JPS6142882Y2 - - Google Patents
Info
- Publication number
- JPS6142882Y2 JPS6142882Y2 JP3753384U JP3753384U JPS6142882Y2 JP S6142882 Y2 JPS6142882 Y2 JP S6142882Y2 JP 3753384 U JP3753384 U JP 3753384U JP 3753384 U JP3753384 U JP 3753384U JP S6142882 Y2 JPS6142882 Y2 JP S6142882Y2
- Authority
- JP
- Japan
- Prior art keywords
- container
- closed
- liver
- vessel
- entrance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004185 liver Anatomy 0.000 claims description 18
- 230000008014 freezing Effects 0.000 claims description 10
- 238000007710 freezing Methods 0.000 claims description 10
- 230000002262 irrigation Effects 0.000 claims description 2
- 238000003973 irrigation Methods 0.000 claims description 2
- 239000003507 refrigerant Substances 0.000 description 7
- 230000010412 perfusion Effects 0.000 description 3
- 238000010257 thawing Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 208000001940 Massive Hepatic Necrosis Diseases 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
【考案の詳細な説明】
本考案は各種のものを凍結し、凍結したものを
保存し、さらにこれを解凍して使用するのに好適
な容器に関するものである。[Detailed Description of the Invention] The present invention relates to a container suitable for freezing various things, storing frozen things, and further thawing them for use.
上記被凍結物として最適なものは、人工肝臓で
あるが、これは劇症肝炎などの肝不全患者に対し
て、その肝機能を補助するために用いられている
人工肝補助装置に採択して好適なもので、特に当
該人工肝臓が長期間の保存に耐え、必要に応じて
これを適時用い得るようにするため、生体肝を凍
結することが行われている。 The most suitable material to be frozen is an artificial liver, which has been adopted as an artificial liver assist device used to assist liver function in patients with liver failure such as fulminant hepatitis. It is preferable to freeze a living liver, especially in order to ensure that the artificial liver can withstand long-term storage and can be used as needed.
この凍結手段としては、血液が除去され、かつ
人または動物から摘出した肝臓を、例えば角状等
の細片となるよう切断し、当該肝臓片をヘリウム
ガスなどによつて凍結するのであるが、本考案は
このような凍結の実施に用いて好適な容器に関す
る。 This freezing method involves cutting the liver, which has been removed from a person or animal and from which blood has been removed, into small pieces, such as horns, and freezing the liver pieces using helium gas or the like. The present invention relates to a container suitable for use in carrying out such freezing.
従来この種の容器としては、単なる器物が用い
られているだけで特別な工夫が施されておらず、
このため上記の如き肝臓片に対して特に要求され
る瞬間的な凍結についても望ましい結果が得られ
ず、また当該器物は一回で収容できる量が決つて
おり、これを大巾に増減することができず、しか
も凍結物を保存したり、また解凍後の使用時には
役立たず、別途他の器具等を用いなくてはならな
い不便があつた。 Conventionally, this type of container was just a simple utensil without any special innovations.
For this reason, the desired results cannot be obtained even with the instant freezing that is especially required for liver pieces such as those mentioned above, and the amount that can be stored in the container at one time is fixed, and this can be greatly increased or decreased. Moreover, it is not useful when storing frozen items or when using them after thawing, and it is inconvenient that other equipment must be used separately.
本考案は上記の諸点に鑑み検討し、従来の難点
を解消しようとするもので、これを図示の実施例
によつて詳記すれば、テフロン等の合成樹脂など
で形成した円筒等による器体1には、その上部2
と下部3とにあつて、その中心部に夫々上位連結
口4、下部連結口5を貫設する。 The present invention was developed in consideration of the above-mentioned points and attempts to solve the conventional difficulties.The present invention is described in detail by the illustrated embodiment. 1 has its upper part 2
and lower part 3, an upper connecting port 4 and a lower connecting port 5 are provided through the center thereof, respectively.
ここで図示の各連結口4,5は、夫々上下に向
けて突設されているだけでなく、その外周部に雄
螺子としての連結螺部6,7が刻設されており、
このようにして、当該連結口4,5には後述する
血液の潅流に際し、潅流用等の配管を螺着により
連結したり、また第2図に一点鎖線で示す如く閉
栓8,8′を螺嵌して、これを閉塞できるように
してあるが、この際連結螺部6,7を刻設するこ
となく、当該連結を単なる嵌合手段によつて行う
ようにしても、また同部6,7を雌螺子により形
成することもできる。 The connection ports 4 and 5 shown here not only project upward and downward, but also have connection threads 6 and 7 as male screws carved on their outer peripheries.
