JPS6034457A - blood purification device - Google Patents
blood purification deviceInfo
- Publication number
- JPS6034457A JPS6034457A JP58143080A JP14308083A JPS6034457A JP S6034457 A JPS6034457 A JP S6034457A JP 58143080 A JP58143080 A JP 58143080A JP 14308083 A JP14308083 A JP 14308083A JP S6034457 A JPS6034457 A JP S6034457A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- activated carbon
- purification device
- blood purification
- cylindrical container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004369 blood Anatomy 0.000 title claims description 17
- 239000008280 blood Substances 0.000 title claims description 17
- 238000000746 purification Methods 0.000 title claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 24
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 229940109239 creatinine Drugs 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 101100136650 Mus musculus Pigo gene Proteins 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
本発明は、活性炭を用いた直接血液潅流法ｃ以下り、Ｈ
，Ｐ法という）に使用する装置に関するもので、詳しく
は円筒型容器に棒状活性炭を充填した血液浄化装置に関
するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention provides direct blood perfusion using activated carbon.
, P method), and more specifically, it relates to a blood purification device in which a cylindrical container is filled with rod-shaped activated carbon.
活性炭によるり、Ｈ，Ｐ、法は、近年、活発に研究され
ており、その吸着能はもとより、材質、コーティングな
どの面でも飛躍的な発展を遂げ急性薬物中毒に対しての
補助肝としての地位を確立、また肝不全などの疾患に対
しても広く使用されている。H, P, and activated carbon methods have been actively researched in recent years, and dramatic advances have been made not only in terms of their adsorption capacity, but also in terms of materials and coatings, making them useful as an auxiliary liver for acute drug poisoning. It is widely used to treat diseases such as liver failure.
しかし、従来、使用されている活性炭は、単位重量あた
りの表面積、血液適合性などの点から、球ないし粒状を
呈しておシ、そのため血液を通液する際に、吸着速度を
早くする目的のだめ、粒子径が小さくするが、その場合
抵抗が大きく、ポンプ等の駆動装置で高い圧力をかけな
ければならず、血球成分、血管への影響が大であった。However, conventionally used activated carbon has a spherical or granular shape due to its surface area per unit weight and blood compatibility. However, in this case, the resistance is large and high pressure must be applied using a drive device such as a pump, which has a large effect on blood cell components and blood vessels.
本発明者は、この点に関して、鋭意検討した結果、内径
と有効長の比が特定範囲にある円筒型容器に棒状活性炭
を均密に充填することにょシ本発明に到達した。すなわ
ち、本発明はり、Ｈ。As a result of intensive studies on this point, the inventors of the present invention have arrived at the present invention by uniformly filling rod-shaped activated carbon into a cylindrical container having a ratio of the inner diameter to the effective length within a specific range. That is, the beam of the present invention, H.
Ｐ、法において、ポンプ等の駆動装置を使用することな
く、血液浄化することを目的とするものである。しかし
て、その目的は円筒型容器に該円筒の軸方向に対してほ
ぼ平行に棒状活性炭を均密に充填し、該容器の内径りと
有効長りの比（Ｌ ／ Ｄ ）がＯ１Ｓ〜ｊ、Ｑ とす
ることにより達せられる。In the P. method, the purpose is to purify blood without using a drive device such as a pump. Therefore, the purpose is to uniformly fill a cylindrical container with rod-shaped activated carbon almost parallel to the axial direction of the cylinder, so that the ratio of the inner diameter to the effective length (L/D) of the container is O1S~j , Q.
本発明における円筒型容器はプラスチック製セラミック
製又はステンレス製等のオートクレーブ滅菌に耐えるも
のが適しておシ、該円筒型容器の両端にはメツシュを備
えたトラップキャップを設けである。The cylindrical container in the present invention is suitably made of plastic, ceramic or stainless steel that can withstand autoclave sterilization, and trap caps with meshes are provided at both ends of the cylindrical container.
寸だ、該容器の形状は内径りと有効長りの比（Ｌ／Ｄ
）がＯ１夕〜ｓ、ｏ 、好ましくは７．０〜２Ｊのもの
がよいが、この数値は、円筒型容器に充填する棒状活性
炭の直径に関係するものであり、すなわち、直径の大き
い棒状活性炭を使用する場合は、単位体積らたりの表面
積が小さくなり、（Ｌ／Ｄ）を大きくする必要があり、
逆に小さな径のものの場合は、血流の圧力損失の点から
（Ｌ ／ Ｄ ）は小さい方がよい。また、上記範囲よ
り（Ｌ／Ｄ ）が小さい場合、流通する血液の活性炭に
接触する時間が短くなり不利となり、大きい場合は、圧
力損失が増大しポンプ等の血流駆動装置が必要となる。The shape of the container is the ratio of the inner diameter to the effective length (L/D
) is preferably 7.0 to 2 J, but this value is related to the diameter of the rod-shaped activated carbon to be filled in the cylindrical container. When using, the surface area per unit volume becomes smaller and (L/D) needs to be increased.
On the other hand, in the case of a small diameter one, (L/D) should be smaller in terms of blood flow pressure loss. Further, if (L/D) is smaller than the above range, the contact time of circulating blood with the activated carbon will be shortened, which is disadvantageous; if it is larger, pressure loss will increase and a blood flow driving device such as a pump will be required.
該棒状活性炭は、活性炭を直径０．３ｍｆｎ〜３１ｒｒ
ｍ〈それにより、該容器が破損しない限り活性炭が折れ
る心配がなく、流通する血液の圧力損失を最少限度にお
さえることができ、生体の血圧程度で血液を循環させる
ことができ、少量のヘパリンを添加した遅い流れにもか
かわらず１、該容器に血液がつまることなく使用できた
。The rod-shaped activated carbon has a diameter of 0.3 mfn to 31 rr.
