JPS62253036A - 凝固促進剤入採血管 - Google Patents

凝固促進剤入採血管

Info

Publication number: JPS62253036A
Authority: JP; Japan
Prior art keywords: blood; blood collection; collection tube; thrombin; protamine sulfate
Prior art date: 1986-04-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP61096473A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0319776B2 (2

Inventor

直井　啓次

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Terumo Corp

Original Assignee

Terumo Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-25

Filing date

1986-04-25

Publication date

1987-11-04

1986-04-25 Application filed by Terumo Corp filed Critical Terumo Corp

1986-04-25 Priority to JP61096473A priority Critical patent/JPS62253036A/ja

1987-11-04 Publication of JPS62253036A publication Critical patent/JPS62253036A/ja

1991-03-15 Publication of JPH0319776B2 publication Critical patent/JPH0319776B2/ja

Status Granted legal-status Critical Current

Links

230000015271 coagulation Effects 0.000 title claims description 18
238000005345 coagulation Methods 0.000 title claims description 18
238000010241 blood sampling Methods 0.000 title description 3
210000004369 blood Anatomy 0.000 claims description 99
239000008280 blood Substances 0.000 claims description 99
102000007327 Protamines Human genes 0.000 claims description 40
108010007568 Protamines Proteins 0.000 claims description 40
229950008679 protamine sulfate Drugs 0.000 claims description 38
108090000190 Thrombin Proteins 0.000 claims description 34
229960004072 thrombin Drugs 0.000 claims description 34
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 22
229960002897 heparin Drugs 0.000 description 22
229920000669 heparin Polymers 0.000 description 22
238000000034 method Methods 0.000 description 9
230000000052 comparative effect Effects 0.000 description 8
210000002966 serum Anatomy 0.000 description 7
238000012360 testing method Methods 0.000 description 7
238000010876 biochemical test Methods 0.000 description 6
238000002474 experimental method Methods 0.000 description 5
102000009123 Fibrin Human genes 0.000 description 4
108010073385 Fibrin Proteins 0.000 description 4
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 4
230000002429 anti-coagulating effect Effects 0.000 description 4
229950003499 fibrin Drugs 0.000 description 4
108010049003 Fibrinogen Proteins 0.000 description 3
102000008946 Fibrinogen Human genes 0.000 description 3
239000003146 anticoagulant agent Substances 0.000 description 3
229940127219 anticoagulant drug Drugs 0.000 description 3
238000000502 dialysis Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000004745 nonwoven fabric Substances 0.000 description 3
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
230000002411 adverse Effects 0.000 description 2
-1 antiprothrombin Proteins 0.000 description 2
230000023555 blood coagulation Effects 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
229940012952 fibrinogen Drugs 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
239000000203 mixture Substances 0.000 description 2
239000000843 powder Substances 0.000 description 2
229940048914 protamine Drugs 0.000 description 2
238000003756 stirring Methods 0.000 description 2
PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
206010018910 Haemolysis Diseases 0.000 description 1
108090000778 Platelet factor 4 Proteins 0.000 description 1
102000004211 Platelet factor 4 Human genes 0.000 description 1
108010094028 Prothrombin Proteins 0.000 description 1
102100027378 Prothrombin Human genes 0.000 description 1
241000277331 Salmonidae Species 0.000 description 1
108010000499 Thromboplastin Proteins 0.000 description 1
102000002262 Thromboplastin Human genes 0.000 description 1
238000008050 Total Bilirubin Reagent Methods 0.000 description 1
LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
230000004913 activation Effects 0.000 description 1
230000003186 anti-thromboplastin Effects 0.000 description 1
239000004019 antithrombin Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
229940109239 creatinine Drugs 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000008588 hemolysis Effects 0.000 description 1
230000023597 hemostasis Effects 0.000 description 1
108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000002243 precursor Substances 0.000 description 1
229940039716 prothrombin Drugs 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
229940116269 uric acid Drugs 0.000 description 1

Landscapes

Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

JP61096473A 1986-04-25 1986-04-25 凝固促進剤入採血管 Granted JPS62253036A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP61096473A JPS62253036A (ja)	1986-04-25	1986-04-25	凝固促進剤入採血管

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP61096473A JPS62253036A (ja)	1986-04-25	1986-04-25	凝固促進剤入採血管

Publications (2)

Publication Number	Publication Date
JPS62253036A true JPS62253036A (ja)	1987-11-04
JPH0319776B2 JPH0319776B2 (2)	1991-03-15

Family

ID=14166011

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP61096473A Granted JPS62253036A (ja)	1986-04-25	1986-04-25	凝固促進剤入採血管

Country Status (1)

Country	Link
JP (1)	JPS62253036A (2)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6416717B1 (en) *	1998-08-31	2002-07-09	Nipro Corporation	Evacuated blood collection tube for rapid blood coagulation
JP2014524027A (ja) *	2011-07-05	2014-09-18	ベクトン・ディキンソン・アンド・カンパニー	凝固制御剤およびそれを含む装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS581460A (ja) *	1981-06-26	1983-01-06	テルモ株式会社	凝固促進剤入採血管

1986
- 1986-04-25 JP JP61096473A patent/JPS62253036A/ja active Granted

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS581460A (ja) *	1981-06-26	1983-01-06	テルモ株式会社	凝固促進剤入採血管

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6416717B1 (en) *	1998-08-31	2002-07-09	Nipro Corporation	Evacuated blood collection tube for rapid blood coagulation
JP2014524027A (ja) *	2011-07-05	2014-09-18	ベクトン・ディキンソン・アンド・カンパニー	凝固制御剤およびそれを含む装置
US9949473B2 (en)	2011-07-05	2018-04-24	Becton, Dickinson And Company	Coagulation controlling agents and devices comprising the same

Also Published As

Publication number	Publication date
JPH0319776B2 (2)	1991-03-15

Legal Events

Date	Code	Title	Description
2006-03-15	LAPS	Cancellation because of no payment of annual fees

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