JPS6040403B2 - Anti-dandruff cleansers or lotions - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an anti-dandruff cleanser or lotion.

More specifically, the present invention is aimed at treating pityriasis capitis (dry seborrhea, commonly known as "
Prevention of dandruff and scratchy feeling associated with seborrheic dermatitis, which sometimes causes inflammation and hair loss due to its negative state (dandruff).
Concerning a cleansing agent or lotion useful for protecting the scalp and hair. Various drugs have been used for the above purpose, but none have been satisfactory due to their effectiveness, bad odor during use, formulation problems, etc.

Currently, the causes of dandruff are considered to be: (1) infection by microorganisms (Pit ospommovale), (2) proliferation of dead skin cells, and excessive secretion of sebum.

Therefore, the drug for preventing dandruff is PitMosp
It is necessary to have antibacterial activity against ommovale and anti-seborrhea effect.

Therefore, the present inventor conducted a search for a compound having such properties, and as a result, discovered that 2-hexyloxybenzamide satisfies the requirements, and completed the present invention.

Accordingly, the present invention provides an anti-dandruff detergent or lotion containing 2-hexyloxybenzamide as an active ingredient.

2-Hexyloxybenzamide is represented by the following formula (1) and is also known by the common name of exalamide.

Therefore, it is hereinafter referred to as exalamide in this specification. The results of testing the antibacterial activity of exalamide against Mt. Pityrospor movale are as follows.

{1} Ospommovale and 00 of test bacteria Pit
656 ■ Preparation of test bacterial solution Ptero in IFO medium 103
Inoculated with spor skin movele IFO0656, 37
The cocoons cultured for 04 hours were suspended in sterile physiological saline (52
Adjust absorbance on enemy skin to 0.02).

{3} Toji IFO medium 103 for sensitivity measurement 200 pieces of potato were subdivided and boiled for 1 hour.
fco) 10 Yeast extract (Di
fco) 10 Tabact Agar (Dif
co) 15 tsp olive oil
25 upper pH 7.5'4} Drug dilution Exalamide 10 was suspended in a 50% aqueous solution of sterilized polyethylene glycol 400, then diluted several times with sterilized water,
Adjust the dilution solution for each concentration.

'5) Plate preparation and operation method Diluted solution of each concentration 2. ``0 medium 103'' in which the ridges were dissolved by heating
22.5', stir, dispense into a petri dish with an inner diameter of 9c, and allow to solidify.

After solidification, draw about 2 lines of the test bacterial solution on a flat surface with a platinum loop,
370 for 7 days. {6} Judgment 37q After culturing for 7 days, the minimum drug concentration on the agar plate that showed complete inhibition of growth was judged as MIC.

[7- Results (10: growth, 1: growth inhibition) The cleaning agent and lotion of the present invention are produced by blending exalamide into the general composition.

The detergent contains at least one anionic, cationic, nonionic or amphoteric surfactant and exalamide, which may be in liquid, emulsion, cream, gel, paste, bilayer liquid, solid or It can be in powder form.

Examples of the surfactant in this case include the following. anionic surfactant lauryl sulfate ester salt (sodium lauryl sulfate, triethanolamine lauryl sulfate) polyoxyethylene alkyl ether sulfate (sodium polyoxyalkyl ether sulfate) polyoxyethylene alkyl (phenyl) ether phosphate N-acyl amino acid salt (monosodium N-acylglutamate, disodium N-acylglutamate) cationic surfactant penzalkonium chloride penzethonium chloride stearyltrimethylammonium chloride distearyldimethylammonium chloride stearyldimethylbenzylammonium chloride amphoteric surfactant alkyl diamino hydrochloride Ethylglycine 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine lauryl dimethyl amino acetate betaine nonionic surfactant glycerin monostearate N-acylamino acid ester sucrose fatty acid ester fatty acid alkylolamidosorbitan fatty acid ester polyoxy Ethylene sorbitan fatty acid ester polyoxyethylene sorbitan fatty acid ester fatty acid ester of glycerin/polyglycerin and acetate ester propylene glycol fatty acid ester glycerin.

Ethylene oxide conductor of pyrene glycol fatty acid ester Polyethylene glycol fatty acid ester Polyoxyethylene alkyl ether Polyoxyethylene polyoxypropylene alkyl ether Polyoxyethylene alkyl phenyl ether Polyoxyethylene Castor oil/Hydrogenated castor oil Conductor La/Rin・Millou derivative polyoxyethylene alkyl amine and fatty acid amide Lotion also contains the above surfactants, exalamide, and other bases such as emulsifiers, thickeners, sequestering agents, pH adjusters, emollients, etc. in alcohol. Contain in

The cleaning agent or lotion of the present invention preferably contains 0.1 to 5% by weight, particularly 0.5 to 3% by weight of exalamide.

In addition, the cleaning agent and lotion of the present invention may contain a keratin softening exfoliant such as sulfur (sublimated sulfur, purified sulfur, precipitated sulfur), thioxolone, selenium sulfide, resorcinol, salicylic acid, etc. Flavors, preservatives, dyes, etc. can be added as appropriate.
Next, an example will be given and explained.

Example 1 Lotion consisting of the following composition: Triethanolamine lauryl sulfate 5 Jetanolamide talauric acid 2 Taioh
5 evening exalamide
0.1 carboxymethylcellulose
0.2 evening 70% ethanol
Total amount: 100 Z Example 2 Lotion consisting of the following composition Trietanolamine lauryl sulfate 5 Sodium tamonolauryl sulfosuccinate 1 Tathioxolone
0.5 Taexalamide
0.3 TAcarboxymethyl cellulose 0.2 70% ethanol Total amount Loo Example 3 Lotion consisting of the following composition Sodium lauryl sulfate 5 Tasalicylic acid 1 Resorcinol
1 evening exalamide
0.1970% ethanol
Total amount of loo [Example 4 Cream consisting of the following composition Sodium laurate 10 Condensation product of cobra fatty acid and methyl taurine (Hoechst
(Commercially available under the product name "Hostapon C.T." from the company)
4. Lauric acid monoethanolamide 2. Taglycerin 4. Resorcinol 1. Exalamide 3. Perfume
0.2 evening 70% ethanol
Total amount 100 kites [Example 5 Powdered cleaning agent consisting of the following composition: Sodium lauryl sulfate 40 Tanaconol 10 Selenium sulfide
1 evening exalamide
1 Evening fragrance
Dissolve this product in 1 volume of water before use.

Example 6 Shampoo exalamide consisting of the following composition: 1.0 (%) Trietanolamin lauryl sulfate 16.0 Sodium polyoxyethylene lauryl ether sulfate
4.4 Lauric acid jetanolamide 3.0 Fragrance o3 Pigment
Q. S. Complete amount with purified water
Set it to 100.

Example 7 Shampoo polyoxyethylene lanolin consisting of the following composition 2.0 (%) Sodium polyoxyethylene alkyl ether sulfate 2
0.0 Polyoxyethylene alkyl ether sulfate trietanolamine 25.0 Lauryldimethylaminoacetic acid betaine 4.0 Lauric acid jetanolamide 4.0 Propylene glycol 5.0 Exalamide
5.0 Methylparaben
0.1f.

Lopil/graben 0.1 Make the total volume 100 with purified water. 60～
Add to 70 oz and stir to dissolve uniformly.

Example 8 Shampoo-like ethylene glycol distearate consisting of the following composition: 2.5 (%), triethanolamine lauryl sulfate, 20.0, betaine lauryl dimethylaminoacetate, 6.5, jetanolamide lauric acid, 5.5, exalamide 2.0 Methylparaben
0.1 propyl/graben
0.1 [B} Sodium lauryl sulfate
5.0 Purified water total amount 1000
shall be.

Heat and melt at 75 to 85 qC for both Fukoku and make it homogeneous by adding (B) to it while holding the light.Example 9 Adding exalamide to the base of commercially available shampoo [Tama no Hada Soap■, "Tama no Hada Medicated Shampoo"] The effect of the shampoo containing 1% (the shampoo of the present invention, FK of Example 6) was tested.

As comparison products, the same commercially available shampoo [containing 1% zinc pyrithione (Kin)] and a shampoo containing selenium disulfide [Kowa Shinyaku ■, Micalon "Kowa" (Se)] were used. {1} Subject diagnosed with seborrheic eczema on the scalp whose main symptom is dandruff.

'21 How to use shampoo Before this test or S
Although there were cases where shampoo was used, the shampoo of the present invention was used at the beginning of the test, and after 2 to 8 weeks, it was crossed over with the standard shampoo.

Furthermore, in some cases where phantom was used before the test, only the shampoo of the present invention was used, and in some cases where ZP was used, Se was crossed over. The shampoo was used 2 to 3 times a week. '3} As a general rule, observations were made once every two weeks for dandruff, flushing, scratching, and hair loss, and the effects were evaluated based on the following criteria.

River: cured or significantly improved JP: Skin findings have significantly improved. 10: Cortical findings are “slight” -: Unchanged ×: Skin findings worsened t41 results As shown in Table 1.

Table 1 (Western) W: 1 week As is clear from Table 1, the shampoo of the present invention has the same or better anti-dandruff effect than conventional shampoos containing zinc pyrithione or selenium disulfide.

Claims (1)

[Scope of Claims] 1. A detergent or lotion for preventing dandruff, characterized by containing 2-hexyloxybenzamide as an active ingredient. 2 Content of 2-hexyloxybenzamide is 0.1
A cleansing agent or lotion according to claim 1, wherein the amount is 5% by weight.