As a result, there is no need to worry about the activated carbon breaking unless the container is damaged, the pressure loss of circulating blood can be kept to a minimum, the blood can be circulated at the same level as the blood pressure of a living body, and a small amount of heparin can be used. Despite the slow flow added, 1 the container was usable without clogging with blood.
すなわち、本発明の方法を用いればポンプ等の駆動装置
を必要としない血液浄化が可能となり、通常の人工透析
装置の他に、多量の薬物中以下、実施例により本発明の
詳細な説明する。That is, by using the method of the present invention, blood purification that does not require a driving device such as a pump is possible, and in addition to a conventional artificial dialysis machine, the present invention will be described in detail with reference to Examples.
実施例
頚部動静脈間に外シャントを造設した、体重助長Ｌ ／
／ Ｏｆｉ、 Ｌ／Ｄ＝、２．０）は、直径約０−
’ＩＦＬＭの棒状活性炭を約５ｏｏｏ本（約、ｚｓｏｙ
）を充填したもので、高圧蒸気滅菌後、Ｄ、Ｈ，Ｐ、開
始前及び開始後！、／！１３０，６０、／２０及びｉｇ
ｏ分値においてカラム前後により採血、血球成分並びに
血清クレアチニン値の変動を測定した。ヘパリンの添加
量は最初７２０単位／ｋｙ、後は１時間毎にｔｏ単位／
ｋｙまたり、Ｈ，Ｐに際し圧
ては、血液ポンプを使用せず、生体の血液のみ損失の変
動を調べた。Example Weight support L/with external shunt created between the carotid arteries and veins
/ Ofi, L/D=, 2.0) is approximately 0-
'Approximately 500 pieces of IFLM rod-shaped activated carbon (approximately, zsoy
), after high-pressure steam sterilization, D, H, P, before and after starting! ,/! 130, 60, /20 and ig
At the o minute value, blood was collected before and after the column, and changes in blood cell components and serum creatinine values were measured. The amount of heparin added was 720 units/ky at first, then to units/ky every hour thereafter.
Regarding the pressure during KY, H, and P, a blood pump was not used, and changes in the loss of only biological blood were investigated.
その結果、圧力損失は１０關Ｈｇ 前後と安定し、血液
ポンプを使用することなく、Ｄ、Ｈ，Ｐが施行でき、ま
た血液量約１０−／ ｊ Ｏｍｅ／ｍｉｎと安定してい
た。血小板においては、Ｄ、Ｈ，Ｐｉｇｏ分値において
７０％の減少が観察され、白血球も同様な傾向を示した
。血中クレアチニンの除去率については、約５３％〜約
７２係の除去率を示し、血漿蛋白については／〜−１！
■／ｄｉの低下が見られた。As a result, the pressure loss was stable at around 10 degrees Hg, D, H, and P could be performed without using a blood pump, and the blood volume was stable at about 10 −/j Ome/min. In platelets, a 70% decrease in D, H, and Pigo values was observed, and leukocytes showed a similar trend. Regarding the removal rate of blood creatinine, the removal rate is about 53% to about 72%, and the removal rate of plasma protein is /~-1!
■ A decrease in /di was observed.
Claims (2)
に棒状活性炭を均密に充填してなる血液浄化装置(1) A blood purification device in which a cylindrical container is evenly filled with rod-shaped activated carbon almost parallel to the axial direction of the cylinder.
（Ｌ／Ｄ ）がｏ、 ｓ −ｊ、 ｏの範囲にあシ、か
つ両端にフィルターを設けたことを特徴とする特許請求
の範囲第１項記載の血液浄化装置(2) The cylindrical container is characterized in that the ratio (L/D) of the inner diameter (D) to the effective length (L) is in the range o, s - j, o, and filters are provided at both ends. Blood purification device according to claim 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58143080A JPS6034457A (en) | 1983-08-04 | 1983-08-04 | blood purification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58143080A JPS6034457A (en) | 1983-08-04 | 1983-08-04 | blood purification device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6034457A true JPS6034457A (en) | 1985-02-22 |
Family
ID=15330444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58143080A Pending JPS6034457A (en) | 1983-08-04 | 1983-08-04 | blood purification device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6034457A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60246765A (en) * | 1984-05-22 | 1985-12-06 | 旭化成工業株式会社 | Adsorbing column for purifying body fluids |
| JPS6340947U (en) * | 1986-09-01 | 1988-03-17 | ||
| JP2015008932A (en) * | 2013-06-28 | 2015-01-19 | 旭化成メディカル株式会社 | Drug removal filter, drug removal system, and drug removal method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6021765A (en) * | 1983-07-19 | 1985-02-04 | 株式会社トンボ鉛筆 | Rod-shaped activated carbon for artificial organ |
-
1983
- 1983-08-04 JP JP58143080A patent/JPS6034457A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6021765A (en) * | 1983-07-19 | 1985-02-04 | 株式会社トンボ鉛筆 | Rod-shaped activated carbon for artificial organ |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60246765A (en) * | 1984-05-22 | 1985-12-06 | 旭化成工業株式会社 | Adsorbing column for purifying body fluids |
| JPS6340947U (en) * | 1986-09-01 | 1988-03-17 | ||
| JP2015008932A (en) * | 2013-06-28 | 2015-01-19 | 旭化成メディカル株式会社 | Drug removal filter, drug removal system, and drug removal method |
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