JPS63229059A - Elastic member for living body - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] This biomaterial is used for bones, teeth, etc. of humans and animals, and is particularly elastic.

``Prior art'' High-strength materials such as stainless steel and alumina porcelain have been used to replace bones, teeth, etc. in humans and animals when they are missing.
Because it has poor affinity with living organisms and is difficult to bond with living organisms,
Phosphoric acid sintered sintered apatite began to be used.

However, these materials are inferior in strength to stainless steel and alumina porcelain, so in JP-A-58-150505 ``High Strength Biological Materials'', a tubular body made of calcium phosphate and an adhesive are fitted onto the inner surface of the tubular body. disclosed a "high-strength biological component" consisting of a metal base that is integrally bonded. However, while the bones of humans and animals are quite flexible, the biological components mentioned above are extremely hard and have almost no deformation ability, so they are completely unable to follow the deformation of bones during exercise. , it was easy to peel off at and near the joint with the bone.

"Problems to be solved by the invention" In order to solve the above problems, the invention has high strength and biocompatibility, and
It is an object of the present invention to provide a biological member having elasticity and flexibility that can respond to bone deformation.

"Means for Solving the Problem" A base body consisting of a tubular body whose main component is calcium phosphate and a base body which is stronger than the tubular sintered body whose main component is calcium phosphate, which is bonded to the inner surface of the tubular body with silicone rubber. The present invention provides a living body member having elasticity.

Here, regarding the sintered body mainly composed of calcium phosphate, calcium with a Ca/P atomic ratio of 1.4 to 1.75 is disclosed in JP-A No. 55-56058 "Method for producing high-strength calcium phosphate sintered body". 0.0% to the calcium phosphate component after firing to a powder mainly composed of phosphates.
5-15 wt% Ca/P atomic ratio 0.2-0.75
Add and mix a force μsium phosphate frit with
Particularly strong meltable materials, or 0.5 to 15% by weight of alkali metals, zinc and/or the above calcium phosphate.
Or a sintered product containing an alkaline earth metal oxide/phosphoric acid frit (Japanese Patent Application Laid-Open No. 140756/1983)
"High strength calcium phosphate sintered body") or JP-A-55-8
Yz is used as a reinforcing agent in a sintered body obtained by sintering a powder mainly composed of a phosphate of phosphoric acid and a calcium and phosphoric acid frit, which is disclosed in No. 0771 "High-strength phosphoric acid p-sicum sintered body". Some are characterized by containing 3 to 28% Ox. However, the calcium phosphate defined in the present invention is not limited to this, and includes everything from what is commonly called a material containing a large amount of calcium phosphate to what is called an apatite ceramic.

Next, base materials with higher strength than calcium phosphate include biometals such as stainless steel, Co-Cr alloys, and Ti alloys, as well as materials and ceramics whose surfaces are coated with W, Mo, Ge, etc. that are harmless to living organisms. Use a coated one,
High-strength ceramics such as silicon nitride, partially stabilized zirconia, and alumina porcelain, as well as high-strength plastics called engineering plastics and FRP can also be used.

Next, silicone rubber is a self-adhesive adhesive that can be used without solvents, so there are no reaction by-products, no toxicity problems, and it is preferable that it is flexible, has a long pot life, and good workability. - Absorbs shock well.

"Example" Co-Cr alloy is molded into a columnar shape with a diameter of 8t and a length of 60mm, and a powder mainly composed of μsium phosphate containing YzOx and calcium and phosphoric acid frit are mixed. After sintering, the outer diameter was 7 mm, the inner diameter was 5 mm, and the length was 60 mm. A tubular body with a tubular shape (2) was obtained. Next, using tone silicone 5E1F00 adhesive, mix the main agent and catalyst in 10=1
The surface of the substrate and the inner surface of the tubular body were coated with a paste mixed in a weight ratio of
The bonding was completed by heating at C for 60 minutes and at 150 C for 20 minutes. When this was used on the front of a dog's head, it bonded well with other fronts after eight months, and was able to maintain good bonding even after a year, whereas epoxy, which does not have the usual flexibility, One year after bonding with resin, peeling was observed at the joint with the bone.

In addition, calcium phosphate yosu without a high-strength base embedded inside lacked strength and could not withstand use.

``Actions and Effects of the Invention'' During the movement of living organisms, bones have elasticity and undergo slight deformation over and over again, whereas conventional hard living body parts are unable to do so at all. Since the adhesive layer of the living body member has elasticity, the adhesive layer can be deformed by about 20%, so that it can follow the movement of the bones of the living body. And since the surface is calcium phosphate,
Silicone rubber can be assimilated into living bones, and even after assimilation, it remains harmless to living organisms and has sufficient strength due to its base material, making it extremely useful for replacing missing bones in living organisms. .

Claims (1)

[Claims] A living body member having elasticity, comprising a tubular body mainly composed of calcium phosphate, and a base body having a higher strength than the calcium phosphate sintered body bonded to the inner surface of the tubular body with silicone rubber.