JPS63500893A - 固体基質に生物学的物質を付着する方法 - Google Patents

固体基質に生物学的物質を付着する方法

Info

Publication number: JPS63500893A
Authority: JP; Japan
Prior art keywords: biological; substrate; group; substances; ion bombardment
Prior art date: 1985-08-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP61504517A

Other languages

English (en)

Japanese (ja)

Inventor

スード、ディネシュ・クマー

グリーン、ラルフ・エドワード・ブランドフォード

Original Assignee

ロイアル・メルボルン・インスティチュ−ト・オブ・テクノロジ−・リミテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-19

Filing date

1986-08-18

Publication date

1988-03-31

1986-08-18 Application filed by ロイアル・メルボルン・インスティチュ−ト・オブ・テクノロジ−・リミテッド filed Critical ロイアル・メルボルン・インスティチュ−ト・オブ・テクノロジ−・リミテッド

1988-03-31 Publication of JPS63500893A publication Critical patent/JPS63500893A/ja

Status Pending legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims description 48
239000000758 substrate Substances 0.000 title claims description 36
239000012620 biological material Substances 0.000 title claims description 16
239000007787 solid Substances 0.000 title claims description 8
239000000126 substance Substances 0.000 claims description 25
238000010849 ion bombardment Methods 0.000 claims description 20
229920003023 plastic Polymers 0.000 claims description 19
239000004033 plastic Substances 0.000 claims description 18
239000007790 solid phase Substances 0.000 claims description 13
-1 polypropylene Polymers 0.000 claims description 11
210000003743 erythrocyte Anatomy 0.000 claims description 10
239000000463 material Substances 0.000 claims description 10
239000004743 Polypropylene Substances 0.000 claims description 9
229920001155 polypropylene Polymers 0.000 claims description 9
210000004027 cell Anatomy 0.000 claims description 8
239000012528 membrane Substances 0.000 claims description 7
230000008569 process Effects 0.000 claims description 5
229920002799 BoPET Polymers 0.000 claims description 4
239000005041 Mylar™ Substances 0.000 claims description 4
239000004793 Polystyrene Substances 0.000 claims description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
239000004809 Teflon Substances 0.000 claims description 4
229920006362 Teflon® Polymers 0.000 claims description 4
239000001913 cellulose Substances 0.000 claims description 4
229920002678 cellulose Polymers 0.000 claims description 4
229920002223 polystyrene Polymers 0.000 claims description 4
239000011521 glass Substances 0.000 claims description 3
239000005556 hormone Substances 0.000 claims description 3
229940088597 hormone Drugs 0.000 claims description 3
241000894006 Bacteria Species 0.000 claims description 2
108090000790 Enzymes Proteins 0.000 claims description 2
102000004190 Enzymes Human genes 0.000 claims description 2
108060003951 Immunoglobulin Proteins 0.000 claims description 2
241000700605 Viruses Species 0.000 claims description 2
230000001413 cellular effect Effects 0.000 claims description 2
102000018358 immunoglobulin Human genes 0.000 claims description 2
229940072221 immunoglobulins Drugs 0.000 claims description 2
239000000377 silicon dioxide Substances 0.000 claims description 2
102000006395 Globulins Human genes 0.000 claims 2
108010044091 Globulins Proteins 0.000 claims 2
108010015776 Glucose oxidase Proteins 0.000 claims 1
239000004366 Glucose oxidase Substances 0.000 claims 1
241000220317 Rosa Species 0.000 claims 1
239000013566 allergen Substances 0.000 claims 1
229940088598 enzyme Drugs 0.000 claims 1
229940116332 glucose oxidase Drugs 0.000 claims 1
235000019420 glucose oxidase Nutrition 0.000 claims 1
210000000265 leukocyte Anatomy 0.000 claims 1
230000027455 binding Effects 0.000 description 15
230000000694 effects Effects 0.000 description 12
150000002500 ions Chemical class 0.000 description 11
239000000427 antigen Substances 0.000 description 10
102000036639 antigens Human genes 0.000 description 10
108091007433 antigens Proteins 0.000 description 10
239000001506 calcium phosphate Substances 0.000 description 6
229910000389 calcium phosphate Inorganic materials 0.000 description 6
235000011010 calcium phosphates Nutrition 0.000 description 6
239000000203 mixture Substances 0.000 description 6
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 6
238000010884 ion-beam technique Methods 0.000 description 5
239000010408 film Substances 0.000 description 4
230000035939 shock Effects 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
239000000872 buffer Substances 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
238000003018 immunoassay Methods 0.000 description 3
230000003993 interaction Effects 0.000 description 3
230000005865 ionizing radiation Effects 0.000 description 3
239000007788 liquid Substances 0.000 description 3
230000009870 specific binding Effects 0.000 description 3
239000000725 suspension Substances 0.000 description 3
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
