JPS5896633A - Provision of hydrophobic membrane with hydrophilic nature - Google Patents
Provision of hydrophobic membrane with hydrophilic natureInfo
- Publication number
- JPS5896633A JPS5896633A JP19522881A JP19522881A JPS5896633A JP S5896633 A JPS5896633 A JP S5896633A JP 19522881 A JP19522881 A JP 19522881A JP 19522881 A JP19522881 A JP 19522881A JP S5896633 A JPS5896633 A JP S5896633A
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- membrane
- water
- space
- porous membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012528 membrane Substances 0.000 title claims description 70
- 230000002209 hydrophobic effect Effects 0.000 title claims description 28
- 239000007788 liquid Substances 0.000 claims description 66
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 44
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 26
- 239000012510 hollow fiber Substances 0.000 claims description 19
- 235000019441 ethanol Nutrition 0.000 claims description 15
- 239000007864 aqueous solution Substances 0.000 claims description 11
- -1 polyethylene Polymers 0.000 claims description 9
- 239000011148 porous material Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000002504 physiological saline solution Substances 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 2
- 239000008223 sterile water Substances 0.000 claims description 2
- 239000002033 PVDF binder Substances 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
- 239000003206 sterilizing agent Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 9
- 238000001914 filtration Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000012466 permeate Substances 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001707 polybutylene terephthalate Polymers 0.000 description 1
- 229920005597 polymer membrane Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- External Artificial Organs (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
本発明は疎水性多孔質膜を効率的に親水化する方法に関
するものであり、同時に疎水性多孔質膜からなる医療用
機器類の親水化と滅菌方法を提供するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a method for efficiently making a hydrophobic porous membrane hydrophilic, and at the same time provides a method for making medical equipment made of a hydrophobic porous membrane hydrophilic and sterilizing it. It is.
近年、膜を使用する分離、ｅ過、抽出、接触などの技術
は工業分野、医療分野に広く利用されている。また、こ
こで使用される膜の種類も多種・多様であり、夫々の特
性を活かした利用がなされている。In recent years, techniques such as separation, e-filtration, extraction, and contact using membranes have been widely used in the industrial and medical fields. Furthermore, there are many types of membranes used here, and each type is utilized to take advantage of its characteristics.
高分子膜を界面特性からみて分類すれば、親水性膜と疎
水性膜に分類することができるが、これらの膜鉱水を対
象とする場合には利用技術内容において明確に区別され
るものである。If polymer membranes are classified based on their interfacial properties, they can be classified into hydrophilic membranes and hydrophobic membranes, but when these membranes are used for mineral water, there is a clear distinction based on the technology used. .
例えば疎水性多孔質膜を隔てて水と気体が存在する場合
には、水は膜内へ浸入することができず、したがって膜
面な介して、水と気体を安定して接触させることが可能
であり、かかる応用例としてポリオレフィン系多孔質中
空糸を使用した人工肺、あるいは廃水処理槽中の水中へ
の空気散気材を挙げることができる。For example, when water and gas exist across a hydrophobic porous membrane, water cannot penetrate into the membrane, and therefore it is possible to stably contact water and gas through the membrane surface. Examples of such applications include artificial lungs using polyolefin porous hollow fibers and air diffusers for water in wastewater treatment tanks.
一方、親水性多孔質膜を同じ用途に用いることは、体液
の洩漏を起こしたり、あるいは廃水が膜内へ浸入し散気
が行なえ゛なくなるなどの理由から実用に供することは
困難である。On the other hand, it is difficult to put a hydrophilic porous membrane to practical use for the same purpose because it may cause leakage of body fluids or wastewater may enter the membrane, making it impossible to diffuse air.
しかしながら、疎水性多孔質膜を水又は水溶液の濾過膜
として利用する場合に鉱、水又は水溶液が疎水性多孔質
膜の細孔の中へは浸入することが極めて困難であるため
に、そのま〜では濾過膜としては使用できず、これを濾
過膜として利用するためには、親水化処理を予め施こす
必要がある。However, when using a hydrophobic porous membrane as a filtration membrane for water or an aqueous solution, it is extremely difficult for minerals, water, or an aqueous solution to penetrate into the pores of the hydrophobic porous membrane. - cannot be used as a filtration membrane, and in order to use it as a filtration membrane, it is necessary to perform a hydrophilic treatment in advance.
