JPS6036404A - Dental composition - Google Patents
Dental compositionInfo
- Publication number
- JPS6036404A JPS6036404A JP58145057A JP14505783A JPS6036404A JP S6036404 A JPS6036404 A JP S6036404A JP 58145057 A JP58145057 A JP 58145057A JP 14505783 A JP14505783 A JP 14505783A JP S6036404 A JPS6036404 A JP S6036404A
- Authority
- JP
- Japan
- Prior art keywords
- powder
- aqueous solution
- alpha
- solution containing
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 6
- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 4
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 4
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000001263 FEMA 3042 Substances 0.000 claims abstract 2
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 claims abstract 2
- 238000004898 kneading Methods 0.000 claims abstract 2
- 150000007524 organic acids Chemical class 0.000 claims abstract 2
- 159000000000 sodium salts Chemical class 0.000 claims abstract 2
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 claims abstract 2
- 229940033123 tannic acid Drugs 0.000 claims abstract 2
- 235000015523 tannic acid Nutrition 0.000 claims abstract 2
- 229920002258 tannic acid Polymers 0.000 claims abstract 2
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- WEQHQGJDZLDFID-UHFFFAOYSA-J thorium(iv) chloride Chemical compound Cl[Th](Cl)(Cl)Cl WEQHQGJDZLDFID-UHFFFAOYSA-J 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 abstract description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000010452 phosphate Substances 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- BOXNENYOGRMVAM-UHFFFAOYSA-L [Na+].[Na+].[O-]P([O-])(Cl)=O Chemical compound [Na+].[Na+].[O-]P([O-])(Cl)=O BOXNENYOGRMVAM-UHFFFAOYSA-L 0.000 abstract 1
- -1 acrylate compound Chemical class 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 235000010216 calcium carbonate Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003479 dental cement Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 229920001864 tannin Polymers 0.000 abstract 1
- 235000018553 tannin Nutrition 0.000 abstract 1
- 239000001648 tannin Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 description 7
- 229910052586 apatite Inorganic materials 0.000 description 5
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 4
- 239000000920 calcium hydroxide Substances 0.000 description 4
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 4
- 239000004568 cement Substances 0.000 description 4
- 229910010272 inorganic material Inorganic materials 0.000 description 3
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 235000011007 phosphoric acid Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000012568 clinical material Substances 0.000 description 1
- 239000003564 dental alloy Substances 0.000 description 1
- 239000005548 dental material Substances 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002894 organic compounds Chemical group 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 1
- 239000002672 zinc phosphate cement Substances 0.000 description 1
Landscapes
- Dental Preparations (AREA)
Abstract
Description
【発明の詳細な説明】 本発明は生体適応性に優れた歯科用組成物に関する。[Detailed description of the invention] The present invention relates to a dental composition with excellent biocompatibility.
歯４４の臨床分野における従来よりの無機質材料として
は、酸化亜鉛を正リン酸水溶液で練和して用いるリン酸
亜鉛セメント、酸化硅素を正リン酸水溶液で練和して用
いるケイ酸七メント、水酸化カルシウムを主成分とする
裏装剤、補綴材料としての歯科用合金等がめθ初期の時
代より使用され現在も多用され続けている。 歯科用カ
ルボキシレート七メント、イオノマーセメント等の様に
高分子化学の進歩により無機材料の一部を有機化合物で
代替した臨床用材料も導入されでいるが、いずれも生体
親和性の点で充分とは言えない。 これらの無機質の歯
科臨床用材料のうち牛体親和性が特にＭ要視されるのは
歯科用七〆ントと裏装剤である。Conventional inorganic materials in the clinical field of teeth 44 include zinc phosphate cement, which is made by mixing zinc oxide with an aqueous solution of orthophosphoric acid, heptamentum silicate, which is made by mixing silicon oxide with an aqueous solution of orthophosphoric acid, and Relining materials containing calcium hydroxide as a main component, dental alloys as prosthetic materials, etc. have been used since the early days of the θ era and continue to be widely used today. Advances in polymer chemistry have led to the introduction of clinical materials in which some of the inorganic materials are replaced with organic compounds, such as dental carboxylate cement and ionomer cement, but these materials are insufficient in terms of biocompatibility. I can't say that. Among these inorganic clinical dental materials, dental septa and lining materials are particularly important for their compatibility with the bovine body.
本発明は、この生体親和性に優れた＠イ」用セメントと
裏装剤の組成物を提供することにある。The object of the present invention is to provide a composition of cement and backing material for this type of cement that has excellent biocompatibility.
