JPS6359931A - 血液グルコース濃度測定装置 - Google Patents

血液グルコース濃度測定装置

Info

Publication number: JPS6359931A
Authority: JP; Japan
Prior art keywords: membrane; electrode; oxygen; electrode holding; holding member
Prior art date: 1986-06-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP62140155A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0472541B2 (de

Inventor

リチャード・ラインハート

フレッド・レターリオ

ピーター・プグリーズ

カール・リター

グレン・ルブラーノ

ジェリー・ギルボールト

クリストファー・ファイステル

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

JIENTA Inc

Original Assignee

JIENTA Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-05

Filing date

1987-06-05

Publication date

1988-03-15

1987-06-05 Application filed by JIENTA Inc filed Critical JIENTA Inc

1988-03-15 Publication of JPS6359931A publication Critical patent/JPS6359931A/ja

1992-11-18 Publication of JPH0472541B2 publication Critical patent/JPH0472541B2/ja

Status Granted legal-status Critical Current

Links

WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims description 71
239000008103 glucose Substances 0.000 title claims description 71
238000000034 method Methods 0.000 title claims description 30
239000008280 blood Substances 0.000 title claims description 28
210000004369 blood Anatomy 0.000 title claims description 28
239000012528 membrane Substances 0.000 claims description 105
210000004379 membrane Anatomy 0.000 claims description 104
239000001301 oxygen Substances 0.000 claims description 58
229910052760 oxygen Inorganic materials 0.000 claims description 58
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 57
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 56
235000019420 glucose oxidase Nutrition 0.000 claims description 23
210000002200 mouth mucosa Anatomy 0.000 claims description 19
239000000523 sample Substances 0.000 claims description 19
230000002093 peripheral effect Effects 0.000 claims description 18
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238000003780 insertion Methods 0.000 claims description 9
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238000007254 oxidation reaction Methods 0.000 claims description 7
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229920006395 saturated elastomer Polymers 0.000 claims description 5
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239000004417 polycarbonate Substances 0.000 claims description 2
238000009434 installation Methods 0.000 claims 6
150000001875 compounds Chemical class 0.000 claims 4
239000008151 electrolyte solution Substances 0.000 claims 1
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WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 60
108090000790 Enzymes Proteins 0.000 description 20
102000004190 Enzymes Human genes 0.000 description 20
229940088598 enzyme Drugs 0.000 description 20
108010015776 Glucose oxidase Proteins 0.000 description 16
239000004366 Glucose oxidase Substances 0.000 description 16
229940116332 glucose oxidase Drugs 0.000 description 16
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 8
239000000758 substrate Substances 0.000 description 8
238000004458 analytical method Methods 0.000 description 7
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238000006243 chemical reaction Methods 0.000 description 5
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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
239000004020 conductor Substances 0.000 description 4
238000009792 diffusion process Methods 0.000 description 4
239000000463 material Substances 0.000 description 4
238000005502 peroxidation Methods 0.000 description 4
229910052697 platinum Inorganic materials 0.000 description 4
230000002255 enzymatic effect Effects 0.000 description 3
210000003491 skin Anatomy 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
239000004809 Teflon Substances 0.000 description 2
229920006362 Teflon® Polymers 0.000 description 2
XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 2
230000004888 barrier function Effects 0.000 description 2
238000006555 catalytic reaction Methods 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
238000004891 communication Methods 0.000 description 2
230000002950 deficient Effects 0.000 description 2
210000004207 dermis Anatomy 0.000 description 2
238000001514 detection method Methods 0.000 description 2
206010012601 diabetes mellitus Diseases 0.000 description 2
239000012530 fluid Substances 0.000 description 2
239000012774 insulation material Substances 0.000 description 2
210000004877 mucosa Anatomy 0.000 description 2
150000002926 oxygen Chemical class 0.000 description 2
230000001681 protective effect Effects 0.000 description 2
229910052709 silver Inorganic materials 0.000 description 2
239000004332 silver Substances 0.000 description 2
238000007920 subcutaneous administration Methods 0.000 description 2
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
206010013786 Dry skin Diseases 0.000 description 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
241000282412 Homo Species 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
238000009529 body temperature measurement Methods 0.000 description 1
239000000872 buffer Substances 0.000 description 1
238000005266 casting Methods 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000005515 coenzyme Substances 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
239000007822 coupling agent Substances 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
229910001882 dioxygen Inorganic materials 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000037336 dry skin Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
238000006911 enzymatic reaction Methods 0.000 description 1
239000003822 epoxy resin Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
210000003722 extracellular fluid Anatomy 0.000 description 1
230000003176 fibrotic effect Effects 0.000 description 1
-1 glucose Chemical class 0.000 description 1
238000007446 glucose tolerance test Methods 0.000 description 1
150000002433 hydrophilic molecules Chemical class 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
238000002513 implantation Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
239000011810 insulating material Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
239000000644 isotonic solution Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
210000000713 mesentery Anatomy 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
210000003097 mucus Anatomy 0.000 description 1
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
GQPLMRYTRLFLPF-UHFFFAOYSA-N nitrous oxide Inorganic materials [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 1
238000006395 oxidase reaction Methods 0.000 description 1
230000010287 polarization Effects 0.000 description 1
238000003969 polarography Methods 0.000 description 1
229920000647 polyepoxide Polymers 0.000 description 1
230000000291 postprandial effect Effects 0.000 description 1
239000003761 preservation solution Substances 0.000 description 1
238000010405 reoxidation reaction Methods 0.000 description 1
230000027756 respiratory electron transport chain Effects 0.000 description 1
238000005070 sampling Methods 0.000 description 1
238000009738 saturating Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000000243 solution Substances 0.000 description 1
241000894007 species Species 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
210000000434 stratum corneum Anatomy 0.000 description 1
230000002277 temperature effect Effects 0.000 description 1
230000008467 tissue growth Effects 0.000 description 1
238000012549 training Methods 0.000 description 1
210000003462 vein Anatomy 0.000 description 1

