JPS62155209A - Composition for oral cavity - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an oral composition containing berberine, and more specifically to an oral composition with suppressed bitterness due to berberine and a good feeling of use.

Prior Art and Problems to be Solved by the Invention It has been known in the past to incorporate crude drug extracts containing berberine into oral compositions, such as Oriental persimmon extract and Oriental lotus extract.
JP-A-57-56415, JP-A No. 57-85319, JP-A No. 5 B-39615, JP-A No. 58-57320, etc.)
These berberine-containing crude drug extracts have anti-inflammatory and antibacterial effects, and when incorporated into oral compositions, they have the effect of inhibiting bacterial adhesion to tooth surfaces, inhibiting plaque formation, and preventing bad breath. However, crude drug extracts containing 4 ruberi have a bitter taste based on berberine, which has the problem of worsening the usability and taste of oral compositions.

The present invention was developed in view of the above circumstances, and an object of the present invention is to provide an oral composition that suppresses the bitterness caused by berberine and has an improved feeling of use.

Ninth Means and Effects for Solving the Problems In order to achieve the above object, the present inventors conducted extensive research and found that when Mido was blended, the bitterness due to berberine was suppressed, leading to the present invention. It is something.

The present invention will be explained in more detail below.

The oral composition according to the present invention includes dentifrices such as toothpaste, moisturized toothpaste, liquid toothpaste, mouthwash, troche, chewing gum, oral Noyasuta, gingival pine surge cream,
It is used as a liquid mouth freshener, a solid mouth freshener, etc., and contains berberine.

Here, berberine is a herbal medicine extract containing berberine, such as Huangbo extract, Huanglium extract, and yellow berberine-containing herbal medicine extract, whose blending amount is o, o o in the entire oral composition.
It is preferable to set it as i-3 (weight range, the same below). In addition, in this blended amount, berberine is about 1 to 30
Contains 00 ppm.

The oral composition of the present invention contains berberine-derived Contains an on-active agent to suppress the bitter taste caused by the product.

Nonionic activators include fatty acid alkanolamide, silasugar fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, glycerin fatty acid ester, sorbitan sacrificial fatty acid ester, polyoxyethylene glycerin fatty acid ester, I-lyoxyethylene sorbitan fatty acid ester, polyoxy ethylene hydrogenated castor oil,
Examples include polyoxyethylene fatty acid esters, and one or more of these may be used, but among these, fatty acid alkanolamide is most preferably used because it more effectively suppresses the bitterness of berberine. Ru.

In this case, the fatty acid alkanolamide preferably has a fatty acid group having 9 to 18 carbon atoms and an alkanol group having 2 or 3 carbon atoms. The fatty acid may be saturated or unsaturated, linear or branched, and may be a mixed fatty acid. in particular,
Capric acid monoethanolamide, lauric acid jetanolamide, myristic acid jetanolamide, 9-lumitilic acid monoisozolopanolamide, etc.
Among them, lauric acid jetanolamide and myristic acid jetanolamide are preferably used.

The amount of nonionic activator is 0.1 to 5, especially 0.2 to 5.
3 ゛ is preferred. If the amount is less than 0.1, the bitterness reducing effect of berberine may not be sufficient, and if it exceeds 5, the foaming speed may be slow and the feeling of use may be poor.

In the present invention, in addition to the nonionic activator, water-soluble salts of alkyl sulfates having 8 to 18 carbon atoms such as sodium lauryl sulfate and sodium myristyl sulfate, sodium lauryl monoglyceride sulfate, sodium coconut oil fatty acid monoglyceride sulfate, and higher The number of carbon atoms in the fatty acid group is 10 to 1, such as fatty acid monoglyceride sodium monosulfate.
Water-soluble higher fatty acid monoglyceride sulfate, α
-olefin sulfonate, / mother olefin sulfonate)
, N-methyl-N-no and lumitoyltaurideum salts, and one or more surfactants such as cationic surfactants and amphoteric surfactants may be blended.

In addition to the above-mentioned components, the oral composition of the present invention may contain appropriate components, such as abrasives,
A binder, a thickening agent, a fragrance, a sweetener, a preservative, various active ingredients, and the like can be added, and can be prepared by a conventional method.

Effects of the Invention As described above, the oral composition according to the present invention has a suppressed bitterness and a good feeling of use due to the blending of a nonionic active agent, particularly a fatty acid alkanolamide, into an oral composition containing berberine. has been significantly improved.

Hereinafter, the effects of the present invention will be specifically explained with reference to experimental examples.

[Experiment example]

A toothpaste with the following formulation was prepared, and the effect of reducing bitterness was sensory evaluated by a specialist.

Here, the feeling of use was determined as #41 when using the toothpaste in a normal manner using a toothbrush with approx.

The results are shown in Table 1.