現在までの公知の技術のうちで最も生体親和性に優れた
素材としでは水酸化カルシウムアパタイトが注目を集め
ているが、このアパタイトは粉末状で化学活性が低いた
め高温高圧で固形化してインプラントオオ等として用い
られている。 また、多官能メタクリレート等の反応硬
化性樹脂を混オ０しで用いる例等があるが、樹刀后側の
生体親和性が良好でないとアパタイト本来の特性である
生体親和性を生かした材料とはなり得ない。Among the known technologies to date, calcium hydroxide apatite is attracting attention as the material with the best biocompatibility, but since this apatite is in powder form and has low chemical activity, it is solidified at high temperature and pressure and used for implant surgery. It is used as such. In addition, there are examples of using reactive hardening resins such as polyfunctional methacrylate without mixing, but if the biocompatibility of the back side of the tree is not good, it will not work as a material that takes advantage of the biocompatibility, which is the inherent property of apatite. It can't be.
この活性の傅いアバフィト化合物に関連する無機質化合
物のうち比較的活性のある素材としては、グーリン酸三
カルシウムが考えられる。Among the inorganic compounds related to this moderately active abaphyte compound, tricalcium gluphosphate can be considered as a relatively active material.
グーリン酸三カルシウムは水利反応により各ＰＨ条件下
においてリン酸水素カルシウム、リン酸へカルシウム、
水酸化カルシウムアパタイトが生成されることが知られ
でいる。Tricalcium gluphosphate converts into calcium hydrogen phosphate, calcium phosphate,
It is known that calcium hydroxide apatite is produced.
（＋） ＰＨ５，５以下で
Ｃａ３ （ＰＯ４）２ ＋ ４Ｈ２Ｑ →２ＣｊａＨＰ
０４ ・２Ｈ２０＋ ０ａ（ＯＨ）２（２） ＰＨ５，
５〜７．５で
３（！ａ３（ＰＯ４）２ ＋７Ｈ２０→ＣａＢＨ２（Ｐ
Ｏ４）、ｓ 拳５８２０＋（＋ａ（ＯＨ）２
（３） ＰＨ７，５以上で
（ｔｏ Ｚ）Ｃａ３（ＰＯ４）２ ＋３（２＋ｎ Ｚ）
Ｈ２Ｏ−＋３（！ａ、。−２（ＨＦＯ２）２（ＰＯ４）
６−２（Ｏｌｌ）２−２− ｎＨ２Ｏ＋２（Ｉ Ｚ）Ｈ
３ＰＯ４
この仲にグーリン酸三カルシウムは化学活性が高（水Ｘ
１１反応により水酸化カルシウムアパタイトを生成する
ことを利用して生体親和性の高い歯科用組成物を提供す
ることが可能となった。 即ち、問題の多い多官能アク
リレート化合物を用いずに短時間内（５分〜１５分）に
硬化可能で、かつ生体親和性に優れた組成物を提供し得
るのである。(+) At PH5.5 or lower, Ca3 (PO4)2 + 4H2Q →2CjaHP
04 ・2H20+ 0a(OH)2(2) PH5,
5 to 7.5 is 3(!a3(PO4)2 +7H20→CaBH2(P
O4), s fist 5820+(+a(OH)2 (3) PH7.5 or higher (to Z)Ca3(PO4)2 +3(2+n Z)
H2O-+3(!a,.-2(HFO2)2(PO4)
6-2(Oll)2-2- nH2O+2(IZ)H
3PO4 Among these, tricalcium gluphosphate has high chemical activity (water
It has become possible to provide a dental composition with high biocompatibility by utilizing the production of calcium hydroxide apatite through the No. 11 reaction. That is, it is possible to provide a composition that can be cured within a short time (5 to 15 minutes) and has excellent biocompatibility without using polyfunctional acrylate compounds, which are problematic.
本発明の基本成分であるグーリン酸三カルシウムは、と
−ビロリン酸カルシウムと炭酸カルシウムを等モル量混
和し均一化した後、１，２００°Ｃに昇温し１時間保持
した後、急冷ぎせる。 これを用途に応じて微粉化（１
５０メツシュ通過）する。このθ−リン酸三カルシウム
に必要に応じて０〜１３重世％の範囲で亜鉛、アルミニ
ウム、マグネシウムの酸化物を添加して１，０００℃以
下で１時間焼入後微粉化して用いる。Tricalcium gluphosphate, which is a basic component of the present invention, is made by mixing equimolar amounts of calcium pyrophosphate and calcium carbonate to make the mixture homogeneous, then heated to 1,200°C, held for 1 hour, and then rapidly cooled. This is pulverized (1
Pass 50 metshu). If necessary, oxides of zinc, aluminum, and magnesium are added to this θ-tricalcium phosphate in a range of 0 to 13% by weight, quenched at 1,000° C. or lower for 1 hour, and then pulverized and used.
