JPS5862114A - 血小板の凝集を防止するための製薬組成物 - Google Patents

血小板の凝集を防止するための製薬組成物

Info

Publication number: JPS5862114A
Authority: JP; Japan
Prior art keywords: acetylsalicylic acid; pharmaceutical composition; preventing; dipyridamole; aluminum salt
Prior art date: 1981-09-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP57085043A

Other languages

English (en)

Japanese (ja)

Inventor

ミゲ−ル・マルガリ−ト・タヤ

ルネ・リカ−ル・サラ

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ROKADOORU SA

Original Assignee

ROKADOORU SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-09-18

Filing date

1982-05-21

Publication date

1983-04-13

1982-05-21 Application filed by ROKADOORU SA filed Critical ROKADOORU SA

1983-04-13 Publication of JPS5862114A publication Critical patent/JPS5862114A/ja

Status Pending legal-status Critical Current

Links

239000008194 pharmaceutical composition Substances 0.000 title claims description 5
230000004520 agglutination Effects 0.000 title 1
210000001772 blood platelet Anatomy 0.000 title 1
IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims description 11
229960002768 dipyridamole Drugs 0.000 claims description 11
GKJRJGXKDYCFNF-UHFFFAOYSA-K aluminum;2-acetyloxybenzoate Chemical compound [Al+3].CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O.CC(=O)OC1=CC=CC=C1C([O-])=O GKJRJGXKDYCFNF-UHFFFAOYSA-K 0.000 claims description 8
208000010110 spontaneous platelet aggregation Diseases 0.000 claims description 3
229960001138 acetylsalicylic acid Drugs 0.000 description 12
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 11
239000000203 mixture Substances 0.000 description 10
230000007062 hydrolysis Effects 0.000 description 6
238000006460 hydrolysis reaction Methods 0.000 description 6
239000000843 powder Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000007903 gelatin capsule Substances 0.000 description 3
229920002472 Starch Polymers 0.000 description 2
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
206010061216 Infarction Diseases 0.000 description 1
229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
150000001447 alkali salts Chemical group 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
238000007907 direct compression Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
238000013112 stability test Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
238000011282 treatment Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

JP57085043A 1981-09-18 1982-05-21 血小板の凝集を防止するための製薬組成物 Pending JPS5862114A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8117659		1981-09-18
FR8117659A FR2513118A1 (fr)	1981-09-18	1981-09-18	Composition pharmaceutique a base de dipyridamol et de sel d'aluminium de l'acide acetylsalicylique pour combattre l'agregation plaquettaire

Publications (1)

Publication Number	Publication Date
JPS5862114A true JPS5862114A (ja)	1983-04-13

Family

ID=9262274

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP57085043A Pending JPS5862114A (ja)	1981-09-18	1982-05-21	血小板の凝集を防止するための製薬組成物

Country Status (6)

Country	Link
JP (1)	JPS5862114A (fr)
CH (1)	CH651207A5 (fr)
DE (1)	DE3230834A1 (fr)
FR (1)	FR2513118A1 (fr)
GB (1)	GB2105988B (fr)
IT (1)	IT1157271B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6348219A (ja) *	1986-08-13	1988-02-29	ドクトル　カルル　ト−マエ　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング	ジピリダモル又はモピダモルと、０―アセチルサリチル酸とを含む製薬組成物、及びその製造方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3623331A1 (de) *	1986-07-11	1988-01-21	Hoechst Ag	Konfektionspackungen, enthaltend arzneimittelkombinationen fuer zeitlich abgestufte anwendung
WO1998057643A1 (fr) *	1997-06-16	1998-12-23	Janssen Pharmaceutica N.V.	Utilisation d'analogues de draflazine dans le traitement de la douleur
CA2322824A1 (fr) *	1998-03-13	1999-09-16	Merck & Co., Inc.	Therapie associee destinee au syndrome ischemique coronarien aigu ainsi qu'a des troubles connexes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2368280A1 (fr) *	1976-10-20	1978-05-19	Theramex	Nouvelle composition therapeutique presentant une activite anti-agregante plaquettaire, et son procede de preparation
LU77353A1 (fr) *	1977-05-16	1979-01-19

1981
- 1981-09-18 FR FR8117659A patent/FR2513118A1/fr active Pending
1982
- 1982-04-14 GB GB08210802A patent/GB2105988B/en not_active Expired
- 1982-05-06 IT IT21120/82A patent/IT1157271B/it active
- 1982-05-21 JP JP57085043A patent/JPS5862114A/ja active Pending
- 1982-05-25 CH CH3208/82A patent/CH651207A5/fr not_active IP Right Cessation
- 1982-08-19 DE DE3230834A patent/DE3230834A1/de not_active Withdrawn

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6348219A (ja) *	1986-08-13	1988-02-29	ドクトル　カルル　ト−マエ　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング	ジピリダモル又はモピダモルと、０―アセチルサリチル酸とを含む製薬組成物、及びその製造方法

Also Published As

Publication number	Publication date
IT1157271B (it)	1987-02-11
GB2105988B (en)	1985-05-30
DE3230834A1 (de)	1983-03-31
IT8221120A0 (it)	1982-05-06
FR2513118A1 (fr)	1983-03-25
GB2105988A (en)	1983-04-07
CH651207A5 (fr)	1985-09-13

Publication	Publication Date	Title
JP2568401B2 (ja)	1997-01-08	水溶性メグルミン塩及びグルカミン塩、その製造方法並びにこれを含有する医薬組成物
US4261970A (en)	1981-04-14	Theophylline sustained release granule
US5244881A (en)	1993-09-14	Compositions based on imipyramine
WO1997004789A1 (fr)	1997-02-13	Comprimes contenant une resine echangeuse d'anions
JPH11514629A (ja)	1999-12-14	安定な甲状腺ホルモン含有薬剤
US2795528A (en)	1957-06-11	Therapeutic composition containing a tetracycline and a phosphate other than orthophosphate
CN106606476A (zh)	2017-05-03	一种布洛芬混悬滴剂及其制备方法
SU1009467A1 (ru)	1983-04-07	Средство дл растворени мочевых конкрементов
EP0479777A1 (fr)	1992-04-15	Composition de spironolactone.
US4428951A (en)	1984-01-31	Long acting pharmaceutical composition
BRPI0619774A2 (pt)	2011-10-18	composição de liberação prolongada do ativo, respectivo processo de preparação e respectiva utilização
US2407412A (en)	1946-09-10	Therapeutic solutions
JPS60252415A (ja)	1985-12-13	サリチル酸コリンを含有する安定な固体薬剤用組成物
EP0338092A1 (fr)	1989-10-25	Agent anti-vih
EP0159777A1 (fr)	1985-10-30	4-Carbamoyl-imidazolium-5-stabilisé
US2906665A (en)	1959-09-29	L-amphetamine alginate
US3068147A (en)	1962-12-11	Analgesic compositions containing o-propoxybenzamide with salicylamide or acetyl-p-aminophenol or mixtures thereof
GB2105988A (en)	1983-04-07	Anti-platelet aggregation dipyridamole with Al aspirin
US20130217772A1 (en)	2013-08-22	Ibuprofen intravenous infusion
US3132993A (en)	1964-05-12	Tetracycline formulations stabilized by bisulfittes
AU651758B2 (en)	1994-07-28	Side-effect alleviant
US3443014A (en)	1969-05-06	1,3-benzoxazine - 2:4 - dione and pharmacologically acceptable alkali metal salts thereof as analgesics
WO1999024072A1 (fr)	1999-05-20	Agent a liberation prolongee pour medicaments et composition pharmaceutique a liberation prolongee
JP3897367B2 (ja)	2007-03-22	イブプロフェンの昇華防止方法
US3172814A (en)	1965-03-09	Oral blood sugar lowering compositions

JPS5862114A - 血小板の凝集を防止するための製薬組成物 - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (1)

Family

ID=9262274

Family Applications (1)

Country Status (6)

Cited By (1)

Families Citing this family (3)

Family Cites Families (2)

Cited By (1)

Also Published As

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