JPS60183032A - Emulsified composition - Google Patents

Abstract

PURPOSE:To obtain uniform fine emulsified particles, by mixing an emulsified composition consisting of glycolipid, protein, water soluble polyhydric alcohol and an oil component with water. CONSTITUTION:2-95wt% of polyhydric alcohol (e.g., ethylene glycol, propylene glycol or glycerine) is mixed with a compound of glycolipid (e.g., sphengolipid or phytoglycolipid) and protein (e.g., soy protein, gluten, collagen or amylase) of which the wt. ratio is 2:8-8:2 so that the compounding wt. ratio of said compound and polyhydric alcohol is 1:1-1,000 and, further, an oil component such as tallow, squalane or hydrocarbon is mixed so as to adjust the total amount of polyhydric alcohol, glycolipid and protein to the oil component to 20% or more while the resulting mixture is stirred by a homomixer to obtain a composition. This composition is mixed with water and the resulting mixture is further treated by the homomixer.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention is a naturally occurring antigen, which has recently been used as an immunogenic antigen, and is intended to be effectively utilized in cosmetics, medicines, foods, etc.
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In recent years, numerous studies have been conducted on emulsification, many emulsifiers have been developed, and advances in emulsification technology have been remarkable, and extremely stable emulsions have been widely used in all industries. A nonionic agent containing an oxyethylene chain is used as an emulsifier, and many general consumers in particular have concerns about safety.

As a result of research, it was discovered that if glycolipids were dissolved in polyhydric alcohol and oil was added thereto, it was possible to produce emulsions with fine particle size and good stability (Japanese Patent Application No. 57-150353 ).

However, when using only glycolipids, there was a tendency that the results were not as good as those of emulsified compositions.

Therefore, as a result of intensive research, the present inventors found that if a combination of protein and glycolipid was dissolved in polyhydric alcohol and an oil was added to this, the viscosity of the resulting emulsified composition could be reduced. The present inventors have discovered that an oil-in-water emulsion composition containing water, even at a low level, exhibits good oral stability when water is added thereto, leading to the completion of the present invention.

An emulsion composition containing a water-soluble polyhydric alcohol having a hydroxyl group and an oil component, and a stable oil-in-water emulsion having uniform and fine emulsion particles obtained by further mixing the emulsion composition marked with ○ with water. A composition is provided.

The emulsified composition obtained according to the present invention is a transparent or translucent viscous liquid or gel, and the oil-in-water emulsified composition obtained by adding water is an emulsion of milky white fine particles.

The reason for this fine particle formation is thought to be that glycolipids and proteins are effectively oriented at the polyhydric alcohol/oil interface and interact with each other.

Next, the configuration of the present invention will be described.

The water-soluble polyhydric alcohol used in the present invention is
Water-soluble polyhydric alcohols containing two or more hydroxyl groups in the molecule, such as EVA, ethylene glycol, propylene glycol, 1,3-phthylene gelicol, 1,4-butylene glycol, dipropylene glycol, glycerin,
and polyglycerin such as diglycerin, triglycerin, and tetraglycerin, glucose, maltose, maltitol, sucrose, fructose, xylitol, sorbitol, maltotriostol, starch-degrading sugar-reducing alcohol, and one or two of these. The above is used. ``The blending amount is 2 to 95% by weight (hereinafter simply referred to as %) of the emulsified composition consisting of glycolipid, protein, polyhydric alcohol, and oil phase.

It is a substance containing carbohydrates. namely, the glycolipids commonly known as glycosphingolipids, phytoglycolipids, glycosylglyceride F, and other glycolipids. Glycosphingolipids include monohexosylceramide (cerebroside), dihexosylceramide such as D-galactosyl-(1-4)'-D-galactosyl-(l-)ce,
Neutral oligosylceramides such as monohexosylceramide fatty acid ester, sulfatides such as galactosylcerami F' sulfate ester, D-galactosylmyl (1-, 3
)-1)-galactosyl- (1→4)-〇-galactosyl-(L.4)-D,-gulninosyl- (1-・
) ceramide (G I:]boside I), I)-galactodi-
Mil-(l→4)-D-galactosyl(1→4)-1)
- Globosides such as glucosyl-(1-=)ceramide,
N-acetylneuraminic acid-12-3) Il-galactosyl-(l→4)~1]-glucosyl-(1-・)
It is a ganglioside such as ceramide, sialic acid ÷ hexose amine + hexose + cerami). Examples of phytoglycolipids include inositol + glucuronic acid + glucosa chloride + hexose.

Examples of glucosylglycerides include monogalactyl diglyceride F, digalactosyl diglyceride, and digalactosyl diglyceride. Furthermore, other glycolipids include and.

The above-mentioned substances are obtained from a wide variety of plants, ranging from higher plants such as seeds of soybeans, corn, flax, linseed, and wheat to algae and photosynthetic bacteria. In addition, in animals, 1j′I is especially obtained from cerebral blood, sperm, etc.
In addition, among microorganisms, mycobacteria (MycQb
acteria), Arthob
actor), Pseudomonas (+'seudom
onas ) Lactobacillus
us), Torulopsis
It can be obtained from a wide range of bacteria and yeast.