次に実験例の粉末組成１．容液組成を記し、それらの組
合せによる物性を測定した。Next, powder composition 1 of the experimental example. The liquid composition was recorded and the physical properties of the combinations were measured.
試験法は、ＪＩＳＴ ６６Ｑ２に従った。The test method followed JIST 66Q2.
喀粉末Ｐ＞ ＜溶液Ｌ） （練和組成物） 薯Powder P＞ <Solution L) (Kneaded composition) Yam
Claims (1)
亜鉛、アルミニウム、マグネシウムの酸化物のうちの１
種以上を０〜１３盾＃％の範囲で加えた粉末をタンニン
酸、モノフロロリン酸ナトリウム、塩化すトリウム、有
機酸のナトリウム塩の１種以上を含有させた水溶液で練
和することを特徴とする歯科用組成物。One of the oxides of zinc, aluminum, and magnesium as necessary when thermally synthesizing d-tricalcium phosphate.
It is characterized by kneading a powder containing at least 0 to 13% of acetic acid with an aqueous solution containing one or more of tannic acid, sodium monofluorophosphate, thorium chloride, and a sodium salt of an organic acid. Dental composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58145057A JPS6036404A (en) | 1983-08-10 | 1983-08-10 | Dental composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58145057A JPS6036404A (en) | 1983-08-10 | 1983-08-10 | Dental composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6036404A true JPS6036404A (en) | 1985-02-25 |
Family
ID=15376378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58145057A Pending JPS6036404A (en) | 1983-08-10 | 1983-08-10 | Dental composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6036404A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6183107A (en) * | 1983-10-27 | 1986-04-26 | Mirai Kagaku Kenkyusho:Kk | Dental cement composition |
| JPH01166763A (en) * | 1987-12-22 | 1989-06-30 | Nitta Gelatin Inc | Medical and dental curable material |
| GB2236676A (en) * | 1988-09-29 | 1991-04-17 | Sangi Kk | Antimicrobial hydroxyapatite powders |
| US5145520A (en) * | 1989-08-29 | 1992-09-08 | Kyoto University | Bioactive cement |
| US5223029A (en) * | 1988-08-10 | 1993-06-29 | Nitta Gelatin Inc. | Hardening material for medical and dental use |
| US5238491A (en) * | 1988-07-23 | 1993-08-24 | Nitta Gelatin Inc. | Hardening material for medical and dental use |
| US5683667A (en) * | 1994-11-04 | 1997-11-04 | Norian Corporation | Reactive tricalcium phosphate compositions |
-
1983
- 1983-08-10 JP JP58145057A patent/JPS6036404A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6183107A (en) * | 1983-10-27 | 1986-04-26 | Mirai Kagaku Kenkyusho:Kk | Dental cement composition |
| JPH01166763A (en) * | 1987-12-22 | 1989-06-30 | Nitta Gelatin Inc | Medical and dental curable material |
| US5238491A (en) * | 1988-07-23 | 1993-08-24 | Nitta Gelatin Inc. | Hardening material for medical and dental use |
| US5223029A (en) * | 1988-08-10 | 1993-06-29 | Nitta Gelatin Inc. | Hardening material for medical and dental use |
| GB2236676A (en) * | 1988-09-29 | 1991-04-17 | Sangi Kk | Antimicrobial hydroxyapatite powders |
| GB2236676B (en) * | 1988-09-29 | 1992-01-22 | Sangi Kk | Antimicrobial hydroxyapatite powders |
| US5145520A (en) * | 1989-08-29 | 1992-09-08 | Kyoto University | Bioactive cement |
| US5683667A (en) * | 1994-11-04 | 1997-11-04 | Norian Corporation | Reactive tricalcium phosphate compositions |
| US5709742A (en) * | 1994-11-04 | 1998-01-20 | Norian Corporation | Reactive tricalcium phosphate compositions |
| US5885540A (en) * | 1994-11-04 | 1999-03-23 | Norian Corporation | Reactive tricalcium phosphate compositions |
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