かかる親水化処理法としては、例えばプルロニック型非
イオン界面活性剤を多孔質膜の細孔内へ含浸させる方法
あるいは水と混合可能な有機溶剤に層全体を浸漬し、こ
れを湿潤状態を保ったまへ水と置換する方法が、かかる
疎水性膜の後処理的親水化方法として当業者に公知の方
法である。Such hydrophilic treatment methods include, for example, impregnating a pluronic type nonionic surfactant into the pores of a porous membrane, or immersing the entire layer in an organic solvent that is miscible with water and keeping it moist. The method of replacing the membrane with water is a method known to those skilled in the art as a post-treatment hydrophilization method for such a hydrophobic membrane.
ここに述べた方法を用いることにより疎水性多孔質膜も
親水性多孔質膜と何ら変らない濾過膜として利用できる
。By using the method described herein, a hydrophobic porous membrane can also be used as a filtration membrane no different from a hydrophilic porous membrane.
しかしながら、有機溶剤に層全体を浸漬し、これを湿潤
状態を保ったま〜水と置換する方法は、膜で隔てられた
二つの空間の、いずれの側にも、予め有機溶剤を導入し
、しかる後に水と置換するために親水化処理に使用する
溶剤量と溶剤を置換する水蓄が多量に必要となり、かつ
一度使用した有機溶剤は水と混合希釈されるために、そ
のまへでは再び親水化処理に使えないという欠点を有し
ていた。However, the method of immersing the entire layer in an organic solvent and replacing it with water while keeping it in a wet state involves introducing the organic solvent in advance into either side of the two spaces separated by the membrane, and A large amount of solvent is required for the hydrophilization treatment to replace water later, and a large amount of water storage is required to replace the solvent.Also, once used organic solvent is mixed with water and diluted, it will not become hydrophilic again. It had the disadvantage that it could not be used for chemical treatment.
また、有機溶剤の使用蓋を減らすために、疎水性膜を有
機溶剤中に浸漬した後、溶剤を大部分除去し、しかる後
に水と接触させる方法もとりうるが、溶剤除去の量のコ
ントロールが難しく、また溶剤の蒸発も起こるため、溶
剤の付着斑を避けることができず、親水化斑を生じやす
い。In addition, in order to reduce the amount of organic solvent used, it is possible to immerse a hydrophobic membrane in an organic solvent, remove most of the solvent, and then contact it with water, but it is difficult to control the amount of solvent removed. Also, since the solvent evaporates, it is impossible to avoid solvent adhesion spots, and hydrophilic spots are likely to occur.
本発明者らは、かかる現状を鑑み、上記欠点を解決すべ
く鋭意検討した結果、本発明に到達した。すなわち、本
発明は疎水性多孔質膜を親水化する方法に関し、疎水性
多孔質膜によって隔てられた二空間のうち、一方に予め
水又は水溶液（以下液体Ａと略す）を存在させておき、
しかるのち他方の空間に疎水性多孔質膜の細孔内へ浸透
可能で、かつ液体入と混合しうる液体（以下液体Ｂと略
す）を導入することを特徴とする親水化方法であり、親
水化に要する液体Ａ。In view of the current situation, the present inventors have conducted extensive studies to solve the above-mentioned drawbacks, and as a result, have arrived at the present invention. That is, the present invention relates to a method for making a hydrophobic porous membrane hydrophilic, which involves pre-existing water or an aqueous solution (hereinafter referred to as liquid A) in one of two spaces separated by a hydrophobic porous membrane;
This hydrophilization method is characterized by introducing a liquid (hereinafter referred to as liquid B) that can penetrate into the pores of the hydrophobic porous membrane and mix with the liquid into the other space into the other space. Liquid A required for conversion.
液体Ｂの使用量を減少させ、かつ短時間操作が可能であ
り、さらに親水化処理効果の変動の少ない極め゛ＣＣ未
来な親水化方法である。This is a very advanced hydrophilic method that reduces the amount of liquid B used, can be operated in a short time, and has little variation in the hydrophilic treatment effect.
−以下、本発明をさらに詳しく説明する。-Hereinafter, the present invention will be explained in more detail.
本発明において使用される疎水性多孔Ｉｊ［膜とは、水
あるいは水浴液によって濡れない膜であり、かかる代表
的な膜としてはポリエチレ／、ポリプロピレン、ポリ弗
化ビニリゾ／、ポリテトラフルオロエチレン、ポリスチ
レン、ポリスルフォノ、ポリジメチルシロキサン、ポリ
ブチレンテレフタレートなどを主成分とする膜であり、
界面特性からみれば純水に対する接触角が７０°以上を
示す素材からなる膜である。水との接触角が９０°以上
であれば、水の細孔内への浸透には圧力が必要であり、
細孔径が１μ以下の多孔質膜では、水の圧力が１気圧以
下では、水の浸透は全く起こらない。また接触角が９０
°未満でも、接触角が９０°に近いと実質的に水の浸透
は起こらず実用的な意味で水の浸透が起こるためには接
触角は６０°以下が必要であり、従つて７０°以上の素
材からなる多孔質膜が本発明の対象となる。また本発明
に云う液体入は膜素材に対する接触角が７０°以上にな
る液体であり、Ｍ！膜素材同一であっても、水溶液の場
合には溶質の性質、一度に応じて接触角が変わるが、接
触角が７０°以上なら本発明に使用しうる液体である。The hydrophobic porous Ij [membrane] used in the present invention is a membrane that does not get wet by water or water bath liquid, and typical examples of such membranes include polyethylene/, polypropylene, polyvinyliso/fluoride, polytetrafluoroethylene, and polystyrene. It is a film whose main components are polysulfono, polydimethylsiloxane, polybutylene terephthalate, etc.
In terms of interfacial properties, it is a film made of a material that exhibits a contact angle of 70° or more with respect to pure water. If the contact angle with water is 90° or more, pressure is required for water to penetrate into the pores.
In a porous membrane with a pore diameter of 1 μm or less, water does not penetrate at all when the water pressure is 1 atmosphere or less. Also, the contact angle is 90
Even if the contact angle is close to 90°, water penetration will not substantially occur.In order for water penetration to occur in a practical sense, the contact angle must be 60° or less, and therefore 70° or more. The porous membrane made of this material is the object of the present invention. Furthermore, the liquid contained in the present invention is a liquid that has a contact angle of 70° or more with respect to the membrane material, and M! Even if the membrane material is the same, in the case of an aqueous solution, the contact angle changes depending on the properties of the solute and the contact angle, but if the contact angle is 70° or more, the liquid can be used in the present invention.
かかる液体Ａとしては蒸留水、無菌水、生理食塩水、２
＊ホルマリン水、１０％アルコール水、その他一般水が
例として挙げることができる。Such liquid A includes distilled water, sterile water, physiological saline, 2
* Examples include formalin water, 10% alcohol water, and other general water.
以上の疎水性膜によって隔てられた二つの空間、すなわ
ち空間１、空間２のうち、一方の空間１に液体Ａを存在
させた系は、他方の空間２に気体あるいは膜との接触角
が７０°以上の液体が存在する場合には液体Ａの膜内部
への浸透は全く起こらず、１過膜としては使用できない
。In a system in which liquid A is present in one space 1 of the two spaces separated by the above hydrophobic film, that is, space 1 and space 2, the contact angle with the gas or film in the other space 2 is 70 If there is a liquid with a temperature of 100°C or more, the liquid A will not penetrate into the membrane at all, and it cannot be used as a one-pass membrane.
これに対して、空間２に疎水性膜の細孔内へ浸透可能で
かつ、液体Ａと混合しうる液体（液体Ｂ）を導入すると
、液体Ｂは膜内を透過し、ある時間経過後に空間１に到
達する。液体Ｂが膜内部へ浸透するために紘接触角が６
０’以下、好ましくは４０°以下である必要がある。ま
た、親水化のために液体Ｂが具備すべき性質としては、
液体Ａと混合しうる性質が挙げられる。On the other hand, when a liquid (liquid B) that can permeate into the pores of the hydrophobic membrane and mix with liquid A is introduced into space 2, liquid B permeates through the membrane, and after a certain period of time, the liquid Reach 1. Because liquid B penetrates into the membrane, the contact angle is 6.
It needs to be 0' or less, preferably 40° or less. In addition, the properties that liquid B should have in order to become hydrophilic are as follows:
One example is the property of being able to mix with liquid A.
