JPS643196A - Production of 2',3'-dideoxycytidine - Google Patents

Production of 2',3'-dideoxycytidine

Info

Publication number
JPS643196A
JPS643196A JP15454087A JP15454087A JPS643196A JP S643196 A JPS643196 A JP S643196A JP 15454087 A JP15454087 A JP 15454087A JP 15454087 A JP15454087 A JP 15454087A JP S643196 A JPS643196 A JP S643196A
Authority
JP
Japan
Prior art keywords
expressed
formula
compound
bromo
dideoxycytidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15454087A
Other languages
Japanese (ja)
Other versions
JPH0692394B2 (en
JPH013196A (en
Inventor
Yasuko Tsujino
Hajime Matsushita
Yoshihiro Watabe
Hajime Kaneko
Toshimi Takiguchi
Yoshitaka Naoi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UKI GOSEI KOGYO CO Ltd
Japan Tobacco Inc
Original Assignee
UKI GOSEI KOGYO CO Ltd
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UKI GOSEI KOGYO CO Ltd, Japan Tobacco Inc filed Critical UKI GOSEI KOGYO CO Ltd
Priority to JP15454087A priority Critical patent/JPH0692394B2/en
Publication of JPH013196A publication Critical patent/JPH013196A/en
Publication of JPS643196A publication Critical patent/JPS643196A/en
Publication of JPH0692394B2 publication Critical patent/JPH0692394B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a remedy for AIDS (acquired immunodeficiency syndrome) in high yield at a low cost using readily available raw materials, by debrominating and hydrogenating bromo-didehydro- dideoxycytidine.
CONSTITUTION: 2'-Bromo-2',3'-didehydro-2',3'-dideoxycytidine expressed by formula I is debrominated and hydrogenated to afford the aimed compound expressed by formula II. Furthermore, the compound expressed by formula I which is a starting raw material is a novel substance and can be produced by, e.g. mesylating an N,O5'-diacylcytidine, prepared by mesylating cytidine and expressed by formula III to provide an N,O5'-diacyl-O2',O3'-dimesylcytidine expressed by formula IV, reacting the resultant compound with lithium bromide in a nonaqueous solvent to afford an N,O5'-diacyl-O3'-mesyl-2'-bromo-2'-deoxycytidine expressed by formula V and reacting the obtained compound with an alkali metal alcoholate.
COPYRIGHT: (C)1989,JPO&Japio
JP15454087A 1987-06-23 1987-06-23 Method for producing 2 ', 3'-dideoxycytidine Expired - Lifetime JPH0692394B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15454087A JPH0692394B2 (en) 1987-06-23 1987-06-23 Method for producing 2 ', 3'-dideoxycytidine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15454087A JPH0692394B2 (en) 1987-06-23 1987-06-23 Method for producing 2 ', 3'-dideoxycytidine

Publications (3)

Publication Number Publication Date
JPH013196A JPH013196A (en) 1989-01-06
JPS643196A true JPS643196A (en) 1989-01-06
JPH0692394B2 JPH0692394B2 (en) 1994-11-16

Family

ID=15586492

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15454087A Expired - Lifetime JPH0692394B2 (en) 1987-06-23 1987-06-23 Method for producing 2 ', 3'-dideoxycytidine

Country Status (1)

Country Link
JP (1) JPH0692394B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1297565C (en) * 2004-03-15 2007-01-31 陆锦康 Method for preparing 2',3'2-dideoxycytidine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1297565C (en) * 2004-03-15 2007-01-31 陆锦康 Method for preparing 2',3'2-dideoxycytidine

Also Published As

Publication number Publication date
JPH0692394B2 (en) 1994-11-16

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