JPS6426579A - Production of guanine crystal - Google Patents
Production of guanine crystalInfo
- Publication number
- JPS6426579A JPS6426579A JP18139387A JP18139387A JPS6426579A JP S6426579 A JPS6426579 A JP S6426579A JP 18139387 A JP18139387 A JP 18139387A JP 18139387 A JP18139387 A JP 18139387A JP S6426579 A JPS6426579 A JP S6426579A
- Authority
- JP
- Japan
- Prior art keywords
- guanine
- mineral acid
- solution
- crystal
- alkali
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 title abstract 16
- 239000013078 crystal Substances 0.000 title abstract 5
- 239000002253 acid Substances 0.000 abstract 5
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 5
- 239000011707 mineral Substances 0.000 abstract 5
- 239000003513 alkali Substances 0.000 abstract 4
- 239000000243 solution Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000012266 salt solution Substances 0.000 abstract 1
Abstract
PURPOSE:To obtain the titled crystal having large crystal particle size in high purity, by crystallizing a crude guanine as a guanine mineral acid salt so as to exclude a nucleic acid-related substance accompanying as an impurity and colored substance, then dissolving the salt in an alkali while heating, neutralizing the salt solution with a mineral acid and crystallizing the neutralized product. CONSTITUTION:An alkali solution of guanine heated at >=60 deg.C, especially heated mineral acid solution of crude guanine containing hypoxanthine is cooled and crystallized and an alkali is added to the resultant guanine mineral acid salt and while or after adding a mineral acid to the resultant alkali solution of guanine heated at >=60 deg.C, the solution is cooled to 20 deg.C to provide the guanine crystal having excellent deliquid properties and short filtration time. The crystal is readily separated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18139387A JPS6426579A (en) | 1987-07-21 | 1987-07-21 | Production of guanine crystal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18139387A JPS6426579A (en) | 1987-07-21 | 1987-07-21 | Production of guanine crystal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6426579A true JPS6426579A (en) | 1989-01-27 |
Family
ID=16099958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18139387A Pending JPS6426579A (en) | 1987-07-21 | 1987-07-21 | Production of guanine crystal |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6426579A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005113685A1 (en) * | 2004-05-22 | 2005-12-01 | Engelhard Corporation | Natural pearl in butylene glycol |
| JP2020189819A (en) * | 2019-05-24 | 2020-11-26 | 国立大学法人山口大学 | Method for manufacturing guanine crystal |
| JP2023035310A (en) * | 2021-09-01 | 2023-03-13 | 新日本製薬株式会社 | Cosmetic composition, whitening gel cosmetic, cream cosmetic for eye area and cream cosmetic for foundation |
-
1987
- 1987-07-21 JP JP18139387A patent/JPS6426579A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005113685A1 (en) * | 2004-05-22 | 2005-12-01 | Engelhard Corporation | Natural pearl in butylene glycol |
| JP2020189819A (en) * | 2019-05-24 | 2020-11-26 | 国立大学法人山口大学 | Method for manufacturing guanine crystal |
| JP2023035310A (en) * | 2021-09-01 | 2023-03-13 | 新日本製薬株式会社 | Cosmetic composition, whitening gel cosmetic, cream cosmetic for eye area and cream cosmetic for foundation |
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