JPS6185949A - Single needle type membrane type serum sampling system - Google Patents
Single needle type membrane type serum sampling systemInfo
- Publication number
- JPS6185949A JPS6185949A JP59205734A JP20573484A JPS6185949A JP S6185949 A JPS6185949 A JP S6185949A JP 59205734 A JP59205734 A JP 59205734A JP 20573484 A JP20573484 A JP 20573484A JP S6185949 A JPS6185949 A JP S6185949A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- plasma
- membrane
- blood cell
- red blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012528 membrane Substances 0.000 title claims description 28
- 238000005070 sampling Methods 0.000 title 1
- 210000002966 serum Anatomy 0.000 title 1
- 239000008280 blood Substances 0.000 claims description 56
- 210000004369 blood Anatomy 0.000 claims description 54
- 210000003743 erythrocyte Anatomy 0.000 claims description 36
- 239000012141 concentrate Substances 0.000 claims description 30
- 238000000926 separation method Methods 0.000 claims description 13
- 230000036770 blood supply Effects 0.000 claims description 12
- 230000032258 transport Effects 0.000 claims description 7
- 210000004204 blood vessel Anatomy 0.000 claims description 6
- 210000000601 blood cell Anatomy 0.000 claims description 3
- 230000010100 anticoagulation Effects 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 230000002429 anti-coagulating effect Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 description 5
- 229940127219 anticoagulant drug Drugs 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012510 hollow fiber Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229920002284 Cellulose triacetate Polymers 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は献血による採血に際し、膜型血漿分離器を使用
して血漿のみを採取し、血球成分を献血者に返送するシ
ングルニードル式膜分離型血漿採取システムに関する。[Detailed Description of the Invention] [Industrial Application Field] The present invention is a single-needle membrane separation method that uses a membrane-type plasma separator to collect only plasma and returns blood cell components to the blood donor when blood is collected from donated blood. Regarding type plasma collection system.
し従来の技術〕
［吠面による採某システムの１つとして遠心法があるが
、高価な設備を必要とするので不経済であり、また複雑
な設備を必要としない沈降法は血漿今離：こ長時間を要
するので実用的でない。[Conventional technology] [Centrifugation is one of the systems for plasma collection, but it is uneconomical because it requires expensive equipment, and the sedimentation method, which does not require complicated equipment, is currently used to separate plasma. This is not practical as it takes a long time.
１漢型血こｑ分離器を使用した膜型採薬システムは＋
Ｊｆ＃皿豪中に血小板等の有形成分を含有しないので最
も何効な方法であるが従来の方法は両腕の静脈のそれぞ
れに留置針を穿入させ該留置針を経由する体外血液循環
によるものであるから献血者に与える負担が大であった
。1 Membrane-type drug collection system using a Chinese type blood separator is +
This is the most effective method because it does not contain platelets or other formed components, but the conventional method involves inserting indwelling needles into the veins of both arms and circulating blood through the indwelling needles outside the body. This placed a heavy burden on blood donors.
そのため本発明者等は上記の欠点を解決するための単針
式膜型血梁採取システムを開発し、献血者に与える負担
を半減させることに成功した。しかし該／ステムは献血
者からの膜型血漿分離器への送血と該分離器からの献血
者への返送とを交互しで実施する間欠作動方式を採用し
、送血時に前記膜型血漿分離器によって血液から血漿が
分離された赤血球濃厚液を返送側で容器中に一時的に貯
留して返送を停止し、返送時には送血を停止して前記容
器中の赤血球濃厚、夜を献血者に返送するサイクルが時
間制御によって行われるものであった。Therefore, the present inventors developed a single-needle membrane type blood cell collection system to solve the above-mentioned drawbacks, and succeeded in reducing the burden on blood donors by half. However, the stem/stem adopts an intermittent operation method in which blood is alternately sent from the donor to the membrane-type plasma separator and returned from the separator to the donor. The red blood cell concentrate, in which plasma has been separated from the blood by the separator, is temporarily stored in a container on the return side and the return is stopped, and at the time of return, the blood supply is stopped and the red blood cell concentrate in the container is transferred to the donor. The cycle of sending it back to the factory was time-controlled.
〔発明が解決しようとする問題点Ｊ
前記単針式膜型血某採取システムは送血と返送とを時間
制御によって実施するものであったから前記容器内の赤
血球ａＦＸ液叶の管理Ｖて正確さを欠くことがあり、血
漿採取に際して慎重な監視がＺ、要とされていた。[Problem to be solved by the invention J: Since the single-needle membrane type blood collection system performs blood feeding and return by time control, it is difficult to accurately manage the red blood cell aFX fluid in the container. Careful monitoring was required when collecting plasma.
〔問題点を解決するための手段］
本発明は上記の問題点を解決するためＫなされたもので
あって、ドナーの血管に留置された留１針と、この留置
針から膜型血漿分離器に血液をポンプ輸送する送血ライ
／と、前記膜型血漿分離器において、前記血液からこの
膜型血漿分離器に装備された分離膜を通過した血漿が分
離された赤血球濃厚液を前記留置針に返送する返送ポン
プを配備した返送ラインと、前記血漿を血漿容器に輸送
する血漿ライ／とよりなり、前記送血ライ／（では、こ
の送血ライン内を輸送される血ｉｔ抗凝血化させる抗凝
血化手段を備え、前記返送ラインは前記返送ポンプの上
流側の該返送ラインと連通ずる赤血球濃厚液容器を備え
、該赤血球濃厚液容器は該容器を針金する計量手段を備
え、該計量手段は該計量値に応じて送血と返送とを交互
に行わせる制御手段と接続するものである。[Means for Solving the Problems] The present invention has been made to solve the above problems, and includes a single indwelling needle placed in a blood vessel of a donor, and a membrane-type plasma separator from this indwelling needle. and a blood supply line for pumping blood to the indwelling needle, and in the membrane plasma separator, a concentrated red blood cell solution from which plasma that has passed through the separation membrane equipped on the membrane plasma separator is separated from the blood is transferred to the indwelling needle. It consists of a return line equipped with a return pump for returning the plasma to the plasma container, and a plasma line for transporting the plasma to the plasma container. the return line includes a red blood cell concentrate container communicating with the return line upstream of the return pump, the red blood cell concentrate container includes metering means for wire-wiring the container; The measuring means is connected to a control means for alternately sending and returning blood according to the measured value.
前記制御手段は前記計量値が規定の上限値に達したとき
に送血を停止させるととも罠前記赤血球濃厚液容器から
の貯留赤血球濃厚液の返送を開始させ、該赤血球濃厚液
容器の計量値が規定の下限値に達したときに送血を開始
させるとともに返送を停止ヒさせて赤血球濃厚液を前記
赤血球濃厚液容器に貯留させるサイクルの繰返しによっ
て膜型血漿分離器からの採漿が行われる。The control means stops blood feeding when the measured value reaches a predetermined upper limit, starts returning the stored red blood cell concentrate from the red blood cell concentrate container, and adjusts the measured value of the red blood cell concentrate container. Plasma is collected from the membrane-type plasma separator by repeating a cycle in which when the blood flow reaches a specified lower limit, blood supply is started, return is stopped, and the red blood cell concentrate is stored in the red blood cell concentrate container. .
以下本発明の実施例を図面に基づいて説明する。 Embodiments of the present invention will be described below based on the drawings.
図面は本発明の実施例の流路系図である。図面、におい
で１はシフグルニードル式膜分離型血漿採取７ステムで
ある。このシステム１はドナー（献血者）Ｄの血管ンζ
留置された留置針２と、この留置針２から膜型血漿分離
器３に血液を送血ボ／ブ１０の作動によって輸送する送
血ライン４と、前記膜型血漿分離器３において、前記血
液からこの膜型血漿分離器３１（装備された分離膜を通
過した血漿が分離された赤血球濃厚液を前記留置針２を
経て前記ドナーＤの血管に返送する返送ライ１５と、前
記分離膜を通過した血漿を好ましくは血液バッグ形式の
血漿容器７に輸送する血漿ライン６とよりなり、この血
漿ライン６に前記血漿を輸送する血漿ポンプ１５を配備
することができる。前記送血ライン４はこの送血ライン
４内を輸送される血液を抗１疑血化させる抗凝血化手段
を備え、該手段は抗１疑血剤容器８から抗凝血剤を前記
送血ライン４に添加する抗１疑血剤ライン９を備え、前
記抗凝血剤は重力流下またはポンプ輸送によって前記送
血ライン４内の血流に対して規定の割合で添加され前記
血液は抗凝血化される。抗凝血剤として各種のものを使
用できるが、Ａ、ＣＤ液を使用するとき血液流ｆｆ１Ｋ
対して］／９が添加される。前記送血ポンプ１０を図示
の２連弐ローラーボ７プとして、該ポ／ブ１０に前記抗
・疑血剤ライ／９をも配備し、前記送血ライ／４と前記
抗、疑血剤うイノ９との内断面積比を９＝１とすると、
１台の送血ポンプ１Ｏｔｃよって送血と、該送血に対す
る規定比の抗凝血剤の添ｔｔｎをすることかで・きる。The drawing is a flow path system diagram of an embodiment of the present invention. In the figure and the smell, 1 is a Schifgl needle type membrane separation type plasma collection 7 stem. This system 1 is the blood vessel ζ of donor (blood donor) D.
