JPS61244366A - Drug component gradual release powder - Google Patents
Drug component gradual release powderInfo
- Publication number
- JPS61244366A JPS61244366A JP60086838A JP8683885A JPS61244366A JP S61244366 A JPS61244366 A JP S61244366A JP 60086838 A JP60086838 A JP 60086838A JP 8683885 A JP8683885 A JP 8683885A JP S61244366 A JPS61244366 A JP S61244366A
- Authority
- JP
- Japan
- Prior art keywords
- powder
- drug component
- gradual release
- terpene
- release powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 title claims description 15
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 150000003505 terpenes Chemical class 0.000 claims description 10
- 235000007586 terpenes Nutrition 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 8
- 239000008187 granular material Substances 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 6
- 238000013268 sustained release Methods 0.000 claims description 5
- 239000012730 sustained-release form Substances 0.000 claims description 5
- 230000002459 sustained effect Effects 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 2
- 239000003921 oil Substances 0.000 description 12
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 5
- 229960005233 cineole Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 238000003287 bathing Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 229930007050 cineol Natural products 0.000 description 2
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 229930003658 monoterpene Natural products 0.000 description 2
- 150000002773 monoterpene derivatives Chemical class 0.000 description 2
- 235000002577 monoterpenes Nutrition 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- 241000218645 Cedrus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002386 air freshener Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 229930004069 diterpene Natural products 0.000 description 1
- 125000000567 diterpene group Chemical group 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003535 tetraterpenes Chemical class 0.000 description 1
- 235000009657 tetraterpenes Nutrition 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Landscapes
- Paints Or Removers (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fats And Perfumes (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は薬効成分を徐放する粉粒体に関するものであシ
、容器に収納して開栓することにより、徐放する薬効成
分が室内に漂うて健康の保持向上、殺菌、防虫、防カビ
等の効果をもたらす利用法のほか、室内に施工する塗料
に混合したシ、内装材料製造に使用される接着剤に混合
したシ、シート材料に抄き込んだシ多種多様な展開が可
能な室内空間の環境条件の向上に有益な材料を提案する
ものである。Detailed Description of the Invention (Industrial Field of Application) The present invention relates to powder and granules that release medicinal ingredients in a sustained manner.By storing them in a container and opening the container, the medicinal ingredients to be released in a sustained manner can be released indoors. In addition to being used to maintain and improve health, sterilize, repel insects, and prevent mold, it can also be used as a mixture in paints applied indoors, as a mixture in adhesives used to manufacture interior materials, and as sheet materials. This paper proposes a material that is useful for improving the environmental conditions of indoor spaces and can be used in a wide variety of ways.
（従来の技術）
森林が発散するテルペン類が芳香とともに人間のｓｉｔ
、生活環境の改善に有益なことは、これまで種々の成書
に記載されてきたが、最近の著書では、「フィトンチッ
ドと森林浴」（谷田貝光克著、溜）林業科学技術振興所
発行）に詳細に記載されている。かかる状況のなかで森
林発散成分であるテルペン類を室内芳香剤として噴霧し
たシ、入浴剤中に添加したシした商品が市販されてきた
が、何れも液状のため室内でこぼして床面を汚染する欠
点があった。(Conventional technology) Terpenes emitted by forests can be used as aromatic substances for humans.
Phytoncides and forest bathing have been described in various books so far as being beneficial for improving the living environment, but in a recent book, ``Phytoncides and Forest Bathing'' (written by Mitsukatsu Yatagai, published by Tame Forestry Science and Technology Agency). Described in detail. Under these circumstances, products that are sprayed with terpenes, which are forest-derived ingredients, as indoor air fresheners or added to bath salts have become commercially available, but because they are in liquid form, they can be spilled indoors and contaminate the floor. There was a drawback.
また、液状のまま内装材料用の塗料や接着剤に混入して
徐放せしめる場合にも、主剤に均一に吸着させるのに手
間と時間がかかり、家庭で簡単に混合使用することは、
素人には無理なことであった。Furthermore, even when mixed in liquid form with paints and adhesives for interior decoration materials for sustained release, it takes time and effort to ensure uniform adsorption to the base material, making it difficult to mix and use easily at home.
