JPS6038314A - Hair tonic - Google Patents
Hair tonicInfo
- Publication number
- JPS6038314A JPS6038314A JP58145843A JP14584383A JPS6038314A JP S6038314 A JPS6038314 A JP S6038314A JP 58145843 A JP58145843 A JP 58145843A JP 14584383 A JP14584383 A JP 14584383A JP S6038314 A JPS6038314 A JP S6038314A
- Authority
- JP
- Japan
- Prior art keywords
- glucopyranoside
- protopanaxatriol
- saponin
- hair
- glucopyranosyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
この発明は実質的（・こオタネニンジン中Ｑこ存在する
サポニン成分のみまたはその成分であるギンゼノサイド
Ｒｈｘ、ギンゼノサイドＲｇＱ、キ゛ンゼノサイドＲｇ
、、ギンゼノサイドＲｅ、ギンゼノサイドＲｂ、のｒｌ
ｉ−もしくは混合物を有効成分として含む育毛剤Ｇこ関
する。DETAILED DESCRIPTION OF THE INVENTION The present invention substantially comprises only the saponin component present in Panax ginseng, or its components such as ginsenoside Rhx, ginsenoside RgQ, and ginsenoside Rg.
,, rl of Ginsenoside Re, Ginsenoside Rb,
A hair growth agent G containing i- or a mixture as an active ingredient.
ウコギ科に属するオタネニンジン（パナックスギンゼン
グ、シー、エイ、メイヤー； Ｐａｎａｘｇｉｎｓｅｎ
ｇ％Ｃ，Ａ、■花Ｒ）は−名チヨウセンニンジンと呼ば
れ、古来より疲労回復、強精、消炎、利尿、胃腸衰弱改
善、抗糖尿用の薬剤として用いられてきたことは広く知
られていることである。Panax ginseng (Panax ginseng, Si, Ei, Meyer) belonging to the family Araliaceae
g%C, A, ■Flower R) is known as Panax ginseng, and it is widely known that it has been used since ancient times as a drug for recovering from fatigue, strengthening virility, anti-inflammatory, diuretic, improving gastrointestinal weakness, and as an anti-diabetic agent. This is what is happening.
近時、これらの薬効がチョウセンニンジン中のサポニン
成分によるのではないかとの研究が進められている。Recently, research has been underway to investigate whether these medicinal effects may be due to the saponin components in ginseng.
しかしながらこのサポニンがヒト細胞賦活特に育毛の効
果を有することは全く知られていない。However, it is completely unknown that this saponin has the effect of activating human cells, especially hair growth.
白毛症（いわゆる白髪）や脱毛症には決定的な治療法が
存在しないことは周知の事実である。過去に畝素剤、ビ
タシンＡ、パラアミノ安息香酸、パントテン酸カルシウ
ムなどが試みられたことがあるが、いづれも適確な効果
が得られていない。It is a well-known fact that there is no definitive treatment for albinism (so-called gray hair) and alopecia. In the past, ridge agents, Vitacin A, para-aminobenzoic acid, calcium pantothenate, etc. have been tried, but none of them have been effective.
従って、白髪の悩をこは染髪が唯一の解決法となりかつ
脱毛症にはカッテが唯一の解決法となっているが、この
目的に使用される染髪剤は皮膚炎を起すことが多く、ま
た染髪後、時間の経過と共に毛髪基部の白髪がかえって
目立つ様になるなどの欠点を有し、又カッテは何ら根本
的な解決法とはいえない欠点を有する。それ故、前記方
法も必ずしも好ましい解決策とはいい難い。Therefore, hair dye is the only solution to the problem of gray hair, and hair cut is the only solution to hair loss, but hair dyes used for this purpose often cause dermatitis, and After hair dyeing, there are drawbacks such as gray hair at the base of the hair becoming more noticeable as time passes, and haircuts also have drawbacks that cannot be said to be a fundamental solution. Therefore, the above method is not necessarily a preferable solution.
本発明者らは、実際的な効果を有する育毛治療剤を開発
すべく、長年Ｏこ渡って研究を重ねた結果、オタネニン
ジンのサポニン成分Ｏこ育毛活性があることを見出し、
本発明を完成するをこ至った。The present inventors have conducted extensive research over many years in order to develop a hair growth treatment with practical effects, and have discovered that the saponin component of Panax ginseng has hair growth activity.
We have now completed the present invention.
