JPS6415A - Absorption-improving drug preparation - Google Patents

Absorption-improving drug preparation

Info

Publication number
JPS6415A
JPS6415A JP63061930A JP6193088A JPS6415A JP S6415 A JPS6415 A JP S6415A JP 63061930 A JP63061930 A JP 63061930A JP 6193088 A JP6193088 A JP 6193088A JP S6415 A JPS6415 A JP S6415A
Authority
JP
Japan
Prior art keywords
capsule
oils
drug
preparation
miniature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63061930A
Other languages
Japanese (ja)
Other versions
JPH0354926B2 (en
JPH0115A (en
Inventor
Shimesu Motoyama
Satoru Sato
Seiichi Umeda
Hirotsune Yasumi
Emiko Sudo
Takuichi Tsujino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Freund Corp
Original Assignee
Freund Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Freund Corp filed Critical Freund Corp
Priority to JP63-61930A priority Critical patent/JPH0115A/en
Priority claimed from JP63-61930A external-priority patent/JPH0115A/en
Publication of JPS6415A publication Critical patent/JPS6415A/en
Publication of JPH0115A publication Critical patent/JPH0115A/en
Publication of JPH0354926B2 publication Critical patent/JPH0354926B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: To obtain a drug preparation having improved absorptivity of a drug and remarkably improved bioavailability, by dispersing a hardly water-soluble solid drug in oils which are liquid at normal temperature, filling the dispersion in a seamless miniature capsule and integrating the capsule and a digestive enzyme in each preparation unit.
CONSTITUTION: A hardly water-soluble solid drug is dispersed on oils which are liquid at normal temperature (e.g. fats and oils, essential oil or mineral oil) in molecular state and/or in the state of fine particles, the dispersion is filled in a seamless miniature capsule having a particle diameter of 3W1mm and the surface of the capsule is coated with a group of enzymes containing digestive enzyme to obtain the objective absorption-improving preparation. As an alternative method, said miniature capsule is filled in other capsule together with the enzyme group. The oils are preferably those having high affinity with the solid drug as far as possible.
COPYRIGHT: (C)1989,JPO&Japio
JP63-61930A 1988-03-17 Absorption improving preparation Granted JPH0115A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63-61930A JPH0115A (en) 1988-03-17 Absorption improving preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63-61930A JPH0115A (en) 1988-03-17 Absorption improving preparation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP55146362A Division JPS5770815A (en) 1980-10-21 1980-10-21 Absorption improver

Publications (3)

Publication Number Publication Date
JPS6415A true JPS6415A (en) 1989-01-05
JPH0115A JPH0115A (en) 1989-01-05
JPH0354926B2 JPH0354926B2 (en) 1991-08-21

Family

ID=

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683858A (en) * 1985-06-17 1987-08-04 Nippondenso Co., Ltd. Apparatus for controlling engine
US6895826B1 (en) 1998-05-29 2005-05-24 Oval Corporation Coriolis mass flowmeter
JP2006521366A (en) * 2003-03-28 2006-09-21 シグモイド・バイオテクノロジーズ・リミテッド Solid oral dosage forms containing seamless microcapsules
KR100762304B1 (en) 2005-07-22 2007-10-05 넨시스(주) Spherical Digestive Enzyme Granules and Preparation Method thereof
JP2008109910A (en) * 2006-10-31 2008-05-15 Toshihiro Nomura Enzyme-compounded granule acting in intestine, and enzyme-compounded food using the enzyme-compounded granule
JP2009046498A (en) * 1995-06-07 2009-03-05 Eastman Chem Co Use of essential oils to enhance the bioavailability of oral pharmacological compounds
WO2009087938A1 (en) * 2008-01-10 2009-07-16 Takeda Pharmaceutical Company Limited Capsule formulation
DE112007002244T5 (en) 2006-09-28 2009-07-30 Mitsubishi Electric Corp. Error detection device, error detection method and error detection program
WO2017022248A1 (en) * 2015-08-04 2017-02-09 富士カプセル株式会社 Enteric capsule
US9675558B2 (en) 2007-04-04 2017-06-13 Sigmoid Pharma Limited Pharmaceutical cyclosporin compositions
US9821024B2 (en) 2010-11-25 2017-11-21 Sigmoid Pharma Limited Immunomodulatory compositions
US9878036B2 (en) 2009-08-12 2018-01-30 Sigmoid Pharma Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
US9950051B2 (en) 2012-07-05 2018-04-24 Sigmoid Pharma Limited Formulations
US9999651B2 (en) 2009-05-18 2018-06-19 Sigmoid Pharma Limited Composition comprising oil drops
US10434138B2 (en) 2013-11-08 2019-10-08 Sublimity Therapeutics Limited Formulations
US10993987B2 (en) 2014-11-07 2021-05-04 Sublimity Therapeutics Limited Compositions comprising Cyclosporin

