JPS6310789B2 - - Google Patents

Info

Publication number: JPS6310789B2
Authority: JP; Japan
Prior art keywords: creatinine; alkaline; bilirubin; acid; periodic acid
Prior art date: 1980-06-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP8251180A

Other languages

English (en)

Japanese (ja)

Other versions

JPS577558A (en

Inventor

Kan Kasahara

Kuniaki Tokuda

Yasushi Takagi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fujifilm Wako Pure Chemical Corp

Original Assignee

Wako Pure Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-18

Filing date

1980-06-18

Publication date

1988-03-09

1980-06-18 Application filed by Wako Pure Chemical Industries Ltd filed Critical Wako Pure Chemical Industries Ltd

1980-06-18 Priority to JP8251180A priority Critical patent/JPS577558A/ja

1982-01-14 Publication of JPS577558A publication Critical patent/JPS577558A/ja

1988-03-09 Publication of JPS6310789B2 publication Critical patent/JPS6310789B2/ja

Status Granted legal-status Critical Current

Links

DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 56
229940109239 creatinine Drugs 0.000 claims description 28
238000000034 method Methods 0.000 claims description 26
150000001414 amino alcohols Chemical class 0.000 claims description 20
KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims description 20
210000001124 body fluid Anatomy 0.000 claims description 12
239000010839 body fluid Substances 0.000 claims description 12
239000007800 oxidant agent Substances 0.000 claims description 12
238000006243 chemical reaction Methods 0.000 claims description 8
150000003839 salts Chemical class 0.000 claims description 8
238000011002 quantification Methods 0.000 claims description 2
BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 34
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 18
235000019441 ethanol Nutrition 0.000 description 11
239000000243 solution Substances 0.000 description 11
239000000523 sample Substances 0.000 description 10
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
238000002835 absorbance Methods 0.000 description 9
210000002966 serum Anatomy 0.000 description 9
239000007864 aqueous solution Substances 0.000 description 6
239000012085 test solution Substances 0.000 description 6
150000001298 alcohols Chemical class 0.000 description 5
230000000694 effects Effects 0.000 description 5
239000000203 mixture Substances 0.000 description 5
239000000872 buffer Substances 0.000 description 4
239000003153 chemical reaction reagent Substances 0.000 description 4
239000003795 chemical substances by application Substances 0.000 description 4
CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 4
238000005259 measurement Methods 0.000 description 4
230000001590 oxidative effect Effects 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
238000007375 Jaffe assay Methods 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
229910019142 PO4 Inorganic materials 0.000 description 3
229910021538 borax Inorganic materials 0.000 description 3
238000000354 decomposition reaction Methods 0.000 description 3
230000007423 decrease Effects 0.000 description 3
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 3
UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
239000010452 phosphate Substances 0.000 description 3
239000004328 sodium tetraborate Substances 0.000 description 3
235000010339 sodium tetraborate Nutrition 0.000 description 3
239000000126 substance Substances 0.000 description 3
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
230000001476 alcoholic effect Effects 0.000 description 2
239000012670 alkaline solution Substances 0.000 description 2
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
239000004327 boric acid Substances 0.000 description 2
238000011088 calibration curve Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
229960003624 creatine Drugs 0.000 description 2
239000006046 creatine Substances 0.000 description 2
238000011161 development Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000008213 purified water Substances 0.000 description 2
JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
239000012086 standard solution Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
210000002700 urine Anatomy 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
MLIWQXBKMZNZNF-KUHOPJCQSA-N (2e)-2,6-bis[(4-azidophenyl)methylidene]-4-methylcyclohexan-1-one Chemical compound O=C1\C(=C\C=2C=CC(=CC=2)N=[N+]=[N-])CC(C)CC1=CC1=CC=C(N=[N+]=[N-])C=C1 MLIWQXBKMZNZNF-KUHOPJCQSA-N 0.000 description 1
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
229940058020 2-amino-2-methyl-1-propanol Drugs 0.000 description 1
UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
208000037157 Azotemia Diseases 0.000 description 1
206010028289 Muscle atrophy Diseases 0.000 description 1
OHUHAKQCZVMIOF-UHFFFAOYSA-N OS(O)(=O)=O.[SeH2] Chemical compound OS(O)(=O)=O.[SeH2] OHUHAKQCZVMIOF-UHFFFAOYSA-N 0.000 description 1
102000003992 Peroxidases Human genes 0.000 description 1
208000001647 Renal Insufficiency Diseases 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
238000010306 acid treatment Methods 0.000 description 1
CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
URGYLQKORWLZAQ-UHFFFAOYSA-N azanium;periodate Chemical compound [NH4+].[O-]I(=O)(=O)=O URGYLQKORWLZAQ-UHFFFAOYSA-N 0.000 description 1
239000012472 biological sample Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
150000004683 dihydrates Chemical class 0.000 description 1
-1 etc. Substances 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000010200 folin Substances 0.000 description 1
238000005194 fractionation Methods 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000011630 iodine Substances 0.000 description 1
208000017169 kidney disease Diseases 0.000 description 1
201000006370 kidney failure Diseases 0.000 description 1
230000003902 lesion Effects 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
230000020763 muscle atrophy Effects 0.000 description 1
230000004118 muscle contraction Effects 0.000 description 1
201000000585 muscular atrophy Diseases 0.000 description 1
201000008383 nephritis Diseases 0.000 description 1
PESSIQDIMKDTSP-UHFFFAOYSA-N periodic acid;dihydrate Chemical compound O.O.OI(=O)(=O)=O PESSIQDIMKDTSP-UHFFFAOYSA-N 0.000 description 1
108040007629 peroxidase activity proteins Proteins 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
208000009852 uremia Diseases 0.000 description 1
229940116269 uric acid Drugs 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)