The proteins used in the present invention are proteins obtained from natural sources, such as soybean protein, wheat protein, glutelin, whey powder, soybean casein, soybean flour, fibroin,
Glucagon, 21lagen, gelatin, elastin, egg white lysozyme, amylase, fifirinogen, myosin, coninolase, chymotrypsinogen, histones, actin, keratin, moglobin, avidin, pepsin, gliadin, growth hormone, albumin, globulin, myoglobin, casein , papa, in, β-galactosodase, inso-1, lysothyme, and caclase.

When the above-mentioned glycolipids and proteins are used as salts, substances that form salts include inorganic and organic bases and basic inorganic and organic salts, including lithium ions, sodium ions, potassium ions, cesium ions, and ammonium ions; Basic amino acids such as arginine, histidine, lysine, ornithine, basic oligopeptides containing these as residues, monoethanolamine, dienones -
bases such as basic amines such as triamine, triethanolamine, and amino sugar; inorganic acids such as hydrochloric acid, sulfuric acid, nitric acid, and carbonic acid; organic acids such as acetic acid, citric acid, maleic acid, and fumaric acid; glutamic acid, and aspartic acid. Acidic amino acids such as and oligopeptides containing these as residues are used.

The salt may be reacted in advance to form a salt and added from the beginning, or may be added separately and reacted to form a salt during the manufacturing process of the emulsion composition. Any number of circles 1 of the salt aqueous solution of glycolipids and proteins may be used, but it is preferable that the isoelectric point of the protein be lowered if possible.

In the present invention, one or more of the above-mentioned glycolipids and proteins can be selected and used.

When the weight ratio of glycolipid and protein is in the range of 2:8 to 8:2, a significantly better emulsified composition can be obtained than when each is used alone.

The total amount of glycolipids and proteins and the amount of polyhydric alcohol are as follows:
The weight ratio is in the range of l:1 to 1000. If the amount of polyhydric alcohol is less than 1 based on the total amount of glycolipids and proteins, the solubility of the glycolipids and proteins will be poor, and if it exceeds 1000, the emulsion stability will be poor.

The oils used in the present invention include animal and vegetable oils and fats such as beef tallow, squalane, olive oil, and rice bran oil; hydrocarbons; mineral oils such as liquid paraffin and petrolatum; isopromevil myristate-1- and pentaerythritol-tetra-2-
For ethylhexane, vitamin A balmite 1-,
Ester oils such as vitamin E acetate, silicone oils such as methylphenyl silicone, dimethyl silicone, etc.
It is an oil commonly used in the cosmetics, pharmaceutical, food, and other industries. In the present invention, C is one or two of these.
It is desirable to select and use at least one type of oil and adjust the total amount of polyhydric alcohol, glycolipid, and protein to 20% or more of the oil content.

In addition to the above-mentioned essential components, the emulsified composition according to the present invention may include nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, drugs, ultraviolet absorbers, Preservatives, antioxidants, etc. may be mixed and added. Furthermore, alcohol, fatty acids, other water-soluble polymers, etc. may be added for the purpose of homogeneity stabilization and viscosity adjustment.

The emulsified composition of the present invention can be obtained by dissolving glycolipids and proteins in a polyhydric alcohol or an aqueous solution thereof, and gradually adding an oil component while stirring. In this case, it is preferable to perform a homomixer treatment, but a good emulsified composition can be prepared even with a weak stirring force such as manual stirring.

The emulsified composition obtained here is a uniform, transparent or translucent gel or viscous liquid, so it can be used as is, such as sun care jelly, beauty serum, edible jelly, medicated jelly, pine surge jelly, lubricating oil, etc. It can be used in all fields such as cosmetics, medicine, and feed.

The oil-in-water emulsion composition according to the present invention can be obtained by mixing the above-described emulsion composition and water.

In this case, it is desirable to perform homomixer treatment. The oil-in-water emulsion composition obtained here has extremely excellent stability.

Depending on the purpose, water phase components commonly used in the cosmetics, pharmaceutical, food, and other industries are added to the water, such as wetting agents, water-soluble vitamins, water-soluble preservatives, water-soluble drugs, and water-soluble polymers. You can also do that.

The quantitative relationship between the emulsified composition and water can be selected from a very wide range, but is usually 99.5 to 20 parts of water to 0.5 to 80 parts of the emulsified composition.

The oil-in-water emulsion composition obtained here is a milky white viscous or low-viscosity liquid in which uniform fine particles are dispersed, so it can be used in cosmetics such as emulsions, creams, and foundations, shampoos, and conditioners even in its original form. It can be suitably used in various fields such as toiletry products such as urea cream, pharmaceutical products such as acne cream, and food products such as mayonnaise. In addition, other water-soluble polymers, drugs, surfactants, powders, etc. may be added to stabilize homogeneity, adjust viscosity, or impart medicinal effects.