かかる液体Ｂとしては多くの有機溶剤類が含まれる。例
えばアルコール類、ケトン類、エステル類、エーテル類
、有機酸類、アンド系溶剤などが用いることのできる溶
剤である。これらは単一成分とし【用いてもよく、二種
以上の混合物でもかまわない。また、有機溶剤類が１０
０チでなくても高濃度水溶液でもかまわない。液体Ｂと
しては水と相溶性の良いメチルアルコール、エチルアル
コール、エチレングリコール、グリセリン等のアルコー
ル類が好ましく、特に５０チ以上のエチルアルコールを
含むエチルアルコール水溶、液が好ましい。Such liquid B includes many organic solvents. Examples of solvents that can be used include alcohols, ketones, esters, ethers, organic acids, and-based solvents. These may be used as a single component, or a mixture of two or more types may be used. In addition, organic solvents are 10
A high concentration aqueous solution may be used instead of 0%. As the liquid B, alcohols having good compatibility with water such as methyl alcohol, ethyl alcohol, ethylene glycol, and glycerin are preferable, and an ethyl alcohol aqueous solution or liquid containing 50 or more ethyl alcohol is particularly preferable.
本発明による親水化方法の特徴は、液体Ｂが疎水性多孔
質膜を透過した瞬間に完了することであり、親水化処理
時間の短縮が可能であること、また従来の方法の如く、
疎水性多孔質膜によって隔てられた二つの空間夫々を液
体Ｂで充填する必要がないために溶剤使用量が少なくて
済むことである。特にこの％徴は中空糸膜の如く、膜で
隔”〔られた空間の一方の容積が大きく異なる場合に顕
著であり、液体入を容積の大きい空間−に充填し、液体
Ｂを容積の小さい空間から導入する方法が、本発明の効
果を大きくする。The feature of the hydrophilization method according to the present invention is that the process is completed the moment the liquid B passes through the hydrophobic porous membrane, so that the hydrophilization treatment time can be shortened, and unlike the conventional method,
Since there is no need to fill each of the two spaces separated by the hydrophobic porous membrane with liquid B, the amount of solvent used can be reduced. This percentage characteristic is particularly noticeable when the volume of one side of the space separated by the membrane is significantly different, such as in the case of hollow fiber membranes. The method of introducing from space increases the effect of the present invention.
本発明の親水化方法において、親水化処理は、液体Ａと
Ｂが混合して完了するが、膜全体が同時に親水化完了す
る場合には、特に問題はないが、広い面積の平膜や多数
本あるいは長い中空糸膜の如く、親水化処理に時間差が
あって同時に完了しない場合には、親水化が完了した部
分において液体Ａ、Ｂが混合し、その結果、液体Ａを多
く含む液が液体Ｂ側へ浸入して液体Ｂを希釈し、液体Ｂ
の表面張力が高くなると、以後の十分な親水化が行なえ
ない場合がある。このような好ましくない現象を避ける
ためには、膜全体の親水化が完了するまで、液体Ｂを液
体Ａよりも圧力を高くすれば効果的である。In the hydrophilization method of the present invention, the hydrophilization treatment is completed by mixing liquids A and B. However, if the entire membrane is hydrophilized at the same time, there is no particular problem. If the hydrophilic treatment is not completed at the same time due to a time lag, such as with a hollow fiber membrane or a long hollow fiber membrane, liquids A and B will mix in the area where hydrophilicity has been completed, and as a result, the liquid containing a large amount of liquid A will become liquid. It enters the B side and dilutes liquid B.
If the surface tension of the material increases, sufficient hydrophilization may not be possible thereafter. In order to avoid such undesirable phenomena, it is effective to make the pressure of liquid B higher than that of liquid A until hydrophilization of the entire membrane is completed.
また、液体Ｂは水を含んでいてもかまわないし、また単
独では水と実質的に混合しない有機溶剤を含んでいても
、残りの大部分の有機溶剤が水溶性であれば、水と混合
可能であることが多く、この場合も本発明に用いること
ができる。Liquid B may contain water, and even if it contains an organic solvent that is not substantially miscible with water by itself, it can be mixed with water if most of the remaining organic solvent is water-soluble. This is often the case, and this case can also be used in the present invention.