Toothpaste prescription Dibasic calcium phosphate 45 Silicic anhydride
2.0 propylene glycol
2.5 sorbit 2
Sodium oxymethyl cellulose
0.5 caradanan 0.5 sodium lauryl sulfate 0.5 lauric acid diethanolamide Amount shown in Table 1 Huangbai Water Extract (periperine content approx. 54) 0.1 Fragrance
0.5 Satucalin Sodium 0.
1100.0 Regret Table 1 The evaluation bases are as follows.

O: No bitterness felt.

Δ: Slightly bitter taste.

It was found that the bitterness of berberine could be improved by adding ``(nonionic activator)''.

Examples are shown next, but the present invention is not limited to the following examples. Example 1 Toothpaste dicalcium phosphate 45 Silicic anhydride 2 Sodium Cal-R oxymethylcellulose
0.5 caradanan 0.5 sorbit 25 glycerin
15 Propylene glycol 3 Sodium lauryl sulfate 0.5 Sodium lauroyl sarcosinate 0.5 Lauric acid diethanolamide 0.5 Tocopherol acetate 0.1 Tranexamic acid
0.05β-glycyrrhetinic acid 0
．． 01 Yellow phase water extract 0.1 Methyl-4-) pen 0.1 Sodium benzoate 0.5 Saccharin sodium
0.1 fragrance 1.0
100.0 [Example 2] Toothpaste dicalcium phosphate 50 Mical? Sodium oxymethylcellulose 1.0
Sorbitsu 15 Glycerin
15 Propylene glycol 2 Ethyl alcohol 0.5 Sodium lauryl sulfate *0.5 Sodium lauroyl sarcosinate
0.3 Lauric acid diethanolamide
1.0 Tocopherol acetate 0.056-
Aminocaproic acid 0.03β-Glycyrrhetinic acid o, oi Huangxinsang 30 Winter Ethanol Extract 0.1 Isopropylmethylphenol 0.01 Ethylparaben
0.1 Sodium benzoate
0.5 Satucalin Sodium 0.
1 Fragrance 1.0 100.0 Sodium lauryl sulfate 1 C4゜20~12 壬C1□: 50~8゜C44: 10~30 C46: 0~15 Contains 98 or more of the above in the carbon number distribution . same as below.

[Example 3] Toothpaste calcium carbonate 45 Sodium calxexymethylcellulose 1.5 Sorbit 25 Glycerin
10 Propylene glycol 3 Sodium lauryl sulfate 2.0 Lauric acid diethanolamide 1.0 Myristic acid diethanolamide 0.5 Dipotassium glycyrrhizinate 0.01 Sodium chloride
7.0 Yellow lotus water extract 0
, 1 Ethyl paraben 0.03 Sodium benzoate 1.0 Saccharin sodium 0.1 Fragrance 1.0 Purified water Balance 100.0 [Example 4] Toothpaste aluminum hydroxide 40 Karadanan 1.0 Glossy bit
30 Propylene glycol 3 Sodium lauryl sulfate 1.5 Lauric acid diethanolamide 1.5 Valmitic acid diethanolamide 0.5 Tranexamic acid 0.05 Chlorhexidine hydrochloride
Kiss 0.001 Yellow
0.1 Ethylparaben 0.05 Sodium benzoate 0.3 Saccharin sodium 0.1 Fragrance 1.0 100.0 [Example 5] Toothpaste aluminum hydroxide 45 Silicic anhydride
2 carragnan 1,0 sodium alginate 0.5 sorbitol
35 Sodium lauryl sulfate *1.0 Myristic acid jetanolamide 1.5-2 Cocoa oil fatty acid zoethanolamide PO33 Dextranase
2ooou/1 monofluorophosphate 0.
76 Yellow Phase 30 Ethanol Extract 0.05 Methylparaben 0.2 Sodium Benzoate
0.3 Stevioside 0
．． 1 Fragrance 1.0 [Example 6] Toothpaste secondary phosphate 40 Xanthan gum 1.0 Glycerin
25 Propylene glycol 5 Ethyl alcohol 0.5 Sodium lauryl sulfate *1.0 Sodium lauroyl sarcosinate 0.5 Sucrose lauric acid monoester 0.1 Wtl
“Lumitic acid monoester 0.1yf?+J
Oxyethylene sorbitan monolaurate o, i tocopherol acetate 0.17 lantoine)
0.01 Yellow lotus water extract
0.1 Eternograpene 0.02 Sodium benzoate 1.0 As/'9 Rutime 0.1 Fragrance 1.0 [Example 7] Toothpaste silicic anhydride 30 Udanan 1.5 Sorbit
15 Glycerin 2
5 Polyethylene glycol 5 Sodium lauryl sulfate 1.5 Sodium lauroyl sarcosinate 0.3 Lauric acid diethanolamide 0.7 Myristate diethanolamide 0.3 Polyoxyethylene hardening and mustard oil 0.3 Tocopherol nicotinate 0.3 β
- Glycyrrhetinic acid 0.077 Sodium fluoride 0.2 Yellow phase 30 Ethanol extract 0.005 Methyl nogura pen
0.1 Sodium benzoin 0.5 Sodium saccharin 0.1 Flavoring
1.0 Seiunsui Remaining 100.0 [Example 8] Toothpaste Aluminum Hydroxide 45 Color Rnan 0.3 Hydroxyethyl Cellulose 1.5 Sorbit
40 Sodium lauryl sulfate *0.7 Polyoxyethylene hydrogenated castor oil
1.0 Tocopherol acetate 0.5β
- Glycyrrhetinic acid 0.04 fluoride @1
Tin 0.4 yellow phase water extract
1.0 Petyl no arm lapen
0.02 Sodium benzoate 0
．． 3 Saccharin Sodium 0.1 Fragrance
1.0 100.0 [Example 9] Toothpaste Calcium Pyrophosphate 50 Width Cal?
Sodium oxymethylcellulose
1.5 glycerin 30 lauri,
sodium sulfate 0.5 lauric acid diethanolamide 2.0 myristic acid diethanolamide 0.5 tocopherol nicotinate 0.05 monofluorophore) 0.76 yellow phase water extract 0.5 ethyl nophthalmos
0.05 Sodium benzoate
0.5 Satucalin Sodium
0.1 Fragrance 1.0 Remains of purified ice [Example 101 Toothpaste insoluble calcium metaphosphate 50%
Cal? Sodium oxymethylcellulose
1.0 Sorbit 10 Glycerin 20 Sodium lauryl sulfate 0.7 Sodium lauroyl sarcosinate 0.3 Lauric acid diethanolamide 1.5 β-glycyrrhetinic acid 0.1 Yellow phase 30 ethanol extract 0.05 Yellow phase 304 ethanol extract 0.05゛ Puchirno mother pen
0.1 Sodium benzoate
0.1 Satucalin Sodium 0.
1 Fragrance 1.0 [Example 11] Toothpaste calcium pyrophosphate 20 Sodium xymethyl cellulose 1
．． 0 caradanan 1.0 glycerin 40 polyethylene glycol 3 sodium lauryl sulfate
2゜0 Lauric Diethanolamide
1. θ myristic acid jetanolamide
0.5 coconut oil fatty acid diethanolamide
0.5 Valmitic acid diethanolamide
0.5 tocopherol acetate
0.3ε-7 minocaderonic acid 0
．． 03β-Glycyrrhetinic acid 0.0
2. Yellow phase water extract 0.05 Yellow lotus water extract 0.05 Methylnobraben 0.05 Sodium benzoate 0.5 Saccharin sodium 0.1 Flavor
1.0 100.0 [Example 12] Moisturizing toothpaste calcium carbonate 70 Sorbitol 2 Glycerin
8 Sodium lauryl sulfate 1.5 Lauric acid diethanolamide 1.0 Tocopherol acetate 0.1 Yellow phase 30cII ethanol extract 0.05 Saccharin sodium 0.1 Flavor
1.0100.0 [Example 13] Liquid toothpaste glycerin 35.0 9 Propylene glycol 5.0 Sodium polyacrylate 2.5 Sodium lauryl sulfate 1,0 Lauric acid diethanolamide 1.5 Yellow phase 30 Superior ethanol diΦ vinegar
0.5 Saccharin Sodium 0
．． 3 Fragrance 5.0 100.0 [Example M 14] Mouthwash ethyl alcohol (96) 20.0 Polyoxyethylene hydrogenated castor oil 0.5
Sodium lauryl sulfate 0.5 Lauric acid diethanolamide 1. O Huangbai 20
4 Ethanol extract 0.2 Saccharin sodium 0.4 Fragrance
3.0 [Example 15] Gusta hydroxyethyl cellulose 4.0
1 Sorbit 40.0 Sodium lauryl sulfate O15 Lauric acid jetanolamide 2.0 Yellow phase'aottt ethanol extract 0.4 Methylnoya Lapen
0.02 Satucalin Sodium
0.02 Flavor 1.0 All of the oral compositions of the above examples have suppressed bitterness and have a good feeling of use.

Claims (1)

[Scope of Claims] 1. An oral composition characterized by blending a nonionic active agent into an oral composition containing berberine. 2. The oral composition according to claim 1, wherein the berberine is derived from Oriental oak extract. 3. The amount of Oriental oak extract is 0.001 to 3 of the total composition.
The oral composition according to claim 2, which is % by weight. 4. The oral composition according to any one of claims 1 to 3, wherein the nonionic active agent is a fatty acid alkanolamide. 5. The amount of nonionic activator is 0.1 to 5 of the total composition.
The oral composition according to any one of claims 1 to 4, which is % by weight.