JPS60204708A - Humectant - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel moisturizing agent, and more specifically, to a moisturizing agent that has an excellent moisturizing effect and is composed of a combination of a specific water-soluble silicon compound and a water-soluble polymeric substance. .

The skin acts as the interface between the outside world and the living body, protecting the living body from SB, humidity, light, microorganisms, chemicals, mechanical stimuli, etc., and maintaining the homeostasis of the living body by appropriately regulating moisture evaporation. There is. The stratum corneum is the outermost layer of the skin and normally retains a moderate amount of moisture, but when it is no longer able to retain moisture due to various external and internal factors, the skin becomes dry and coarse. This results in a decrease in flexibility and extensibility, and the above-mentioned functions are no longer fulfilled.

To achieve this, it is necessary to supply and retain moisture in the stratum corneum in some way, and to prevent the moisture in the stratum corneum from evaporating excessively. Contains moisturizer.

As such humectants, propylene glycol, glycerin, sodium pyrrolidone carboxylate, sodium lactate, sorbitol, and the like have conventionally been used in relatively large amounts in cosmetics from the viewpoint of their affinity for the skin and their feel when used. However, these moisturizers tend to cause a sticky feeling on the skin, and when used at low humidity,
They have the disadvantage that moisture may be drawn into the skin from the skin into cosmetics containing moisturizers, causing the skin to become dry.

Recently, mucopolysaccharides such as chondroitin sulfate, hyaluronic acid, mucoprotein, and caronine sulfate, collagen, and polypeptides have been discovered as compounds that exist in the skin and have a moisturizing effect, and are used in cosmetics. There is. However, although these have the effect of preventing the aging phenomenon of the skin to some extent, their moisturizing effect is not necessarily sufficient.

In view of these circumstances, the present inventors conducted intensive research to provide a moisturizing agent that does not have a sticky feeling and has an excellent moisturizing effect. It was discovered that a combination of substances is suitable for the purpose, and based on this knowledge, the present invention was completed.

That is, the present invention provides a humectant comprising a combination of (a) a silicon compound having at least one silanol group in the gradient molecule and (i) a water-soluble polymeric substance.

In the humectant of the present invention, the silicon compound used as the Al component must have at least one silanol group in the molecule, and examples of such compounds include monosilanol compounds having one silicon atom in the molecule. and polysilanol compounds having two or more silicon atoms,
Preferably, it is a silanol compound having 1 to 3 silicon atoms in the molecule, and more preferably a silanol compound having the general formula % (%) (in which R is an alkyl group having 1 to 6 carbon atoms, an aralkyl group, or an alkenyl group). , cycloalkyl group or alkoxy group, two or more R's may be the same or different <s
is 0 or an integer from 1 to 3) or a silanoate in which some of the hydrogen atoms of its hydroxyl group are substituted with a basic substance, such as an alkali metal, an alkaline earth metal, or an amine.

Examples of the compound represented by the general formula (1) include silanol, trimethylsilanol, dimethylsilanediol, methylethylsilanediol, methylsilanetriol, triethylsilanol, diethylsilanediol, ethylsilanetriol, and di-n-1 day pill. Silanediol, diisopropylsilanediol, di-n-
Butylsilanediol, diisobutylsilanediol,
Examples include di-tert-butylsilanediol, diallylsilanediol, triphenylsilanol, diphenylsilanediol, phenylsilanetriol, methylcyclohexylsilanediol, dicyclohexylsilanediol, and the like. Examples of polysilanol compounds include nato-2methyldisiloxane-1,3-diol, tetramethyldisylmethylene-1,3-diol, tetramethyldisylethylene-1,4-diol, and bis(methylvinyl). Examples include disiloxane diol.

These silanol compounds are generally unstable and easily polymerized, but they become multi-stabilized when combined with a water-soluble polymer substance (Bl component). Although the mechanism of this stabilization is not necessarily clear, water-soluble 10H in polymeric substances
It is thought that a hydrogen bond is formed between the group or -NH2 group and 810H in the silanol compound to stabilize it.

The water-soluble polymer used as component (B) in the moisturizing agent of the present invention preferably has at least one hydroxyl group or amine group or both in the molecule. Examples include water-soluble biopolymer substances such as polysaccharides and water-soluble proteins, cellulose derivatives, starch derivatives, and polyvinyl alcohol, and each of these may be used alone or in combination of two or more.