Hereinafter, the present invention will be explained in more detail with reference to Examples and Comparative Examples. The present invention is not limited thereto.

Examples 1 to 7, Comparative Examples 1 to 6 Glycolipids, proteins, polyhydric alcohols, purified water, and oil components were blended in the composition and amounts shown in Table 1, and treated with a homomixer at 70°C to form an emulsified composition. Had made. Furthermore, 10 times the amount of water was added to this emulsified composition at room temperature while stirring to prepare a reduced ice Nakaura type emulsified composition. The conditions of the emulsified composition and oil-in-water emulsified composition were observed, and the characteristic values were measured, and the results are shown in Table 1. Note that the numbers for each component are weight %.

(Note 1 in Table 1) The condition of the oil-in-water emulsion composition was evaluated based on the following criteria after being left for one day.

■ Emulsified particle size 1μ or less Ol~5μ △ 5~lOμ x 10μ or more Table-2 (Note-2) 5 Very good 4 Good 3 Fairly good 2 Fairly poor 1 Very poor As is clear from Table-1, sugar When lipids were used alone as emulsifiers (Comparative Examples 1 to 3.'6), the viscosity of the emulsified compositions was low, and the viscosity of the oil-in-water emulsified composition obtained by mixing with water was lower than room temperature after one month. stability is not good. On the other hand, when protein is used alone as an emulsifier (Comparative Examples 4 and 5), the viscosity is high, but the emulsion particle size is 10 μm.
The oil-in-water emulsion composition was separated. On the other hand, in Examples 1 to 7 according to the present invention, transparent or translucent viscous liquids or gels with very good "ζ" values were obtained at all levels, and furthermore, they were obtained by adding water. The resulting oil-in-water emulsion composition was a stable emulsion in which very fine particles were dispersed.

Example 8 Aqueous facial jelly (% by weight) (A) Lambtulipid R-12.0 Caseinna I.Rium 1.0 Glycerin 20.0 Maltitol (70% aqueous solution) 10.0 Vitamin E acetate 0.5 Preservative 0. 5 Fragrance U Stir the (A) phase at 70°C for 70°C, and stir the (B) phase at 70°C.
The mixture was melted at 0° C. and added to the (Δ) phase with stirring. This product was treated with a homomixer, stirred and cooled to obtain an aqueous cosmetic oil. This cosmetic oil has a viscous, slightly fluid, transparent gel-like appearance, and is an emulsion that is highly safe for the skin and has excellent stability over time.When applied to the skin, it spreads very well. It had properties that could be used over a wide range in small amounts.

Example 9 Nutrient emulsion (% by weight) (A> Pharmacopoeia glycerin 20.0 1.3-butylene glycol 5.0 Soybean protein IW (molecular weight 10000) 1.0 Water-soluble collagen 1.0 Boar 1--- Glucosamine hexose luglucuronic acid 0.5 Distearyl diglucosyl diglyceride 1.0 Alane-1-yne 0.2 Sodium hydroxide 0.1 (B) Squalane 10.0 Joboha oil 5.0 Pentaerythritol-Rute 1-lar 2 -Ethylhequinanocony-1-5,0 Vaseline 4.0 Fragrance 0.3 (C) Purified water 45.2 Sodium alginate O11 Xanthine gum 0.1 According to the manufacturing method of Example 8, (A) phase ( An emulsion composition was obtained from phase B), heated to 70°C, diluted and dispersed with a thickener aqueous solution (phase C) prepared separately and maintained at 70°C, and then cooled to obtain a nutritional emulsion of an oil-in-water emulsion. The viscosity of this emulsion was 5,600 cp at 30°C, and the emulsion particle size was 1 to 3.
It had a stable feel of approximately μ and a smooth texture.

Example 1 O Chin Care Cream (Weight: (A) Diglycerin 20.0 Soj) 21--L (70% Water'/41 Peel) 8.0 Fruit 2
1!7 (50% aqueous solution)2. O Sibalmyl 1-yl monogalactosyl diglyceride 0.5 Fructo-Slipino F' 3.0 Sodium ceine 0.5 (13) Squalane 21.5 Isozolobyl myristate 10.0 Sohiline 5.
0 Stearyl alcohol 5.0 )) ΔB A 2.0 Preservative 0.5 Fragrance (), Glf, 5 (C) Purified water Human's quince ethyl cell (1)) Mixed powder 1.0 Titanium dioxide 2.0 A tin care cream was obtained by following the manufacturing method of Example 8. At this time, the (C) phase was used as a frosting phase after dispersing and homomixing the (D) phase at 70°C.

This chin care cream has a hardness of 26 at 25°C, is slightly transparent, and has a stable oil-in-water emulsion composition with an emulsion particle size of about 1 to 3μ, making it suitable for use under sunlight. It could be used for.

Patent applicant: Shiseido Co., Ltd.

Claims (1)

[Claims] +11 11i One or more types of lipid and/or its salt and one or more types of protein and/or its salt
1. An emulsified composition comprising: a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule; and an oil component. An oil-in-water emulsion composition characterized by: