JPS6410173A - Method for measuring blood fibrinolytic activity - Google Patents
Method for measuring blood fibrinolytic activityInfo
- Publication number
- JPS6410173A JPS6410173A JP16549287A JP16549287A JPS6410173A JP S6410173 A JPS6410173 A JP S6410173A JP 16549287 A JP16549287 A JP 16549287A JP 16549287 A JP16549287 A JP 16549287A JP S6410173 A JPS6410173 A JP S6410173A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- fibrinolytic activity
- activity
- human
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003480 fibrinolytic effect Effects 0.000 title abstract 6
- 210000004369 blood Anatomy 0.000 title abstract 5
- 239000008280 blood Substances 0.000 title abstract 5
- 101000783712 Homo sapiens Alpha-2-antiplasmin Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000002381 plasma Anatomy 0.000 abstract 2
- 102000001938 Plasminogen Activators Human genes 0.000 abstract 1
- 108010001014 Plasminogen Activators Proteins 0.000 abstract 1
- 102000010752 Plasminogen Inactivators Human genes 0.000 abstract 1
- 108010077971 Plasminogen Inactivators Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 229940127126 plasminogen activator Drugs 0.000 abstract 1
- 239000002797 plasminogen activator inhibitor Substances 0.000 abstract 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
PURPOSE:To easily measure blood fibrinolytic activity by adding a monoclonal antibody which neutralizes the specific antifrbrinolytie activity to the human blood or blood-plasma. CONSTITUTION:The monoclonal antibody which is supplied to the human alpha2-plasmin inhibitor to neutralize the antifibronlytic characteristic of the human alpha2-plasmin inhibitor is added to the human blood or blood-plasma. The direct and rapid measurement of the fibrinolytic activity state by a plasminogen activator and plasminogen activator inhibitor is then enabled. This antibody is particularly effective as the index for the condition of the biofibrinolytic activity such as the promotion of the fibrinolytic activity in the thrombosis and DIC and the degradation in the fibrinolytic activity in diabetes, etc. The blood fibrinolytic activity is thereby easily measured.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62165492A JP2520424B2 (en) | 1987-07-03 | 1987-07-03 | Method for measuring blood fibrinolytic activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62165492A JP2520424B2 (en) | 1987-07-03 | 1987-07-03 | Method for measuring blood fibrinolytic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6410173A true JPS6410173A (en) | 1989-01-13 |
| JP2520424B2 JP2520424B2 (en) | 1996-07-31 |
Family
ID=15813428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62165492A Expired - Fee Related JP2520424B2 (en) | 1987-07-03 | 1987-07-03 | Method for measuring blood fibrinolytic activity |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2520424B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5810523A (en) * | 1995-02-28 | 1998-09-22 | Kabushiki Kaisha Miyanaga | Apparatus for drilling a hole having an undercut space |
| WO2023074864A1 (en) * | 2021-10-29 | 2023-05-04 | 国立大学法人浜松医科大学 | Method for evaluating fibrinolysis resistance activity in blood plasma |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58209999A (en) * | 1982-05-13 | 1983-12-07 | ネ−デルランドセ・セントラレ・オルガニザテイエ・フ−ル・テゲパスト−ナトウ−ルベテンシヤツペリ−ク・オンデルツエク | Method and kit for inspecting activity of tissue plasminogen activator |
| JPS60222426A (en) * | 1984-04-17 | 1985-11-07 | Teijin Ltd | Monoclonal antibody, hybridoma cell, and preparation of monoclonal antibody |
| JPS6197230A (en) * | 1984-10-18 | 1986-05-15 | Teijin Ltd | Selective adsorbent for human alpha2-plasmin inhibitor and separation of human alpha2-plasmin inhibitor in human plasma |
-
1987
- 1987-07-03 JP JP62165492A patent/JP2520424B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58209999A (en) * | 1982-05-13 | 1983-12-07 | ネ−デルランドセ・セントラレ・オルガニザテイエ・フ−ル・テゲパスト−ナトウ−ルベテンシヤツペリ−ク・オンデルツエク | Method and kit for inspecting activity of tissue plasminogen activator |
| JPS60222426A (en) * | 1984-04-17 | 1985-11-07 | Teijin Ltd | Monoclonal antibody, hybridoma cell, and preparation of monoclonal antibody |
| JPS6197230A (en) * | 1984-10-18 | 1986-05-15 | Teijin Ltd | Selective adsorbent for human alpha2-plasmin inhibitor and separation of human alpha2-plasmin inhibitor in human plasma |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5810523A (en) * | 1995-02-28 | 1998-09-22 | Kabushiki Kaisha Miyanaga | Apparatus for drilling a hole having an undercut space |
| WO2023074864A1 (en) * | 2021-10-29 | 2023-05-04 | 国立大学法人浜松医科大学 | Method for evaluating fibrinolysis resistance activity in blood plasma |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2520424B2 (en) | 1996-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |