JPS6426558A - Novel indolylpropanol, manufacture and drug - Google Patents
Novel indolylpropanol, manufacture and drugInfo
- Publication number
- JPS6426558A JPS6426558A JP63159056A JP15905688A JPS6426558A JP S6426558 A JPS6426558 A JP S6426558A JP 63159056 A JP63159056 A JP 63159056A JP 15905688 A JP15905688 A JP 15905688A JP S6426558 A JPS6426558 A JP S6426558A
- Authority
- JP
- Japan
- Prior art keywords
- denotes
- group
- alkylsulphonylalkoxy
- alkylsulphinylalkoxy
- alkoxyalkylsulphinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XQEGFCUBRXTJNF-UHFFFAOYSA-N 1-(1h-indol-2-yl)propan-1-ol Chemical compound C1=CC=C2NC(C(O)CC)=CC2=C1 XQEGFCUBRXTJNF-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 difluoromethoxy, difluoromethylthio Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 4
- 125000004984 dialkylaminoalkoxy group Chemical group 0.000 abstract 4
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004076 pyridyl group Chemical group 0.000 abstract 3
- 125000001544 thienyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020852 Hypertonia Diseases 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000009090 positive inotropic effect Effects 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3721260.5 | 1987-06-27 | ||
| DE19873721260 DE3721260A1 (de) | 1987-06-27 | 1987-06-27 | Neue indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6426558A true JPS6426558A (en) | 1989-01-27 |
| JP2577442B2 JP2577442B2 (ja) | 1997-01-29 |
Family
ID=6330413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63159056A Expired - Fee Related JP2577442B2 (ja) | 1987-06-27 | 1988-06-27 | 新規インドリルプロパノール及びその製造方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4935414A (ja) |
| EP (1) | EP0297380B1 (ja) |
| JP (1) | JP2577442B2 (ja) |
| AT (1) | ATE112565T1 (ja) |
| AU (1) | AU609359B2 (ja) |
| CA (1) | CA1312078C (ja) |
| CY (1) | CY1910A (ja) |
| DE (2) | DE3721260A1 (ja) |
| ES (1) | ES2064328T3 (ja) |
| HK (1) | HK87696A (ja) |
| ZA (1) | ZA884388B (ja) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009220797A (ja) * | 2008-03-19 | 2009-10-01 | Tokuo Suzuki | 特に広範囲な視野を持つバックミラー |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ234087A (en) * | 1989-06-19 | 1991-08-27 | Teikoku Hormone Mfg Co Ltd | 2-(3-aryloxy(2-hydroxy-propylamino))-2-methylpropyl- aminophenyl pyridazine derivatives |
| US5221674A (en) * | 1989-06-19 | 1993-06-22 | Teikoku Hormone Mfg. Co., Ltd. | Pyridazinone derivatives |
| DE4002391A1 (de) * | 1990-01-27 | 1991-08-01 | Beiersdorf Ag | Indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
| CA2154318A1 (en) * | 1994-08-25 | 1996-02-26 | Richard David Poole | Adaptable radio telephone handset |
| US5789402A (en) * | 1995-01-17 | 1998-08-04 | Eli Lilly Company | Compounds having effects on serotonin-related systems |
| US5614523A (en) * | 1995-01-17 | 1997-03-25 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5627196A (en) * | 1995-01-17 | 1997-05-06 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5741789A (en) | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| CA2228938A1 (en) * | 1995-10-03 | 1997-04-10 | Beiersdorf-Lilly Gmbh | Treatment of atherosclerosis |
| EP0766962A3 (en) * | 1995-10-03 | 2000-05-10 | Beiersdorf-Lilly GmbH | Treatment of atherosclerosis |
| US5843938A (en) * | 1995-10-03 | 1998-12-01 | Beiersdorf-Lilly Gmbh | Treatment of atherosclerosis |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4137331A (en) * | 1974-06-19 | 1979-01-30 | Sandoz Ltd. | 3-Piperidino-2-hydroxypropoxy substituted-2-indolinones |
| DE2737630A1 (de) * | 1977-08-20 | 1979-03-01 | Boehringer Mannheim Gmbh | Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE2651574A1 (de) * | 1976-11-12 | 1978-05-18 | Boehringer Mannheim Gmbh | Ein neues aminopropanol-derivat und verfahren zu dessen herstellung |
| DE2824677A1 (de) * | 1978-06-06 | 1979-12-20 | Hoechst Ag | Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung |
| WO1980000152A1 (fr) * | 1978-07-03 | 1980-02-07 | Sandoz Ag | Derives d'un 3-aminopropoxy-aryle, leur preparation et utilisation |
| EP0025111B1 (en) * | 1979-08-10 | 1984-07-25 | Sandoz Ag | 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them |
| DE3200304A1 (de) * | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| FR2543952B1 (fr) * | 1982-09-03 | 1986-02-21 | Bristol Myers Co | Composes hydrocarbones heterocycliques appartenant aux series indoliques et leur application pharmacologique |
| DE3524955A1 (de) * | 1984-07-19 | 1986-01-30 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| GB2163150B (en) * | 1984-07-19 | 1988-05-25 | Sandoz Ltd | 3-aminopropoxyaryl derivatives |
| GB8502887D0 (en) * | 1985-02-05 | 1985-03-06 | Sandoz Ltd | Pharmaceutical compositions |
-
1987
- 1987-06-27 DE DE19873721260 patent/DE3721260A1/de not_active Ceased
-
1988
- 1988-06-17 US US07/207,997 patent/US4935414A/en not_active Expired - Lifetime
- 1988-06-20 AT AT88109770T patent/ATE112565T1/de not_active IP Right Cessation
- 1988-06-20 EP EP88109770A patent/EP0297380B1/de not_active Expired - Lifetime
- 1988-06-20 ZA ZA884388A patent/ZA884388B/xx unknown
- 1988-06-20 ES ES88109770T patent/ES2064328T3/es not_active Expired - Lifetime
- 1988-06-20 DE DE3851720T patent/DE3851720D1/de not_active Expired - Fee Related
- 1988-06-22 CA CA000570083A patent/CA1312078C/en not_active Expired - Lifetime
- 1988-06-24 AU AU18334/88A patent/AU609359B2/en not_active Ceased
- 1988-06-27 JP JP63159056A patent/JP2577442B2/ja not_active Expired - Fee Related
-
1996
- 1996-05-16 HK HK87696A patent/HK87696A/xx not_active IP Right Cessation
-
1997
- 1997-03-07 CY CY191097A patent/CY1910A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009220797A (ja) * | 2008-03-19 | 2009-10-01 | Tokuo Suzuki | 特に広範囲な視野を持つバックミラー |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0297380A3 (en) | 1990-05-09 |
| JP2577442B2 (ja) | 1997-01-29 |
| CY1910A (en) | 1997-03-07 |
| HK87696A (en) | 1996-05-24 |
| ES2064328T3 (es) | 1995-02-01 |
| EP0297380A2 (de) | 1989-01-04 |
| US4935414A (en) | 1990-06-19 |
| ZA884388B (en) | 1989-03-29 |
| DE3721260A1 (de) | 1989-01-12 |
| EP0297380B1 (de) | 1994-10-05 |
| DE3851720D1 (de) | 1994-11-10 |
| AU1833488A (en) | 1989-01-05 |
| CA1312078C (en) | 1992-12-29 |
| AU609359B2 (en) | 1991-04-26 |
| ATE112565T1 (de) | 1994-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |