JPS6416708A - Composition for extracting sphingolipid and method for extraction thereof - Google Patents
Composition for extracting sphingolipid and method for extraction thereofInfo
- Publication number
- JPS6416708A JPS6416708A JP62170752A JP17075287A JPS6416708A JP S6416708 A JPS6416708 A JP S6416708A JP 62170752 A JP62170752 A JP 62170752A JP 17075287 A JP17075287 A JP 17075287A JP S6416708 A JPS6416708 A JP S6416708A
- Authority
- JP
- Japan
- Prior art keywords
- sphingolipid
- composition
- agent
- sulfatide
- sphingomyelin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 150000003408 sphingolipids Chemical class 0.000 title abstract 3
- 238000000605 extraction Methods 0.000 title abstract 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- 229930183167 cerebroside Natural products 0.000 abstract 2
- RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 206010048218 Xeroderma Diseases 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 206010021198 ichthyosis Diseases 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012046 mixed solvent Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000003223 protective agent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 abstract 1
- 230000009278 visceral effect Effects 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PURPOSE:To obtain the titled composition, containing cerebroside, sulfatide and sphingomyelin in specific amounts or more as main constituent substances and useful as an emulsion stabilizer for cosmetics or medicines, liposome forming agent, etc. CONSTITUTION:A sphingolipid contained in a visceral tissue, such as bovine brain, is extracted. In the process, a mixed solvent containing hexane and isopropanol at 9:5 ratio of the former to the latter is used a solvent in crude extraction thereof to efficiently afford the aimed sphingolipid extract composition, containing cerebroside, sulfatide and sphingomyelin as main constituent substances in a high purity of >=30.0% when determined as sphingosine and useful as the above-mentioned stabilizer, agent and a protecting agent for the skin or hair, remedy for xeroderma accompanied by pruritis, etc., on an industrial production scale by simple operation. Furthermore, phospholipid can also be extracted in high purity without waste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62170752A JPS6416708A (en) | 1987-07-08 | 1987-07-08 | Composition for extracting sphingolipid and method for extraction thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62170752A JPS6416708A (en) | 1987-07-08 | 1987-07-08 | Composition for extracting sphingolipid and method for extraction thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6416708A true JPS6416708A (en) | 1989-01-20 |
Family
ID=15910732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62170752A Pending JPS6416708A (en) | 1987-07-08 | 1987-07-08 | Composition for extracting sphingolipid and method for extraction thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6416708A (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692781A1 (en) * | 1992-06-24 | 1993-12-31 | Sederma Sa | Cosmetic compsn., for improving skin - contains sphingomyelin(s) of milk or fish as natural precursor ceramide(s), avoiding use of sphingo:lipid(s) from mammals, esp. cattle |
| JPH06179613A (en) * | 1992-12-12 | 1994-06-28 | Taiyo Kagaku Co Ltd | Cosmetics |
| JPH06199627A (en) * | 1992-12-26 | 1994-07-19 | Taiyo Kagaku Co Ltd | Cosmetics |
| JPH08506811A (en) * | 1993-02-11 | 1996-07-23 | スベンスカ、メジェリールナス、リクスフェレニング、エコノミー、アクチェボラーグ | Sphingomyelin extraction method |
| JPH08217666A (en) * | 1995-02-10 | 1996-08-27 | Mikimoto Pharmaceut Co Ltd | Oil-in-water type cream base |
| FR2752526A1 (en) * | 1996-08-26 | 1998-02-27 | Dong Kook Pharm Co Ltd | ANTIHEMOLYTIC LIPOSOMAL PREPARATION |
| US5912152A (en) * | 1995-02-28 | 1999-06-15 | Yakurigaku Chuo Kenkyusho | Process for preparing sphingomyelin and ceramide from erythrocyte as a starting material and a curing agent or cosmetic formulated with ceramide |
| JP2002003378A (en) * | 2000-06-22 | 2002-01-09 | Kanebo Ltd | External antipruritic agent |