JP8251180A 1980-06-18 1980-06-18 Determination of creatinine Granted JPS577558A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP8251180A JPS577558A (en)	1980-06-18	1980-06-18	Determination of creatinine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP8251180A JPS577558A (en)	1980-06-18	1980-06-18	Determination of creatinine

Publications (2)

Publication Number	Publication Date
JPS577558A JPS577558A (en)	1982-01-14
JPS6310789B2 true JPS6310789B2 (fr)	1988-03-09

Family

ID=13776540

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP8251180A Granted JPS577558A (en)	1980-06-18	1980-06-18	Determination of creatinine

Country Status (1)

Country	Link
JP (1)	JPS577558A (fr)

1980
- 1980-06-18 JP JP8251180A patent/JPS577558A/ja active Granted

Also Published As

Publication number	Publication date
JPS577558A (en)	1982-01-14

Publication	Publication Date	Title
Taras	1950	Phenoldisulfonic acid method of determining nitrate in water. Photometric study
Koepsell et al.	1952	Microdetermination of pyruvic and α-ketoglutaric acids
WO1992011524A2 (fr)	1992-07-09	Reactif et procedes pour determiner la concentration de calcium
Nagashima et al.	1981	Spectrophotometric determination of cyanide with isonicotinic acid and barbituric acid
US6326208B1 (en)	2001-12-04	Assay for total and direct bilirubin
JPS6310789B2 (fr)	1988-03-09
Beale et al.	1961	Rapid incremental methods for the determination of serum iron and iron-binding capacity
JPH0358467B2 (fr)	1991-09-05
JPH0532040B2 (fr)	1993-05-14
US3894843A (en)	1975-07-15	Determination of serum creatinine
JPS6230379B2 (fr)	1987-07-02
Okamura	1981	A specific method for determination of total ascorbic acids in urine by the α, α-dipyridyl method
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US3511611A (en)	1970-05-12	Blood urea nitrogen test
Hashim et al.	1999	Wet vs. dry chemical analysis of renal stones
Novotny et al.	1984	Indophenol method for acetaminophen in serum examined.
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JPS6038666B2 (ja)	1985-09-02	クレアチニン測定用試薬
JPH0365160B2 (fr)	1991-10-09
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EP0095302A1 (fr)	1983-11-30	Plaquette d'examen pour la détection du sang occulte