以上の如く、本発明における親水化方法においては、疎
水性膜の一方の空間に水又は水溶液（液体入）を存在さ
せておき、しかるのちに他方の空間に疎水性膜の細孔内
へ浸透可能でかつ液体Ａと混合可能な液体Ｂを導入する
ために、液体Ａは膜内には入り得ないが層界面の極く近
傍に存在しており、液体Ｂが゛膜内を浸透し、液体Ａの
存在する層界面に到達すると直ちに液体ＡとＢの混合が
起り、親水化処理が完了する。As described above, in the hydrophilicization method of the present invention, water or an aqueous solution (liquid) is allowed to exist in one space of a hydrophobic membrane, and then it penetrates into the pores of the hydrophobic membrane into the other space. In order to introduce a liquid B that is possible and miscible with liquid A, liquid A cannot enter the membrane but is present in close proximity to the layer interface, and liquid B 'penetrates inside the membrane. Immediately upon reaching the layer interface where liquid A exists, mixing of liquids A and B occurs, and the hydrophilic treatment is completed.
すなわち、液体ＡとＢの混合直後に於いては、膜内に存
在す・る液体は未だ液体Ｂとｔｔ ｘ等しい組成である
５ものの、そのま〜放置するか、もしくは液体Ａ１１ｌ
ｌを加圧してやれば液体Ａは膜内へ浸透することが可能
であり、親水化が達成できる。That is, immediately after mixing liquids A and B, the liquid existing in the membrane still has the same composition as liquid B, but it is either left as is or liquid A11l is
If 1 is pressurized, liquid A can permeate into the membrane, making it hydrophilic.
上に述べた如くシ【親水化処理が完了すれば、以後膜を
液体に浸漬したま〜保持しておくことにより親水化処理
の効果は保持される。また必要ならば腺を浸漬したまｋ
Ａ、Ｂが混合した液体を所望の別の液体Ｃに置き換える
こともできる。As mentioned above, once the hydrophilic treatment is completed, the effect of the hydrophilic treatment can be maintained by keeping the membrane immersed in the liquid. You can also soak the glands if necessary.
It is also possible to replace the liquid mixture of A and B with another desired liquid C.
この液体Ｃは液体入と同じでもよく、又全く別の液体で
も構わない。液体Ｃは空間１、空間２のいずれ側から通
液しても構わない。しかし、液体Ｂ成分を系外に放出す
るためには液体Ｃは空間１＠の空間から通液することが
効率的である。疎水性膜が中空糸膜のときには特に効率
が高い。かくして親水化処理を施され、必要に応じて所
望の水又は水溶液に置換された膜は、医療用途あるいは
水処理用途に十分利用されうるものである。This liquid C may be the same as the liquid container, or may be a completely different liquid. The liquid C may be passed from either side of the space 1 or the space 2. However, in order to release the liquid B component out of the system, it is efficient to pass the liquid C through the space 1@. The efficiency is particularly high when the hydrophobic membrane is a hollow fiber membrane. The membrane thus subjected to hydrophilic treatment and substituted with desired water or aqueous solution as necessary can be fully utilized for medical purposes or water treatment purposes.
以下実施例で本発明をさらに説′明するが、本発明はこ
れに限定されるものではない。The present invention will be further explained below with reference to Examples, but the present invention is not limited thereto.
実施例１
高密度ポリエチレン（ＭＩ値５．０、密度（Ｌ９６８
ｆ／ＣＣ）を円形ノズルを用いて紡糸し、得られた未延
伸糸を室温で５０％延−伸し、さらに熱延伸を４００％
施こし、内径３００μ、膜厚６０μ、空孔率６５ｃＩｋ
の多孔質ポリエチレン中空糸を得た。この中空糸を外筒
に充填し、端部な接着剤で固定し、図に示すｆ１通用モ
ジュールを作成した。このモジュールの中空糸内部空間
（１）の容積と中空糸外部と外筒との間の空間（２）の
容積は夫々５２ｄと１６０−であった。Example 1 High density polyethylene (MI value 5.0, density (L968
f/CC) using a circular nozzle, and the resulting undrawn yarn was stretched by 50% at room temperature, and then hot-stretched by 400%.
