JPS5829710A - Ｐｇ類による骨孔症の治療 - Google Patents

Ｐｇ類による骨孔症の治療

Info

Publication number: JPS5829710A
Authority: JP; Japan
Prior art keywords: bone; alkyl; methyl; hydrogen; formula
Prior art date: 1981-03-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP4573182A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0216288B2 (de

Inventor

ジヨン・エドワ−ド・ランド

ワンダ・バ−ナ−デツト・ハイ

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pharmacia and Upjohn Co

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-03-25

Filing date

1982-03-24

Publication date

1983-02-22

1982-03-24 Application filed by Upjohn Co filed Critical Upjohn Co

1983-02-22 Publication of JPS5829710A publication Critical patent/JPS5829710A/ja

1990-04-16 Publication of JPH0216288B2 publication Critical patent/JPH0216288B2/ja

Status Granted legal-status Critical Current

Links

150000003180 prostaglandins Chemical class 0.000 title claims description 47
208000001132 Osteoporosis Diseases 0.000 title claims description 6
229940094443 oxytocics prostaglandins Drugs 0.000 title description 27
-1 acetamidophenyl Chemical group 0.000 claims description 96
210000000988 bone and bone Anatomy 0.000 claims description 93
238000000034 method Methods 0.000 claims description 44
241001465754 Metazoa Species 0.000 claims description 36
150000001875 compounds Chemical class 0.000 claims description 34
125000000217 alkyl group Chemical group 0.000 claims description 28
239000003795 chemical substances by application Substances 0.000 claims description 26
201000010099 disease Diseases 0.000 claims description 25
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
229910052739 hydrogen Inorganic materials 0.000 claims description 20
239000001257 hydrogen Substances 0.000 claims description 20
230000003262 anti-osteoporosis Effects 0.000 claims description 15
238000011282 treatment Methods 0.000 claims description 15
206010017076 Fracture Diseases 0.000 claims description 14
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
230000012010 growth Effects 0.000 claims description 13
230000001965 increasing effect Effects 0.000 claims description 13
230000035876 healing Effects 0.000 claims description 12
208000010392 Bone Fractures Diseases 0.000 claims description 10
150000001768 cations Chemical class 0.000 claims description 9
125000001309 chloro group Chemical group Cl* 0.000 claims description 8
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
102000055006 Calcitonin Human genes 0.000 claims description 6
108060001064 Calcitonin Proteins 0.000 claims description 6
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 6
239000003263 anabolic agent Substances 0.000 claims description 6
229940070021 anabolic steroids Drugs 0.000 claims description 6
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims description 6
229960004015 calcitonin Drugs 0.000 claims description 6
229910052698 phosphorus Inorganic materials 0.000 claims description 6
239000011574 phosphorus Substances 0.000 claims description 6
125000003710 aryl alkyl group Chemical group 0.000 claims description 5
159000000007 calcium salts Chemical class 0.000 claims description 5
125000000753 cycloalkyl group Chemical group 0.000 claims description 5
229960002986 dinoprostone Drugs 0.000 claims description 5
230000001158 estrous effect Effects 0.000 claims description 5
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
229910001506 inorganic fluoride Inorganic materials 0.000 claims description 5
230000002265 prevention Effects 0.000 claims description 5
150000003431 steroids Chemical class 0.000 claims description 5
229930003316 Vitamin D Natural products 0.000 claims description 4
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 4
150000002431 hydrogen Chemical group 0.000 claims description 4
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
230000006872 improvement Effects 0.000 claims description 4
239000008194 pharmaceutical composition Substances 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
239000011710 vitamin D Substances 0.000 claims description 4
235000019166 vitamin D Nutrition 0.000 claims description 4
150000003710 vitamin D derivatives Chemical class 0.000 claims description 4
229940046008 vitamin d Drugs 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 3
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
125000004990 dihydroxyalkyl group Chemical group 0.000 claims description 3
210000003041 ligament Anatomy 0.000 claims description 3
239000002207 metabolite Substances 0.000 claims description 3
HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims description 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
208000014151 Stomatognathic disease Diseases 0.000 claims description 2
125000003545 alkoxy group Chemical group 0.000 claims description 2
125000005242 carbamoyl alkyl group Chemical group 0.000 claims description 2
125000004181 carboxyalkyl group Chemical group 0.000 claims description 2
125000004966 cyanoalkyl group Chemical group 0.000 claims description 2
239000002552 dosage form Substances 0.000 claims description 2
230000002708 enhancing effect Effects 0.000 claims description 2
230000001747 exhibiting effect Effects 0.000 claims description 2
125000002768 hydroxyalkyl group Chemical group 0.000 claims description 2
XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 2
XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 2
GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 claims 1
NCTHHJRIJGFPTG-UHFFFAOYSA-N 6,7-bis(aziridin-1-yl)-4-[7-[[6,7-bis(aziridin-1-yl)-5,8-dioxoquinazolin-4-yl]amino]heptylamino]quinazoline-5,8-dione Chemical compound C1CN1C=1C(=O)C2=C(NCCCCCCCNC=3C=4C(=O)C(N5CC5)=C(N5CC5)C(=O)C=4N=CN=3)N=CN=C2C(=O)C=1N1CC1 NCTHHJRIJGFPTG-UHFFFAOYSA-N 0.000 claims 1
UOELMDIOCSFSEN-FVZZCGLESA-N 7-Dehydrositosterol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)C=C[C@H](C)C(C)C)=CC=C1C[C@@H](O)CCC1=C.C1[C@@H](O)CCC2(C)C(CC[C@@]3([C@@H]([C@H](C)C=C[C@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 UOELMDIOCSFSEN-FVZZCGLESA-N 0.000 claims 1
235000007575 Calluna vulgaris Nutrition 0.000 claims 1
101150040663 PGI1 gene Proteins 0.000 claims 1
125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
229960000711 alprostadil Drugs 0.000 claims 1
230000003054 hormonal effect Effects 0.000 claims 1
208000006278 hypochromic anemia Diseases 0.000 claims 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
150000004702 methyl esters Chemical class 0.000 claims 1
108700039855 mouse a Proteins 0.000 claims 1
UICBCXONCUFSOI-UHFFFAOYSA-N n'-phenylacetohydrazide Chemical compound CC(=O)NNC1=CC=CC=C1 UICBCXONCUFSOI-UHFFFAOYSA-N 0.000 claims 1
GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 claims 1
230000008521 reorganization Effects 0.000 claims 1
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims 1
238000007910 systemic administration Methods 0.000 claims 1
150000001408 amides Chemical class 0.000 description 23
230000000694 effects Effects 0.000 description 15
230000008569 process Effects 0.000 description 10
241000282472 Canis lupus familiaris Species 0.000 description 9
239000003153 chemical reaction reagent Substances 0.000 description 9
125000004432 carbon atom Chemical group C* 0.000 description 8
230000011164 ossification Effects 0.000 description 8
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208000006386 Bone Resorption Diseases 0.000 description 5
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125000001424 substituent group Chemical group 0.000 description 5
JLLYLQLDYORLBB-UHFFFAOYSA-N 5-bromo-n-methylthiophene-2-sulfonamide Chemical compound CNS(=O)(=O)C1=CC=C(Br)S1 JLLYLQLDYORLBB-UHFFFAOYSA-N 0.000 description 4
208000020084 Bone disease Diseases 0.000 description 4
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125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 4
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RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
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JQVDAXLFBXTEQA-UHFFFAOYSA-N dibutylamine Chemical compound CCCCNCCCC JQVDAXLFBXTEQA-UHFFFAOYSA-N 0.000 description 3
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LMYRWZFENFIFIT-UHFFFAOYSA-N toluene-4-sulfonamide Chemical compound CC1=CC=C(S(N)(=O)=O)C=C1 LMYRWZFENFIFIT-UHFFFAOYSA-N 0.000 description 1
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JJPVWQWOOQYHCB-UHFFFAOYSA-N triethyl(phenyl)azanium Chemical compound CC[N+](CC)(CC)C1=CC=CC=C1 JJPVWQWOOQYHCB-UHFFFAOYSA-N 0.000 description 1
QFKMMXYLAPZKIB-UHFFFAOYSA-N undecan-1-amine Chemical compound CCCCCCCCCCCN QFKMMXYLAPZKIB-UHFFFAOYSA-N 0.000 description 1
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239000011800 void material Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP4573182A 1981-03-25 1982-03-24 Ｐｇ類による骨孔症の治療 Granted JPS5829710A (ja)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US247421		1981-03-25
US30558081A	1981-09-25	1981-09-25
US305580		1981-09-25
US353549		1999-07-14

