JPS6317111B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention is directed to a foaming aerosol composition that immediately forms a foam when injected and has a high defoaming rate, in which the foam disappears within a short period of time, particularly a foaming aerosol composition that forms an emulsion foam. It is related to. Generally, in cosmetics such as shaving cream and others, the stock solution is often used in the form of a foam, and in such cases, the use of an aerosol device is extremely effective and convenient. Conventionally, an aerosol composition used to obtain such a foam consists of a solution or dispersion in which a necessary drug is dissolved or dispersed in a water-soluble and volatile solvent such as ethanol, and water. is the main component, and a surfactant is added to stabilize the mixed emulsified state of both, and this is used as a stock solution, and this is sprayed with a propellant, and when the pressurized state is released, the solvent vaporizes. This fact is utilized to obtain a foam from the stock solution. However, in such conventional compositions, since no highly effective surfactant was known, a volatile water-soluble solvent was used as the foaming agent. However, for foams formed with such foaming agents, the defoaming rate from the time the foam begins to disappear until the time it completely disappears depends on the temperature. When they are different, there is a drawback that the defoaming speed is greatly different and the feeling of use is also greatly different. In addition, in order to obtain sufficient foaming power, it is necessary to use a large amount of the solvent, so water may be added to
Since the water content is so high, a light foam cannot be obtained, and in the case of a product applied to the human body, the product has a disadvantage of poor usability. Furthermore, since water solubility and volatility are required, the range of solvents that can be used is limited, which often causes various problems in incorporating desired drugs as ingredients. The present invention eliminates the above-mentioned drawbacks, and makes it possible to obtain a stable state in the stock solution, and to form a suitable foam with stable properties since the defoaming rate does not vary greatly depending on the temperature. The purpose of the present invention is to provide a foaming aerosol composition that can be used. In the present invention, a dioctyl sulfosuccinate such as dioctyl sodium sulfosuccinate or dioctyl calcium sulfosuccinate is used as an emulsifying agent, and thereby a solution of a hydrophobic oil agent in which a drug is dissolved is mixed with water. The emulsified liquid obtained by emulsifying is used as a stock solution, and the stock solution and a propellant constitute an aerosol composition.
Here, the proportions of each component are 0.1 to 10.0% by weight of emulsifier activator, 0.5 to 10% by weight of oil, 10 to 40% by weight of water, and 55 to 85% by weight of propellant. As the oil agent, any one suitable for the drug used may be used, such as benzyl alcohol, oleyl alcohol, stearyl alcohol, various esters, kerosene, etc., and as the propellant, various types of freon gas, dimethyl ether, liquefied petroleum gas, etc. can be used. It is also possible to mix liquefied gas or compressed gas, or carbon dioxide gas, nitrous oxide gas, etc., in an amount of, for example, 0.01 to 0.8% by weight. As the drug to be dissolved in the oil agent, any drug can be used depending on the purpose, and it is of course possible to mix fragrances, emollients, or various drugs normally used in formulations in this field as necessary. be. The dioctyl sodium sulfosuccinate is a sponge-like substance represented by the following structural formula. The aerosol composition of the present invention is as described above, and because it uses dioctyl sulfosuccinate as an emulsifying agent, a very large emulsifying effect can be obtained. A liquid or water-insoluble oil agent can be used, and a stable emulsion-like stock solution can be obtained by adding a small amount of water. In addition, the emulsifying agent has a large surfactant effect, and the surface tension of the stock solution becomes very small, so that when it is injected as an aerosol by the driving force of the propellant, the propellant immediately forms a foam with trapped air bubbles. begins to form. The foam obtained here is created by bubbles produced by the injected gas, so it is almost unaffected by the temperature of the environment in which it is used, and is always in the same state. Even when the usage environment temperature differs, the defoaming rate from the time when the foam starts to disappear until it ends disappears does not substantially differ, and a suitable foam with stable properties can be formed. . In addition, as mentioned above, the proportion of water used may be small, and the oil agent is not required to have characteristics such as volatility or hydrophilicity, so the selection range of this oil agent is wide, depending on the drug to be used. Preferred ones can be arbitrarily selected, and the range of possible uses as medicines is widened. As mentioned above, since the water content used can be as small as 40% by weight or less, it is possible to obtain a light foam, which is suitable for use when applied to the human body. It becomes a feeling. An example of the specifications for an actual aerosol product is that the original pressure is 2.5 to 4.0 kg/kg at a temperature of 20°C.
cm ² , injection amount is 10 minutes at 20°C.
The amount may be about 0.5 to 5.0 g. Examples of the present invention are listed in the following table. In all of these Examples, satisfactory emulsion foams could be formed. In addition, "OTP-100" and "OTP-75" in the table are
Each represents pure dioctyl sodium sulfosuccinate and its 75% by weight solution.

【table】
(Unit: weight%)

Claims (1)

[Claims] 1. A stock solution consisting of an emulsion of water and a hydrophobic oil agent emulsified by an emulsifying agent consisting of dioctyl sulfosuccinate, and a propellant, wherein the proportion of water is 10 to 40% by weight, and the hydrophobic oil agent The percentage of
0.5-10% by weight, the proportion of the emulsifying activator is 0.1-10% by weight
10.0% by weight and the proportion of the propellant is 55 to 85% by weight, a drug is contained in the stock solution, and a foam of the emulsion is formed by injection.