Applied, inner diameter 300μ, film thickness 60μ, porosity 65cIk
A porous polyethylene hollow fiber was obtained. This hollow fiber was filled into an outer cylinder and fixed with an adhesive at the end to create the f1 general module shown in the figure. The volume of the hollow fiber internal space (1) and the volume of the space (2) between the hollow fiber exterior and the outer cylinder of this module were 52 d and 160 d, respectively.
このモジュールを親水化するにあたり、空間（２）の入
口（３）より水を通水し、出口（４）より流出させ、気
泡を追い出しながら中空糸外部と外筒の間の空間に水を
充填した。この間中空糸内部空間（１）と連通ずる入口
（５）、出口（６）からは水は流出せず、膜は疎水性で
あることを示した。次に入口（５）よりエタノールを通
液し、出口（６）より流出させた。この間入口（３）の
コック（７）を閉じ、出口（４）は開放した。エタノー
ルが出口（６）より流出しはじめてからコック（８）を
閉じ、引き続き５秒間エタノールを通液した後コック（
９）を閉じた。数分後コック（７）を開いて入口（３）
より通水しながらコック（９）を開けるとエタノールを
含んだ水が入口（６）より流出し続けたので疎水性の多
孔質膜が親水化されていた。この処理に必要なエタノー
ルは８０−であった。To make this module hydrophilic, water is passed through the inlet (3) of the space (2) and flows out from the outlet (4), filling the space between the outside of the hollow fiber and the outer cylinder while expelling air bubbles. did. During this time, water did not flow out from the inlet (5) and outlet (6) communicating with the hollow fiber internal space (1), indicating that the membrane was hydrophobic. Next, ethanol was passed through the inlet (5) and flowed out through the outlet (6). During this time, the cock (7) at the inlet (3) was closed, and the outlet (4) was opened. After ethanol begins to flow out from the outlet (6), close the cock (8), continue to let the ethanol flow for 5 seconds, and then close the cock (8).
9) was closed. After a few minutes, open the cock (7) and open the entrance (3).
When the cock (9) was opened while water was flowing, water containing ethanol continued to flow out from the inlet (6), and the hydrophobic porous membrane was made hydrophilic. The ethanol required for this treatment was 80-.
比較例１
実施例１に使用した同型のモジュールを用いて、入口（
３）よりエタノールを通液し、中空糸内部空間と、中空
糸外部空間の双方にエタノールを充填した。数分後、入
口（５）より水を通液するとモジュールの出入口（３）
、（４）より水が流出しつづけ、親−水化が行なわれて
いた。Comparative Example 1 Using the same type of module used in Example 1, the entrance (
3) Ethanol was passed through the tube to fill both the inner space of the hollow fiber and the outer space of the hollow fiber. After a few minutes, when water is passed through the inlet (5), the module's inlet/outlet (3)
, (4), water continued to flow out, and hydrophilization was occurring.
この処理に必要なアルコールは２２０−であり、実施例
１よりも多く要した。The amount of alcohol required for this treatment was 220, which was more than in Example 1.
図は本発明の親水化方法を示す中空糸膜を用いた１過装
置である。
１・・・・中空糸膜（中空糸膜内部空間）２・・・・中
空糸膜外部空間
！ｔ、 ４．５．６・・・・ｒ過装置出入口Ｚ８，９・
・・・コックThe figure shows a one-filter device using a hollow fiber membrane, showing the hydrophilization method of the present invention. 1... Hollow fiber membrane (hollow fiber membrane inner space) 2... Hollow fiber membrane outer space! t, 4.5.6...r Passage device entrance Z8, 9.
