JPS628186B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a hair growth promoting device. Recently, various wigs designed for alopecia have been commercially available and have been well received, but it goes without saying that they are not a fundamental treatment for alopecia. A variety of chemical and physical treatments have been attempted for alopecia areata, mid-age alopecia, glucose alopecia, atrophic alopecia, and symptomatic alopecia. efforts have been made. Nevertheless, many of the alopecias mentioned above are permanent, and even if treatment is possible, complete recovery usually takes several weeks to several years. One reason for this is that hair growth promoters applied to the skin are not efficiently absorbed into the dermal papilla tissue located deep in the scalp, and in some types of alopecia, physical and mental overwork may occur. Since the cause is psychological factors, it is thought that applying chemicals to the affected area or irradiating the affected area with ultraviolet rays cannot easily achieve the goal. As described above, a few patent applications have attempted to apply electronic therapy to alopecia, which has a wide variety of causes and is extremely difficult to treat. A typical example thereof is disclosed in, for example, Japanese Patent Laid-Open No. 136067/1983. Here, a special hat-shaped treatment tool equipped with electrodes is used, and low frequency waves are applied to the electrodes to ionize the hair growth promoter and introduce it into the skin, while also stimulating the autonomic nerves to promote hair growth. It is something to do. Although it is highly appreciated that the aim is to completely cure alopecia caused by physical and mental factors by stimulating the autonomic nervous system through iontophoresis of a hair growth promoter and low-frequency stimulation, in this attempt, the use of iontophoresis It is a smooth alternating current with a low frequency of 3000 to 4000 hertz,
In addition, since the low frequency for nerve stimulation is alternating current of 4 to 60 hertz, smooth alternating current tends to cause deep burns, and simple alternating current cannot withstand the stimulation. In addition, since the low frequency is applied while being switched appropriately, operational inconvenience is unavoidable, and the problem cannot be said to be sufficiently solved. The present inventor has investigated hair growth promoters that have even higher therapeutic effects than the hair growth promoters conventionally used in chemotherapy, such as vitamins, hormones, and inorganic salts, and carried out iontophoresis more efficiently. We carefully considered the equipment. As a result, we were able to use aminovinyl photosensitive dyes, which had never been used in iontophoresis methods up until now.
It has been discovered that by applying a certain superimposed low frequency voltage and performing iontophoresis, remarkable hair growth promotion can be easily obtained without changing the waveform of the applied low frequency as in the past, and that all the problems of the present invention can be solved. I got it. That is, the present invention generates a waveform that approximates the waveform of a biphasic action potential wave generated in a human nerve with a pulse width of 1/200 seconds to 1/600 seconds by a first low-frequency oscillator as a biphasic action potential wave at a pulse interval of 1. This occurs every 1/20 seconds to 1/300 seconds, thereby stimulating the skin and contributing to metabolism, and the second low frequency oscillator generates a positive potential once every 0.5 seconds to 2 seconds. Generate an extremely low frequency rectangular wave consisting of a zero potential current, connect this second low frequency oscillator in series with the first low frequency oscillator, and apply the superimposed waveform voltage of the two waveforms to the therapeutic guide. An aminovinyl-based photosensitive dye that ionizes the aminovinyl-based photosensitive pigment, promotes its penetration into the skin, and at the same time provides appropriate stimulation to the affected area to alleviate nervous fatigue and promote the growth of hair roots. The present invention provides a hair growth promoting device that is most suitable for ion introduction into areas affected by pigment hair loss. The biphasic action potential wave referred to in the present invention refers to a diphasic action potential obtained by electrical means such as an oscillator. Biphasic action potential is, for example, "Iwanami Biological Dictionary", No. 157