In this way, perfusion pipes can be connected to the connecting ports 4 and 5 by screwing during blood perfusion, which will be described later, and stoppers 8 and 8' can be screwed into the connecting ports 4 and 5 as shown by the dashed lines in FIG. Although it is possible to close this by fitting it, it is also possible to perform the connection by a simple fitting means without cutting the connecting screw parts 6, 7. 7 can also be formed by a female screw.
次に上記器体1内は、二枚以上の横設されたメ
ツシユ板9,9……によつて上下に画成し、これ
によつて所要数の収納室10を形成してあり、第
1,第2図にあつては二枚のメツシユ板9,9に
よつて、1つの収納室10を形成しただけである
が、第3図の実施例では5枚のメツシユ板9,9
……を横設して4つの収納室10,10……に区
画してある。 Next, the interior of the vessel 1 is defined vertically by two or more horizontally installed mesh plates 9, 9, etc., thereby forming a required number of storage chambers 10. 1. In the case of FIG. 2, only one storage chamber 10 is formed by two mesh plates 9, 9, but in the embodiment shown in FIG. 3, five mesh plates 9, 9 are formed.
... are laid out horizontally and divided into four storage chambers 10, 10....
ここでメツシユ板9,9……の横設手段として
図示されているのは、器体1の周側壁11にあつ
て、その内面に突設した支承突条12,12……
の支承溝13に、メツシユ板9,9……を係嵌す
る構成としたもので、この際最上段のメツシユ板
9については、これの上に後述の如く肝臓片等の
被凍結物Aを載置しないので、これについては第
4図に示す如く、小さいメツシユ板を用いて器体
1の上部内面に、上位連結口4を閉成するよう接
着固定させるようにしてもよい。 Here, what is illustrated as the horizontal installation means for the mesh plates 9, 9... is the support ridges 12, 12..., which are provided on the circumferential side wall 11 of the container body 1 and protrude from the inner surface thereof.
The structure is such that the mesh plates 9, 9... are fitted into the support grooves 13 of the mesh plate 9. At this time, the uppermost mesh plate 9 has an object A to be frozen such as a piece of liver on top of it as described later. Since it is not mounted, a small mesh plate may be used to adhesively fix it to the upper inner surface of the container body 1 so as to close the upper connecting port 4, as shown in FIG.
さらに本考案では上記周側壁11にあつて、収
納室10,10……と対応する位置に出入口14
を開口させると共に、当該出入口14を開閉自在
とした閉蓋15を設けるのである。 Furthermore, in the present invention, in the circumferential wall 11, an entrance/exit 14 is located at a position corresponding to the storage chambers 10, 10, . . .
In addition, a closing lid 15 is provided which allows the entrance/exit 14 to be opened and closed.
図示例では閉蓋15がヒンジ16により回動自
在に枢着され、17はシール部材を示しており、
従つて第2図では閉蓋15が1個であるが、第3
図では収納室10,10……と同じく4個設けら
れており、図中18は閉蓋15の操作ハンドル、
19が、当該ハンドル18を回動操作により係止
することで閉蓋状態を保持するため、周側壁11
から突設した係止片を示している。 In the illustrated example, the closing lid 15 is rotatably attached by a hinge 16, and 17 indicates a sealing member.
Therefore, although there is one closing lid 15 in FIG. 2, there is only one closing lid 15.
In the figure, there are four storage chambers 10, 10, etc., and 18 in the figure is the operating handle of the closing lid 15;
19 holds the handle 18 in a closed state by locking the handle 18 by rotating the circumferential wall 11.
A locking piece protruding from the top is shown.
そこで、これを用いるには閉蓋15を開けて、
出入口14から、例えば凍結しようとする前記肝
臓片Aを入れ、これを最上段のメツシユ板を除い
た他のメツシユ板9,9……上に載置した後、閉
蓋15を閉じ、さらに下位連結口5に図示しない
冷媒供給管を連結する。 Therefore, to use this, open the closing lid 15,
For example, the liver piece A to be frozen is put in through the entrance/exit 14 and placed on the other mesh plates 9, 9 except for the uppermost mesh plate, and then the closing lid 15 is closed and the lower A refrigerant supply pipe (not shown) is connected to the connection port 5.
このようにすることで、ガス状ヘリウム等の冷
媒は器体1内に進入した後、上位連結口4から外
界へ放出され、この際メツシユ板9,9……上の
肝臓片Aは全面的に当該冷媒に触れて瞬間凍結さ
れる。 By doing this, after the refrigerant such as gaseous helium enters the container 1, it is released to the outside world from the upper connection port 4, and at this time, the liver piece A on the mesh plates 9, 9... When it comes into contact with the refrigerant, it freezes instantly.
そしてこのとき第2,第3図の何れの場合にあ
つても、最上段のメツシユ板は、下位連結口5か
ら噴入される冷媒によつて、メツシユ板9上の肝
臓片が上位連結口4から不本意に放出されてしま
うことを阻止するための役割を果している。 At this time, in either of the cases shown in FIGS. 2 and 3, the uppermost mesh plate is caused by the refrigerant injected from the lower connection port 5, so that the liver piece on the mesh plate 9 is moved to the upper connection port. It plays a role in preventing involuntary release from 4.
このようにして、凍結処理が終れば、第2図の
ように上役、下位連結口4,5に閉栓8,8′を
施し、この状態にて例えば液体窒素による保冷器
内等に入れて保存したり、これを取り出して運搬
または携帯することができる。 When the freezing process is completed in this way, the upper and lower connecting ports 4 and 5 are closed with caps 8 and 8' as shown in Fig. 2, and in this state they are placed in a refrigerator using liquid nitrogen, for example. You can store it, take it out and carry it with you.
さらに上記のようにして保存しておいた凍結肝
臓片を使用しようとするときは、閉栓8,8′を
外して所定手段により解凍し、その後前記した人
工肝補助装置における潅流用配管を、上位、下位
連結口4,5に連結することで、同装置を稼動さ
せ、かくして、患者の血液を当該肝臓片に通した
後、人体に戻してやることができる。 Furthermore, when it is desired to use the frozen liver pieces stored as described above, the caps 8 and 8' are removed and thawed using a prescribed means, and then the perfusion piping of the artificial liver assist device described above is connected to the upper , by connecting to the lower connections 4, 5, the device can be operated, thus allowing the patient's blood to pass through the liver piece and then return to the human body.
本考案は図示の実施例によつて具現される通
り、器体1の上部2と下部3には、潅流用等の配
管が連結自在にして、閉栓8,8′により閉塞可
能な夫々上位連結口4、下位連結口5を貫設し、
当該器体1内を横設した二枚以上のメツシユ板
9,9……により上下に画成すると共に、器体1
の周側壁11には、上記画成により形成の収納室
10に対応して出入口14を開口し、当該出入口
14を閉蓋15により開閉自在としたので、下位
連結口5から導入される冷媒を上位連結口4から
放出してやることで、急速に当該冷媒を、メツシ
ユ板上の肝臓片等に接触させることができ、従つ
て望ましい瞬間凍結を行うことが可能となる。 As embodied by the illustrated embodiment, the present invention is such that the upper part 2 and the lower part 3 of the container body 1 are connected with pipes for irrigation, etc., and are connected to upper parts thereof which can be closed by stoppers 8 and 8'. The opening 4 and the lower connecting opening 5 are provided through the
The inside of the vessel 1 is defined vertically by two or more mesh plates 9, 9 placed horizontally, and the inside of the vessel 1 is
An inlet/outlet 14 is opened in the peripheral side wall 11 of the housing 11 in correspondence with the storage chamber 10 formed by the above definition, and the inlet/outlet 14 is made openable and closable with a closing lid 15, so that the refrigerant introduced from the lower connecting port 5 can be opened and closed. By discharging the refrigerant from the upper connection port 4, the refrigerant can be brought into rapid contact with the liver pieces on the mesh plate, thereby making it possible to perform desired instant freezing.
さらに上記両連結口4,5には、潅流用配管や
閉栓8,8′を連結または施すことができるよう
にしたから、前記の如く解凍後の使用に際して
は、当該容器をそのまま人工肝補助装置の系内に
接続して使用することができ、また保存や運搬に
も閉栓8,8′の使用により取扱いが便利とな
り、最上位のメツシユ板によつて被凍結物が不本
意に放出されてしまう虞れもない。 Furthermore, since perfusion piping and stoppers 8, 8' can be connected or attached to both the connecting ports 4, 5, when used after thawing as described above, the container can be used as is for the artificial liver assist device. It can be connected and used in a system, and the use of closures 8 and 8' makes handling convenient for storage and transportation, and the uppermost mesh plate prevents the frozen material from being released inadvertently. There's no danger of it getting lost.
第1図は本考案に係る凍結用容器の正面図、第
2図は同縦断正面図、第3図は他の使用態様を示
した同縦断正面図、第4図は第2図とは別異の実
施例による同容器の上部箇所を示す縦断正面図で
ある。
1……器体、2……上部、3……下部、4……
上位連結口、5……下位連結口、8,8′……閉
栓、9……メツシユ板、10……収納室、11…
…周側壁、14……出入口、15……閉蓋。
Fig. 1 is a front view of the freezing container according to the present invention, Fig. 2 is a longitudinal sectional front view of the same, Fig. 3 is a longitudinal sectional front view of the same showing another mode of use, and Fig. 4 is different from Fig. 2. FIG. 7 is a longitudinal sectional front view showing the upper part of the same container according to a different embodiment. 1... vessel body, 2... upper part, 3... lower part, 4...