この発明は、オタネニンジン中のサポニン成分が育毛作
用を有し、特にギンゼノザイドＲｈ、：２０ｓ−プロト
パナキザＩ・リオールー６、− ｏ−β−Ｄ−ダルコビ
ラノシド、
ギンゼノサイトＲｇ２：２０ｓ ７’ロトパナキサトリ
オール−６−ｏ−α−Ｌ−ラムノピラノシル（ｌ→２）
−β−Ｄ−グルコピラノシド、
ギンゼノザイドＲｇ、：２０ｓ−プロトパナキサトリオ
ール−６，２０−ジー０−β−Ｄ−グルコピラノシト、
ギンゼノサイトＲｅ ：２０ｓ−プロトパナサキトリオ
ール−６−〔ｏ−α−Ｌ−ラムノピラノシル（し
１＋２）−β−Ｄ−グルコピラノシド’］−２０−０−
β−Ｄ−グルコピラノシド、
ギンゼノサイドＲｂ、：２０ｓ−プロトバナキサジオー
ル−３−〔ｏ−β−Ｄ−グルコピラノシル（１→２）−
β−Ｄ−ダルコピラノシド）−２０−（０−β−Ｄ−グ
ルコピラノシル（１−６）−β−Ｄ−グルコピラノシド
〕にその効果が著しいという新しい知見に基づいてなさ
れたものである。This invention provides that saponin components in Panax ginseng have a hair-growth effect, particularly ginzenozide Rh: 20s-protopanaxatriol-6, -o-β-D-darcobylanoside, ginzenocyte Rg2: 20s 7' lotopanaxatriol-6 -o-α-L-rhamnopyranosyl (l→2)
-β-D-glucopyranoside, ginzenozide Rg,: 20s-protopanaxatriol-6,20-di0-β-D-glucopyranosite, ginzenocyte Re: 20s-protopanaxatriol-6-[o-α-L- rhamnopyranosyl (1+2)-β-D-glucopyranoside']-20-0-
β-D-glucopyranoside, ginsenoside Rb,: 20s-protovanaxadiol-3-[o-β-D-glucopyranosyl (1→2)-
This was based on the new finding that the effect is remarkable on β-D-darcopyranoside)-20-(0-β-D-glucopyranosyl(1-6)-β-D-glucopyranoside).
この発明で使用するオタネニンジンの生薬からサポニン
成分を得る方法としては、例えば次のような方法で得る
ことができる。 すなわち、原料となるニンジンを脱脂
せずに、あるいは通常の脂溶性有機溶媒を用いて脱脂後
、水または低級脂肪族アルコール類あるいは含水低級脂
肪族アルコールを用いてその有効成分を抽出し、抽出液
を蒸発濃縮して抽出エキスとする。 これをｎ−ブタノ
ールに溶解し、該溶解液に水を加えて振帰した後静置し
てｆ溶性物質を除去し、ｎ−ブタノール層を蒸発乾固す
る。As a method for obtaining the saponin component from the herbal medicine of Panax ginseng used in this invention, it can be obtained, for example, by the following method. That is, the carrots used as raw materials are degreased without being defatted, or after being defatted using a normal fat-soluble organic solvent, and the active ingredients are extracted using water, lower aliphatic alcohols, or hydrous lower aliphatic alcohols, and the extract is made into an extract. is evaporated and concentrated to obtain an extract. This is dissolved in n-butanol, water is added to the solution, shaken and left to stand to remove f-soluble substances, and the n-butanol layer is evaporated to dryness.
残留物を低級脂肪族アルコールに溶解後、エーテル中に
攪拌注入して得られた析出物を戸取すればよい。（特公
昭４８−５０１６号参照）。After dissolving the residue in a lower aliphatic alcohol, the resulting precipitate may be collected by stirring and pouring into ether. (See Special Publication No. 48-5016).
このようにして得られた抽出物は実質的にサポニン成分
のみを含むものであって、そのままこの発明の有効成分
として使用できる。The extract thus obtained contains substantially only saponin components and can be used as is as an active ingredient in the present invention.
この発明によるサポニン成分は、原料とするオタイ・ニ
ンジンの栽培年数などにまって構成される成分の種類・
量に若干の差があるが、後述するごとき式（１）、（Ｉ
Ｉ）および（ｍ）の化合物を含有するものである。サポ
ニン成分の全体の性状としては、いずれも黄白色〜かっ
色の粉末で苦味を有し、水、メタノール、希メタノール
に易溶、エタノールに可溶、クロロホルム、エーテル、
四塩化炭素に不溶である。 また酸加水分解をこまって
必ず水可溶部からブドウ糖が得られ、水不溶部からバナ
キサジオール（Ｃ３ｏ）ＬＯｓ 、ｍｐ ２０５℃）お
よび／または、バナキサトリオール（Ｃ８０Ｈ６２０４
、ｍｐ ２３８〜２３９℃）が得られる。The saponin component according to this invention is composed of different types of components depending on the number of years the ginseng used as the raw material was cultivated.
Although there is a slight difference in the amount, Equations (1) and (I
It contains the compounds I) and (m). The overall properties of the saponin components are that they are all yellowish-white to brownish powders with a bitter taste, easily soluble in water, methanol, diluted methanol, soluble in ethanol, chloroform, ether,
Insoluble in carbon tetrachloride. In addition, glucose is always obtained from the water-soluble part after acid hydrolysis, and vanaxadiol (C3o) LOs (mp 205°C) and/or vanaxatriol (C80H6204) is obtained from the water-insoluble part.
, mp 238-239°C).
また組織培養によりサポニンを得るには例えばノツプ（
Ｋｎｏｐ）培養液（硫酸カルシウム１０００ｍど１１硝
酸カリウム２５０ｍｇ／ｌ、硫酸マダイ・シウム２５０
ｍｇ／ｌ、第１燐酸カリウム２５０ｍｇ／ｌ ） ５
００ｍ４、ヘラ−（ｄ’Ｈｅ１ｌｅｒ）のミネラル液１
ｍｅ／ ｌ 、ブ１”７糖５係、ビタミンＢ １０−
’ ｇ、ヒオチン１ｏ−６ｇ、カイ＋−ｙ−ンｌｏ−ｅ
ｇ、寒天１係よりなる培地にオタネニンジンの根の組織
片を入れ、２６℃に保って培養増殖せしめ、ニンジンカ
ルスを得る。In addition, to obtain saponin by tissue culture, for example, Nopu (
Knop) culture solution (calcium sulfate 1000ml, potassium nitrate 250mg/l, red sea bream sulfate 250ml)
mg/l, monobasic potassium phosphate 250mg/l) 5
00m4, d'He1ler mineral liquid 1
me/l, bu 1” 7 sugars 5, vitamin B 10-
' g, hyotine 1o-6g, chi+-y-n lo-e
g. A piece of root tissue of Panax ginseng is placed in a medium consisting of 1 part agar and cultured and grown at 26°C to obtain carrot callus.
次いでこのカルスを同一の培地を用いて大計増殖させ、
このものを前記した抽出法と同様にして抽出精製するこ
とによってサポニン成分を得ることができる。This callus was then grown to a large scale using the same medium,
The saponin component can be obtained by extracting and purifying this product in the same manner as the extraction method described above.
また、この発明Ｑこおけるサポニン成分中には次の式（
１）または（ＩＩ）で表わされるギンゼノザイｔ” （
ｇｉｎｅｎｏｓｉｄｅ）順の少なくとも一種類が含まれ
、さらに場合にまり式（ｍ）で表わされるβ−Ｄ−グル
コビラノシルオレアネー）−（３）−β−Ｄ−グルコピ
ラノシル（］−１２）−／１−Ｄ−グルクロノ式中、Ｒ
、＋はβ−Ｄ−グルコピラノシル（１１２）−β−Ｄ−
グルコピラノシル基を示り、Ｒ’はβ−Ｄ〜グルコピラ
ノシル（１→６）−β−Ｄ−グルコピラノシル基、α−
Ｌ−アラビノピラノシル（１−６）−／１−Ｄ−グルコ
ピラノシル基、β−Ｄ−キシロピラノシル（１→６）β
−Ｄ−グルコピラノシル基、α−Ｌ−アラビノフラノシ
ル（］→６）−β−Ｄ−グルコピラノシル基マタはβ−
Ｄ−グルコピラノシル基を示ス。In addition, the saponin component of this invention Q contains the following formula (
1) or (II)
β-D-glucobyranosyloleane)-(3)-β-D-glucopyranosyl(]-12)-/ In the 1-D-glucurono formula, R
, + is β-D-glucopyranosyl (112)-β-D-
Represents a glucopyranosyl group, R' is β-D~glucopyranosyl (1→6)-β-D-glucopyranosyl group, α-
L-arabinopyranosyl (1-6)-/1-D-glucopyranosyl group, β-D-xylopyranosyl (1→6)β
-D-glucopyranosyl group, α-L-arabinofuranosyl (]→6)-β-D-glucopyranosyl group is β-
Indicates D-glucopyranosyl group.
式中、Ｒ′１はα−Ｌ−ラムノピラノシル（１→２）−
β−Ｄ−グルコピラノシル基、β−Ｄ−グルコピラノシ
ル（１→２）−β−Ｄ−グルコピラノシル基、β−Ｄ−
ダルコピラノシル基またはα−Ｌ−ラムノピラノシル（
！→２）−β−Ｄ−グルコピラノシル基を示し、Ｒ′は
水素原子またはβ−Ｄ−グルコピラノシル基を示す。In the formula, R'1 is α-L-rhamnopyranosyl (1→2)-
β-D-glucopyranosyl group, β-D-glucopyranosyl (1→2)-β-D-glucopyranosyl group, β-D-
darcopyranosyl group or α-L-rhamnopyranosyl (
! →2) -β-D-glucopyranosyl group, R' represents a hydrogen atom or β-D-glucopyranosyl group.
式中、Ｒ５はβ−Ｄ−グルコピラノシル基を示し、Ｒ６
はβ−Ｄ−グルコピラノシル（］−＋２）−β−Ｄ−グ
ルクロノピラノシル基を示す。In the formula, R5 represents a β-D-glucopyranosyl group, and R6
represents a β-D-glucopyranosyl (]-+2)-β-D-glucuronopyranosyl group.