~Page 158, published by Iwanami Shoten Co., Ltd. (1960), it is a voltage waveform observed in stimulated bodies such as excited muscles and nerves, as shown in Figure 2 A. Although it has positive and negative voltage components with respect to zero potential, it differs from alternating current such as a sine wave in that it has sharp parts, that is, spike potentials, near the maximum and minimum potentials. In addition, the aminovinyl photosensitive dye referred to in the present invention refers to a photosensitive dye with an aminovinyl skeleton that promotes hair growth by ion introduction using the device of the present invention, and usually has an aromatic ring at the 1st and 2nd positions of the vinyl group. Either or both of these bonds are nitrogen-containing heterocycles, and one of the nitrogen atoms has an anion such as a halide to form a quaternary salt. Aminovinyl photosensitive dyes generally exhibit unique coloration and exhibit strong absorption in the ultraviolet region. For example, commercially available 6-[2-[(5
-Bromo-2-pyridyl)amino]vinyl]-1
-Ethyl-2-picolinium iodide (trade name "Koshinsen No. 301", manufactured by Nippon Kanko Shiki Co., Ltd.) and 2 (2-anilinovinyl) -3,4-
Dimethyl-oxazolinium iodide (trade name "Kousensoru No. 401", manufactured by Nippon Kanko Shiki Co., Ltd.) can be particularly advantageously used in the present invention. To ion-introduce an aminovinyl-based photosensitive dye, for example, first, the aminovinyl-based photosensitive dye to be ion-introduced is prepared in an aqueous alcoholic salt solution or the like to a concentration of several tens to hundreds of ppm, preferably about 50 to 500 ppm. After applying it to the affected area or impregnating it into a moisturizing therapeutic electrode,
Square wave with only zero and positive voltage components of 0.5 to 2 Hz, pulse width 1/200 to 1/600 seconds, pulse interval
A composite wave obtained by superimposing biphasic action potential waves of 1/20 to 1/300 seconds is applied to several volts to several tens of volts, preferably 5 to 30 volts, and is applied to the patient's symptoms and the condition of the affected area. 0.1 per treatment with consideration
A current of ~50 milliamps, preferably 5 to 30 milliamps, may be applied. It depends on the symptoms, but for adults, for example, 200ppm
A methanolic saline solution of an aminovinyl photosensitive dye is applied to the affected area approximately 1 c.c. per treatment, or it is absorbed into a roller-shaped moisturizing treatment guide for several minutes to several tens of minutes. Apply the superimposed voltage described above. Then, repeat the process once to several times a day while observing the hair growth situation in the area affected by hair loss. Also, if necessary, acetylcholine, steroids, DCNB
Iontophoresis may be performed in combination with hair growth promoters such as hair growth promoters, or may be performed in parallel with ultraviolet irradiation treatment. Next, a hair growth promoting device according to the present invention suitable for carrying out the above hair growth promoting method will be described. FIG. 1 shows a block diagram of a hair growth promoting device according to the present invention. 1 is a first low frequency oscillator, which has a pulse width t ₁ =1/200 seconds to 1/600 seconds, and a pulse interval as shown in Figure A of the waveform diagram shown in Figure 2.
A biphasic action potential wave of t ₂ =1/20 seconds to 1/300 seconds is generated. 2 is a second low frequency oscillator, which oscillates an ultra-low frequency rectangular wave with a frequency of 0.5 Hz to 2 Hz as shown in the waveform diagram shown in FIG. 2, and generates a current between zero potential and positive potential. occur alternately. The waveform shown in Figure A caused by this first low frequency oscillator 1,
When the waveform of the second low frequency oscillator 2 shown in Figure B is superimposed, the waveform shown in Figure C of Figure 2 is obtained, and the ions of the hair growth promoter are introduced in the waveform part of K→L, and the waveform of the hair growth promoter is introduced in the waveform part of L→M. The waveform part stimulates the skin and nerves to improve metabolism. The low frequency output voltage obtained in this way, ie, the superimposed wave voltage, is guided to a therapeutic guide consisting of a roller electrode 5 and a grip electrode 6 connected to terminals 3 and 4, and is applied to the affected skin. FIG. 3 shows the hair growth promoting device of the present invention, which is a more specific version of the block diagram shown in FIG. In this illustrated device, the first low frequency oscillator 1
The oscillation circuit is used as a blocking oscillation circuit to oscillate a biphasic action potential wave, and its output is guided to the connection terminal 3 of the therapeutic conductor via the transformer T. on the other hand,
The oscillation circuit of the second low frequency oscillator 2 is composed of a multivibrator, and the oscillation circuit is configured to oscillate from 0.5 Hz to 2 Hz.