Upper connection port, 5... lower connection port, 8, 8'... closure, 9... mesh plate, 10... storage chamber, 11...
...Surrounding wall, 14...Entrance/exit, 15...Closing lid.
Claims (1)
結自在にして、閉栓により閉塞可能な夫々上位
連結口、下位連結口を貫設し、当該器体内を横
設した二枚以上のメツシユ板により上下に画成
すると共に、器体の周側壁には、上記画成によ
り形成の収納室に対応して出入口を開口し、当
該出入口を閉蓋により開閉自在とした肝臓片等
の凍結用容器。 (2) 最上位のメツシユ板は、載置用に供すること
なしに、上位連結口を閉成するため器体上部の
内面に当接固定してある実用新案登録請求の範
囲第1項記載の肝臓片等の凍結用容器。[Scope of Claim for Utility Model Registration] (1) The upper and lower parts of the vessel are connected to pipes for irrigation, etc., with upper and lower connecting ports that can be closed by plugging, respectively. The interior of the vessel is defined by two or more mesh plates installed horizontally in the upper and lower sides, and an entrance/exit is opened in the circumferential wall of the vessel corresponding to the storage chamber formed by the above-mentioned definition, and the entrance/exit is closed and covered. A container for freezing liver pieces, etc. that can be opened and closed freely. (2) The uppermost mesh plate is fixed to the inner surface of the upper part of the container body in order to close the upper connection port without being used for mounting. Container for freezing liver pieces, etc.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3753384U JPS60152602U (en) | 1984-03-16 | 1984-03-16 | Container for freezing liver pieces, etc. |
| AU34125/84A AU584312B2 (en) | 1984-01-17 | 1984-10-11 | Method of fabricating frozen fine liver pieces for artificial liver, apparatus for freezing the same, and freezing vessel |
| CA000466053A CA1245989A (en) | 1984-01-17 | 1984-10-22 | Method of fabricating frozen fine liver pieces for artificial liver, apparatus for freezing the same, and freezing vessel |
| EP19880108277 EP0292922B1 (en) | 1984-01-17 | 1984-10-24 | Apparatus for freezing liver for use in an auxiliary liver device |
| DE8888108277T DE3484656D1 (en) | 1984-01-17 | 1984-10-24 | DEVICE FOR FREEZING LIVER FOR USE IN AN ARTIFICIAL LIVER. |
| EP19840307325 EP0150569B1 (en) | 1984-01-17 | 1984-10-24 | Method of fabricating frozen fine liver piece for artificial liver |
| DE8484307325T DE3479088D1 (en) | 1984-01-17 | 1984-10-24 | Method of fabricating frozen fine liver piece for artificial liver |
| US07/245,925 US4883452A (en) | 1984-01-17 | 1988-09-16 | Method of fabricating frozen fine liver pieces for artificial liver, apparatus for freezing the same, and freezing vessel |
| AU30971/89A AU617432B2 (en) | 1984-01-17 | 1989-03-03 | Apparatus for freezing liver for use in an auxiliary liver device |
| US07/408,111 US4987921A (en) | 1984-01-17 | 1989-09-15 | Method of fabricating frozen fine liver piece for artificial liver, apparatus for freezing the same and freezing vessel |
| US07/407,660 US4984430A (en) | 1984-01-17 | 1989-09-15 | Method of fabricating frozen fine liver pieces for artificial liver, apparatus for freezing the same, and freezing vessel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3753384U JPS60152602U (en) | 1984-03-16 | 1984-03-16 | Container for freezing liver pieces, etc. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60152602U JPS60152602U (en) | 1985-10-11 |
| JPS6142882Y2 true JPS6142882Y2 (en) | 1986-12-05 |
Family
ID=30543701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3753384U Granted JPS60152602U (en) | 1984-01-17 | 1984-03-16 | Container for freezing liver pieces, etc. |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60152602U (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5224703B2 (en) * | 2007-03-13 | 2013-07-03 | 株式会社北里バイオファルマ | Collected tissue piece vitrification cryopreservation tool, tissue piece cryopreservation plate, and harvested tissue piece vitrification cryopreservation method |
| US10173219B2 (en) * | 2011-02-07 | 2019-01-08 | 1Cryobio Ag | Breakable vessel for sample storage |
| JP6653200B2 (en) * | 2016-03-25 | 2020-02-26 | 大陽日酸株式会社 | Biological sample freezing device |
-
1984
- 1984-03-16 JP JP3753384U patent/JPS60152602U/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60152602U (en) | 1985-10-11 |
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