···cock
Claims (1)
方の空間に予め水または水溶液（液体入）を存在させて
おき、しかるのち他方の空間に疎水性多孔質膜の細孔内
へ浸透可能で、かつ液体入と混合し５る液体Ｂを導入す
ることを特徴とする疎水性多孔質膜の親水化方法。 ２、疎水性多孔質膜が、ポリエチレン、ポリプロピレン
、ポリ弗化ビニリデン、ポリテトラフルオロエチレンで
ある特許請求の範囲第１項記載の親水化方法。 １ 疎水性多孔質膜が中空糸である特許請求の範囲第１
項又は第゛２項記載の親水化方法。 ４、 液体Ａを存在させておく空間が中空糸の外部空間
である特許請求の範囲第６項記載の親水化方法。 ５ 液体Ａが生理的食塩水、無菌水又は滅菌剤入りの水
溶液である特許請求の範囲第１項又は第２項又は第３項
又は第４項記載の親水化方法。 ＆ 液体Ｂがアルコール類である特許請求の範囲第１項
又は第２項又は第３項又は第４項又は第５項記載の親水
化方法。 ｌ 液体Ｂがエチルアルコールを主成分とする水溶液で
ある特許請求の範囲第１項又は繍２項又は第６項又は第
４項又は第５項記載の親水化方法。 ＆ 液体Ｂの圧力を液体入の圧力よりも為い状態で操作
することを特徴とする特許請求の範囲第１項記載の親水
化方法。[Claims] t Of two spaces separated by a hydrophobic porous membrane, water or an aqueous solution (liquid contained) is pre-existing in one space, and then a hydrophobic porous membrane is placed in the other space. A method for making a hydrophobic porous membrane hydrophilic, which comprises introducing a liquid B that can penetrate into pores and mix with the liquid. 2. The hydrophilization method according to claim 1, wherein the hydrophobic porous membrane is polyethylene, polypropylene, polyvinylidene fluoride, or polytetrafluoroethylene. 1 Claim 1 in which the hydrophobic porous membrane is a hollow fiber
The hydrophilization method according to item 2 or item 2. 4. The hydrophilization method according to claim 6, wherein the space in which liquid A is allowed to exist is an external space of the hollow fiber. 5. The hydrophilization method according to claim 1 or 2 or 3 or 4, wherein liquid A is physiological saline, sterile water, or an aqueous solution containing a sterilizing agent. & The hydrophilization method according to claim 1, 2, 3, 4, or 5, wherein liquid B is an alcohol. 1. The hydrophilization method according to claim 1 or 2 or 6 or 4 or 5, wherein liquid B is an aqueous solution containing ethyl alcohol as a main component. & The hydrophilization method according to claim 1, characterized in that the pressure of liquid B is operated in a state where it is lower than the pressure of the liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19522881A JPS5896633A (en) | 1981-12-04 | 1981-12-04 | Provision of hydrophobic membrane with hydrophilic nature |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19522881A JPS5896633A (en) | 1981-12-04 | 1981-12-04 | Provision of hydrophobic membrane with hydrophilic nature |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5896633A true JPS5896633A (en) | 1983-06-08 |
Family
ID=16337598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19522881A Pending JPS5896633A (en) | 1981-12-04 | 1981-12-04 | Provision of hydrophobic membrane with hydrophilic nature |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5896633A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63172745A (en) * | 1987-01-12 | 1988-07-16 | Terumo Corp | Hydrophilic porous polyvinylidene fluoride membrane and its production |
| US5837365A (en) * | 1996-04-08 | 1998-11-17 | The Penn State Research Foundation | Hydrophilic polypropylene membranes |
| WO2006051807A1 (en) | 2004-11-10 | 2006-05-18 | Mitsubishi Rayon Engineering Co., Ltd. | Hydrophilizing agent for hydrophobic porous film and methods of hydrophilizing and inspecting hydrophobic porous film with the same |
| WO2009034769A1 (en) * | 2007-09-11 | 2009-03-19 | Agc Si-Tech Co., Ltd. | Porous membrane, process for production of the same, and process for production of inorganic spheres |
-
1981
- 1981-12-04 JP JP19522881A patent/JPS5896633A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63172745A (en) * | 1987-01-12 | 1988-07-16 | Terumo Corp | Hydrophilic porous polyvinylidene fluoride membrane and its production |
| US5837365A (en) * | 1996-04-08 | 1998-11-17 | The Penn State Research Foundation | Hydrophilic polypropylene membranes |
| WO2006051807A1 (en) | 2004-11-10 | 2006-05-18 | Mitsubishi Rayon Engineering Co., Ltd. | Hydrophilizing agent for hydrophobic porous film and methods of hydrophilizing and inspecting hydrophobic porous film with the same |
| WO2009034769A1 (en) * | 2007-09-11 | 2009-03-19 | Agc Si-Tech Co., Ltd. | Porous membrane, process for production of the same, and process for production of inorganic spheres |
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