JPS61165663A - Simple test agent for diabetes - Google Patents
Simple test agent for diabetesInfo
- Publication number
- JPS61165663A JPS61165663A JP29591785A JP29591785A JPS61165663A JP S61165663 A JPS61165663 A JP S61165663A JP 29591785 A JP29591785 A JP 29591785A JP 29591785 A JP29591785 A JP 29591785A JP S61165663 A JPS61165663 A JP S61165663A
- Authority
- JP
- Japan
- Prior art keywords
- glucose
- carrier
- diabetes
- reagent
- molded body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012360 testing method Methods 0.000 title claims abstract description 23
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 17
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 17
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 15
- 239000008103 glucose Substances 0.000 claims abstract description 15
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 238000000465 moulding Methods 0.000 claims abstract description 5
- 210000002700 urine Anatomy 0.000 abstract description 9
- 239000000126 substance Substances 0.000 abstract description 8
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract description 6
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract description 6
- 108010015776 Glucose oxidase Proteins 0.000 abstract description 4
- 239000004366 Glucose oxidase Substances 0.000 abstract description 4
- 125000003118 aryl group Chemical group 0.000 abstract description 4
- 229940116332 glucose oxidase Drugs 0.000 abstract description 4
- 235000019420 glucose oxidase Nutrition 0.000 abstract description 4
- OCJBOOLMMGQPQU-UHFFFAOYSA-N 1,4-dichlorobenzene Chemical compound ClC1=CC=C(Cl)C=C1 OCJBOOLMMGQPQU-UHFFFAOYSA-N 0.000 abstract description 3
- NUIURNJTPRWVAP-UHFFFAOYSA-N 3,3'-Dimethylbenzidine Chemical compound C1=C(N)C(C)=CC(C=2C=C(C)C(N)=CC=2)=C1 NUIURNJTPRWVAP-UHFFFAOYSA-N 0.000 abstract description 3
- 239000001301 oxygen Substances 0.000 abstract description 3
- 229910052760 oxygen Inorganic materials 0.000 abstract description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001877 deodorizing effect Effects 0.000 abstract 1
- 238000002845 discoloration Methods 0.000 abstract 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 description 3
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 235000004280 healthy diet Nutrition 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
【発明の詳細な説明】
本発明は、例えば男子便器内に入れておくことによって
日常生活のなかで糖尿病の早期発見を可能とした糖尿病
簡易検査剤に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a simple diabetes test agent that enables early detection of diabetes in daily life by being placed in a men's toilet bowl, for example.
従来、糖尿病の検査方法としては、一般に試薬を含浸し
た試験紙が用いられている。黙しながら、この試験紙を
用いる検査方法にあっては、尿を容器に採取した後試験
管に分取し試験紙を浸漬するという操作が必要で大変煩
わしいものである。又、上記試験紙は、高価である上に
糖尿病の診断時に使用されるのみで日常生活のなかでは
検査の煩雑さやためらいの為使用されていない。従って
、一般に日常生活のなかで早期に糖尿病を発見すること
は不可能である。Conventionally, test strips impregnated with reagents have generally been used to test for diabetes. However, this testing method using test strips is very cumbersome as it requires the steps of collecting urine in a container, dispensing it into a test tube, and dipping the test strip. Furthermore, the above test strips are expensive and are only used for diagnosing diabetes, but are not used in daily life due to the complexity and hesitation of testing. Therefore, it is generally impossible to detect diabetes early in daily life.
本発明は上述の点に鑑みてなされたもので、昇華性又は
水溶性の担体中へブドウ糖の存在によって変色する試薬
を混合し成形したことにより、例えば排尿時に尿がかか
るように男子便器内へ入れておくことよって、日常生活
のなかで日頃糖尿病の自覚のない人の早期発見を可能と
した糖尿病簡易検査剤を提供することを目的とする。The present invention has been made in view of the above-mentioned points, and by mixing and molding a reagent that changes color due to the presence of glucose into a sublimable or water-soluble carrier, for example, it can be used in a men's urinal so that urine can be splashed on it during urination. The purpose of the present invention is to provide a simple diabetes test agent that enables early detection in people who are not aware of diabetes in their daily lives.
又、本発明の他の目的は、上記のように成形したことに
より、簡易に検査ができ而かも［１ｉｌｉｌ産に適する
糖尿病簡易検査剤を提供するにある。Another object of the present invention is to provide a simple diabetes test agent suitable for easy testing by molding as described above.
更に、本発明の他の目的は、ナフタリン、Ｐ−ジクロル
ベンゼン等の昇華性を有する芳香物質を担体にすること
により、便器乃至はトイレの防臭を兼用できるようにし
た糖尿病簡易検査剤を提供するにある。Furthermore, another object of the present invention is to provide a simple diabetes test agent that can also be used to deodorize a toilet bowl or toilet by using a sublimable aromatic substance such as naphthalene or P-dichlorobenzene as a carrier. There is something to do.
次に本発明の実施例を図面を参照して説明する。Next, embodiments of the present invention will be described with reference to the drawings.
糖尿病簡易検査剤１はＰ−ジクロルベンゼン、ナフタリ
ン等の昇華性を有する芳香物質を担体２としてこの担体
２中へブドウ糖の存在により変色する試１３を混合して
球状に成形されている。上記担体２としては、昇華性物
質でなく常温では固体の水溶性物質であってもよく、単
体又は複合体のいずれでもよい。又、試薬３としては、
ブドウ糖酸化酵素、ニューランダー試薬等が用いられる
。The simple diabetes test agent 1 is formed into a spherical shape by using a sublimable aromatic substance such as P-dichlorobenzene or naphthalene as a carrier 2 and mixing sample 13, which changes color in the presence of glucose, into the carrier 2. The carrier 2 may be not a sublimable substance but a water-soluble substance that is solid at room temperature, and may be either a single substance or a composite. In addition, as reagent 3,
Glucose oxidase, Neulander reagent, etc. are used.
