JPS60225567A - 組織接着剤の適用に用いる装置 - Google Patents

組織接着剤の適用に用いる装置

Info

Publication number
JPS60225567A
JPS60225567A JP60066422A JP6642285A JPS60225567A JP S60225567 A JPS60225567 A JP S60225567A JP 60066422 A JP60066422 A JP 60066422A JP 6642285 A JP6642285 A JP 6642285A JP S60225567 A JPS60225567 A JP S60225567A
Authority
JP
Japan
Prior art keywords
connecting head
needle
containers
paragraph
catheter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60066422A
Other languages
English (en)
Other versions
JPH0371894B2 (ja
Inventor
ハインツ・レードル
ゲオルグ・ハビソン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oesterreichisches Institut fuer Haemoderivate
Original Assignee
Immuno AG
Immuno AG fuer Chemisch Medizinische Produkte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3505786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS60225567(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immuno AG, Immuno AG fuer Chemisch Medizinische Produkte filed Critical Immuno AG
Publication of JPS60225567A publication Critical patent/JPS60225567A/ja
Publication of JPH0371894B2 publication Critical patent/JPH0371894B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/005—Medical syringes, e.g. enemata; Irrigators comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Materials For Medical Uses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)
  • Treatment Of Fiber Materials (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Nozzles (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。