式（Ｉ）および式（■）゛で表わされるサポニンはトリ
テルペンのダンマラン系配糖体に属するサポニンである
。 これら式（Ｉ）および式（ＴＩ）のサポニンは、現
在のところオタネニンジンの如き薬用ニンジンにのみに
特異的に含まれることが判明しているものである。The saponins represented by formulas (I) and (■) are saponins belonging to the dammarane glycosides of triterpenes. These saponins of formula (I) and formula (TI) are currently known to be specifically contained only in medicinal ginseng such as Panax ginseng.
式（Ｄで表わされる化合物の個々の具体名としては、２
０ｓ−プロトバナキサジオール−３−（ｏ−β−Ｄ−グ
ルコピラノシル（１→２）−β−Ｄ−グルコピラノシド
）−２０−［：ｏ−β−Ｄ−グルコピラノシル（１→６
）−β−Ｄ−グルコピラノシ１’〕（ギンゼノサイドＲ
ｂ、 ）、２０ｓ−プロトバナキサジオール−３−Ｃｏ
−β−Ｄ−グルコピラノシル（１→２）−β−Ｄ−グル
コピラノシド〕−２０−（ｏ−α−Ｌ−アラビノピラノ
シル（１→６）−β−Ｄ−グルコピラノシド〕（ギンゼ
ノサイドＲｂ２）、２０ｓ−プロトパナキサジオール−
３−〔０−β−Ｄ−ダルコピラノシル（１→２）−β−
Ｄ−グルコピラノシド）−２０−（ｏ−α−Ｌ−アラビ
ノフラノシル（１→６）−β−Ｄ−グルコピラノシド〕
（ギンゼノサイドＲｃ）、 ２０ｓ−プロトバナキサジ
オール−３−（ｏ−β−Ｄ−グルコピラノシル（１→２
）−β−Ｄ−グルコピラノシド）−２Ｏ−Ｃｏ−β−Ｄ
−キシロピラノシル（１→６）−β−Ｄ−グルコピラノ
シド〕（ギンゼノサイドＲｂ２）および２０ｓ−プロト
パナキサジオール−３−〔ｏ−β−Ｄ−グル゛コピラノ
シル（１→２）−β−Ｄ−グルコピラノシド）−２０−
Ｃｏ−β−り一グルコピラノシド〕（ギンゼノサイドＲ
’ｄ）が挙げられる。As individual specific names of the compound represented by the formula (D), 2
0s-protovanaxadiol-3-(o-β-D-glucopyranosyl(1→2)-β-D-glucopyranoside)-20-[:o-β-D-glucopyranosyl(1→6
)-β-D-glucopyranosi 1'] (ginsenoside R
b, ), 20s-protovanaxadiol-3-Co
-β-D-glucopyranosyl (1→2)-β-D-glucopyranoside]-20-(o-α-L-arabinopyranosyl (1→6)-β-D-glucopyranoside) (ginzenoside Rb2), 20s-protopanaxadiol-
3-[0-β-D-darcopyranosyl (1→2)-β-
D-glucopyranoside)-20-(o-α-L-arabinofuranosyl (1→6)-β-D-glucopyranoside]
(Ginsenoside Rc), 20s-protovanaxadiol-3-(o-β-D-glucopyranosyl (1→2
)-β-D-glucopyranoside)-2O-Co-β-D
-xylopyranosyl(1→6)-β-D-glucopyranoside] (ginzenoside Rb2) and 20s-protopanaxadiol-3-[o-β-D-glucopyranosyl(1→2)-β-D-glucopyranoside) -20-
Co-β-ri-glucopyranoside] (Ginsenoside R
'd).
式（ＩＩ）で表わされる化合物の具体名としては２０ｓ
−プロトパナキサトリオール−６−〔Ｏ−α−Ｌ−ラ
ムノピラノシル（１→２）−β−Ｄ−グルコピラノシド
］−２０−ｏ−β−Ｄ−グルコピラノシト（ギンゼノサ
イドＲｅ）、２０ｓ−プロトパナキサトリオールー６−
ｏ−β−Ｄ−グルコピラノシル（ｌ→２）−β−Ｄ−グ
ルコピラノシド（ギンゼノサイドＲｆ）、２０ｓ−プロ
トパナキサトリオールー６．２０−ジー０−β−Ｄ−グ
ルコピラノシド（ギンゼノサイドＲｇ＋ ）、２０ｓ−
プロトパナキサトリオール−６−０−α−Ｌ−ラムノピ
ラノシル（１→２）−β−Ｄ−グルコピラノシド（ギン
ゼノサイドＲｇ、）、２０ｓ−プロトパナキサトリオー
ルー６−〔０−β−Ｄ−グルコピラノシル（１→２）−
β−Ｄ−グルコピラノシド’］−２０−０−β−グルコ
ピラノシド（ギンイノサイド２０−グルコ−Ｒｆ）およ
び２０ｓ −プロトパナキサトリオール−６−０−β−
Ｄ−グルコビラノド（ギンゼノサイドＲｈ、 ）が挙げ
られる。A specific name of the compound represented by formula (II) is 20s
-Protopanaxatriol-6-[O-α-L-rhamnopyranosyl (1→2)-β-D-glucopyranoside]-20-o-β-D-glucopyranoside (ginzenoside Re), 20s-protopanaxatriol- 6-
o-β-D-glucopyranosyl (l→2)-β-D-glucopyranoside (ginzenoside Rf), 20s-protopanaxatriol-6.20-di0-β-D-glucopyranoside (ginzenoside Rg+), 20s-
Protopanaxatriol-6-0-α-L-rhamnopyranosyl (1→2)-β-D-glucopyranoside (ginzenoside Rg, ), 20s-protopanaxatriol-6-[0-β-D-glucopyranosyl (1 →2)-
β-D-glucopyranoside']-20-0-β-glucopyranoside (gininoside 20-gluco-Rf) and 20s-protopanaxatriol-6-0-β-
Examples include D-glucobyranod (ginzenoside Rh).
