JPS5879923A - Shampoo composition for skin treatment - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION A composition in the form of a shampoo for treating scalp diseases, especially dry hair.
The present invention relates to a shampoo composition used for the treatment of.

Psoriasis is a particularly frequent skin disease that is found not only on the 11, 11, and 115 s lower limbs and sacrum-lumbar region, but also on the scalp.

Among the various substances already recommended for the treatment of psoriasis are anthralin or dithranol (/,,
! '，? Although this substance has been found to be particularly active, it is important to note that during its use, this compound is very easily transformed by oxidation to form a dark-colored polymeric substance. It has the disadvantage of causing stains on objects, skin and clothing.

In addition, known compositions based on petrolatum as a carrier are generally not very suitable for treating the scalp, since it is difficult to exclude the use of such a carrier.

Compositions in the form of shampoos have never been recommended due to the extreme instability of anthralin or its derivatives in aqueous solutions. In fact, after only a few hours the composition changes color, indicating that the anthralin has degraded and is also due to the presence of surfactants which can have a degrading effect.

The present inventor conducted various research on such compositions and as a result, completed a shampoo with good oxidation resistance that can be stored at a temperature of about +4° C. for about a week without deterioration. Furthermore, the composition according to the invention in the form of a soap can be treated several times in succession with the same shampoo after mixing its anhydrous and water-containing components without the need for fresh mixing immediately before each use. It can be used for.

This good stability of the shampoo according to the invention is essentially due to certain fatty acid alkyl esters of the glaze and certain surfactants, especially anionic or nonionic surfactants, present in the composition.

According to the present invention, in an aqueous solution or aqueous dispersion of anthralin or a derivative thereof, at least /S and There is provided an oxidation-stable shampoo composition for treating skin debris, characterized in that it contains at least /a+ of an anionic or nonionic surfactant.

The shampoo compositions of the present invention are stable against oxidation for about a week when stored warm at about +q.degree.

Fatty acid alkyl esters that meet the above conditions include indecyl neopentanoate, cetyl octanoate, stearyl octoate, isozorobyl laurin, ethyl myristate, isopropyl myristate, isopropyl palmitate, 2-ethylhexine nomylumitate, phthyl stearate, and stearin. Mention may be made of isopropyl acid, 2-ethylhexyl stearate, isocetyl stearate and mixtures thereof.

Anthralin derivatives which can be similarly stabilized by fatty acid alkyl esters include French Patent Application No. S'0.
+2 Tsuku J No. 4 and ZA No. 0. Compounds described in Kokogu JS No. Meikaku 1 can be mentioned.

Anionic or non-ionic Table m1 activators which can be used in the compositions according to the invention are those whose solutions remain unchanged in the foaming properties over a period of 2 months at +j°C and whose pH decreases by more than a unit. It's something that doesn't exist.

Anionic surfactants that meet this condition include bl-01@furkyl sulfate, sodium lauryl sulfate oxidized with 2.2 moles of ethylene oxide, c8-Cts acid, rusarcosine and salts thereof, sodium cocoyl-sarcosinate, cto-c2o
α-olefin sulfonate, C14-C16-α
- Sodium olefin-sulfonate can be prepared.

Preferred nonionic surfactants for use in the present invention that meet the above conditions are monoalcohols, alpha-diols, alkylphenols or condensation products of alkanolamides and glycidol.

A particularly desirable nonionic surfactant has the following formula % formula %
: ) In the formula, Rt iJ is an aliphatic group, an alicyclic group, or an arylaliphatic group having 7 to 27 carbon atoms, or a mixture thereof, and the aliphatic chain is an ether or thioether group. - or hydroxymethylene-, and p is / to 10. These compounds are described in particular in French Painting Patent No. 209/, 3/.

,2) R2-0moo2)(,O-(0H20H)
-) In the formula H, R2 represents an alkyl-, arsenyl- or alkylaryl group, and q is an average value of / to 10: These compounds are particularly described in French Painting Patent No. 1'1770t.
It is stated in the R specification.

,? ) R30ONH-OH2-0H2-0-C Peng0
1 mu〇fOH2-0f(OH-OH2-0-)-rH
In the formula, R3 is a linear or side-chained, saturated or unsaturated, optionally 7 or more hydroxyl group, a natural or synthetic aliphatic group having from g to 30 carbon atoms; , and r is an integer or decimal number from / to 5, and represents the average degree of condensation. These compounds are described in particular in French Painting Patent No. 2.7.2713.

Nonionic surfactants which give particularly favorable results in the compositions according to the invention are those represented by the following formula.

/) R1-0HOH-OH2-0-(0l-h-O
HOH-OH20-), H in the formula R1 represents a mixture of 9 to 72 carbon atoms + 1) alkyl group, p is 3.5
This is the statistical value of

-ri R2-0-[02H10(OH20H):]
In the formula H, R2 represents the digit 2H25 and is the statistical value of q Id xi to S.

3) R3-0ONH-CH2-CH2-0-OF1
2-0112-0-(0H2-OIJOH-OH2-0
)-H In the formula, R3 represents a rust conductor group of lauric acid, myristic acid, oleic acid, and coconut oil r):I-, ?
It is the general value of q.

7. The concentration of the anthralin or anthralin derivative in the composition according to the invention is usually from 0.03 to 3X1, preferably from 0.03 to 2%, and the concentration of the fatty acid alkylnisder is from g to &7. The concentration of the anionic or nonionic surfactant is between 2.5 and 31% (the above percentages are by weight based on the total weight of the composition).

Shampoo compositions may also contain various ingredients that do not adversely affect stability, such ingredients may include, among others, certain thickening agents, such as silica and polyethylene powder. , these are preferably 0. / to 20% by weight, especially from 2 to 73% by weight.

Shampoo compositions according to the present invention are generally prepared for first use by mixing the anhydrous and water-containing components of the product, preferably provided as a two-pack package.

The first component, the anhydrous component, contains anthralin or seven of its derivatives as a solution or dispersion in a fatty acid alkyl ester, stabilizer or antioxidant'! f
- It is stable against oxidation without the need for contamination, and the ingredients of Shoko, i.e. the water-containing components, are aqueous solutions of anionic or non-ionic surfactants! 11. The pH is generally 3 to 7, preferably acidic and 3 to 5. If necessary, an acid such as citric acid, lactic acid or acetic acid is added.

The concentration of anthralin or its derivative in the anhydrous component is 0.
7 to 5%, and the concentration of fatty acid alkylnisdel is go
This component may also contain a thickening agent.

The concentration of the anionic or nonionic surfactant in the water-containing component is preferably S to yo%, particularly 7 to 2%, and may also contain a thickener.

Upon initial use, both components are mixed in various ratios depending on the desired efficiency, typically a ratio of anhydrous component to water component of 10 to so:so. The mixture then obtained is applied to the scalp and hair in approximately 20 to 3010 parts. After applying it for about 5 minutes to 7 hours, mix it with water and rinse with enough water. From then on, use the same composition stored at a temperature of +Y℃ every day or every other day. Continue.

Typically, the two-pack package is such that, after mixing, it can be used approximately every seven days or twice for weekly processing.

The anhydrous components are preferably packaged in sealed glass ambiences and the water-containing components are packaged in vials. At the moment of use, pour the tip of the Anzor into a vial of rupturing solution or dispersion.

It is recommended to shake the mixture well before each use.

Good results in dry treatments are generally obtained after 3 to S weeks.

Examples of compositions according to the invention are shown below.

Example/ A shampoo according to the invention is packaged in the form of the following two components: /) Anhydrous component: Anthralin 0. g 3F by adding the so:so mixture of cetyl octoate and stearyl octoate to 100 min, 2)
Water-containing sodium sodium lamouryl ether sulfate, ethylene oxytoco, 2 moles of oxyethylene /λ V
Milk i: Add the necessary amount of water to make po4t.
1007 Immediately before use, add anhydrous ingredients (1
1, 2, 5% and 73% of water-containing component (2).

The resulting composition has a milky appearance and is applied to the scalp and hair.

After leaving for 111J for 20 minutes, emulsify with water and rinse.

The remaining composition remains stable for about 7 days when stored at a temperature of about 10 degrees Celsius and can be shampooed an additional λ to 3 times every other day.

After 2 weeks, a reduction in soft marks is observed, but treatment can be continued at 2-meat intervals.

In this example, the anhydrous component can be replaced with one of the following compositions: a) anthralin os-V isozoroby myristate added at 100 v; b) anthralin
0.971 Add all ethyl myristate 100
yC) Anthralin 100 v with addition of 0.20 V isocetyl stearate Treatment of scalp drywood was carried out with the shampoo obtained after mixing the following two-component composition according to the same method as in Example /: Example λ / ) Anhydrous component anthralin 0.2 Add inpropyl myristate 100 1 Add) Water-containing component formula R, -0HOII・01 (2-0+ OH20HOH
0H2-0+pHR, diOs-012 alkyl, p=
Non-ionic surfactant, 20 r formaldehyde o, otv ken&p
Add the amount of water necessary to make l-1 = 3.
ioo y Immediately before use, add anhydrous ingredients (11,
2s% and 78% of water-containing component (2) are mixed.

Example 3 /) Add anhydrous component anthralin o, q'it palmitin-branched isopropyl 700 v, 2)
Water content formula TL4-011011-OE12-0+0H2-CH
OH-CI-5-09HR+ = Oe -Ot r alkyl P = 3. ．． 3 nonionic surfactants, 20 1
Formaldehyde o, oty Citric acid Add the amount of water necessary to bring the pH to 100 V Immediately before use, mix the anhydrous component (11-2j%) and the water-containing component (2) 75%.

Examples/) Anhydrous component anthralin 0. ti7V
Add ethyl myristate to 700 v2) Water-containing component cocoyl-sarcosinic acid (commercially available from IIAMPSFFIIRE under the name "I-IAMI) O8YL-0") 77 v (active substance) Sodium carbonate pH== tI-13 and - The effort EDTA necessary for J
O,07? add water
100 r Just before use, remove the anhydrous ingredients (11/,!;
% and water-containing component (21gj%).

