JPS6137713A - Whitening cosmetic - Google Patents

Abstract

PURPOSE:A whitening cosmetic, obtained by incorporating isokojic acid having improved inhibitory action on melanization in a cosmetic base, capable of exhibiting improved whitening and antisuntan effect, and useful for skin cosmetic, e.g. safe toilet water, cream or milky lotion. CONSTITUTION:A whitening cosmetic obtained by incorporating water-soluble isokojic acid (=6-hydroxy-2-hydroxymethyl-1,4-pyrone) expressed by the formula in an amount of 0.01-10% in a usually used cosmetic base or assistant, etc. used in toilet water, milky lotion, pack, etc. The isokojic acid produced by cultivation of a microorganism or chemical synthetic product may be used as the above-mentioned isokojic acid. For example, in the case of tiolet water, a protectant, e.g. glycerol, and a skin nutriment, etc. are dissolved in purified water, an a preservative, perfume, etc. are dissolved in an alcohol. Both are then mixed and solubilized at room temperature to give the tiolet water. In the above- mentioned general production of the toilet water, 0.01-10% isokijic acid expressed by the formula is added to the water-soluble part to afford the aimed whitening toilet water.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to cosmetics, particularly fair skin cosmetics.

[Conventional technology]

Conventional 10 fair skin cosmetics include cosmetics containing peroxides such as hydrogen peroxide, zinc peroxide, magnesium peroxide, zinc perborate, magnesium perborate, sodium perborate, or blue lead agents or mercury agents. However, the former, peroxide, was an extremely unstable substance and had problems in terms of formulation, while the latter, such as blue lead and mercury, had strong side effects and were problematic in terms of safety. In recent years, vitamin C, cysteine.

Although there are cosmetics that contain colloidal sulfur, they are still not expected to be sufficiently effective.

Furthermore, the present inventors have previously discovered cosmetics containing kojic acid (
Japanese Patent Publication No. 56-18569), cosmetics containing derivatives of kojic acid (Japanese Patent Publication No. 56-79616).

Japanese Patent Publication No. 56-7710) and a cosmetic containing ergothioneine (Japanese Patent Publication No. 55-27883).

[Problem that the invention seeks to solve]

As a result of various research into substances that have a safe and effective skin-whitening effect that are different from the active ingredients of known skin-whitening cosmetics, the present invention discovered that isokojic acid has an excellent melanin production inhibiting effect. The purpose of the present invention is to provide a novel skin-lightening cosmetic that has excellent skin-whitening and sunscreen effects and is safe.

Means for Solving Problems c] The present invention is a fair-skinned cosmetic composition containing isokojic acid (6-hydroxy-2-hydroxymethyl-4-pyrone) in a cosmetic base.

Isokojic acid, the active ingredient of the present invention, has the formula 6
-Hydroxy-2-hydroxymethyl-1-4-pyrone, molecular weight 142. Melting point 183°C, C6Hs
04 is a water-soluble substance that turns red when it reacts with ferric chloride, and forms a light green precipitate when it reacts with copper.

Isokojic acid used in the present invention is obtained from microbial culture (GluCo).
nobacter 1equefaciens, G
luconobacteroseus Asai etc.)
Chemically synthesized products can also be used.

The skin fairing cosmetics of the present invention are mainly skin cosmetics such as lotions, creams, emulsions, and punctures, and the above-mentioned isokojic acid is added to 0.01% of the cosmetic base and auxiliary agents that are commonly used in these cosmetics. ~10% is added to make cosmetics.

For example, in lotions, moisturizers such as glycerin and propylene glycol, skin nutrients, etc. are dissolved in purified water, preservatives, fragrances, etc. are dissolved in alcohol, and the two are mixed and solubilized at room temperature. In the production of a lotion, the isokojic acid of the present invention is added to the water-soluble portion at a concentration of 0.01 to 10% to form a lotion.

In creams, hydrophilic ingredients such as humectants such as glycerin and sorbitol are added to purified water to form the aqueous phase.
The oil phase is beeswax and paraffin.

Oily components such as preservatives and surfactants are added to solid oils such as microcrystalline wax, ceresin, higher fatty acids, and hydrogenated oils, as well as liquid oils such as squalane, liquid paraffin, and various ester oils. In the production of general cream, the aqueous phase obtained in this way is heated, and the oil phase heated to the same temperature is gradually added while gently stirring to emulsify the cream. Isokojic acid, an active ingredient, is added to the aqueous phase at a concentration of 0.01 to 10% to form a cream.

