JPS6326574A - Automatic blood-plasma separator - Google Patents

Abstract

(57) [Abstract] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] (b) Industrial application fields The present invention relates to automation of plasma separation devices.

(b) Conventional technology In biochemical analysis, centrifugation is the predominant method of pre-processing specimens (blood). I was transferring it with

Additionally, as an alternative to the centrifugal separation method, the applicant has proposed a method in which secretions such as blood are circulated using an integrated rotating body and the liquid components are separated (!I
! (Gan Sho 59-189715).

In this method, the book and plasma cup after fractionation were manually set into the biochemical analyzer.

(c) Problems to be solved by the invention As mentioned above, in the past, transferring the sample to a sample cup, etc. was done manually, which took time, and it also took time to transfer the sample from the blood collection tube to the sample cup corresponding to the sample. There were also many errors (samples swapped) during the transfer process.

2) Means for Solving the Problems The present invention fully automates sample pretreatment (separation of plasma),
The purpose is to eliminate the above-mentioned mistakes during transfer and to shorten the time required for pretreatment.

The present invention includes a mechanism for mounting a plurality of plasma separation units on a turn tape μ, a mechanism for transferring blood from a blood collection tube into the unit, a mechanism for removing the unit and separation membrane after separation, and a mechanism for removing the unit and the separation membrane after separation. ) and a mechanism for washing and drying the separation membrane, a mechanism for attaching the unit and the membrane after washing and drying, a sampler section for passing the separated sample under the separation unit, and a storage unit for storing the separated sample. .

(E) Function The present invention involves transferring blood from a blood collection tube to a plasma separation unit, disassembling the plasma separation unit, washing and drying each part,
Automatically installs after cleaning and drying.

(f) Example Embodiments of the present invention will be described based on the drawings.

FIG. 1(a) is a plan view of an automatic plasma separator according to the present invention, and FIG. 1(b) is a side view.

(1) is the sampler, (2) is the turn tape/L', (
3) is a blood transfer mechanism, (4) is a separated sample storage unit, (5) is a washing/drying mechanism, and (6) is a plasma separation unit. The plasma separation unit (6) is shown in Figure 1 (
As shown in b), the plasma separation membrane holder (8) is easily attached and detached, and revolves together with the turn tape /u +2). Plasma cup (9) on turn tape 1v (2)
A rack (b) containing blood collection tubes αG is installed.

Note that A to H indicate the points of the plasma separation unit (6).

Next, the operation will be explained.

1. Take out the rack αυ from the sampler (1) at the person's point and set it up so that the plasma cup (9) is located directly below the plasma unit (6). A magic hand mechanism is used to receive and remove the membrane holder (8).
) is attached.

2. Bring the plasma separation unit (6) and rack αυ to point B by rotating the next trap turn tape fi/(2) 45 times. At point B, the blood transfer mechanism (3) transfers the blood in the blood collection tube αQ into the plasma separation unit (6).

The blood transfer mechanism (3) has the configuration shown in FIG. 2. In Fig. 2, (6) is an air cylinder, (Ll is a nozzle, Q4) is a motor, and α is a syringe.

As shown in Figures 2(a) to (d), the operations are as follows: downward movement of the nozzle/I/Q3 by the air cylinder (2) (Figure 2(a)), and blood sampling (Figure 2(b)). )J, upward movement of the nozzle head ((C) in the same figure), and movement of the nozzle α apex to the plasma separation unit (6) by the motor α→.

In addition, the blood transfer mechanism (3) is equipped with a turntable (2).
) does not move with the plasma separation unit (6), but remains in place, and there is a small hole (6) for blood supply in the upper side wall of the plasma separation unit (6).
There is.

3. Once the blood transfer is completed, the plasma separation unit (6)
The screen (7) is rotated by a drive mechanism (not shown) K to perform plasma separation. The separated plasma enters the plasma cup (9) in the rack Qυ.

When the plasma separation unit (6) reaches point E via points C and D, the plasma has been separated] and the rack aη is transferred to the separated sample storage unit (4). A magic hand mechanism (not shown) is used to transfer the racks.

5. When you reach point F, remove the membrane holder (8) and take it to the cleaning/drying mechanism (5).

FIG. 3 shows the means for attaching and detaching the membrane holder (8) and the cleaning/drying mechanism.

In FIG. 3, α· and Qη each indicate a magic hand.

The membrane holder (8) is removed from the separation unit (6) using Magic Hand 06 and passed to the cleaning/drying mechanism (5). It has water spraying] areas (I to J) and drying (airflow blows off water droplets and hot air drying) areas (J, K).Washing and drying are performed as the turn tape/V (G) rotates. The membrane is attached to the separation unit (6) again using the magic hand aη.

6. The separation unit (6) with the membrane holder (8) attached at point H returns to point A and returns to (1) above (5
) is repeated.

Incidentally, in the embodiment shown in Figure 1, the plasma separation unit (
6) can be separated at a speed of 8 f'L samples/cycle using 8 columns.

Note that (1) and (4) in Figure 1 may be carried out by a belt conveyor, in which case the specimen flowing on the conveyor is separated,
After separation, the sample is transferred to a conveyor, and if an analyzer is placed at the tip or midway of the conveyor, analysis without pretreatment can be performed simply by placing the sample on the conveyor.

(g) Effects According to the present invention, since everything is automated, the pretreatment time can be shortened and there are no transfer errors.

[Brief explanation of drawings]

FIG. 1(a) is a plan view of the automatic plasma separator according to the present invention, FIG. 1(b) is a side view, FIGS. 2(a) to 2(d) are operational diagrams of the blood transfer mechanism, and FIG. This figure shows a membrane holder attachment/detachment means and a cleaning/drying mechanism. (1)...Sampler (2)...Turn tape!
(3)...Blood transfer mechanism (4)...Separated sample storage unit (5)...Washing/drying mechanism (6)...Plasma separation unit (8)...Plasma separation membrane holder

Claims (1)

[Claims] 1. A mechanism for mounting a plurality of plasma separation units each having a separation membrane on a turntable and transferring blood in a blood collection tube into the unit, a mechanism for removing the unit and separation membrane after separation, and a removed unit. a mechanism for washing and drying the separated unit and the separation membrane, a mechanism for attaching the washed and dried unit and the separation membrane, a sampler section for supplying the final separated sample to the bottom of the unit, and a separated unit for storing the separated sample. An automatic plasma separation device equipped with a sample storage unit.