JPS5962050A - 皮膚貼付剤 - Google Patents

皮膚貼付剤

Info

Publication number
JPS5962050A
JPS5962050A JP57172930A JP17293082A JPS5962050A JP S5962050 A JPS5962050 A JP S5962050A JP 57172930 A JP57172930 A JP 57172930A JP 17293082 A JP17293082 A JP 17293082A JP S5962050 A JPS5962050 A JP S5962050A
Authority
JP
Japan
Prior art keywords
fibers
layer
flat
section
flat fibers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57172930A
Other languages
English (en)
Other versions
JPH0337522B2 (ja
Inventor
英雄 木村
田渕 正大
元一 岩崎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Vilene Co Ltd
Original Assignee
Japan Vilene Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Vilene Co Ltd filed Critical Japan Vilene Co Ltd
Priority to JP57172930A priority Critical patent/JPS5962050A/ja
Priority to US06/529,557 priority patent/US4569343A/en
Priority to DE8383109469T priority patent/DE3368514D1/de
Priority to EP83109469A priority patent/EP0107051B1/de
Publication of JPS5962050A publication Critical patent/JPS5962050A/ja
Publication of JPH0337522B2 publication Critical patent/JPH0337522B2/ja
Granted legal-status Critical Current

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    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
    • D04H1/425—Cellulose series
    • D04H1/4258—Regenerated cellulose series
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    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A—HUMAN NECESSITIES
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Textile Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Nonwoven Fabrics (AREA)

