JPS588010A - ユビデカレノン含有リポソ−ム - Google Patents

ユビデカレノン含有リポソ−ム

Info

Publication number: JPS588010A
Authority: JP; Japan
Prior art keywords: ubidecarenone; liposome; blood; molar ratio; sterol
Prior art date: 1981-07-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP56105689A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0321525B2 (de

Inventor

Masahiro Takada

高田　正博

「ゆずりは」　輝昭

Teruaki Yuzuriha

Koichi Katayama

片山　幸一

Junzo Sunamoto

砂本　順三

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eisai Co Ltd

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-07-08

Filing date

1981-07-08

Publication date

1983-01-18

1981-07-08 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

1981-07-08 Priority to JP56105689A priority Critical patent/JPS588010A/ja

1982-07-07 Priority to ES513789A priority patent/ES8401526A1/es

1982-07-07 Priority to CA000406797A priority patent/CA1197463A/en

1982-07-08 Priority to DE8282106124T priority patent/DE3273949D1/de

1982-07-08 Priority to PH27536A priority patent/PH17553A/en

1982-07-08 Priority to KR8203038A priority patent/KR880002036B1/ko

1982-07-08 Priority to EP82106124A priority patent/EP0069399B1/de

1983-01-18 Publication of JPS588010A publication Critical patent/JPS588010A/ja

1991-03-22 Publication of JPH0321525B2 publication Critical patent/JPH0321525B2/ja

Status Granted legal-status Critical Current

Links

ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims abstract description 29
235000017471 coenzyme Q10 Nutrition 0.000 title claims abstract description 28
ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title claims abstract description 27
229960004747 ubidecarenone Drugs 0.000 title claims abstract description 27
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 12
239000012528 membrane Substances 0.000 claims abstract description 11
150000003904 phospholipids Chemical class 0.000 claims abstract description 11
229930182558 Sterol Natural products 0.000 claims abstract description 10
150000003432 sterols Chemical class 0.000 claims abstract description 10
235000003702 sterols Nutrition 0.000 claims abstract description 10
235000012000 cholesterol Nutrition 0.000 claims abstract description 6
239000002502 liposome Substances 0.000 claims description 24
REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 claims description 3
RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 claims description 3
239000000463 material Substances 0.000 claims description 3
PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims description 2
ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims description 2
AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 2
239000008280 blood Substances 0.000 abstract description 17
210000004369 blood Anatomy 0.000 abstract description 17
210000000056 organ Anatomy 0.000 abstract description 10
239000000126 substance Substances 0.000 abstract description 7
238000012546 transfer Methods 0.000 abstract description 6
-1 cholesterol Chemical class 0.000 abstract description 2
230000004217 heart function Effects 0.000 abstract description 2
TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 abstract 1
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 abstract 1
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 abstract 1
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 1
150000008104 phosphatidylethanolamines Chemical class 0.000 abstract 1
239000000523 sample Substances 0.000 description 16
239000013068 control sample Substances 0.000 description 12
238000012360 testing method Methods 0.000 description 9
HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Substances ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 7
210000002216 heart Anatomy 0.000 description 7
230000008034 disappearance Effects 0.000 description 5
238000000034 method Methods 0.000 description 5
210000004556 brain Anatomy 0.000 description 4
238000013508 migration Methods 0.000 description 4
230000005012 migration Effects 0.000 description 4
239000000203 mixture Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
102000002322 Egg Proteins Human genes 0.000 description 3
108010000912 Egg Proteins Proteins 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
238000007796 conventional method Methods 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000003814 drug Substances 0.000 description 3
235000013345 egg yolk Nutrition 0.000 description 3
210000002969 egg yolk Anatomy 0.000 description 3
230000008030 elimination Effects 0.000 description 3
238000003379 elimination reaction Methods 0.000 description 3
238000004108 freeze drying Methods 0.000 description 3
239000011521 glass Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
210000004185 liver Anatomy 0.000 description 3
239000002504 physiological saline solution Substances 0.000 description 3
239000000243 solution Substances 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
241000700198 Cavia Species 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
239000011324 bead Substances 0.000 description 2
230000037396 body weight Effects 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
210000003191 femoral vein Anatomy 0.000 description 2
238000005259 measurement Methods 0.000 description 2
239000010409 thin film Substances 0.000 description 2
210000003462 vein Anatomy 0.000 description 2
241000700199 Cavia porcellus Species 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
235000002597 Solanum melongena Nutrition 0.000 description 1
210000004100 adrenal gland Anatomy 0.000 description 1
238000011166 aliquoting Methods 0.000 description 1
230000003064 anti-oxidating effect Effects 0.000 description 1
238000009395 breeding Methods 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
239000005515 coenzyme Substances 0.000 description 1
238000011109 contamination Methods 0.000 description 1
229940093541 dicetylphosphate Drugs 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003480 eluent Substances 0.000 description 1
239000010408 film Substances 0.000 description 1
230000006870 function Effects 0.000 description 1
239000007789 gas Substances 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
210000005240 left ventricle Anatomy 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
230000002688 persistence Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
210000001747 pupil Anatomy 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000009210 therapy by ultrasound Methods 0.000 description 1
230000005945 translocation Effects 0.000 description 1
238000002525 ultrasonication Methods 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP56105689A 1981-07-08 1981-07-08 ユビデカレノン含有リポソ−ム Granted JPS588010A (ja)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
JP56105689A JPS588010A (ja)	1981-07-08	1981-07-08	ユビデカレノン含有リポソ−ム
ES513789A ES8401526A1 (es)	1981-07-08	1982-07-07	"un procedimiento para preparar un liposoma que contiene ubidecarenona".
CA000406797A CA1197463A (en)	1981-07-08	1982-07-07	Ubidecarenon-containing liposome
DE8282106124T DE3273949D1 (en)	1981-07-08	1982-07-08	Pharmaceutical composition containing ubidecarenone containing liposomes
PH27536A PH17553A (en)	1981-07-08	1982-07-08	Ubidecarenone-containing liposome
KR8203038A KR880002036B1 (ko)	1981-07-08	1982-07-08	유비데카레논 함유 리포솜의 제조방법
EP82106124A EP0069399B1 (de)	1981-07-08	1982-07-08	Pharmazeutische Zusammensetzung, die die Ubidecarenone enthaltende Liposome enthält