The mucopolysaccharides refer to mucopolysaccharides in a broad sense, and examples include acidic mucopolysaccharides such as neutral mucopolysaccharides, hyaluronic acid, chondroitin, chondroitin sulfate, heparin, and heparan sulfate, mucoproteins, glycoproteins, and glycolipids. As the water-soluble tannin, for example, ribo-peptide obtained by condensing the amino group of a protein hydrolyzate with the carboxyl group of a fatty acid, soluble collagen, soluble elastin, soluble keratin, etc. can be used. Examples of cellulose derivatives include carboxymethylcellulose (OMO), methylcellulose (MC), hydroxyethylcellulose (110), and hydroxyglobilcellulose.As for starch derivatives, those that are more water-soluble than normal starch are preferred, for example, slightly Examples include hydrolyzed dextrin, acetic acid derivatives of starch, phosphoric acid derivatives, and hydroxyalkyl derivatives.

Furthermore, the solubility of polyvinyl alcohol in water varies depending on the degree of polymerization and degree of saponification, but it is generally desirable to use one whose degree of saponification is not so high (approximately 97 mole or less).

Among these water-soluble polymer substances, water-soluble biopolymer substances such as mucopolysaccharides and water-soluble proteins are suitable because they themselves have an effective pharmacological effect on the skin and also have a moisturizing effect. be.

In the humectant of the present invention, the preferred blending ratio of the silanol compound as the gradient component and the water-soluble polymer substance as the component (B) is selected in the range of 1:10 to 10:1 on a weight basis.

The humectant of the present invention is obtained by stabilizing the silanol compound (A) with the water-soluble polymer substance (B). As for this stabilization method, a silanol compound may be added to the aqueous solution of the water-soluble polymer substance, but since the silanol compound is generally unstable and easily polymerized, the following method should be used. is preferred.

That is, first, a relatively stable aqueous solution of a silanoate compound is prepared, an aqueous solution of a water-soluble polymer substance is added thereto, and then the silanoate compound is converted into a silanol compound using an H-type cation exchange resin or the like. The silanoate compound is stabilized to obtain the humectant of the present invention.

The aqueous solution of the silanoate compound can be prepared by, for example, using a hydrocarbon-substituted silane derivative containing a silane as a starting material, hydrolyzing this silane derivative, collecting the generated hydrolyzate, and recovering the resulting hydrolyzate. , into an aqueous solution of an alkali metal hydroxide in such a proportion that at least one amount of base is present per silicon atom [Journal of the Chemical '71 Sci.
nal of thechemi, ca180Qiet
7), Vol. 105, p. 679], a halogen-containing hydrocarbon-substituted silane derivative is prepared by adding at least 1 equivalent of a base per silicon atom in addition to the neutralization equivalent derived from the halogen of the derivative. It is prepared by adding it to an aqueous solution of an alkali metal hydroxide prepared as described above.

For example, when preparing an aqueous solution of a monosilanoate compound, silicon tetrachloride, methyltrichlorosilane, and phenyl trichlorosilane are used as starting materials for preparing an aqueous solution of a monosilanoate compound. Examples include chlorosilane, diphenyldichlorosilane, dimethyldichlorosilane, chloromethyltrichlorosilane, trimethylchlorosilane, chlorophenyltrichlorosilane, methylcyclosilane, benzyltrichlorosilane, and the like.

The moisturizer of the present invention can be used, for example, in addition to regular skin conditioning and nutritional lotions, astringent lotion, shave lotion,
Water-based cosmetic lotions such as body lotions and liquid packs, creams such as nutritional creams, eye creams, body creams, neck creams, pine surge creams, cold creams, and emollient creams, nutritional emulsions, body emulsions, neck emulsions,・It is used in skin cosmetics such as emulsions such as skin milk lotions and packs, and can also be used in hair cosmetics such as shampoos and conditioners.

When using the humectant of the present invention for such purposes, the humectant may be used with the necessary ingredients added, or the humectant may be used as an aqueous solution or dispersion containing the necessary ingredients, or as a solid base. It may be added in an appropriate amount to the cosmetic composition, and the amount thereof is usually preferably used in the range of 0.1 to 10% by weight based on the cosmetic composition.

Next, the present invention will be explained in more detail with reference to Reference Examples and Examples.

Reference Example 1 Collect the precipitate generated by hydrolyzing methyltrichlorosilane, add an equimolar aqueous sodium hydroxide solution to it,
The mixture was stirred and dissolved to obtain a silanony (0H3Si(OH)2.QNa) aqueous solution with a concentration of 10% (in terms of silanol).

On the other hand, in another beaker, prepare 100cc of a 1% aqueous solution of purified hyaluronic acid (manufactured by Kewpie), which is a type of mucopolysaccharide, and add to this 10C of the 10% aqueous solution of silanoate.
After adding C, the mixture was neutralized to pH 6.5 with an H-type cation exchange resin, and after removing the ion exchange resin, water was added to make a total volume of about 200 cc to obtain a moisturizer. When this product was dried under reduced pressure, the solid content concentration was about 1%.

Reference Example 2 A 4% aqueous solution of water-soluble atelocollagen was prepared by dissolving calf skin insoluble collagen with pepsin and purifying it.

To 80 cc of this aqueous solution, 1Q of a 10% (silanol equivalent) aqueous solution of silanoate prepared in the same manner as in Reference Example 1 was added.
After adding Oc, PH(S,
5, and then water was added to make the whole to 100 QC to obtain a moisturizer. When this product was dried under reduced pressure, the solid content concentration was 5%.

Example 1 Commercially available pig skin cut vertically and horizontally into 2A squares was prepared.

Separately, prepare various moisturizing aqueous solutions as shown in Table 1, and apply a certain amount of each of these moisturizing agents to two pieces of pig skin.
The samples were left in a desiccator maintained at a relative humidity of 65% and 30°C for 24 hours, and the amount of moisture on the surface of the pig's skin was determined by impedance measurement. The results are shown in Table 2.

An impedance measuring device manufactured by IBe was used, and the moisture content was determined from the obtained impedance value using a calibration curve, and the average value of the two sheets was used.

Tables 1 and 2 clearly show that the moisturizing agent stabilized with hyaluronic acid of the present invention has a moisturizing effect superior to that of hyaluronic acid as well as other moisturizing agents. .

Example 2 Commercially available pig skin was cut into 2 cm square pieces lengthwise and widthwise.

Two pieces of this pig skin were immersed in the moisturizer aqueous solution (solid content 5%) prepared in Reference Example 2, the collagen 5% aqueous solution, and water, and then left in a desiccator at a relative humidity of 50% for 6 hours. Then, as in Example 1, the amount of moisture on the surface of the pig's skin was determined by impedance measurement.

As a result, the moisture content of the moisturizer of the present invention obtained in Reference Example 2 was 75%, whereas the moisture content of the collagen 5-ti aqueous solution was 5%.
5%, and water alone was 5%.

Example 3 In the same manner as in Reference Example 2, 5q of dimethylsilanediol-chondroitin sulfate B (weight ratio 1:4) was added as a humectant.
An aqueous solution b was prepared and used to prepare a lotion having the composition shown below.

Dimethylsilanediol-chondroitin sulfate B5 Propylene glycol 1 Ethanol 6 Methyl p-hydroxybenzoate 0.1 Disodium hydrogen phosphate 0.06 Fragrance 0.2 Purified water Balance When 20 women used this lotion, it was found that the skin Improvement effects were observed with a 1% risk rate for firmness, sensitivity, and smoothness.

Example 4 In the same manner as in Reference Example 1, a 1% aqueous solution of ethylsilane trio-hyaluronic acid (weight ratio 1:1) was prepared as a moisturizer, and an emollient cream having the following composition was prepared using this.

Ingredients Content (wt%) Ethylsilane trio-hyaluronic acid 1 liquid paraffin 6 squalane 3 cetyl palmitate 2 cetanol 2 stearic acid 2 antioxidant 3 purified water Balance When 20 women used this cream, it was found that the skin Improvement effects were observed with a 1% risk rate for stiffness, stiffness, and smoothness.

Example 5 In the same manner as in Reference Example 1, a 1% aqueous solution of phenylsilane trio-hyaluronic acid (weight ratio 1:1) was prepared as a humectant, and using this, a shanggu with the following composition was prepared. When used, it showed an excellent moisturizing effect on hair.

Component Content (wt%) Phenylsilane triol-hyaluronic acid 10□4-α
- Sodium olefin sulfonate 1゜triethanolamine lauryl sulfate 5 Fragrance 0.1 Purified water Balance Example 6 A 2% aqueous solution of trimethylsilanol-collagen (weight ratio i: i, s) was prepared in the same manner as in Reference Example 2.
When this was used to prepare a rinse having the composition shown below, it showed an excellent moisturizing effect on hair.

Trimethylsilanol-Collagen 2 Alucard 2H
T , , 2 Setanol 3 Stearyl ethoxyle) (KO5 mol) 1 Fragrance o
, i Purified water balance

Claims (1)

[Scope of Claims] 1. A humectant comprising a combination of (A) a silicon compound having at least one silanol group in its molecule and Φ) a water-soluble polymeric substance. 2. The moisturizing agent according to claim 1, wherein the silicon compound has 1 to 3 silicon atoms in the molecule. 6. The moisturizing agent according to claim 1, wherein the water-soluble polymeric substance has at least one hydroxyl group, one amino group, or both in the molecule. 4. The moisturizer according to claim 1, wherein the water-soluble polymer substance is a water-soluble biopolymer substance.