In emulsions, humectants such as glycerin, acidic or alkaline PU regulators, etc. are added to purified water, heated and mixed, and ethanol is added to form the aqueous phase, which is then mixed with beeswax.

Solid oils such as paraffin, semi-solid oils such as vaseline and lanolin, squalane, and liquid paraffin.

Add and adjust oily components such as preservatives and surfactants to liquid oils such as ester oils, mix and heat to form an oil phase,
In the production of general emulsions, the oil phase is added to the aqueous phase to pre-emulsify, a protective colloid such as carboxyvinyl polymer or carboxymethyl cellulose is added to this, and the emulsion is uniformly emulsified using a homomixer. , 0.01 to 10% of isokojic acid, the active ingredient of the present invention, is added to the aqueous phase.
Add to the aqueous phase to make an emulsion.

The pack contains purified water, moisturizers such as glycerin,
Add a coating agent such as polyvinyl alcohol or Veegum to swell it, and if necessary, add powders such as kaolin, talc, zinc oxide, etc., and add ethanol in which fragrances, preservatives, etc. are dissolved to form a paste. In the general manufacture of punctures, which involves kneading the mixture until the mixture is mixed, isokojic acid, which is the active ingredient of the present invention, is added in an amount of 0.01 to 10% to make punctures.

〔Example〕

Next, examples of the present invention will be given.

Example 1 Cream> Isokojic acid 1.0% Placenta extract 5.0% Polyoxyethylene stearyl ether 2.09% Polyoxyethylene cetyl ether 2.91% Beeswax 4.0% Secnor 3.0% Isopropyl palmitate 2 .0% Liquid paraffin 15.0% Polyethylene glycol monostearate 0.5% Purified water 71.4% Methyl roseoxybenzoate 0.1% Example 2 Emulsion> Isokojic acid 2.0% Placenta extract 4.0% Self-emulsifying glycerol monostearate 1.11% Polyoxyethylene cetyl ether 1.89%M
C stearic acid 2.0% cetanol 1.0% isopropyl myristate 2.0% purified water
89.90% paraoxybenzoic acid 0.1% fragrance
Trace example 3 Kupac> Isokojic acid 0.5% Placenta extract 6.0% Ethanol 3.0% Methyl paraoxybenzoate 0.1% Carboxyvinyl polymer 1.0% Calcium carbonate 0.3% Titanium dioxide
0.02%2% purified water
95.08 Perfume
Trace example 4 Lotion> Isokojic acid 3.0% Placenta extract 10.0% Ethanol 10.0% Methyl paraoxybenzoate 0.1% Citric acid 0.2% Fragrance Trace purified water
86.7% [Effect of the Invention] The effect of isokojic acid, which is the active ingredient of the present invention, will be clarified by a decolorization test using cultured pigment cells.

Test Example 1, Cells used Mouse melanoma B16 cells (hereinafter referred to as B16 cells) 2, Culture conditions Eagle's MEM medium, 10% tallow serum, 2.2 g/
Using a medium supplemented with sodium bicarbonate and 5mM N-2-hydroxyethylpiperazine-N'-ethanesulfonic acid, the cells were cultured in a CO2 culture chamber set at 37°C and 5% CO2.

3. Test area A: Control area, no active ingredient added Area B: Isokojic acid 0.1 mM and 0.5 mM + 1゜0, respectively
Ward C with addition of mM, 2.0 mM, and 3-OmM:
Kojic acid each 0-1 mM + O-5mM + 1.0
Sections with mM + 2.0 mM and 3.0 mM added: 0.1 mM and 0.5 m of ergothioneine, respectively.
M.

1-OmL 2. (L mL 3-OmM added area 4
, Judgment of melanin production inhibiting power Each test group contained 1.2 x 10” B16 cells.
After culturing for 6 days in a l/dish, the proliferated cells were dispersed with trypsin and then incubated at 1000 r, p, m
The samples were centrifuged for 5 min and collected, and the degree of blackening was visually determined.

- Shows the same degree of blackening as the two additive-free plots.

±: Shows a slightly lower degree of blackening after no additives.

+: No additives, clearly showing a low degree of blackening.

++: Indicates a slight degree of blackening.

+++: White to gray, not recognized as black G1゜5, Judgment results as shown in the table below As is clear from the above results, the active ingredient of the present invention was found not only in the additive-free area but also in the kojic acid and ergothioneine test areas. It also shows a remarkable melanin production inhibiting effect.

Claims (1)

[Claims] 1,6-hydroxy-2-hydroxymethyl 1
- A fair-skinned cosmetic characterized by incorporating 4-pyrone into a cosmetic base.