Publications (2)

Publication Number	Publication Date
JPS5829710A true JPS5829710A (ja)	1983-02-22
JPH0216288B2 JPH0216288B2 (de)	1990-04-16

Family

ID=23181389

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP4573182A Granted JPS5829710A (ja)	1981-03-25	1982-03-24	Ｐｇ類による骨孔症の治療

Country Status (1)

Country	Link
JP (1)	JPS5829710A (de)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS63103669A (ja) *	1986-10-17	1988-05-09	Toshiba Corp	電源装置
JPS6483019A (en) *	1987-09-25	1989-03-28	Sunstar Inc	Composition used in oral cavity for orthodontic therapy of tooth
JP2001515885A (ja) *	1997-09-09	2001-09-25	ザプロクターアンドギャンブルカンパニー	Ｆｐアゴニストとして有用な、芳香族のあるｃ１６〜ｃ２０が置換されたテトラヒドロプロスタグランジン類
JP2004526802A (ja) *	2001-05-08	2004-09-02	ヨンスンファインケミカルコーポレーション	プロスタグランジン誘導体の製造方法及びその立体特異的出発物質
US9675539B2 (en)	2000-03-31	2017-06-13	Duke University	Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

1982
- 1982-03-24 JP JP4573182A patent/JPS5829710A/ja active Granted

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS63103669A (ja) *	1986-10-17	1988-05-09	Toshiba Corp	電源装置
JPS6483019A (en) *	1987-09-25	1989-03-28	Sunstar Inc	Composition used in oral cavity for orthodontic therapy of tooth
JP2001515885A (ja) *	1997-09-09	2001-09-25	ザプロクターアンドギャンブルカンパニー	Ｆｐアゴニストとして有用な、芳香族のあるｃ１６〜ｃ２０が置換されたテトラヒドロプロスタグランジン類
JP2010254705A (ja) *	1997-09-09	2010-11-11	Duke Univ	Ｆｐアゴニストとして有用な、芳香族のあるｃ１６〜ｃ２０が置換されたテトラヒドロプロスタグランジン類
US9675539B2 (en)	2000-03-31	2017-06-13	Duke University	Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
JP2004526802A (ja) *	2001-05-08	2004-09-02	ヨンスンファインケミカルコーポレーション	プロスタグランジン誘導体の製造方法及びその立体特異的出発物質

Also Published As

Publication number	Publication date
JPH0216288B2 (de)	1990-04-16

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