試薬３としてブドウ糖酸化酵素を用いれば、このブドウ
糖酸化酵素が尿中のブドウ糖を過酸化水素とグルクロン
酸に酸化分解し、さらにこの過酸化水素を分解酵素で酸
素と水に分解し、この酸素がオルトトリジンと反応して
青又は緑に変色する。If glucose oxidase is used as reagent 3, this glucose oxidase oxidizes and decomposes glucose in urine into hydrogen peroxide and glucuronic acid, and this hydrogen peroxide is further decomposed into oxygen and water by a degrading enzyme, and this oxygen is It reacts with orthotolidine and turns blue or green.
試薬としてニューランダー試薬を用いれば、尿中のブド
ウ糖の還元作用でビスマス金属又は亜酸化物を生成させ
黒又は黒褐色に変色する。上記試薬３の種類は問わない
が、ブドウ糖の存在により瞬時又は短時間に変色するも
のであることが望ましい。When Newlander's reagent is used as a reagent, bismuth metal or suboxide is produced by the reducing action of glucose in urine, resulting in a black or dark brown color change. The type of reagent 3 mentioned above does not matter, but it is desirable that it changes color instantaneously or in a short period of time due to the presence of glucose.
而かして、本発明検査剤１は、例えば男子便器に入れて
使用される。そして、この検査剤１の担体２として芳香
物質を用いれば防臭剤と兼用できるしのである。上記検
査剤１にかけられた尿中にブドウ糖が混入していれば、
担体２中の試薬３が変色して尿中にブドウ糖が混入して
いることを知らしめる。尚、尿中にブドウ糖が混入して
いることが判明したとしても必ずしも糖尿病にかかって
いるとはいえないが、平時より留意して糖尿病の早期発
見或いは摂生の励行になるものである。Thus, the test agent 1 of the present invention is used by being placed in a men's toilet bowl, for example. If an aromatic substance is used as the carrier 2 of the test agent 1, it can also be used as a deodorant. If glucose is mixed in the urine applied to test agent 1,
The reagent 3 in the carrier 2 changes color, indicating that glucose is mixed in the urine. It should be noted that even if it is found that glucose is mixed in the urine, it does not necessarily mean that the patient has diabetes, but it should be kept in mind during normal times to detect diabetes early or to encourage a healthy diet.
又、上記変色した試薬３は非可逆的であるが、担体２は
昇華性又は水溶性物質であるので、表面側の反応した試
薬３は担体２とともに洗い流され、新しい未反応の試薬
３が表面に表われる。Furthermore, although the discolored reagent 3 is irreversible, since the carrier 2 is a sublimable or water-soluble substance, the reacted reagent 3 on the surface side is washed away together with the carrier 2, and new unreacted reagent 3 is added to the surface. It appears in
尚、本発明検査剤１は、多数の層状に形成し順次表面側
の薄い層が剥離していくように構成してもよいものであ
る。The testing agent 1 of the present invention may be formed into many layers, and the thin layers on the surface side may be sequentially peeled off.
本発明は上述のように、昇華性又は氷解性の担体中へブ
ドウ糖の存在によって変色する試薬を混合し成形してな
るもので、例えば男子便器内へ入れておくことにより日
常生活のなかで尿中にブドウ糖が混入しているか否かが
常時わかり、糖尿病の早期発見が可能であり、又何らの
決心をすることなく簡単に検査ができ、廉価量産に適す
る等の効果を有する。As mentioned above, the present invention is made by mixing and molding a reagent that changes color due to the presence of glucose into a sublimable or ice-melting carrier. It is possible to always know whether or not glucose is mixed in, and early detection of diabetes is possible, and the test can be easily performed without making any decisions, making it suitable for low-cost mass production.
図は本発明の実施例を示す一部切欠平面図である。
図中符号１は本発明検査剤、２は担体、３は試薬を示す
。The figure is a partially cutaway plan view showing an embodiment of the present invention. In the figure, reference numeral 1 indicates the test agent of the present invention, 2 indicates the carrier, and 3 indicates the reagent.
Claims (1)
色する試薬を混合し成形したことを特徴とする糖尿病簡
易検査剤。1. A simple diabetes test agent characterized by mixing and molding a reagent that changes color in the presence of glucose into a sublimable or water-soluble carrier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29591785A JPS61165663A (en) | 1985-12-27 | 1985-12-27 | Simple test agent for diabetes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29591785A JPS61165663A (en) | 1985-12-27 | 1985-12-27 | Simple test agent for diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61165663A true JPS61165663A (en) | 1986-07-26 |
Family
ID=17826809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP29591785A Pending JPS61165663A (en) | 1985-12-27 | 1985-12-27 | Simple test agent for diabetes |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61165663A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0217664U (en) * | 1988-07-20 | 1990-02-05 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3713772A (en) * | 1971-07-02 | 1973-01-30 | J Tavel | Method of testing for diabetes |
| JPS48104380A (en) * | 1972-04-14 | 1973-12-27 |
-
1985
- 1985-12-27 JP JP29591785A patent/JPS61165663A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3713772A (en) * | 1971-07-02 | 1973-01-30 | J Tavel | Method of testing for diabetes |
| JPS48104380A (en) * | 1972-04-14 | 1973-12-27 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0217664U (en) * | 1988-07-20 | 1990-02-05 |
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