The rectangular wave output having current components of Hertzian zero potential and positive potential is guided to an emitter follower circuit formed by transistor Tr ₄ , and the resulting low impedance output is guided to the secondary side of transformer T to generate a first low frequency oscillator. It is superimposed on the biphasic action potential wave that oscillates from 1. Battery _B2 is a bias power source. Further, FIG. 4 illustrates the hair growth promoting device of the present invention in which the oscillation circuits of the first low frequency oscillator 1 and the second low frequency oscillator 2 are both constructed by CR multivibrators. The 50 Hz to 300 Hz rectangular wave oscillated by the multivibrator of the first low frequency oscillator 1 is
It is differentiated by capacitor C ₉ and resistor R ₁₅ and becomes a biphasic action potential wave. This biphasic action potential wave is superimposed on a rectangular wave having a current component of zero potential and positive potential of 0.5 to 2 hertz, which is generated by the multivibrator of the second low frequency oscillator 2, as shown in Figure 2C. This becomes a superimposed low frequency voltage suitable for iontophoresis of an aminovinyl photosensitive dye, and is guided to the connection terminals 3 and 4 of the therapeutic conductor. That is, the oscillation frequency of the first low frequency oscillator 1 is 1/20, which is the same period as the pulse interval of the biphasic action potential wave.
seconds to 1/200 seconds, and its output is connected to the roller electrode 5 of the therapeutic conductor via the connection terminal 3, and the other connection terminal 4 is connected to the capacitor of the second low frequency oscillator 2.
Connect to _C12 . On the other hand, since the oscillation low frequency of the second low frequency oscillator 2 is extremely low frequency, it is connected to the capacitor via the resistor _R19 .
If the charging and discharging of C ₁₂ is performed, waveform distortion can be suppressed to a minimum, so that the voltage waveform at both ends of the capacitor C ₁₂ can be obtained as one that approximates a rectangular wave. The rectangular wave oscillated by the first low frequency oscillator 1 contains a lot of high frequency in the biphasic action potential wave differentiated by the capacitor C ₉ and the resistor R ₁₅ , so the impedance of the capacitor C ₁₂ is almost zero. Therefore, the loss is small, and the first low frequency oscillator 1
If a voltage of 1 is applied to the connection terminals 3 and 4, current will be supplied to the therapeutic conductor. Next, we conducted an experiment using the hair growth promoting device shown in FIG. 3, the hair growth promoting device shown in FIG. will be explained in detail. Experiment 1. Aminovinyl photosensitive dye In the hair growth promoting device shown in Figure 3, the oscillation frequency of the blocking oscillation circuit of the first low frequency oscillator is set to a pulse width of 1/200 seconds and a pulse interval of 1/50 seconds. The oscillation frequency of the multivibrator with two low frequency oscillators was set to 1 hertz. Before starting the experiment, silver cream was first applied for a very short time in four symmetrical areas of 5 cm ² on the rabbit's back, and the marks were thoroughly washed to remove hair so as not to damage the skin. did. For this hair removal area, dissolve 0.05% of Kosensen No. 301 or Kosensen No. 401 manufactured by Nippon Kanko Shiki Co., Ltd. in a glycerin solution, and add half of the 95
% alcohol and applied as a test solution, and as a control solution, a mixture of 2 parts glycerin and 1 part 95% alcohol was applied.
A superimposed low frequency voltage oscillated by the hair growth promoting device of the present invention was applied for 10 minutes once a day to a commercially available acetylcholine preparation and a control to which nothing was applied. Experiments were conducted using a frequency therapy device to apply a smooth AC voltage of 3000 Hz for 10 minutes, and to apply no voltage at all, to examine the effect of aminovinyl photosensitive dyes on hair growth promotion based on iontophoresis. did. That is, the hair was cut on the 10th, 20th, and 30th day from the application area, and the length of the hair was calculated based on only the bristles.
100 pieces of each were measured using a microscope fine movement device, and the average value was calculated. The results are shown in Table 1. The results in Table 1 confirm that aminovinyl photosensitive dyes slightly promote hair growth when applied to the affected area, but that an even more remarkable hair growth promoting effect can be obtained by applying low frequency voltage and introducing ions. There is.
Furthermore, when applying a superimposed low frequency voltage using the hair growth promoting device of the present invention, the effect of promoting hair growth is clearly higher than when measuring iontophoresis by applying a smooth AC voltage using a known low frequency treatment device. You can confirm that you can get it.