なお、オタネニンジン中には前述した式（Ｉ）。In addition, Panax ginseng contains the above-mentioned formula (I).
（ＩＩ）およびＣＩｎ ）の構造式を有するサポニンの
ｆＪ！。(II) and CIn) of saponins with the structural formulas fJ! .
に式（Ｉ’）の骨格を有すると考えられるギンゼノサイ
ドＲａと称せられている構造未定のサポニンおよび式（
ＩＩ）の骨格を有すると考えられるギンゼノサイドＲｈ
２と称せられている構造未定のサポニンも含まれており
、これらの物質もこの発明のサポニン成分に含まれる。A saponin with an undetermined structure called ginzenoside Ra, which is thought to have a skeleton of formula (I'), and a saponin of formula (I')
II) Ginsenoside Rh that is thought to have the skeleton
A saponin of undetermined structure called 2 is also included, and these substances are also included in the saponin component of the present invention.
また、ギンゼノサイドＲｈ＋ 、 Ｒｇｘ 、 Ｒｇ＋
、 Ｒｅ。In addition, ginzenoside Rh+, Rgx, Rg+
, Re.
Ｒｂ、は前述の如くして得られたサポニン成分をクロロ
ホルム／メタノール／水系あるいはｎ−ブタノール／酢
酸水系の展開溶剤を用いたシリカゲルカラムクロマトグ
ラフィー、高速液体クロマトグラフィーなどにより各構
成サポニンに分離、精製することによって得ることがで
きる。Rb is obtained by separating and purifying the saponin component obtained as described above into each constituent saponin by silica gel column chromatography, high performance liquid chromatography, etc. using a developing solvent of chloroform/methanol/water system or n-butanol/acetic acid water system. You can get it by doing
夫々性状は次の通りである。The properties of each are as follows.
１、分子式、融点および比旋光度
サポニン名 分子式 剛直（Ｏ比旋光度ギンゼノサイド
Ｒｈｌ Ｃ３６Ｈ６，０９１５６（α’１２２＝＋２０
゜（メタノール）
ギ′ゼ′サイドＲｇ、Ｃ，・■・Ｑ・ １８７〜１８９
〔“〕〕Ｚ−＋デ毛（メタノール）
Ｒｇ、Ｃ，２Ｈ７２Ｑ、・ル１９ト１９６ （α）計＋
３０．３゜（ピリジン）
Ｒｅ Ｃ４８Ｈ８２０１８・ＨＩＤ ２０６〜２０７〔
α）” ＝−３４８゜（メタノール）
Ｒｂ、Ｃ，Ｈ，２Ｑ８−２Ｉ−Ｌ。 ２０５ 〔α躬＝
十Ｉ２７７゜（メタノール）
２、いずれも白色の結晶で苦味を有し水、メタノール、
希メタノールに易溶、エタノールに可溶、クロロホルム
、四塩化炭素に難溶である。1. Molecular formula, melting point, and specific rotation Saponin name
゜(methanol) G'ze' side Rg, C,・■・Q・ 187~189
[“]] Z-+ Demo (methanol) Rg, C, 2H72Q, 196 (α) total +
30.3゜(Pyridine) Re C48H82018・HID 206-207 [
α)” = −348° (methanol) Rb, C, H, 2Q8-2I-L. 205 [α躬=
1277゜ (methanol) 2. Both are white crystals with a bitter taste and contain water, methanol,
Easily soluble in dilute methanol, soluble in ethanol, slightly soluble in chloroform and carbon tetrachloride.
３、いずれも水と共に振るとき持続性の小泡を生じ、リ
ーベルマン反応、ザラコラスキー反応陽性である。3. All of them produce persistent small bubbles when shaken with water, and are positive for Lieberman reaction and Zalacolaski reaction.
４、酸加水分解反応によって、水不溶部よりＲｂ。4. Rb is removed from the water-insoluble portion by acid hydrolysis reaction.