| JP2005002324A (en) * | 2003-03-19 | 2005-01-06 | Fisheries Research Agency | Method for producing sphingolipids from aquatic organisms |
| JPWO2004009041A1 (en) * | 2002-07-22 | 2005-12-08 | 辻製油株式会社 | Skin cosmetic composition |
| WO2007034927A1 (en) * | 2005-09-22 | 2007-03-29 | Snow Brand Milk Products Co., Ltd. | Medicine, food and drink or feed containing sphingomyelin |
| JP2007112793A (en) * | 2005-09-22 | 2007-05-10 | Snow Brand Milk Prod Co Ltd | Sphingomyelin-containing medicine, food or drink or feed |
| JP2012167104A (en) * | 2005-09-22 | 2012-09-06 | Snow Brand Milk Products Co Ltd | Sphingomyelin-containing medicine |
| JP2018524286A (en) * | 2015-05-22 | 2018-08-30 | バイオイベリカ ソシエダッド アノニマ | Process for preparing animal brain extracts |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60163888A (en) * | 1984-02-03 | 1985-08-26 | Pola Chem Ind Inc | Production of lipid component |
| JPS60163806A (en) * | 1984-02-03 | 1985-08-26 | Pola Chem Ind Inc | Skin pharmaceutical for external use |
| JPS61260008A (en) * | 1985-05-15 | 1986-11-18 | Sunstar Inc | Cosmetic composition |
| JPS61271205A (en) * | 1985-05-24 | 1986-12-01 | Kanebo Ltd | Skin cosmetic |
| JPS61286307A (en) * | 1985-06-13 | 1986-12-16 | Kanebo Ltd | Skin cosmetic |
| JPS6256414A (en) * | 1985-09-06 | 1987-03-12 | Noebia:Kk | Cosmetic |
-
1987
- 1987-07-08 JP JP62170752A patent/JPS6416708A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60163888A (en) * | 1984-02-03 | 1985-08-26 | Pola Chem Ind Inc | Production of lipid component |
| JPS60163806A (en) * | 1984-02-03 | 1985-08-26 | Pola Chem Ind Inc | Skin pharmaceutical for external use |
| JPS61260008A (en) * | 1985-05-15 | 1986-11-18 | Sunstar Inc | Cosmetic composition |
| JPS61271205A (en) * | 1985-05-24 | 1986-12-01 | Kanebo Ltd | Skin cosmetic |
| JPS61286307A (en) * | 1985-06-13 | 1986-12-16 | Kanebo Ltd | Skin cosmetic |
| JPS6256414A (en) * | 1985-09-06 | 1987-03-12 | Noebia:Kk | Cosmetic |
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692781A1 (en) * | 1992-06-24 | 1993-12-31 | Sederma Sa | Cosmetic compsn., for improving skin - contains sphingomyelin(s) of milk or fish as natural precursor ceramide(s), avoiding use of sphingo:lipid(s) from mammals, esp. cattle |
| JPH06179613A (en) * | 1992-12-12 | 1994-06-28 | Taiyo Kagaku Co Ltd | Cosmetics |
| JPH06199627A (en) * | 1992-12-26 | 1994-07-19 | Taiyo Kagaku Co Ltd | Cosmetics |
| JPH08506811A (en) * | 1993-02-11 | 1996-07-23 | スベンスカ、メジェリールナス、リクスフェレニング、エコノミー、アクチェボラーグ | Sphingomyelin extraction method |
| AU675116B2 (en) * | 1993-02-11 | 1997-01-23 | Svenska Mejeriernas Riksforening Ekonomi Ab | Method for extracting sphingomyelin from phospholipid con taining fat concentrate |
| JPH08217666A (en) * | 1995-02-10 | 1996-08-27 | Mikimoto Pharmaceut Co Ltd | Oil-in-water type cream base |
| US5912152A (en) * | 1995-02-28 | 1999-06-15 | Yakurigaku Chuo Kenkyusho | Process for preparing sphingomyelin and ceramide from erythrocyte as a starting material and a curing agent or cosmetic formulated with ceramide |
| FR2752526A1 (en) * | 1996-08-26 | 1998-02-27 | Dong Kook Pharm Co Ltd | ANTIHEMOLYTIC LIPOSOMAL PREPARATION |
| JP2002003378A (en) * | 2000-06-22 | 2002-01-09 | Kanebo Ltd | External antipruritic agent |
| JPWO2004009041A1 (en) * | 2002-07-22 | 2005-12-08 | 辻製油株式会社 | Skin cosmetic composition |
| JP2005002324A (en) * | 2003-03-19 | 2005-01-06 | Fisheries Research Agency | Method for producing sphingolipids from aquatic organisms |
| WO2007034927A1 (en) * | 2005-09-22 | 2007-03-29 | Snow Brand Milk Products Co., Ltd. | Medicine, food and drink or feed containing sphingomyelin |
| JP2007112793A (en) * | 2005-09-22 | 2007-05-10 | Snow Brand Milk Prod Co Ltd | Sphingomyelin-containing medicine, food or drink or feed |
| JP2012167104A (en) * | 2005-09-22 | 2012-09-06 | Snow Brand Milk Products Co Ltd | Sphingomyelin-containing medicine |
| US9186366B2 (en) | 2005-09-22 | 2015-11-17 | Megmilk Snow Brand Co., Ltd. | Medicine, food and drink or feed containing sphingomyelin |
| JP2018524286A (en) * | 2015-05-22 | 2018-08-30 | バイオイベリカ ソシエダッド アノニマ | Process for preparing animal brain extracts |
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