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP56105689A JPS588010A (ja)	1981-07-08	1981-07-08	ユビデカレノン含有リポソ−ム

Publications (2)

Publication Number	Publication Date
JPS588010A true JPS588010A (ja)	1983-01-18
JPH0321525B2 JPH0321525B2 (de)	1991-03-22

Family

ID=14414361

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP56105689A Granted JPS588010A (ja)	1981-07-08	1981-07-08	ユビデカレノン含有リポソ−ム

Country Status (7)

Country	Link
EP (1)	EP0069399B1 (de)
JP (1)	JPS588010A (de)
KR (1)	KR880002036B1 (de)
CA (1)	CA1197463A (de)
DE (1)	DE3273949D1 (de)
ES (1)	ES8401526A1 (de)
PH (1)	PH17553A (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000502087A (ja) *	1995-12-15	2000-02-22	ナショナルリサーチカウンシルオブカナダ	アジュバンドおよび送達賦形剤としての、アーケオソーム類、補酵素ｑ▲下１０▼を含有するアーケオソーム類、および補酵素ｑ▲下１０▼を含有する他の種類のリポソーム類
JP2006508990A (ja) *	2002-11-26	2006-03-16	エムシーエスマイクロキャリアシステムズゲーエムベーハー	自己形成リン脂質ゲル
JP2006137684A (ja) *	2004-11-10	2006-06-01	Nippon Fine Chem Co Ltd	リポソーム前駆体の製造方法
JP2007077084A (ja) *	2005-09-14	2007-03-29	Nof Corp	コエンザイムｑ１０含有化粧料用リポソーム

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1988003015A1 (en) *	1986-10-23	1988-05-05	Arval S.P.A.	Cosmetic preparations containing ubidecarenones
IT1214540B (it) *	1986-10-23	1990-01-18	Vincenzo Zappia Mario De Rosa	Formulazioni idrosolubili di ubidecarenoni, procedimento per laloro preparazione e composizioni farmaceutiche che li compongono.
US5690954A (en) *	1987-05-22	1997-11-25	Danbiosyst Uk Limited	Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
GB8723846D0 (en) *	1987-10-10	1987-11-11	Danbiosyst Ltd	Bioadhesive microsphere drug delivery system
US5298246A (en) *	1991-01-09	1994-03-29	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Stable pharmaceutical composition and method for its production
ZA955191B (en) *	1994-07-06	1996-12-23	Colgate Palmolive Co	Aqueous liquid detergent compositions containing deflocculating polymers
US6726924B2 (en) *	1997-09-04	2004-04-27	Biozone Laboratories, Inc.	Oral liposomal delivery system
JP3742602B2 (ja) *	2001-05-09	2006-02-08	株式会社カネカ	還元型補酵素ｑの安定な溶液
CN1208052C (zh) *	2003-03-20	2005-06-29	上海家化联合股份有限公司	一种辅酶q10前体脂质体及其制备方法
ES2836184T3 (es) *	2006-05-02	2021-06-24	Univ Miami	Formulaciones tópicas de co-enzima Q10 y tratamiento de heridas
KR101907411B1 (ko)	2010-03-12	2018-10-12	베르그 엘엘씨	코엔자임 Ｑ10(ＣｏＱ10)의 정맥내 제형 및 이의 사용 방법
JP7173992B2 (ja)	2017-05-17	2022-11-17	バーグエルエルシー	表皮水疱症の治療および防止におけるコエンザイムｑ１０製剤の使用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS49118826A (de) *	1971-10-12	1974-11-13
JPS5287220A (en) *	1976-01-13	1977-07-20	Battelle Memorial Institute	Production of liposome
JPS5356315A (en) *	1976-11-01	1978-05-22	Eisai Co Ltd	Emulsified solution of fat soluble drugs
JPS55118415A (en) *	1979-02-28	1980-09-11	Pii Papahadojiyopo Dometoriosu	Method of encapsulating biologically active substance in lipoid cell

