index, can stabilize the paste, and can provide the user with a refreshing cooling sensation and an irritation-reducing effect.
A high-quality toothpaste composition with excellent usability, good low-temperature stability, and good stability over time can be obtained.

EXAMPLES The present invention will be specifically explained below with reference to Examples.

Example 1 A toothpaste composition having the following composition was produced according to a conventional method.

Example 2 A toothpaste composition having the following composition was produced according to a conventional method.

Example 3 A toothpaste composition having the following composition was produced according to a conventional method.

Example 4 A toothpaste composition having the following composition was produced according to a conventional method.

The toothpaste compositions obtained in Examples 1 to 4 above all foamed well and had an excellent feel when used.

[Brief explanation of the drawing]

Fig. 1 is a graph comparing the foaming power of a calcium sulfate aqueous system and a calcium phosphate aqueous system, and Fig. 2 is a graph showing the foaming power of a calcium sulfate aqueous system when diammonium hydrogen phosphate is blended.

Claims (1)

[Claims] 1. A toothpaste composition characterized in that a soluble ammonium salt is blended into a toothpaste composition containing calcium sulfate as an abrasive and an anionic surfactant as a foaming agent.