JPS6434919A - Aerosol preparation for nasal application - Google Patents
Aerosol preparation for nasal applicationInfo
- Publication number
- JPS6434919A JPS6434919A JP19139687A JP19139687A JPS6434919A JP S6434919 A JPS6434919 A JP S6434919A JP 19139687 A JP19139687 A JP 19139687A JP 19139687 A JP19139687 A JP 19139687A JP S6434919 A JPS6434919 A JP S6434919A
- Authority
- JP
- Japan
- Prior art keywords
- propellant gas
- flon
- powder
- liquefied
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000443 aerosol Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000007789 gas Substances 0.000 abstract 6
- 239000003380 propellant Substances 0.000 abstract 6
- 239000000843 powder Substances 0.000 abstract 3
- 239000007788 liquid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical compound O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 abstract 2
- 229960002739 oxaprozin Drugs 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 abstract 1
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 abstract 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- -1 fatty acid sorbitan ester Chemical class 0.000 abstract 1
- 239000003915 liquefied petroleum gas Substances 0.000 abstract 1
- 210000003928 nasal cavity Anatomy 0.000 abstract 1
- 210000002850 nasal mucosa Anatomy 0.000 abstract 1
- 239000004576 sand Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To obtain an aerosol preparation for nasal cavity application, having durable activity, effective at a small amount of application and free from side effects, by suspending oxaprozin powder in liquefied propellant gas. CONSTITUTION:Oxaprozin powder having particle diameter of 1-50mum preferably 5-25mum is added to a liquefied propellant gas such as liquefied petroleum gas or chlorofluorocarbon (e.g. flon 12 or flon 22) which are conventional propellant gases for medical aerosol agent. The amount of the powder is 0.5-10wt.% based on the whole composition. The particles are suspended in the liquefied propellant gas by mixing the propellant gas with a liquid produced by dissolving (A) a nonionic liquid surfactant (e.g. higher fatty acid sorbitan ester such as Span 80 or Span 83) having an HLB of <=10 sand giving low irritancy to nasal mucosa in an amount of 0.1-1wt.% (based on the whole composition) in (B) a solvent (e.g. flon 11) compatible with the liquefied propellant gas.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19139687A JPS6434919A (en) | 1987-07-30 | 1987-07-30 | Aerosol preparation for nasal application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19139687A JPS6434919A (en) | 1987-07-30 | 1987-07-30 | Aerosol preparation for nasal application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6434919A true JPS6434919A (en) | 1989-02-06 |
Family
ID=16273908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19139687A Pending JPS6434919A (en) | 1987-07-30 | 1987-07-30 | Aerosol preparation for nasal application |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6434919A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002529402A (en) * | 1998-11-05 | 2002-09-10 | アストラゼネカ・アクチエボラーグ | Dry powder pharmaceutical formulation |
-
1987
- 1987-07-30 JP JP19139687A patent/JPS6434919A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002529402A (en) * | 1998-11-05 | 2002-09-10 | アストラゼネカ・アクチエボラーグ | Dry powder pharmaceutical formulation |
| JP4843140B2 (en) * | 1998-11-05 | 2011-12-21 | アストラゼネカ・アクチエボラーグ | Dry powder pharmaceutical formulation |
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