Description

【発明の詳細な説明】 この発明は、創傷を密封し、出血を止めるなどの目的で
、ヒトまたは動物の組織または臓器各部を結合させる手
段として、縫合を行なわずに結合するために、もしくは
縫合を介助する手段として適用されるヒトまたは動物の
たんばく質からなる組織接着剤、特にたんばく質溶液と
血液凝固促進因子溶液を混合することによってその場（
インサイチュ）で形成される組織接着剤、を適用するの
に用いる装置に関するものであって、該装置は、各適用
成分を収容し、その先端が連結部分とつながっている複
数個の容器（好ましくは標準的な、先端が円錐状をなし
ている複数個のプラスチック製使い捨て注射器筒）と、
各適用成分毎の別々の輸送管を含んでいる、該容器にと
り付は可能な連結ヘッドからなることを特徴としている
。
このような型の装置が、米国特許第４，３５９゜０４９
号に既に記載されている。この場合、組織接着剤として
、一方は第Ｘ■因子およびブイプリノーゲン含有溶液、
また他方にはトロンビン含有溶液が使用される。これら
の成分は、連結ヘッドにとり付けられている配合針内で
混合され、処置または保護すべき創傷部位に適用される
。
この既知装置は基本的に成功を収めてはいるが、適用中
に成分の流れを中断したり、長くて細い配合針を使用し
た場合、組織接着剤が配合針の中で凝固してしまう障害
を生じることがある。したがって、配合針はただちに交
換しなければならない。
このような処置は、特に適用部位が例えば体腔内のよう
に容易に到達し難い例では、外科的手術の進行がかなり
妨げられる結果を招来することとなる。
米国特許第４，３５９，０４９号には、構成成分を混合
して噴霧する噴霧構造と、混合すべき成分の細導管に対
しである角度をもって配置されている滅菌ガスの供給管
からなる該装置の修飾態様が記載されている。この噴霧
装置を使用することにより、供給管の開口部から１０〜
２０ｃｍ離れた前方において各成分の噴霧化が起こる。
したがって、この装置は広い区域での使用にのみ適して
おり、手の届きにくい手術分野では矢張り使用できない
。
最後に、凝固性物質を体腔内に適用するプラスチック製
カテーテルからなる装置が、リンソーアおよびファツィ
オ（Ｌｉｎｓｃｈｅｅｒ　ａｎｄ　Ｆａｚｉｏ）の論文
（カストロエンテロロジー（Ｇ　ａｓｔｒｏｅｎｔｅｒ
ｏｌｏｇｙ）、７７巻、６４２〜６４９頁、１９７９年
）により発表されるに至った。この装置は混合すべき成
分毎の複数個の容器からなっており、各容器は、１本の
多筒式カテーテル内の各細導管と分離できない形でつな
がっているチューブ導管へ連結されている。然しなから
、このような装置の場合、前もって作成できず、また内
視鏡と組み合イっせて適用部位へ誘導されることによっ
てのみ使用し得る種々の適用装置と連結したり、交換し
たりすることが全くできない不便さがある。
本発明はこれらの不便さと障害を排除することを目的と
するものであって、処置中に必要となることがある混合
すべき成分の流れの中断にも装置の部品の交換を要さず
、しかも故障なく、到達困難な適用部位にも使用し得る
、先に示したような装置を設計することを目的としてい
る。また、本発明に示した装置は内視鏡を用い、または
用いないいずれの場合にも使用できる。
これらの目的は、連結ヘッドに、他の輸送管（細導管）
と密着してこれと平行している医療用ガス用の、連結ヘ
ッドの前端部へ通じている細導管を追加して設けている
こと、およびこの連結ヘッドがガス細導管を含む多筒式
カテーテルまたは配合（混合）針のいずれかと連続して
いることを特徴とする装置により達成される。
都合よい態様は、連結ヘッドが多筒式カテーテルと継ぎ
目なく作られるか、または該カテーテルの各細導管が連
結ヘッドと一列に並んでつながるようにとり付は得るこ
とである。
更に都合よい態様では、各適用成分に用いる細導管と医
療用ガスの管以外に、カテーテルに、成形ワイヤー用の
細導管が追加して設けられている。
また更に、通過して流れる各成分の乱流を促進する高所
およびくぼみを配合針の内面に設計することもできる。
以上に述べた本発明における装置のすべての態様によっ
て、何らの支障をも起こすことはない。
医療用ガスの圧を増すことによって、配合針の尖端また
はカテーテルの開口部で各成分を微粒子化（噴霧化）さ
せることができ、従って、該装置は小範囲の適用部位に
も使用することができる。
本発明による装置について、添付した図を引用してその
実施態様を例示し、更に詳細な説明を加える。
標準的な２本の使い捨て注射器の筒は１および２で示さ
れ、その一方はトロンビン含有溶液、他の一方は第ＸＩ
［Ｉ因子とフィブリノーゲンを含有する溶液を収容する
のにあてる。注射筒１．２は標準化されたプラスチック
製使い捨て注射器をもって好適に充当できる。この２本
の筒を共に１個の支持体３に挿入する。この支持体はＵ
字型をしている２本の円筒４，５からなっており、それ
ぞれの先端にはつまみ６が作られているので、この円筒
の上方から挿入される注射筒１，２はきっちりとはめこ
まれ、つまみ６で支持体に固定される。
支持体３の根元のところで、Ｕ字型の凹み９゜ｌＯを有
する握り（ｆｉｎｇｅｒ　ｇｒｉｐ）８を、注射筒の根
元に突き出ている該注射筒末端のフランジ１１゜１２へ
とり付けることによって、注射筒はその縦軸の方向Ｉ３
に沿ってしっかりと固定される。支持体の握り部分８に
開けられている穴１６を突き抜け、Ｕ字型円筒４，５の
間の空間部１６へ向けて、ガイド棒１５が設けられてい
る。該ガイド棒は２本の注射器の内筒（ピストン）２０
．２１の頭の部分（ｔｈｕｍ　ｙｏｋｅｓ）　１８　、
　ｌ　９を同時に動かせる共通の可動体Ｉ７と結合され
ている。然し、この２本の内筒がそれぞれ独立して動か
すこともできるのは言うまでもない。
２本の注射筒の円錐先端２５．２６を連結ヘッド２７の
ぴったりあった凹みに差し込むことにより、これと連結
する。区分された細導管からなる１本の輸送管が、各円
錐状の差し込み２５．２６から連結ヘッドの前方部へそ
れぞれ連結ヘッドの中を通っている。連結ヘッド内には
、更にもう１本医療用ガイドの細導管３０が細導管２８
および２９と密着してこれと平行に隣接し連結ヘッドの
前方部へ同様に通じている。
連結ヘッドは４本の細導管に仕切られた多筒式カテーテ
ル３１（第３図）と（完全に月木につながっており、そ
の１本の細導管は細導管２８と、他の１本は細導管２９
とつながり、３番目の細導管はガス細導管３０とつなが
り、また、４番目の細導管３２には成形ワイヤー３３が
挿入されている。
この成形ワイヤーによって、該カテーテルを適用部位ま
で移動させるべく、とのような所望の形にも変形するこ
とが可能である。
あらかじめバルブを開いた後（ガス細導管３０を始動す
る一図面には示されていない）、注射器内筒１８．１９
または可動体１７を加圧することにより混合すべき成分
が適用部位へ供給されるが、この間、輸送管の開口部は
ガスを一定に流すことによって確実に正常に保たれる。
第４図に示した修飾態様では、第１図および第２図に示
したものと同様な方法で設計された連結ヘッド２７がソ
ケット状の突出形３５となっており、平行に並んでいる
３本の細導管２８．２９および３０がその中で一本化さ
れている。ソケット３５を連結部３７に差し込むことに
より、配合針３６をソケットにとりつれることができる
（第１図に示したカテーテル３１を切断して作成しても
よい）。配合針の内面３８は、第５図の拡大図で示した
ように、その中を流れる成分の乱流を促進するため、そ
の表面に３９のように設計さ、れた乱流を促進する溝を
設けてもよい。
適用時における医療用ガスの流通速度および流通量を適
宜選択することによって、カテーテルを用いる態様でも
、配合針を用いる態様でも、いずれの場合も開口部にお
いて成分を液体の形で排出したりあるいは成分を噴霧化
することができ、このようにして装置を大規模に適用す
ることができる。
【図面の簡単な説明】
第１図は本発明の装置の一部切断側面図、第２図は本発
明の装置の部分的断面図、第３図は、第１図の■−■の
線に沿って切断したカテーテルの断面図、第４図は装置
の連結ヘッドの修飾した態様を示す一部切断側面図（こ
れにはとり付けられた配合針も示しである）、第５図は
配合針の特殊態様を示す模式図である。 １および２・・・注射器筒、３・・・支持体、２７・連
結ヘッド、２８および２９・・輸送管（細導管）、３０
・・・医療用ガスの細導管、３１・カテーテル。 特許出願人　イムノ・アクヂエンゲゼルシャフト・フユ
ール・ヘミソユ−メデイツイニッ シエ・プロデュクテ 代理　人　弁理士　青白　葆　外を名