This was impossible for an amateur.
（発明が解決しようとする問題点）
テルペン類のなかでも、モノテルペン、セスキテルペン
は蒸発が比較的早いが、ジテルペン、テトラテルペンと
分子量の増加とともに蒸発は一般に緩慢となる。本発明
において特許請求の範囲、第１項、第２項に２種の態様
を記載した１理由は、比較的蒸発の緩慢なもの、あるい
は室内空間容積（気積）が大なる場合で、薬剤の徐放性
の高さが必要な場合には、特許請求の範囲第１項の粉粒
体が適当であシ、その逆の場合には、第２項の粉粒体が
適当であって、本発明は諸条件への対応が容易である。(Problems to be Solved by the Invention) Among terpenes, monoterpenes and sesquiterpenes evaporate relatively quickly, but as the molecular weight increases with diterpenes and tetraterpenes, evaporation generally becomes slower. One of the reasons why two types of embodiments are described in claims 1 and 2 in the present invention is that the evaporation rate is relatively slow, or the indoor space volume (volume) is large. When a high level of sustained release is required, the powder or granule according to claim 1 is suitable; in the opposite case, the powder or granule according to claim 2 is suitable. , the present invention can easily accommodate various conditions.
従来の所謂森林発散成分から成る液状芳香剤では、かか
る点の解決がなされなかった。Conventional liquid fragrances made of so-called forest-derived ingredients have not solved this problem.
（問題点を解決するための手段）
本発明においては、従来商品の欠点を改良する方法とし
て吸油性の高い有機質または無機質の粉粒体、たとえば
木粉、パルプ粉等の有機粉粒体、無水硅酸、・・・・・
・等の無機粉粒体にテルペン系物質を含浸付着せしめる
のである。また、１．８シネオールやボルネオールに比
較して大気中での蒸発のダ
早い尋ピネンなどの場合には、特許請求の範囲第２項に
示すように、テルペン系物質含有粉粒体の表面を有機質
または無機質の薄膜で囲繞するのが適当である。(Means for Solving the Problems) In the present invention, as a method for improving the drawbacks of conventional products, organic or inorganic powders with high oil absorption, such as organic powders such as wood flour and pulp powder, anhydrous Silicic acid,...
This is done by impregnating and adhering terpene-based substances to inorganic powders such as . In addition, in the case of pinene, which evaporates faster in the atmosphere than 1.8 cineole or borneol, as shown in claim 2, the surface of the terpene-based substance-containing powder or granules is It is appropriate to surround it with an organic or inorganic thin film.
（実施例１）
ネ
１．８シツオール、１．４シネオールを合せて４０戊
重量％、浅部が数種のモノテルペン類から成るテルペン
系物！（安原油脂工業（株）製、商品名シネオールＤ）
を、撹拌しつつある微粒無水硅酸中に徐々に添加し、粉
体重量と同重量のテルペン系物質が吸着された時点で撹
拌を停止した。得られた粉体は含油量５０％であるにも
拘らず油分を感じさせない微粉状であ）、テルペンの芳
香を発散させるものであった。(Example 1) A terpene-based product with a total of 40% by weight of ne1.8 cineole and 1.4 cineole, and the shallow part consists of several types of monoterpenes! (Manufactured by Yasushi Oil Industries Co., Ltd., product name: Cineol D)
was gradually added to the finely divided silicic anhydride that was being stirred, and the stirring was stopped when the same weight of the terpene-based substance as the weight of the powder was adsorbed. The obtained powder was in the form of a fine powder that did not give the impression of oil even though it had an oil content of 50%), and it emitted a terpene aroma.
この粉体を家庭用繊ｍ壁材料を水と混練した中へ重量で
１０％添加混合し、４．５畳の部屋の１畳面約１．５坪
に塗工した。乾燥後その部屋の気中濃度を測定したとこ
ろ５ ｐｐｂが検出され、１ケ年後に詔いても１．８１
）ｐｂが検出され、徐放が長期間にわたシ行われている
ことが判明した。This powder was added and mixed in an amount of 10% by weight to a household fiber wall material kneaded with water, and was applied to about 1.5 tsubo of a 1-tatami surface of a 4.5-tatami room. After drying, the air concentration in the room was measured and found to be 5 ppb, and even after a year, the concentration was still 1.81 ppb.
) pb was detected, and it was found that sustained release was carried out over a long period of time.
なあ、前記シネオールＤのみを家庭用繊維壁材料の水と
の混線物中に添加した場合は、油分が分離浮上して均一
に混合し得なかった。Incidentally, when only Cineol D was added to the mixture of household fiber wall materials and water, the oil separated and floated to the surface and could not be mixed uniformly.
（実施例２）
乾燥した杉材の粉砕粒を、リモネン（安原油脂工業（株
）製、商品名Ｄ−リモネン）中に浸漬し、とシあげ、粒
表面に若干油分を感じる程度まで常温で乾燥したところ
、含油量は２５重量％であったｃこの含油量の表面をポ
リビニールアルコール水溶液噴霧により被覆してさらさ
らとしたか粒状の含油量とした。(Example 2) Dry crushed grains of cedar wood were immersed in limonene (manufactured by Yasushi Oil Industries Co., Ltd., trade name: D-limonene), roasted, and kept at room temperature until a slight oil content was felt on the grain surface. When dried, the oil content was 25% by weight.The surface of this oil content was coated with a polyvinyl alcohol aqueous solution spray to give a smooth or granular oil content.
この含油量５０ｙを食器棚に入れ、寒天培地に大豆粉を
投じてカビの発生を検べたところ、通常の食器棚内の寒
天培地より発カビが１０日問遅れ、防カビ効果のあるこ
とが判った。なか、この効果は５０Ｐの含油量で８ケ月
間持続した。When we put 50 y of this oil in a cupboard and tested the growth of mold by throwing soybean flour on an agar medium, we found that mold growth was delayed by 10 days compared to an agar medium in a normal cupboard, indicating that it has a mold-preventing effect. understood. Among them, this effect lasted for 8 months at an oil content of 50P.
「効果」
以上記載のように、本発明薬効成分徐放性粉粒体は、植
物からの抽出成分である天然精油を含有しているので、
人体に有益であるとともに、取扱いが容易であって産巣
上様々な分野での応用が可能である。"Effect" As described above, the medicinal ingredient sustained release powder of the present invention contains natural essential oils that are extracted from plants.
In addition to being beneficial to the human body, it is easy to handle and can be applied in a variety of fields.
Claims (2)
ルペン系物質を含有せしめたことを特徴とする薬効成分
を徐放する粉粒体。(1) A granular material for sustained release of medicinal ingredients, which is characterized by containing a terpene-based substance in a highly oil-absorbing organic or inorganic granular material.
粉粒体の表面が有機質または無機質薄膜により囲繞され
た薬効成分を徐放する粉粒体。(2) A powder or granule material containing a terpene-based substance as set forth in claim 1, the surface of which is surrounded by an organic or inorganic thin film, which releases a medicinal ingredient in a sustained manner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60086838A JPS61244366A (en) | 1985-04-23 | 1985-04-23 | Drug component gradual release powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60086838A JPS61244366A (en) | 1985-04-23 | 1985-04-23 | Drug component gradual release powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS61244366A true JPS61244366A (en) | 1986-10-30 |
Family
ID=13897949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60086838A Pending JPS61244366A (en) | 1985-04-23 | 1985-04-23 | Drug component gradual release powder |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61244366A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999009826A1 (en) * | 1997-08-21 | 1999-03-04 | Kabushiki Kaisha Nihon Tekuma | Treatment for surface treatment and cleaning, and wooden building material impregnated with said treatment |
| JP2002234801A (en) * | 2001-02-08 | 2002-08-23 | Kumiai Chem Ind Co Ltd | Solid pesticide composition, method for producing the same, and method for dispersing the same |
| WO2013131498A3 (en) * | 2012-03-09 | 2013-12-05 | Tomas Bata University In Zlin | Anti-microbial component and using of the same |
| US8927026B2 (en) | 2011-04-07 | 2015-01-06 | The Procter & Gamble Company | Shampoo compositions with increased deposition of polyacrylate microcapsules |
| US8980292B2 (en) | 2011-04-07 | 2015-03-17 | The Procter & Gamble Company | Conditioner compositions with increased deposition of polyacrylate microcapsules |
| US9162085B2 (en) | 2011-04-07 | 2015-10-20 | The Procter & Gamble Company | Personal cleansing compositions with increased deposition of polyacrylate microcapsules |
| US9186642B2 (en) | 2010-04-28 | 2015-11-17 | The Procter & Gamble Company | Delivery particle |
| US9993793B2 (en) | 2010-04-28 | 2018-06-12 | The Procter & Gamble Company | Delivery particles |
| US12227720B2 (en) | 2020-10-16 | 2025-02-18 | The Procter & Gamble Company | Consumer product compositions with at least two encapsulate populations |
| US12398348B2 (en) | 2020-10-16 | 2025-08-26 | The Procter & Gamble Company | Consumer product compositions comprising a population of encapsulates |
| US12486478B2 (en) | 2020-10-16 | 2025-12-02 | The Procter & Gamble Company | Consumer products comprising delivery particles with high core:wall ratios |
-
1985
- 1985-04-23 JP JP60086838A patent/JPS61244366A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6358623B1 (en) | 1997-08-21 | 2002-03-19 | Kabushiki Kaisha Nihon Tekuma | Treatment for surface treatment and cleaning which contains eucalyptus oil, and wooden building material impregnated with said treatment |
| WO1999009826A1 (en) * | 1997-08-21 | 1999-03-04 | Kabushiki Kaisha Nihon Tekuma | Treatment for surface treatment and cleaning, and wooden building material impregnated with said treatment |
| JP2002234801A (en) * | 2001-02-08 | 2002-08-23 | Kumiai Chem Ind Co Ltd | Solid pesticide composition, method for producing the same, and method for dispersing the same |
| US9186642B2 (en) | 2010-04-28 | 2015-11-17 | The Procter & Gamble Company | Delivery particle |
| US12133906B2 (en) | 2010-04-28 | 2024-11-05 | The Procter & Gamble Company | Delivery particle |
| US11096875B2 (en) | 2010-04-28 | 2021-08-24 | The Procter & Gamble Company | Delivery particle |
| US9993793B2 (en) | 2010-04-28 | 2018-06-12 | The Procter & Gamble Company | Delivery particles |
| US8927026B2 (en) | 2011-04-07 | 2015-01-06 | The Procter & Gamble Company | Shampoo compositions with increased deposition of polyacrylate microcapsules |
| US9561169B2 (en) | 2011-04-07 | 2017-02-07 | The Procter & Gamble Company | Conditioner compositions with increased deposition of polyacrylate microcapsules |
| US9162085B2 (en) | 2011-04-07 | 2015-10-20 | The Procter & Gamble Company | Personal cleansing compositions with increased deposition of polyacrylate microcapsules |
| US10143632B2 (en) | 2011-04-07 | 2018-12-04 | The Procter And Gamble Company | Shampoo compositions with increased deposition of polyacrylate microcapsules |
| US8980292B2 (en) | 2011-04-07 | 2015-03-17 | The Procter & Gamble Company | Conditioner compositions with increased deposition of polyacrylate microcapsules |
| WO2013131498A3 (en) * | 2012-03-09 | 2013-12-05 | Tomas Bata University In Zlin | Anti-microbial component and using of the same |
| US12227720B2 (en) | 2020-10-16 | 2025-02-18 | The Procter & Gamble Company | Consumer product compositions with at least two encapsulate populations |
| US12398348B2 (en) | 2020-10-16 | 2025-08-26 | The Procter & Gamble Company | Consumer product compositions comprising a population of encapsulates |
| US12486478B2 (en) | 2020-10-16 | 2025-12-02 | The Procter & Gamble Company | Consumer products comprising delivery particles with high core:wall ratios |
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