Abstract

(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。

Description

【発明の詳細な説明】 本発明は基材の片面に薬剤を塗布して用いる皮膚貼1」
剤に関するものである。特に基材の片面にカオリンクレ
ー、グリセリン、すIJチル酸メチル、l−メントール
等の薬剤を塗布して用いる、いわゆるパップ剤に関する
ものである。
近年、パップ剤の基材として、綿ネルにイ(え不織布が
用いられるようになってきている。番い□、     
     、    不織布は、綿ネルに比べ価格も安
くまた柔軟性に富むため皮膚になじみ易く、好適な基材
である。
しかしJIf1気度が比較的高く螢・向後の薬剤が背面
ににじみ出すという欠点がある。この欠点を克服するだ
め、不織布の目付を増大させること力;考えられる。し
かしこの方法は必然的に価格上昇、柔軟性の低Fを伴う
もので、不織布の持つ利点を減殺させる方法である。
薬剤のにじみ出しは、不織布を構成する繊維相互聞に形
成される孔が存在するだめである。
そして現在用いられている不織布はこの孔が大きく、か
つ単位面積当り多いためである。
そこで本発明者等は種々検討した結果、構成繊維として
特殊なものを用いることにより、孔を遮へいすることが
でき、従って薬剤のにじみ出しが防止される事を見出し
本発明に至った。
すなわち、本発明は、不織布基材の片面に薬剤を塗布し
てなる皮膚貼付剤において、前記基材は!スベクトレー
シオ(短軸対長軸の比率)1:2以上の偏平繊維を少な
くとも20]i量%以上含む層を有し、かつ、該層を厚
み方向に切断したさいの断面において、該11,4平繊
維の長軸方向と該層の111面方向とのなす角度は平均
75゜以上であることを特徴とする皮膚貼付剤に関す本
発明に周込る偏平繊維とは、土として繊維の横断面が楕
円形、四角形のものをさしている。
この他に横断面が「・〈」の字状のものや「C」字状の
ものも本発明にいう偏平繊維に包含される。通常、不縁
布の原料繊維は横断面が円形であり、これに比べ偏平繊
維は構成繊維相互面で形成された孔を遮へいする効果が
ある。
偏平繊維のアスベクトレーシオはl:2以上であること
が必要である。アスベクトレーシオとは、繊維の横断面
の形状における短軸と長軸の比である。横断面が楕円形
の場合は、楕円の現軸と長軸の比になり、四角形の場合
は塩辺と張込の比になる。また「〈」の字状又は「C」
字状の場合は、左端と右端とを直線で結んだ線が長軸と
なり、繊維の肉厚が短軸となる。アスベクトレーシオが
1=2未満であると横断面が円形に近づき、孔を遮へい
する能力がQ F してゆき、本発明に用いるのには好
ましくない。偏平繊維の繊度は、どのようなものであっ
てもよいが、構成繊維相互面に形成される孔を遮へいし
、出来上がった基材の柔軟性を損なわないだめには、約
lOデニール以Fが好ましい。
偏平繊維は層中に少なくとも20重量%以上混入される
心数がある。ここで層とは、不織布が例えば2つの異な
る組成の繊維集積層で構成されている場合(これを2層
構造の不織布という)の一つの層をいう。これは3層構
造又はそれ以上の層を有する不織布の場合も同様である
。
不織布が単一の組成のものよりなる場合は、不織布全体
が層と呼ばれる。このような層中に偏平繊維が20重量
%未満しか混入されない場合には全体に亙って孔を遮へ
いする効果が劣り好ましくない。偏平繊維以外の繊維と
しては、横断面がほぼ円形の通常の天然繊維、半合成繊
維、合成繊維が用いられる。偏平繊維やその他の繊維の
組成としては、ポリプロピレン、ポリエチレン、ホリア
ミド、ポリエステル、セルロース等従来公知の種々のも
のが用いられる。
偏平繊維を含む層を厚み方向に切断したさいの断面の状
態は図に示す如くである。はは四辺形に見えるのが偏平
繊維であり、円形に見えるのが他の混入されて(へる繊
維である。四辺形の大きさに種々のものがあるのは、偏
平繊維が正確な横断面で切断されておらず、斜めに切断
されている場合もあるからである。
本発明においては偏平繊維の長軸方向と層の平面方向と
のなす角度は平均75°以Fである必要がある。ここで
長袖方向は通常偏平繊維の長袖と一致する。しかし偏平
繊維のアスベクトレーシオが犬きく、長軸が折りたたま
れているときは、長袖の左端と右端とを結ぶ直線が長軸
方向となる。平面方向とは層の面方向、つ1り厚み方向
と垂直な面をさしている。長軸方向と平面方向とは平均
75°以ドの角度をなすことが本発明では重要である。
平均75°より大きく900に近づくと偏平繊維の長軸
方向がほぼ厚み方向を向いていることになり、不織布拭
材の片面に螢られた薬剤かにじみ出す原因となる孔を遮
へいする効果が減殺される。平均75°以トとは任意の
断面において長軸方向と平面方向とのなす角度(鋭角部
の角度をいう)を測定し、これの総和を測定数で割った
ものである。具体的な測定法としては、偏平繊維の断面
が10本〜20本観察しうる部分を5個程度取り出し、
各々を電子顕微鏡等で観察して偏平繊維の長軸方向と層
の平面方向とのなす角度を測定する。そしてそれらの平
均を求めることにより行うことができる。
このような特定の配列をした偏平繊維を含む層は、偏平
繊維をカード法で開繊しながらシート化することにより
得ることができる。まだ偏平繊維を開繊し、集積した後
、軽く加圧することによっても得ることができる。この
層は所望に応じて1例えば機械的強度を向上させるため
、軽くニードリングしてもよい。これにより偏平繊維が
厚み方向に配列する傾向を持つが、長軸方向がj!1−
み方向と一致する傾向にならない限り、差支えない。
このようにしてilられたノーを具備する不織布基材t
よ、片面に種々の薬剤が塗布されて用いられる。そして
層中において偏平繊維が横たわった状態でイ’r゛在す
るため、孔を遮へいし、薬剤が背1n1ににじみ出るこ
とが防止される。
本発明の皮ノー貼f=J剤eよ、パップ剤のみでなく、
ゴム膏薬、副腎皮質ホルモン外用剤、痔薬等の種々の外
用薬として用いることができる。
以1・本発明を実施例に基づいて説明する。
実施例1 アスベクトレーゾ第1:20、繊1jt5テニールの偏
平レイヨン繊維50重量%と、ポリエチレン成分とポリ
プロピレン成分とよりなるサイドバイサイド型の複合繊
維(横断面はPJ形、繊度;3デニール)50゛重址%
とを混合し、カード法により開繊して、シート状のウェ
ブをJub成した。このウェブを加圧上で30 秒ff
1J、140°Cで熱処理を行なった。これによV複合
繊禾庄のパぞリエJ−レン成分が軟化、溶融しウェブの
構h9繊1f1F、相互間が結合される。得られた不織
?Iiは目付60g/  、厚みQ、5Qflであった
。これを入(材として、片面にカオリンクレー(45m
 hk Htζ)、精製水(30重社部)、グリセ1ノ
ン(20血量部)、ポリビニルアルコール(10MEj
it“)をi 成分とし、他に少量のサリチル酸ノチル
ーノ\ツカ油−4−メントール、塩酸ジフェンヒトうミ
ンを加えた軟質外用薬を塗布し、更に軟質外用薬の上に
離型性フィルムを当接して本発明に係る皮膚貼付剤を得
た。
(比較例) 本発明品の性能評価のため、以Fの3種類の比較量を作
成した。
(1)  比較量A 横断面が円形で3デニールのレイヨン繊維50M景%と
、実施例1に用いた複合繊維50重量%と混合し、実施
例1と同様の方法で基材を作成し、同様の軟質外用薬を
塗布してなる皮膚貼付剤。尚、不織布の目けは60gy
、、厚みは0.63nであった。
(2)  比較量B 比較量Aと目付、厚みが相違するのみで、各々90’/
fIl、−0,85Mテある。
(3)  比較量C 比較品人の基材の軟質外用薬の塗布面となる面に目止め
剤として、カオリンクレー(80重量部)、ポリビニル
アルコール(10重量部)、ポリアクリル酸エステル(
10重Ji部)からなる組成物を40g/、塗布した。
この拭材に実施例1で用いた軟質外用薬を塗布した皮膚
貼付剤。
(評価) 本発明品及び比較量A、H,Cを、40′Cの条件下で
1′Cg/lC,x 15□の荷重をかけた状態で経時
的に基布表面への軟質外用薬のにじみ出しを観察した。
尚、観察枚数は各品5枚づつ行なった。この結果は以下
の表のとおシである。
−米 −二にじみ出し5枚ともなし 」二:5枚中にわずかなにじみ出しが見られるものがあ
る。
一ト:5枚いずれにもにじみ出しが見られる。
++:5枚いずれも面積の20%をこえるにじみ出しが
見られる。
実施例2 〆 アスベクトレーシ、il’f 1 : 2.5、繊度L
5デニールの偏平ナイロン繊維50重量%と、横断面が
円形で繊度3デニールのポリエステル4m維30重量%
と、横断面が円形で繊度3デニールのレイヨン繊維20
重量%とを混合し、カード法により開繊して、目140
’/  のシート状のウニブを形成した。このウェブに
構成繊維相互間の結合剤としてポリアクリル酸エステル
のエマルジョンを含浸し、その後乾燥して60”〜の不
織布を得た。これを基材として実施例1′7c用いた軟
質外用薬を堕布して皮膚貼付剤を得た。これは実施例1
と同様の評価方法で20日経過後も5枚ともにじみ出し
が見られなかった。
実施例3 ブスペクトレーシ第1:20、繊度5デニールの偏平レ
イヨン繊維60重量%と、横断面が円形で繊度3デニー
ルのポリエステル繊維40重量%とを混合し、カード法
により開繊して、目f−1−12g/、のウェブを形成
した。このウェブに構成繊維相互間の結合剤としてポリ
アクリル酸エステルのエマルジョンを含浸し、その後乾
燥して15 g/、の不織フリースを得だ。これに横断
面が円形で繊度3デニールのポリエステル繊維からなる
目1=J85 ’、/−のウェブを重合し、ニードルパ
ンチを施して不織布を得た。この不織布は偏平繊維を含
む層と偏平繊維を含まない層とを有し2層構造になって
いる。この後偏平繊維を含む繊維フリース層側に実施例
1で用いた軟質外用薬を塗布して皮膚貼付剤を得た。こ
れを実施例1と同様の方法で評価したところ4週間経過
後においても5枚ともにじみ出しけ見られなかった。
(比較例) 実施例3で用いた偏平繊維に代えて、横断面方円形で繊
度5デニ・−ルのレイヨン繊維を用いて、実施例3と同
様の2層構造不織布を?尋た。
これに軟質外用薬を塗布して皮膚貼付剤を1@た。
これを実施例1と同様の方法で評価したところ2週間経
過後において5枚いずれにもにじみ出しが見られた。
【図面の簡単な説明】
図面は偏平繊維を含む層を厚み方向に切断したさいの横
断面を電子顕微鏡で観察した状部を模型的に示したもの
である。

Claims (1)

    【特許請求の範囲】
  1. 不織布基材の片面に薬剤を美布してなる皮膚貼f=J剤
    において、前記基材はアスベクトレーシオ(短軸対長軸
    の比率)l:2以上の偏平繊維を少なくとも20屯M%
    以上含む層を有し、かつ、該層をjV、み方向に切断し
    ださいの断面において、該偏平繊維の長袖方向と該層の
    平面方向とのなす角度に平均75°以1・であることを
    特徴とする皮膚貼t=J′剤。
JP57172930A 1982-09-30 1982-09-30 皮膚貼付剤 Granted JPS5962050A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP57172930A JPS5962050A (ja) 1982-09-30 1982-09-30 皮膚貼付剤
US06/529,557 US4569343A (en) 1982-09-30 1983-09-06 Skin application medicament
DE8383109469T DE3368514D1 (en) 1982-09-30 1983-09-23 Wound covering for bandages or compresses
EP83109469A EP0107051B1 (de) 1982-09-30 1983-09-23 Wundauflage für Verbände oder Kompressen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57172930A JPS5962050A (ja) 1982-09-30 1982-09-30 皮膚貼付剤

Publications (2)

Publication Number Publication Date
JPS5962050A true JPS5962050A (ja) 1984-04-09
JPH0337522B2 JPH0337522B2 (ja) 1991-06-05

Family

ID=15950984

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57172930A Granted JPS5962050A (ja) 1982-09-30 1982-09-30 皮膚貼付剤

Country Status (4)

Country Link
US (1) US4569343A (ja)
EP (1) EP0107051B1 (ja)
JP (1) JPS5962050A (ja)
DE (1) DE3368514D1 (ja)

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US12685799B2 (en) 2006-05-26 2026-07-21 Teleflex Life Sciences Ii Llc Hemostatic devices
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JP2012096082A (ja) * 2006-10-30 2012-05-24 Z-Medica Corp クレーベースの止血剤およびその送達のためのデバイス
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US9603964B2 (en) 2012-06-22 2017-03-28 Z-Medica, Llc Hemostatic devices
KR20170104620A (ko) * 2015-04-03 2017-09-15 오지 홀딩스 가부시키가이샤 피부접착용 부직포 및 그 제조방법
WO2016157915A1 (ja) * 2015-04-03 2016-10-06 王子ホールディングス株式会社 皮膚貼着用不織布およびその製造方法
JPWO2016157915A1 (ja) * 2015-04-03 2017-11-24 王子ホールディングス株式会社 皮膚貼着用不織布およびその製造方法

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EP0107051A2 (de) 1984-05-02
US4569343A (en) 1986-02-11
JPH0337522B2 (ja) 1991-06-05
EP0107051A3 (en) 1985-07-03
EP0107051B1 (de) 1986-12-30
DE3368514D1 (en) 1987-02-05

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