、よりはパナキサジオール（Ｃ，、ｆ偏０８０ｍｐ２０
５℃）Ｒｈ、、Ｒｇ２、Ｒｇ＋ 、Ｒｅよりはパナキサ
トリオール（Ｃ，、Ｉ−ｂ曾α、ｍｐ２３８℃）が得ら
れる。又、水可溶部より、Ｒｂ、よりはグルコーゼが、
Ｒｈ、よりはグルコーゼ、Ｒｇ２よりはグルコーゼとラ
ムノーゼが、Ｒｇ、よりはグルコーゼが、Ｒｅよりはグ
ルコーゼとラムノーゼが得られる。, more than panaxadiol (C,, f-biased 080mp20
Panaxatriol (C, I-b, mp 238°C) is obtained from Rh, Rg2, Rg+, and Re (5°C). In addition, from the water-soluble part, Rb, or rather glucose,
Glucose is obtained from Rh, glucose and rhamnose are obtained from Rg2, glucose is obtained from Rg, and glucose and rhamnose are obtained from Re.
以上のようにして得られたチョウセンニンジンサポニン
並びをこギンゼノサイドＲｈ、 、 Ｒｇ２． Ｒｇ＋
。The ginseng saponin sequence obtained as above was converted into ginseng xenoside Rh, , Rg2. Rg+
.
Ｒｅ、 ’Ｒｂ＋ はエキスとして１日２０ｍｇ〜５０
０ｍｇ１子ましくは５０ｍｇ〜２００ ｍｇを２〜３回
に分けて投与することにより効力を発揮できる。Re, 'Rb+ is 20mg to 50mg per day as an extract
The efficacy can be exerted by administering 0 mg per dose or 50 mg to 200 mg in 2 to 3 divided doses.
投与は、経口、非経口の何れであってもよい。Administration may be either oral or parenteral.
経口投与の際は、散剤、丸剤、錠剤等とされる。For oral administration, it is administered in the form of powders, pills, tablets, etc.
これらの剤型は、乳糖、澱粉、デキストリン等の賦形剤
に適宜他の添加剤を添加し、通常の製剤化技術に従って
作られる。 また非経口投与の際は例えば坐剤や注射剤
とされる。 注射剤とすれば例えばリンゲル液をここの
発明の有効成分をそのまま又は予め適当な倍量に希釈し
た水性溶液を、添加して注射剤とするのが好ましい。
坐剤は、通常の坐剤の製造技術に従って作られる。These dosage forms are prepared by adding appropriate other additives to excipients such as lactose, starch, and dextrin, and according to conventional formulation techniques. For parenteral administration, it may be administered as a suppository or injection. In the case of an injection, it is preferable to prepare an injection by adding, for example, Ringer's solution containing the active ingredient of the present invention as it is or an aqueous solution which has been previously diluted to an appropriate volume.
Suppositories are made according to conventional suppository manufacturing techniques.
チョウセンニンジンサポニンを上記の投与形態及び量で
約３カ月間服用すれば、育毛の効果が現れるが、内服す
る代りＯこ、チョウセンニンジンサポニンを水性あるい
はアルコール性溶液としテ直接患部に塗布することによ
っても同、１１の効果を期待することができる。If you take ginseng saponin in the above dosage form and amount for about 3 months, you will see the effect of hair growth, but instead of taking it orally, you can make ginseng saponin into an aqueous or alcoholic solution and apply it directly to the affected area. You can also expect the same 11 effects.
次にこの発明の試験例を示す。Next, test examples of this invention will be shown.
試験例１
３９才 男性
３０才頃より白髪力寸１立ち始め、現（Ｅ ｆよほとん
ど呈灰白色。 爪巾状態は普通。Test Example 1 39-year-old male His hair started to grow gray around the age of 30, and is now almost grayish white. His nails are normal in width.
チョウセンニンジンサポニン−日量２０ ｍｇに乳糖を
加えて２ｙとし、よく混和してこれを朝、タ二回分服せ
しめたところ、５０１１１−１ぐらいから黒髪が見え始
め、１年後には約５０係の黒髪が混るようになった。Ginseng saponin - Add lactose to 20 mg per day to make 2 Y, mix well, and take this twice in the morning. Black hair started to appear around 50111-1, and after a year, about 50 people. Black hair started to mix in.
試験例２
６２才 男性
５０才頃より白髪と抜毛が多いよう（二なり、現在はほ
とんど白髪で、爪巾状態も額から頭頂部Ｑこかけて地肌
がすけて姑えるようをこなっ−Ｃいる。Test Example 2 A 62-year-old man who seems to have gray hair and hair loss more frequently than around the age of 50 (he is now almost gray, and his fingernails are in such a condition that his skin is thinning from the forehead to the top of the head.-C There is.
チョウセンニンシンザボニン１目量２０ｍｇを乳糖を加
えて２ｇとし混和してこれを１０個の粗錠に仕立て、朝
、夕に分服せしめた。 約２ケ月後に脱毛が目立たなく
なり、約３ケ月「１頃から白髪の白さが茶から灰色を帯
び始め、１年後には全体の外観が灰白色になり、毛髪に
うすぐろい部分も混るようになった。A daily dose of 20 mg of ginseng sinzabonin was mixed with lactose to make 2 g, and this was made into 10 coarse tablets, which were divided into doses in the morning and evening. After about 2 months, the hair loss becomes less noticeable, and after about 3 months, the whiteness of the gray hair starts to turn from brown to gray, and after a year, the overall appearance becomes grayish-white, and there are brittle spots in the hair. became.
額から頭頂部の透けは、頭初を５０係程度とすると約２
０係ぐらいまで目立って低下した。The transparency from the forehead to the top of the head is about 2 if the beginning of the head is about 50%.
It dropped noticeably to around 0.
試験例３゜
４６オ 女性
外観白髪の程度が、約５０係であったが、試験例２の粗
錠１０個を−１に回分服し、５ケ月後外観白髪率約１０
％にまで回復した。また頭頂部付近の爪巾度も、もとも
と地肌が少し見えていたのが全く見えなくなっていた。Test Example 3゜46o A woman's external appearance was approximately 50% gray hair, but she took 10 tablets of Test Example 2 in -1 doses, and after 5 months, the appearance gray hair rate was approximately 10.
recovered to %. Also, the width of the nails near the top of the head, which originally showed a little skin, was no longer visible at all.
試験例４
２７オ 男性
２５才頃より脱毛が］］立ち、現在頭頂部が常時透けて
見える。その範囲は直径約３ｃｍの円形である。Test Example 4 27o Male Hair loss started around the age of 25. Currently, the top of the head is always visible. The area is circular with a diameter of about 3 cm.
ニンシンザボニン １００ｍｇ
水 ３１’
エタノール ６９．９．９
上記Ｏこより液剤（ヘアートニック）を作り、朝晩二回
頭頂部にふりかけ、よくマツサージをさせた。Garlic Zabonin 100mg Water 31' Ethanol 69.9.9 The above O-coated solution (hair tonic) was prepared and sprinkled on the top of the head twice in the morning and evening to give a good pine surge.
１年後、頭頂部の透けは直射光下でなければ目立たなく
なり、脱毛も従来より明らかに少なくなった。After one year, the transparency on the top of the head was no longer noticeable unless under direct sunlight, and hair loss was noticeably less than before.
以−１−の結果から明らかな如く、この発明に係る育毛
剤は優れた効Ｗを有することが判る。As is clear from the results in -1- below, it is clear that the hair growth agent according to the present invention has excellent efficacy W.
Claims (2)
、エイ、メイヤー）のサポニン成分を有効成分として含
有する育毛剤。(1) A hair growth agent containing the saponin component of Panax ginseng (Panax Ginseng, C., A., Mayer) as an active ingredient.
ｓ−プロトパナキサトリオールー６−０−β−Ｄ−グル
コピラノシド、 ギンゼノサイドＲｇ２：２０ｓ−プロトパナキ°サトリ
オールー６−ｏ−α−Ｌ−ラムノピラノシル（１−２）
−８−Ｄ−グルコピラノシド、 ギンゼノサイドＲｇ、：２０ｓ−プロトパナキサトリオ
ールー６．２０−ジー０−β−Ｄ−グルコピラノシド、 ギンイノサイドＲｅ：２０ｓ−プロトパナキサトリオー
ルー６−〔ｏ−α−Ｌ−ラムノピラノシル（１−２）−
β−Ｄ−グルコピラノシド）−２０−ｏ−Ｒ−Ｄ−グル
コピラノシドおよび ギンゼノザイトＲ１）ｌ：２０３−プロトパナキザジオ
ール−３−Ｃｏ−Ｂ−Ｄ−グルコピラノシル（ｌ−２）
−〇−Ｄ−グルコピラノシド）−２０−〔０−β−Ｄ−
グルコピラノシル（１−６）−β−゛Ｄ−グルコピラノ
シド〕 の単一物または混合物である特許請求の範囲第１項記載
の育毛剤。(2) The saponin component is ginsenoside Rh: 20
s-protopanaxatriol-6-0-β-D-glucopyranoside, ginzenoside Rg2:20s-protopanaxatriol-6-o-α-L-rhamnopyranosyl (1-2)
-8-D-glucopyranoside, ginzenoside Rg,: 20s-protopanaxatriol-6.20-di0-β-D-glucopyranoside, gininoside Re: 20s-protopanaxatriol-6-[o-α-L- Rhamnopyranosyl (1-2)-
β-D-glucopyranoside)-20-o-R-D-glucopyranoside and ginzenozite R1)l: 203-protopanaxadiol-3-Co-B-D-glucopyranosyl (l-2)
-〇-D-glucopyranoside)-20-[0-β-D-
The hair growth agent according to claim 1, which is a single substance or a mixture of glucopyranosyl (1-6)-β-D-glucopyranoside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58145843A JPS6038314A (en) | 1983-08-10 | 1983-08-10 | Hair tonic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58145843A JPS6038314A (en) | 1983-08-10 | 1983-08-10 | Hair tonic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6038314A true JPS6038314A (en) | 1985-02-27 |
Family
ID=15394382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58145843A Pending JPS6038314A (en) | 1983-08-10 | 1983-08-10 | Hair tonic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6038314A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994006402A3 (en) * | 1992-09-17 | 1994-05-11 | Cosmetic or dermatologic composition containing at least one saponine of the ginsenoside type, and its applications particularly to hair care | |
| US5567701A (en) * | 1988-08-25 | 1996-10-22 | L'oreal | Alkylpolyglycoside and pyrimidine derivative based composition for inducing and stimulating hair growth and/or reducing hair loss |
| JP2001288098A (en) * | 2000-04-10 | 2001-10-16 | Maruzen Pharmaceut Co Ltd | Melanin production promoter and white hair improving agent |
| WO2002007732A3 (en) * | 2000-07-26 | 2002-11-07 | Univ Cambridge Tech | Use of panaxatriol for stimulation angiogenesis |
| JP2009530369A (en) * | 2006-03-21 | 2009-08-27 | ヘオング ゲオン チョイ | Natural herbal hair growth promoting composition and method for producing the same |
| JP2011135835A (en) * | 2009-12-28 | 2011-07-14 | Lion Corp | Composition containing dammarane triterpene, and method for improving taste |
| WO2017195841A1 (en) * | 2016-05-13 | 2017-11-16 | 株式会社Ｎｉｌ | Hair pigment enhancer |
| JP2017206497A (en) * | 2016-05-13 | 2017-11-24 | 株式会社Ｎｉｌ | Hair pigment enhancer |
| JP2019038790A (en) * | 2017-08-28 | 2019-03-14 | 共栄化学工業株式会社 | Hair cosmetics |
| JP2019210245A (en) * | 2018-06-05 | 2019-12-12 | 日本メナード化粧品株式会社 | CXCL12 expression promoter |
| JP2021147347A (en) * | 2020-03-18 | 2021-09-27 | Ｇａｉｎ３９２４株式会社 | Hair growing/restoring agent and production metho thereof |
| JP2023521275A (en) * | 2020-02-05 | 2023-05-24 | エルジー ハウスホールド アンド ヘルスケア リミテッド | Composition for preventing hair loss and promoting hair growth |
-
1983
- 1983-08-10 JP JP58145843A patent/JPS6038314A/en active Pending
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567701A (en) * | 1988-08-25 | 1996-10-22 | L'oreal | Alkylpolyglycoside and pyrimidine derivative based composition for inducing and stimulating hair growth and/or reducing hair loss |
| WO1994006402A3 (en) * | 1992-09-17 | 1994-05-11 | Cosmetic or dermatologic composition containing at least one saponine of the ginsenoside type, and its applications particularly to hair care | |
| JP2001288098A (en) * | 2000-04-10 | 2001-10-16 | Maruzen Pharmaceut Co Ltd | Melanin production promoter and white hair improving agent |
| WO2002007732A3 (en) * | 2000-07-26 | 2002-11-07 | Univ Cambridge Tech | Use of panaxatriol for stimulation angiogenesis |
| JP2009530369A (en) * | 2006-03-21 | 2009-08-27 | ヘオング ゲオン チョイ | Natural herbal hair growth promoting composition and method for producing the same |
| JP2011135835A (en) * | 2009-12-28 | 2011-07-14 | Lion Corp | Composition containing dammarane triterpene, and method for improving taste |
| WO2017195841A1 (en) * | 2016-05-13 | 2017-11-16 | 株式会社Ｎｉｌ | Hair pigment enhancer |
| JP2017206497A (en) * | 2016-05-13 | 2017-11-24 | 株式会社Ｎｉｌ | Hair pigment enhancer |
| CN109069385A (en) * | 2016-05-13 | 2018-12-21 | 株式会社Nil | Trichochromes reinforcing agent |
| CN109069385B (en) * | 2016-05-13 | 2021-11-26 | 株式会社Nil | Hair pigment enhancer |
| JP2019038790A (en) * | 2017-08-28 | 2019-03-14 | 共栄化学工業株式会社 | Hair cosmetics |
| JP2019210245A (en) * | 2018-06-05 | 2019-12-12 | 日本メナード化粧品株式会社 | CXCL12 expression promoter |
| JP2023521275A (en) * | 2020-02-05 | 2023-05-24 | エルジー ハウスホールド アンド ヘルスケア リミテッド | Composition for preventing hair loss and promoting hair growth |
| JP2021147347A (en) * | 2020-03-18 | 2021-09-27 | Ｇａｉｎ３９２４株式会社 | Hair growing/restoring agent and production metho thereof |
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