The indwelling needle 2, the blood feeding line 4 that transports blood from the indwelling needle 2 to the membrane plasma separator 3 by the operation of the blood feeding tube 10, and the blood feeding line 4 that transports blood from the indwelling needle 2 to the membrane plasma separator 3, From this membrane type plasma separator 31 (equipped with a separation membrane, the plasma passes through a return line 15 for returning the separated red blood cell concentrate to the blood vessel of the donor D via the indwelling needle 2), A plasma line 6 for transporting the collected plasma to a plasma container 7, preferably in the form of a blood bag, can be provided with a plasma pump 15 for transporting the plasma. Anticoagulation means is provided for converting the blood transported in the blood line 4 into anti-1 suspect blood, and the means adds an anti-coagulant from an anti-1 suspect agent container 8 to the blood feeding line 4. A suspected blood agent line 9 is provided, and the anticoagulant is added to the blood flow in the blood supply line 4 at a prescribed ratio by gravity flow or pump transport, and the blood is anticoagulated. Various types of blood agents can be used, but when using A, CD solution, the blood flow ff1K
]/9 is added. The blood pump 10 is a double roller pump 7 as shown in the figure, and the blood pump 10 is also equipped with the anti-blood agent Ly/9, and the blood pump Ly/4 and the anti-blood suspect drug Ly/9 are arranged in the pump 10. If the internal cross-sectional area ratio with Ino 9 is 9=1,
One blood pump 10tc can transport blood and add an anticoagulant at a prescribed ratio to the blood transport.
もちろん２台のポンプを使用して、送血と抗凝血剤輸送
とを独立に行ってもよい。Of course, two pumps may be used to perform blood delivery and anticoagulant delivery independently.
前記返送ライ１５はこの返送ライン５と連通ずる好まし
くは血液バッグ形式の赤血球濃厚液容器１１と、該容器
１１の下流側に配備された返送ポンプ１２とを備える。The return line 15 includes a red blood cell concentrate container 11, preferably in the form of a blood bag, communicating with the return line 5, and a return pump 12 disposed downstream of the container 11.
前記赤血球濃厚液容器１１は該容器１１を計量する計量
手段１３を備える。該計量手段１３は図示のスプリング
を使用した懸吊タイプばかりでなく前記赤血球濃厚液容
器１１を支持する台秤タイプ等の適宜形式の重量方式、
あるいは超音波ま・たは光学式等によって前記容器１１
内の赤血球濃厚液のレベルを測定する容量方式を採用す
ることができ、この計量手段１３は該計量値に対応する
信号を出力し、この出力信号に従って送血と返送とを交
互に行わせる制御手段１４に接続する。The red blood cell concentrate container 11 is provided with measuring means 13 for weighing the container 11. The measuring means 13 is not only a suspension type using a spring as shown in the figure, but also an appropriate weight type such as a platform scale type that supports the red blood cell concentrate container 11.
Alternatively, the container 11 may be
The measuring means 13 outputs a signal corresponding to the measured value, and controls alternately sending and returning blood according to this output signal. connection to means 14;
この制御手段１４は前記赤血球濃厚液容器１１の計量値
が規定の上限値に達するまで前記送血ポンプ１０を作動
させるとともに返送ポンプ１２を停止させる。その間前
記送血ポンプ１０の作動によって前記送血ライン４内を
輸送される前記ドナーＤからの血液は抗凝血化されて前
記膜型血漿分離器３に輸送される。輸送された血液は該
膜型血漿分離器３に装備された前記分離膜を通過する血
漿と該分離膜を通過しない赤血球濃厚液とに分離される
。前記血漿は前記血漿ライン６を経て前記血漿ポンプ１
５が配備されているときはその作動によって前記血漿容
器７にポンプ輸送される。この血漿ポンプ１５は前記血
漿分離器３から血漿を吸引し血漿採取効率を向上させる
とともに規定流量の血漿採取を可能とするが、前記血漿
ポンプ１５を使用せずに前記送血ライン４からの送血圧
のみによる血漿採取をすることもできる。前記分離膜を
通過しない赤血球濃厚液は前記返送ライン５と連通ずる
前記赤血球濃厚液容器１１に貯留される。The control means 14 operates the blood pump 10 and stops the return pump 12 until the measured value of the red blood cell concentrate container 11 reaches a prescribed upper limit. During this time, the blood from the donor D transported through the blood transport line 4 by the operation of the blood pump 10 is anticoagulated and transported to the membrane plasma separator 3. The transported blood is separated into plasma, which passes through the separation membrane installed in the membrane plasma separator 3, and red blood cell concentrate, which does not pass through the separation membrane. The plasma passes through the plasma line 6 to the plasma pump 1.
5 is deployed, its operation causes the plasma to be pumped into the plasma container 7. This plasma pump 15 sucks plasma from the plasma separator 3, improves plasma collection efficiency, and makes it possible to collect plasma at a specified flow rate. Plasma collection can also be performed based on blood pressure alone. The red blood cell concentrate that does not pass through the separation membrane is stored in the red blood cell concentrate container 11 which communicates with the return line 5.
この赤血球濃厚液容器１１の計量値が前記の規定された
上限値に達すると前記計量手段１３からの上限信号に従
って前記制御手段１４は前記送血ポンプ１０ヲストツプ
させて送血を停止させるとともに返送ポンプ１２を作動
させ、血漿ポンプ１５が設けられているときはこのポン
プ１５をも停止させる。前記返送ポンプ１２の作動によ
って前記赤血球濃厚液容器１１に貯留された赤血球濃厚
液は前記返送ライン５と前記留置針２を経てドナーＤの
血管に返送され、前記計量手段１３が前記の規定の下限
値を検出すると、前記送血ポンプ１０の運転と返送ポン
プ１２の停止が行われ血漿採取と赤血球濃厚液の貯留に
移行し、血漿ポンプ１５が配備されているときは、この
ポンプ１５を作動させる。When the measured value of the red blood cell concentrate container 11 reaches the prescribed upper limit value, the control means 14 stops the blood pump 10 to stop blood feeding in accordance with the upper limit signal from the measuring means 13, and the return pump 12, and if a plasma pump 15 is provided, this pump 15 is also stopped. The red blood cell concentrate stored in the red blood cell concentrate container 11 by the operation of the return pump 12 is returned to the blood vessel of the donor D via the return line 5 and the indwelling needle 2, and the measuring means 13 is adjusted to the specified lower limit. When the value is detected, the blood supply pump 10 is operated and the return pump 12 is stopped, and the process shifts to plasma collection and red blood cell concentrate storage, and if the plasma pump 15 is installed, this pump 15 is activated. .
以下上記サイクルの繰返しによって間欠的な血漿採取を
行うことができる。Thereafter, intermittent plasma collection can be performed by repeating the above cycle.
本実施例において、前記膜型血漿分離器３として、内径
２７０ミクロン、肉厚８０ミクロン、有効膜面積０．１
５ｍ’、有効長１６３ｍｍ、最大ポアサイズ０４ミクロ
ンのセルローストリアセテート中空糸を装備した中空糸
タイプのものを使用し、血液流量を／１５ｍ１Ｚ分、Ａ
ＣＤ液流量を５ｍｖ分、返送流量を５０ｍ〆分とし、重
量上限値をネット１２０ｇ、重量下限値をネット２０ｇ
に設定するとき、約１．５ ｍν分の血漿流量と約３５
ｍｅ７％の赤血球濃厚液貯留流量が得られ、約３分の
送血と約２分の返送サイクルでの６０分運転によって５
００ｍ１！の血漿を採取することができ、間欠作動に原
因する体外ライ／内の凝血は認められず、また体外血液
循環によるドナーの異常は発見されなかった。なお血漿
採取に先立って本システムの関係部分の生理食塩液充填
を実施した。In this embodiment, the membrane type plasma separator 3 has an inner diameter of 270 microns, a wall thickness of 80 microns, and an effective membrane area of 0.1.
A hollow fiber type equipped with cellulose triacetate hollow fibers with an effective length of 5 m', an effective length of 163 mm, and a maximum pore size of 04 microns was used, and the blood flow rate was reduced to /15 m1Z min, A
The CD liquid flow rate is 5 mv, the return flow rate is 50 m, the upper limit of weight is 120 g net, and the lower limit of weight is 20 g net.
When set to
A red blood cell concentrate storage flow rate of me7% was obtained, and a 60-minute operation with a blood transfer cycle of approximately 3 minutes and a return cycle of approximately 2 minutes resulted in a flow rate of 5%.
00m1! We were able to collect plasma from the donor, and no blood clots inside or outside the body due to intermittent operation were observed, and no abnormality in the donor due to extracorporeal blood circulation was found. Prior to plasma collection, the relevant parts of this system were filled with physiological saline.
図面に示された１６．１７はそれぞれ前記送血ライン４
と返送ライ１５に配備されたエアトラップであって、関
係ライン内のエアを捕捉するとともに該関係ライン内の
圧力を指示する圧力計Ｐ１ 、Ｐ２とをそれぞれ備え、
Ｐ３は前記膜型血漿分離器３に装備された分離圧指示用
の圧力計である。16 and 17 shown in the drawing are the blood supply lines 4, respectively.
and an air trap disposed in the return lie 15, each comprising pressure gauges P1 and P2 that capture the air in the related line and indicate the pressure in the related line,
P3 is a pressure gauge installed in the membrane type plasma separator 3 for indicating separation pressure.
本発明はドナーの血管に留置された１本の留置針と、こ
の留置針から膜型血漿分離器に送血する送血ラインと、
前記分離器から前記留置針に至る返送ラインと、この返
送ラインに連通ずる赤血球濃厚液容器とよりなり、送血
作動と返送作動とが前記赤血球濃厚液容器の上限および
下限の計量値の検出によって制御されるものであるから
、シングルニードル式血漿採取において正確な赤血球濃
厚液量の管理ができ、血漿採取において慎重な監視を必
要とすることはない。The present invention includes a single indwelling needle placed in a blood vessel of a donor, a blood supply line that sends blood from this indwelling needle to a membrane-type plasma separator,
It consists of a return line leading from the separator to the indwelling needle, and a concentrated red blood cell container communicating with this return line, and blood feeding and return operations are performed by detecting the upper and lower limits of the measured values of the concentrated red blood cell container. Since it is controlled, it is possible to accurately control the volume of red blood cell concentrate in single-needle plasma collection, and does not require careful monitoring during plasma collection.
図面は本発明の実施例の流路系図であり、２は留置針、
３は膜型血漿分離器、４は送血ライン、５は返送ライン
、６は血漿ライン、７は血漿容器、９は抗凝血剤ライン
、１０は送血ポンプ、１１は赤血球濃厚液容器、１２は
返送ポンプ、１３は計量手段、１４は制御手段。The drawing is a flow path diagram of an embodiment of the present invention, and 2 is an indwelling needle;
3 is a membrane type plasma separator, 4 is a blood supply line, 5 is a return line, 6 is a plasma line, 7 is a plasma container, 9 is an anticoagulant line, 10 is a blood supply pump, 11 is a red blood cell concentrate container, 12 is a return pump, 13 is a metering means, and 14 is a control means.
Claims (3)
から膜型血漿分離器に血液をポンプ輸送する送血ライン
と、前記膜型血漿分離器において、前記血液からこの膜
型血漿分離器に装備された分離膜を通過した血漿が分離
された赤血球濃厚液を前記留置針に返送する返送ポンプ
を配備した返送ラインと、前記血漿を血漿容器に輸送す
る血漿ラインとよりなり、 前記送血ラインには、この送血ライン内を輸送される血
液を抗凝血化させる抗凝血化手段を備え、前記返送ライ
ンは、前記返送ポンプの上流側の該返送ラインと連通す
る赤血球濃厚液容器を備え、該赤血球濃厚液容器は該容
器を計量する計量手段を備え、該計量手段は該計量値に
応じて送血と返送とを交互に行わせる制御手段と接続し
、該制御手段は前記計量値が規定の上限値に達したとき
に送血を停止させるとともに前記赤血球濃厚液容器から
の貯留赤血球濃厚液の返送を開始させ、該赤血球濃厚液
容器の計量値が規定の下限値に達したときに送血を開始
させるとともに返送を停止させて赤血球濃厚液を前記赤
血球濃厚液容器に貯留することを特徴とするシングルニ
ードル式膜分離型血漿採取システム。(1) An indwelling needle placed in a blood vessel of a donor, a blood supply line that pumps blood from the indwelling needle to a membrane plasma separator, and separation of membrane plasma from the blood in the membrane plasma separator. It consists of a return line equipped with a return pump that returns concentrated red blood cells from which plasma has passed through a separation membrane installed in the device to the indwelling needle, and a plasma line that transports the plasma to the plasma container. The blood line is equipped with an anticoagulation means for anticoagulating the blood transported through the blood supply line, and the return line is provided with a concentrated red blood cell solution communicating with the return line upstream of the return pump. The red blood cell concentrate container includes a measuring means for weighing the container, the measuring means is connected to a control means for alternately sending and returning blood according to the measured value, and the control means When the measured value reaches a predetermined upper limit, the blood supply is stopped and the return of the stored red blood cell concentrate from the red blood cell concentrate container is started, and the measured value of the red blood cell concentrate container reaches the predetermined lower limit. 1. A single-needle membrane separation type plasma collection system, characterized in that when the blood cell concentration is reached, blood feeding is started and return feeding is stopped to store the red blood cell concentrate in the red blood cell concentrate container.
請求の範囲第１項記載のシングルニードル式膜分離型血
漿採取システム。(2) The single-needle membrane separation type plasma collection system according to claim 1, wherein the measuring means is a gravimetric system.
請求の範囲第１項記載のシングルニードル式膜分離型血
漿採取システム。(3) The single-needle membrane separation type plasma collection system according to claim 1, wherein the measuring means is of a volumetric type.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59205734A JPS6185949A (en) | 1984-10-01 | 1984-10-01 | Single needle type membrane type serum sampling system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59205734A JPS6185949A (en) | 1984-10-01 | 1984-10-01 | Single needle type membrane type serum sampling system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6185949A true JPS6185949A (en) | 1986-05-01 |
| JPH0116179B2 JPH0116179B2 (en) | 1989-03-23 |
Family
ID=16511778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59205734A Granted JPS6185949A (en) | 1984-10-01 | 1984-10-01 | Single needle type membrane type serum sampling system |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6185949A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61154571A (en) * | 1984-12-26 | 1986-07-14 | 株式会社 ニツシヨ− | Single needle type membrane serum separation system |
| JPH01299566A (en) * | 1988-05-27 | 1989-12-04 | Terumo Corp | Single needle type plasma separating device |
-
1984
- 1984-10-01 JP JP59205734A patent/JPS6185949A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61154571A (en) * | 1984-12-26 | 1986-07-14 | 株式会社 ニツシヨ− | Single needle type membrane serum separation system |
| JPH01299566A (en) * | 1988-05-27 | 1989-12-04 | Terumo Corp | Single needle type plasma separating device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0116179B2 (en) | 1989-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4655742A (en) | Process/apparatus for the withdrawal/return of body fluids | |
| JP2821892B2 (en) | Plasma separation system | |
| JP2847409B2 (en) | Platelet concentrate generator and method | |
| US4648866A (en) | Process/apparatus for the withdrawal/return of body fluids | |
| US4639243A (en) | Process and apparatus for obtaining blood plasma | |
| JPH03502061A (en) | Therapeutic plasmapheresis device | |
| US3459182A (en) | Blood administration method | |
| US20250269102A1 (en) | Plasmapheresis Methods | |
| JPS6185949A (en) | Single needle type membrane type serum sampling system | |
| JP2739251B2 (en) | Single needle continuous blood removal / separation device | |
| JPH0116180B2 (en) | ||
| JPS61109574A (en) | Single needle type serum sampling system | |
| WO1992020383A1 (en) | System for separating blood components | |
| JPH0213582B2 (en) | ||
| JPS6125563A (en) | Single needle membrane separation type serum sampling system | |
| JPS61154571A (en) | Single needle type membrane serum separation system | |
| SU1124979A1 (en) | Apparatus for dividing blood into fractions | |
| JPH0628135Y2 (en) | Autologous blood recovery device | |
| JPS60135066A (en) | Drainage system | |
| JPS6036059A (en) | Serum sampling apparatus | |
| JPS6185951A (en) | Membrane type serum separation system | |
| JPS60156469A (en) | Serum sampling apparatus | |
| JPS61279253A (en) | Membrane separation type serum sampler | |
| JPH01113062A (en) | Donorpheresis device | |
| JPH01153164A (en) | plasma collection device |