210000000170 cell membrane Anatomy 0.000 description 2
239000004927 clay Substances 0.000 description 2
238000000975 co-precipitation Methods 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
238000010168 coupling process Methods 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
239000000284 extract Substances 0.000 description 2
230000008105 immune reaction Effects 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
239000008363 phosphate buffer Substances 0.000 description 2
229920000728 polyester Polymers 0.000 description 2
230000035484 reaction time Effects 0.000 description 2
238000001179 sorption measurement Methods 0.000 description 2
241000894007 species Species 0.000 description 2
238000004544 sputter deposition Methods 0.000 description 2
239000010936 titanium Substances 0.000 description 2
229910052719 titanium Inorganic materials 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
229920000936 Agarose Polymers 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
102000004856 Lectins Human genes 0.000 description 1
108090001090 Lectins Proteins 0.000 description 1
241000239218 Limulus Species 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
241000219833 Phaseolus Species 0.000 description 1
244000046052 Phaseolus vulgaris Species 0.000 description 1
235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
238000005411 Van der Waals force Methods 0.000 description 1
230000004913 activation Effects 0.000 description 1
238000001042 affinity chromatography Methods 0.000 description 1
238000007605 air drying Methods 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000003124 biologic agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
150000001718 carbodiimides Chemical class 0.000 description 1
229940070318 chlo-amine Drugs 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000011109 contamination Methods 0.000 description 1
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
238000000151 deposition Methods 0.000 description 1
230000008021 deposition Effects 0.000 description 1
SOYKEARSMXGVTM-HNNXBMFYSA-N dexchlorpheniramine Chemical compound C1([C@H](CCN(C)C)C=2N=CC=CC=2)=CC=C(Cl)C=C1 SOYKEARSMXGVTM-HNNXBMFYSA-N 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
239000012954 diazonium Substances 0.000 description 1
DCSRPHQBFSYJNN-UHFFFAOYSA-L disodium 4-[(2-arsonophenyl)diazenyl]-3-hydroxynaphthalene-2,7-disulfonate Chemical compound [Na+].[Na+].Oc1c(N=Nc2ccccc2[As](O)(O)=O)c2ccc(cc2cc1S([O-])(=O)=O)S([O-])(=O)=O DCSRPHQBFSYJNN-UHFFFAOYSA-L 0.000 description 1
229920001971 elastomer Polymers 0.000 description 1
239000012530 fluid Substances 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000003053 immunization Effects 0.000 description 1
238000002649 immunization Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000036512 infertility Effects 0.000 description 1
239000004816 latex Substances 0.000 description 1
229920000126 latex Polymers 0.000 description 1
239000002523 lectin Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
238000001000 micrograph Methods 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
239000012071 phase Substances 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
238000000053 physical method Methods 0.000 description 1
229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000005855 radiation Effects 0.000 description 1
239000000700 radioactive tracer Substances 0.000 description 1
239000000376 reactant Substances 0.000 description 1
239000005060 rubber Substances 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000013076 target substance Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000009210 therapy by ultrasound Methods 0.000 description 1
239000010409 thin film Substances 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
238000004506 ultrasonic cleaning Methods 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
- B29C59/16—Surface shaping of articles, e.g. embossing; Apparatus therefor by wave energy or particle radiation, e.g. infrared heating
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/548—Carbohydrates, e.g. dextran
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/552—Glass or silica
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
- B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
- B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
- B29C35/0866—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using particle radiation
- B29C2035/0872—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using particle radiation using ion-radiation, e.g. alpha-rays
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Food Science & Technology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Cell Biology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Inorganic Chemistry (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

JP61504517A 1985-08-19 1986-08-18 固体基質に生物学的物質を付着する方法 Pending JPS63500893A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AU2027		1985-08-19
AUPH202785		1985-08-19

Publications (1)

Publication Number	Publication Date
JPS63500893A true JPS63500893A (ja)	1988-03-31

Family

ID=3771228

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP61504517A Pending JPS63500893A (ja)	1985-08-19	1986-08-18	固体基質に生物学的物質を付着する方法

Country Status (7)

Country	Link
EP (1)	EP0233257A4 (da)
JP (1)	JPS63500893A (da)
BR (1)	BR8606830A (da)
DK (1)	DK200387D0 (da)
FI (1)	FI871599L (da)
HU (1)	HUT43092A (da)
WO (1)	WO1987001120A1 (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009123148A1 (ja) *	2008-03-31	2009-10-08	旭化成せんい株式会社	セルロース誘導体微粒子、その分散液、その分散体及び診断薬

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5055316A (en) *	1988-04-20	1991-10-08	Washington Research Foundation	Tight binding of proteins to surfaces
US5389195A (en) *	1991-03-07	1995-02-14	Minnesota Mining And Manufacturing Company	Surface modification by accelerated plasma or ions
DE19538523A1 (de) *	1995-10-06	1997-04-10	Helmut Prof Dr Kaeufer	Biokompatible Kunststoffe, Verfahren zu deren Herstellung und Anwendungsgebiete
RU2309959C1 (ru) *	2006-02-22	2007-11-10	Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук	Применение немодифицированных полимерных материалов для изготовления подложки биочипов, биочип на их основе и способ его изготовления, способ иммобилизации гидрогелей на немодифицированных полимерных материалах

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3111474A1 (de) *	1981-03-24	1982-10-07	Behringwerke Ag, 3550 Marburg	"mittel zur immunologischen diagnose sowie verfahren zu seiner herstellung"
JPS5980442A (ja) *	1982-09-24	1984-05-09	ベクトン・デイツキンソン・アンド・カンパニ−	大分子結合用の化学的変成表面

1986
- 1986-08-18 WO PCT/AU1986/000235 patent/WO1987001120A1/en not_active Ceased
- 1986-08-18 HU HU864075A patent/HUT43092A/hu unknown
- 1986-08-18 JP JP61504517A patent/JPS63500893A/ja active Pending
- 1986-08-18 BR BR8606830A patent/BR8606830A/pt unknown
- 1986-08-18 FI FI871599A patent/FI871599L/fi not_active Application Discontinuation
- 1986-08-18 EP EP19860905147 patent/EP0233257A4/en not_active Withdrawn
1987
- 1987-04-15 DK DK200387A patent/DK200387D0/da not_active Application Discontinuation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2009123148A1 (ja) *	2008-03-31	2009-10-08	旭化成せんい株式会社	セルロース誘導体微粒子、その分散液、その分散体及び診断薬
JP2015083696A (ja) *	2008-03-31	2015-04-30	旭化成せんい株式会社	セルロース誘導体微粒子、その分散液、その分散体及び診断薬
US9341622B2 (en)	2008-03-31	2016-05-17	Asahi Kasei Fibers Corporation	Cellulose derivative fine particle, dispersion liquid thereof, dispersion body thereof and diagnostic reagent
JP5952522B2 (ja) *	2008-03-31	2016-07-13	旭化成株式会社	セルロース誘導体微粒子、その分散液、その分散体及び診断薬

Also Published As

Publication number	Publication date
DK200387A (da)	1987-04-15
EP0233257A1 (en)	1987-08-26
HUT43092A (en)	1987-09-28
EP0233257A4 (en)	1989-01-26
WO1987001120A1 (en)	1987-02-26
FI871599A7 (fi)	1987-04-13
DK200387D0 (da)	1987-04-15
FI871599A0 (fi)	1987-04-13
FI871599L (fi)	1987-04-13
BR8606830A (pt)	1987-10-27

Publication	Publication Date	Title
US4657873A (en)	1987-04-14	Preactivated plastics surfaces for immobilizing organo-chemical and biologic materials
US4886836A (en)	1989-12-12	Activated medium with low non-specific protein adsorption
US4357311A (en)	1982-11-02	Substrate for immunoassay and means of preparing same
US3966897A (en)	1976-06-29	Medium for use in bioassay and method of using same
US4177253A (en)	1979-12-04	Magnetic particles for immunoassay
US5061640A (en)	1991-10-29	Process for preparing a carrier useful in immunoassays by deposition of a complex of a specifically binding substance with hydrophobic protein, and the resulting carrier
US4410660A (en)	1983-10-18	Binding assay for the detection of mycobacteria
JPS5980442A (ja)	1984-05-09	大分子結合用の化学的変成表面
CA1223859A (en)	1987-07-07	Surface-grafted particulate support, process for its preparation and adsorbants for affinity chromatography incorporating such support, and their use, particularly in biology
US4575484A (en)	1986-03-11	Binding assay for the detection of mycobacteria
JPH0223157B2 (da)	1990-05-23
US4489158A (en)	1984-12-18	Binding assay for the detection of mycobacteria
JPS63500893A (ja)	1988-03-31	固体基質に生物学的物質を付着する方法
CN103333299B (zh)	2015-10-07	甲基丙烯酸缩水甘油酯和聚(乙二醇)甲基丙烯酸酯共聚物微球及其制备方法和应用
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CA1187786A (en)	1985-05-28	Agent for immunological diagnosis and a process for its preparation
US4187075A (en)	1980-02-05	Method of analyzing biological, liquid specimens for antigens or antibodies
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Kumakura et al.	1983	Immobilization of antibodies and enzyme-labeled antibodies by radiation polymerization
JPH052940B2 (da)	1993-01-13
CA2075719A1 (en)	1992-02-14	Activating hydroxyl groups of polymeric carriers using 4-fluorobenzenesulfonyl chloride