[Table] Experiment 2. Superimposed low frequency The first low frequency oscillator 1 and the second low frequency oscillator 2 are connected as shown in Figure 5, and the waveform of the oscillated superimposed low frequency wave is observed with a synchroscope Sy while treatment is carried out. Guided to the guide. The oscillation frequencies of the first low frequency oscillator 1 and the second low frequency oscillator 2 are changed as shown in Table 2, and the photosensitive element
The frequency of the superimposed low frequency applied during the ion introduction of the aminovinyl photosensitive dye was carried out according to the test method of Experiment 1, except that No. 301 was dissolved in alcoholic saline to a concentration of 200 ppm and used as the test solution. We considered this. The results are shown in Table 2. As is clear from Table 2, the frequency of the rectangular wave oscillated from the second low frequency oscillator 2 is around 1 hertz,
It has been confirmed that a significant hair growth promoting effect can be obtained when the frequency of the biphasic action potential wave oscillated from the first low frequency oscillator 1 is in the range of about 50 hertz to about 200 hertz.

【table】

[Table] Based on the above experimental data, photosensor No. 301 and photosensor No. 401 were used to treat alopecia areata, middle age alopecia, glucose alopecia, atrophic alopecia, symptomatic alopecia, etc. When treatments were attempted on patients, good results were obtained for all types of alopecia. The reason why such good results are obtained with the hair growth promoting device of the present invention is that ion introduction of aminovinyl photosensitive dyes is extremely effective in promoting hair growth;
In addition, the biphasic action potential wave superimposed on the square wave for iontophoresis stimulates the skin and promotes metabolism, and also acts effectively on the nerves to promote recovery from nervous fatigue, providing treatment from both the mind and body. It is understood that this is due to the fact that they can be carried out simultaneously. In addition, when performing hair growth promotion treatment using the hair growth promotion device of the present invention, the hair growth promotion or blood circulation improvement points located on the wrist, back of the head, etc., such as the complete bone, paramon, shinmon, and naiguan, etc. , if a low frequency voltage, especially a superimposed low frequency voltage oscillated by the hair growth promoting device of the present invention, is applied simultaneously or sequentially with the application of the superimposed low frequency voltage to the hair loss affected area, the stimulation will be even higher. A hair growth promoting effect can be obtained. and,
The low-frequency voltage applied to this acupuncture point can be applied appropriately by using a separately prepared known low-frequency treatment device, the hair growth promoting device of the present invention, or by extracting a part of the superimposed low frequency oscillated by the hair growth promoting device of the present invention. It is obtained by connecting to an auxiliary electrode having therapeutic elements, and these therapeutic elements are preferably provided with attachments such as strings, bands, rubber bands, etc. for fixing them at the acupoint positions.

[Brief explanation of the drawing]

In the figures, FIG. 1 shows a block diagram of the hair growth promoting device of the present invention, FIG. 2 shows the waveform of the low frequency oscillation in the hair growth promoting device of the present invention, and FIG.
The output waveform of the low frequency oscillator, Figure (b) is the output waveform of the second low frequency oscillator, Figure (c) is the waveform of their superimposed low frequency, and Figure 3 shows the first low frequency oscillator as a blocking type oscillation circuit and the second low frequency oscillator. Figure 4 is a circuit diagram when both low frequency oscillators are configured as a multivibrator type oscillation circuit, Figure 5 is a circuit diagram when both low frequency oscillators are configured as a multivibrator type oscillation circuit, and Figure 5 is a synchronoscope connected to both low frequency oscillators. This is a block diagram of the experimental equipment. The symbols in the figure are explained as follows. 1 is a first low frequency oscillator, 2 is a second low frequency oscillator, 3 and 4 are connection terminals, 5 is a roller electrode, 6 is a grip electrode, B is a battery, C is a capacitor, R is a resistor, S is a switch, Sg is synchronoscope, T
is a transformer, and Tr is a transistor.

Claims (1)

[Claims] 1. Pulse width 1/200 seconds to 1/600 seconds, pulse interval 1/20
The first oscillates a biphasic action potential wave with a duration of 1/300 seconds.
A low frequency oscillator, a second low frequency oscillator that oscillates an extremely low frequency rectangular wave having a current component of zero potential and positive potential with a frequency of 0.5 to 2 Hz, a moisturizing therapeutic conductor, and an indifferent conductor. The output hot side terminal of the first low frequency oscillator is connected to the moisturizing treatment conductor, and the other return terminal is connected to the super low frequency output circuit of the second low frequency oscillator. By connecting the return terminal of the second low frequency oscillator to the indifferent conductor, the first low frequency oscillator and the second low frequency oscillator are connected in series with the therapeutic conductor, and the moisturizing property is increased. A superimposed wave voltage of a first low frequency oscillator output and a second low frequency oscillator output is applied between the therapeutic conductor and the indifferent conductor, and the moisturizing therapeutic conductor contains an aminovinyl photosensitive dye. 1. A hair growth promoting device, which stimulates the skin with a superimposed wave voltage and ion-transfers an aminovinyl photosensitive pigment by contacting the skin with the hair. 2. The hair growth promoting device according to claim 1, wherein the oscillation circuit of the first low frequency oscillator is a blocking oscillation circuit. 3. The hair growth promoting device according to claim 1, wherein the oscillation circuits of the first low frequency oscillator and the second low frequency oscillator are multivibrator circuits. 4 Aminovinyl photosensitive dye is 6-[2-[(5
-Bromo-2-pyridyl)amino]vinyl]-1
-Ethyl-2-picolinium iodide or 2(2-anilinovinyl)-3,4-dimethyl-oxazolinium iodide, the hair growth promotion according to claim 1, 2, or 3. Device.