Claims (1)

  1. 【特許請求の範囲】 ■、創傷を密封したり出血を止めるなどの目的で、ヒト
    または動物の組織または臓器部分を縫い目なく結合した
    り、もしくは縫合を介助する手段として適用されるヒト
    または動物のたんばく質からなる組織接着剤、特にたん
    ばく質溶液と血液凝固促進因子溶液からなる少なくとも
    ２つの成分を混合することによってその場で形成される
    組織接着剤、を適用するのに用いられる装置であって、
    各適用成分を収容し、その先端が連結部とつながってい
    る複数個の容器、該容器の連結部にとり付（Ｊ得る連結
    ヘッドおよび該連結ヘッド内に設置された、成分毎にそ
    れぞれ別個に輸注し得る様に別々に設けられている輸送
    管を含んでいる装置であって、連結ヘッド内に更に医療
    用ガスを送る輸送管が更に設けられており、該輸送管は
    、それぞれ別々に設けられている前記輸送管に密着して
    互いに平行して連結ヘッドの前端部に通じており、該連
    結ヘッドは混合手段へつながっていることを特徴とする
    改良装置。 ２、複数個の容器がプラスチック製の標準化された複数
    個の使い捨て注射器筒からなる第１項に記載の装置。 ３、混合手段が医療用ガスを流通する輸送管を追加して
    含む多筒式カテーテルであることからなる第１項に記載
    の装置。 ４、混合手緩が配合針であることからなる第１項に記載
    の装置。 ５、連結ヘッドが該多筒式カテーテルと継ぎ目なしにつ
    ながって作られていることからなる第３項に記載の装置
    。 ６、多筒式カテーテルが輸送管および追加して設けられ
    た輸送管と一列に並へて連結ヘッドにとり付は得る、も
    のである第３項に記載の装置。 ７、多筒式カテーテルが、各適用成分および医療用ガス
    を通じる複数個の細導管のほかに、更に成形ワイヤを通
    す細導管を有することからなる第３項に記載の装置。 ８、配合針の内部表面に、針を通過して流れる各成分の
    乱入を促進する凸所および凹所を設けた第４項に記載の
    装置。
JP60066422A 1984-03-29 1985-03-28 組織接着剤の適用に用いる装置 Granted JPS60225567A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0106384A AT379311B (de) 1984-03-29 1984-03-29 Vorrichtung zur applikation eines gewebeklebstoffes
AT1063/84 1984-03-29

Publications (2)

Publication Number Publication Date
JPS60225567A true JPS60225567A (ja) 1985-11-09
JPH0371894B2 JPH0371894B2 (ja) 1991-11-14

Family

ID=3505786

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60066422A Granted JPS60225567A (ja) 1984-03-29 1985-03-28 組織接着剤の適用に用いる装置

Country Status (8)

Country Link
US (1) US4631055A (ja)
EP (2) EP0156098B1 (ja)
JP (1) JPS60225567A (ja)
AT (3) AT379311B (ja)
CA (1) CA1225560A (ja)
DE (2) DE3485993D1 (ja)
DK (1) DK165485C (ja)
ES (1) ES8603254A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009213786A (ja) * 2008-03-12 2009-09-24 Terumo Corp 塗布具
JP2010075286A (ja) * 2008-09-24 2010-04-08 Terumo Corp 塗布具
CN101919721A (zh) * 2009-06-09 2010-12-22 基立福有限公司 用于施用纤维蛋白粘合剂的装置
JP2014532479A (ja) * 2011-10-28 2014-12-08 メドトロニック・ゾーメド・インコーポレーテッド スプレーデリバリシステム

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AT379311B (de) 1985-12-27
US4631055A (en) 1986-12-23
EP0315222A2 (de) 1989-05-10
EP0156098A2 (de) 1985-10-02
DE3480328D1 (en) 1989-12-07
ATE47672T1 (de) 1989-11-15
DK165485B (da) 1992-12-07
ES541272A0 (es) 1985-12-16
ATE82518T1 (de) 1992-12-15
DK96785A (da) 1985-09-30
CA1225560A (en) 1987-08-18
DK96785D0 (da) 1985-03-01
ES8603254A1 (es) 1985-12-16
ATA106384A (de) 1985-05-15
EP0156098B1 (de) 1989-11-02
DE3485993D1 (de) 1992-12-24
EP0315222A3 (en) 1990-01-03
EP0315222B1 (de) 1992-11-19
EP0156098A3 (en) 1986-07-30
DK165485C (da) 1993-04-19
JPH0371894B2 (ja) 1991-11-14

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