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683858A (en) * 1985-06-17 1987-08-04 Nippondenso Co., Ltd. Apparatus for controlling engine
JP2009046498A (en) * 1995-06-07 2009-03-05 Eastman Chem Co Use of essential oils to enhance the bioavailability of oral pharmacological compounds
US6895826B1 (en) 1998-05-29 2005-05-24 Oval Corporation Coriolis mass flowmeter
JP2006521366A (en) * 2003-03-28 2006-09-21 シグモイド・バイオテクノロジーズ・リミテッド Solid oral dosage forms containing seamless microcapsules
JP2011121974A (en) * 2003-03-28 2011-06-23 Sigmoid Pharma Ltd Solid oral dosage form containing seamless microcapsule
KR100762304B1 (en) 2005-07-22 2007-10-05 넨시스(주) Spherical Digestive Enzyme Granules and Preparation Method thereof
DE112007002244T5 (en) 2006-09-28 2009-07-30 Mitsubishi Electric Corp. Error detection device, error detection method and error detection program
JP2008109910A (en) * 2006-10-31 2008-05-15 Toshihiro Nomura Enzyme-compounded granule acting in intestine, and enzyme-compounded food using the enzyme-compounded granule
US9675558B2 (en) 2007-04-04 2017-06-13 Sigmoid Pharma Limited Pharmaceutical cyclosporin compositions
US10434140B2 (en) 2007-04-04 2019-10-08 Sublimity Therapeutics Limited Pharmaceutical cyclosporin compositions
US10434139B2 (en) 2007-04-04 2019-10-08 Sublimity Therapeutics Limited Oral pharmaceutical composition
US9844513B2 (en) 2007-04-04 2017-12-19 Sigmoid Pharma Limited Oral pharmaceutical composition
JP5421126B2 (en) * 2008-01-10 2014-02-19 武田薬品工業株式会社 Capsule formulation
EP2455071A1 (en) * 2008-01-10 2012-05-23 Takeda Pharmaceutical Company Limited Capsule Formulation
WO2009087938A1 (en) * 2008-01-10 2009-07-16 Takeda Pharmaceutical Company Limited Capsule formulation
US9999651B2 (en) 2009-05-18 2018-06-19 Sigmoid Pharma Limited Composition comprising oil drops
US9878036B2 (en) 2009-08-12 2018-01-30 Sigmoid Pharma Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
US9821024B2 (en) 2010-11-25 2017-11-21 Sigmoid Pharma Limited Immunomodulatory compositions
US9950051B2 (en) 2012-07-05 2018-04-24 Sigmoid Pharma Limited Formulations
US10434138B2 (en) 2013-11-08 2019-10-08 Sublimity Therapeutics Limited Formulations
US10993987B2 (en) 2014-11-07 2021-05-04 Sublimity Therapeutics Limited Compositions comprising Cyclosporin
WO2017022248A1 (en) * 2015-08-04 2017-02-09 富士カプセル株式会社 Enteric capsule

Also Published As

Publication number Publication date
JPH0354926B2 (en) 1991-08-21

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