Landscapes

Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

JP62140155A 1986-06-05 1987-06-05 血液グルコース濃度測定装置 Granted JPS6359931A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US87111486A	1986-06-05	1986-06-05
US007776		1998-01-16
US871114		2001-05-31

Publications (2)

Publication Number	Publication Date
JPS6359931A true JPS6359931A (ja)	1988-03-15
JPH0472541B2 JPH0472541B2 (de)	1992-11-18

Family

ID=25356762

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP62140155A Granted JPS6359931A (ja)	1986-06-05	1987-06-05	血液グルコース濃度測定装置

Country Status (3)

Country	Link
JP (1)	JPS6359931A (de)
AU (1)	AU594159B2 (de)
ZA (1)	ZA874053B (de)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4650547A (en) *	1983-05-19	1987-03-17	The Regents Of The University Of California	Method and membrane applicable to implantable sensor
US4671288A (en) *	1985-06-13	1987-06-09	The Regents Of The University Of California	Electrochemical cell sensor for continuous short-term use in tissues and blood

1987
- 1987-05-28 AU AU73485/87A patent/AU594159B2/en not_active Ceased
- 1987-06-05 JP JP62140155A patent/JPS6359931A/ja active Granted
- 1987-06-05 ZA ZA874053A patent/ZA874053B/xx unknown

Also Published As

Publication number	Publication date
JPH0472541B2 (de)	1992-11-18
AU594159B2 (en)	1990-03-01
ZA874053B (en)	1988-02-24
AU7348587A (en)	1987-12-10

Publication	Publication Date	Title
US4750496A (en)	1988-06-14	Method and apparatus for measuring blood glucose concentration
US4655880A (en)	1987-04-07	Apparatus and method for sensing species, substances and substrates using oxidase
Clark Jr et al.	1973	Differential anodic enzyme polarography for the measurement of glucose
US6893552B1 (en)	2005-05-17	Microsensors for glucose and insulin monitoring
US5476776A (en)	1995-12-19	Immobilized enzymes for use in an electrochemical sensor
JP2606825B2 (ja)	1997-05-07	組織および血液中の連続，短期使用のための電気化学的電池センサ
JP2770250B2 (ja)	1998-06-25	溶液中の成分の量を測定するセンサ
EP0215678B1 (de)	1993-03-03	Einsetzbarer Gas enthaltender Biosensor und Verfahren zur Bestimmung einer Analyte wie Glukose
US5746898A (en)	1998-05-05	Electrochemical-enzymatic sensor
Jaffari et al.	1995	Recent advances in amperometric glucose biosensors for in vivo monitoring
US8277636B2 (en)	2012-10-02	Glucose sensor and glucose level measuring apparatus
EP0127958B2 (de)	1996-04-10	Sensor-Elektroden
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JPH06510684A (ja)	1994-12-01	透析用電極装置
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