In this example, anhydrous composition (1) can be replaced by one of the following compositions: (a) Anthralin Oloy
Add isopropyl myristate 100 1(b)
Anthralin O, ), OW Add isocetyl stearate 700 F Example J /) Anhydrous component Anthralin 0. ．． Add 2 V isocetyl stearate and 100? 2) Water-containing component 014-016-α olefin sodium sulfonate
/lv (active substance) (“ELFAN OS data” from AKZOOHEMIE company)
(commercially available under the name ``'') Add the amount of water necessary to make citric acid pH = 3J.
100 f/Just before use, mix anhydrous component (1), zO% and water-containing component (2) 10%.

In this example, anhydrous component (1) can be replaced with one of the following compositions: (,) Anthralin 0. 'lW
Add isozolovir myristate to 700 r(b
) Anthralin 0. Well, 3v cetyl octoate and stearyl octoate...! ;0
:A;0 (Add mixture D 7009(c) Anthralin 0J7r Add ethyl myristate 100 v/) Anhydrous component Anthralin 0.4/7f/Add ethyl myristate 100 v, 2 )
Water content formula 114- CHOHOH2-υ+0to1□-0140
11-Cjl (2-0+, ITR□2□g-012 alkyl P = 3., S nonionic surfactant 20
f'Acetic acid Amount necessary to make pH=s Thickener λ・3v Add water to 10oV Immediately before use, mix the anhydrous component (11Jj%) and the water-containing component (2) 75%.

In this example, anhydrous component (1) can be replaced with one of the following compositions: (a) Anthralin, 2f!
Cetyl octoate and stearyl octoate! ;0: 7002(b
) Anthralin/, with the addition of S1 isocetyl stearate 100 v. All examples 1 to 1 showed good stability when stored at 1° C./week and were superior in the treatment of scalp scars. It showed activity.

Continuation of page 1 Priority claim (i April 5, 1982 a France (P
R) (3 ■ 8205864 Q multiple times Akira Braham Schrot France Antibe Pal Bosph Hamou 2

Claims (1)

[Scope of Claims] / At least seven types of fatty acid alkyl esters consisting of a fatty acid having US to /♂ carbon atoms and an alkyl group having 2 to 7 g carbon atoms in an aqueous solution or aqueous dispersion of anthralin or a derivative thereof. and at least seven types of anionic or nonionic surfactants. λ Fatty acid salts include isodecyl neopentanoate, cetyl octanoate, stearyl octoate, isopropyl laurate, ethyl myristate, impropyl myristate, isopropyl palmitate, monoethyl hexyl palmitate, isozorobyl stearate, butyl stearate. , λ-ethylhexyl stearate, isocetyl stearate, and mixtures thereof. 3 The anionic surfactant is 0801B alkyl-
Claim 1 or 2 h (composition 11! !ri. Hiroshi The composition according to claim 7 or 2, wherein the nonionic surfactant is selected from the group consisting of compounds of the following formulas /), , V, ) and 3). Item: / ) R10HOHO■-120-f(]H20H
('lli ('J(2-0) -H (in the formula, R1 represents an aliphatic group, an alicyclic group, or an arylaliphatic group having 7 to 2 carbon atoms, and a mixture thereof; The aliphatic chain may contain ether, thioether or hydroxymethylene groups.
) R, 20fO2H30(OII20H)-3-H
In formula C, R2 is alkyl-, arsenyl- or argyl
represents an aryl group, where q is the average statistical value of / to 10) (wherein R3 is linear or has a side chain, is saturated or unsaturated, and optionally contains 7 or more hydroxyl groups) represents a natural or synthetic aliphatic group or a mixture thereof having a carbon atom number of 30 to 30, and r represents a decimal number from / to 5 and indicates the average degree of condensation) j 7 types of anthralin or its derivatives 0.07 to 5
1%, fatty acid alkyl ester g to y7. sMU:
% and anionic or nonionic y, y surface active agent, S
The composition according to any one of claims 1 to 3, which contains JltM amount %. 6 Thickener 0. The composition according to any one of claims 1 to 5, further comprising a concentration of 1 to 20% by weight. 2. A Zutsukku product which can be used after mixing and which contains any seven of the compositions according to claims 1 to 3, wherein the first component, that is, the anhydrous component is a solution or dispersion in a fatty jlDl alkyl ester. Seven types of anthralin or its derivatives in a liquid state are combined, and the second component, that is, the water-containing component preferably has a pH of 3 to 7. Ir, r, ? A Tsuno Goku product characterized by containing an anionic or nonionic surfactant of S to S as an aqueous solution. 7. The product of claim 7, wherein the anhydrous component further contains a thickening agent. The product according to claim 7, which contains an acid selected from the group consisting of citric acid, milk, and acetic acid for the purpose of maintaining the pH of the water-containing components at 2-7, preferably 3-3.