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2472384A1 (fr) *	1979-12-27	1981-07-03	Sederma Sa	Utilisation en cosmetologie de complexes naturels constitues d'ubiquinones et de phospholipides

1981
- 1981-07-08 JP JP56105689A patent/JPS588010A/ja active Granted
1982
- 1982-07-07 ES ES513789A patent/ES8401526A1/es not_active Expired
- 1982-07-07 CA CA000406797A patent/CA1197463A/en not_active Expired
- 1982-07-08 EP EP82106124A patent/EP0069399B1/de not_active Expired
- 1982-07-08 DE DE8282106124T patent/DE3273949D1/de not_active Expired
- 1982-07-08 KR KR8203038A patent/KR880002036B1/ko not_active Expired
- 1982-07-08 PH PH27536A patent/PH17553A/en unknown

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS49118826A (de) *	1971-10-12	1974-11-13
JPS5287220A (en) *	1976-01-13	1977-07-20	Battelle Memorial Institute	Production of liposome
JPS5356315A (en) *	1976-11-01	1978-05-22	Eisai Co Ltd	Emulsified solution of fat soluble drugs
JPS55118415A (en) *	1979-02-28	1980-09-11	Pii Papahadojiyopo Dometoriosu	Method of encapsulating biologically active substance in lipoid cell

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000502087A (ja) *	1995-12-15	2000-02-22	ナショナルリサーチカウンシルオブカナダ	アジュバンドおよび送達賦形剤としての、アーケオソーム類、補酵素ｑ▲下１０▼を含有するアーケオソーム類、および補酵素ｑ▲下１０▼を含有する他の種類のリポソーム類
JP2006508990A (ja) *	2002-11-26	2006-03-16	エムシーエスマイクロキャリアシステムズゲーエムベーハー	自己形成リン脂質ゲル
JP2006137684A (ja) *	2004-11-10	2006-06-01	Nippon Fine Chem Co Ltd	リポソーム前駆体の製造方法
JP2007077084A (ja) *	2005-09-14	2007-03-29	Nof Corp	コエンザイムｑ１０含有化粧料用リポソーム

Also Published As

Publication number	Publication date
EP0069399A3 (en)	1983-03-30
EP0069399B1 (de)	1986-10-29
KR880002036B1 (ko)	1988-10-13
JPH0321525B2 (de)	1991-03-22
ES513789A0 (es)	1983-12-16
EP0069399A2 (de)	1983-01-12
PH17553A (en)	1984-09-20
KR840000241A (ko)	1984-02-18
ES8401526A1 (es)	1983-12-16
CA1197463A (en)	1985-12-03
DE3273949D1 (en)	1986-12-04

Publication	Publication Date	Title
JPS58201711A (ja)	1983-11-24	ユビデカレノン含有リポソ−ム被覆体
Guo et al.	1991	Novel antifungal drug delivery: stable amphotericin B-cholesteryl sulfate discs
JP2958774B2 (ja)	1999-10-06	アンホテリシンｂリポソームの改良調整法
DE69018460T2 (de)	1995-11-09	Markierung mit liposomen von ischämischen geweben.
KR880002036B1 (ko)	1988-10-13	유비데카레논 함유 리포솜의 제조방법
NO172729B (no)	1993-05-24	Fremgangsmaate for fremstilling av en suspensjon av fosfolipidvesikler.
JPS63502117A (ja)	1988-08-18	放出を制御されたリポソ−ム供給系
EP0065292A2 (de)	1982-11-24	Verfahren zur Lagerung von unilamellaren Phospholipid-Vesikeln
JPS6252724B2 (de)	1987-11-06
JPS60208910A (ja)	1985-10-21	水難溶性薬物・リン脂質複合体の製造方法
EP1674081A1 (de)	2006-06-28	Herstellung von lipidbasierten Nanopartikeln unter Einsatz einer dualen asymmetrischen Zentrifuge
JPH08208457A (ja)	1996-08-13	ステロールリポソームの調製方法
US5556637A (en)	1996-09-17	Water containing liposome system
EP0731689A1 (de)	1996-09-18	Verfahren zur erhöhung der stabilität von hydrophile wirkstoffe enthaltenden liposomensuspensionen
EP1490026A2 (de)	2004-12-29	Vernebelbare liposomen und ihre verwendung zur pulmonalen applikation von wirkstoffen
JP3308010B2 (ja)	2002-07-29	被膜安定化リポソーム及びその製造方法
EP0200068A2 (de)	1986-11-05	Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung
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DE2656333C2 (de)	1985-08-08	Verfahren zur Herstellung von Liposomen, welche Arzneistoffe enthalten
JPS601124A (ja)	1985-01-07	ユビデカレノン含有リポソ−ム被覆体
EP0179879A1 (de)	1986-05-07	Ein ersatz für menschliches blut und verfahren zu dessen herstellung
CN106176608A (zh)	2016-12-07	培美曲塞二钠注射剂及其制备方法
JPH10316555A (ja)	1998-12-02	高分子化合物を含有するリポソーム外用剤

JPS588010A - ユビデカレノン含有リポソ−ム - Google Patents

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